Protein Alignment twy and FBF1

DIOPT Version :10

• Sequence 1: NP_648507.1
• Gene: twy / 39330
• FlyBaseID: FBgn0036206
• Length: 928
• Species: Drosophila melanogaster
• Sequence 2: NP_001306122.1
• Gene: FBF1 / 85302
• HGNCID: 24674
• Length: 1148
• Species: Homo sapiens
• Alignment Length: 1068
• Identity: 236/1068 - (22%)
• Similarity: 429/1068 - (40%)
• Gaps: 257/1068 - (24%)

  Fly     5 DDPLAELLSDNSLDNDNFFETPAGVGHKKPAKLAKPKGKLEDLFGIQEETEADVQGQGTGARKTP 69
            :|||..|||.:.          .|:..:.|...:|.         ..:::.:.|:.||.....||
Human   161 EDPLRGLLSYDE----------GGITKQPPVTQSKT---------ASDKSPSTVRDQGPSIPLTP 206

  Fly    70 NAISTPRIVKQKPSISLD--DDLVEDDDLGFDPKRPKSGGTKRSLFDDLLTSNAEPKKNIFDEIL 132
            .  .||  :::|..:..|  ||::.....|..||     ..||.:.|.   ....|.::..||:|
Human   207 G--DTP--IRKKEELLFDDGDDIMATLGFGDSPK-----AEKRQIGDQ---EGPRPARSTLDELL 259

  Fly   133 A-GDAVK---RPAT------------SKPSMSRQ---STDTTTDNSQARPKTSTGRRSSAQSAT- 177
            . |.|.|   ||.|            .:|..|..   ..|.|....|....:|.||:|..||.:
Human   260 GRGMATKLLARPGTGEHREFKLDKKYQRPQDSEDMWGDEDFTFGAYQPTVVSSEGRQSRRQSVSR 324

  Fly   178 --INMNADPLGLFGRDTNATVSGMSTPVSKKRGTTADWLGLEQE--------PDQR-------PI 225
              .:..|||.|..|...:..::  |:|:..::| .||||||:.|        |.:.       |:
Human   325 FFADSGADPKGEPGSKQSPPMA--SSPIQPRKG-GADWLGLKDEDLDLFPASPTREAHRESSVPV 386

  Fly   226 TPKA-------------QTAKAQPSSE---SPSK-NTADILRLPDSDEN---------------G 258
            ||..             ..::|:|.:|   ||:| :.|..||....::.               .
Human   387 TPSVPPPASQHSTPAGLPPSRAKPPTEGAGSPAKASQASKLRASKEEKEDWLSHALSRKKSQGLA 451

  Fly   259 MEQEA----------------------------EMAAVPAPSVVTAATQNILM--LSNLNLESNH 293
            .||.|                            |.||....|..||..:..:.  :|...:..||
Human   452 REQHAGTSEGLHLAGTAGHPPSGSQPLTSTQGLEHAAAGGSSGTTARERPCVRPGVSGSPVTQNH 516

  Fly   294 KFNAL-----QQQEAQLVIAAQMKSQERTLLEMQRRQEDQDRKFQALIQQQLQRQQQMEEHIKGQ 353
            ..:||     ::..|...::|   ::..|.....::..:.....|.|:.:.|.|  .:....:.|
Human   517 AASALPTGSPKRGTAPGDLSA---TEPATCFPSTQKPTEPSVPVQPLLPESLAR--SLLPSTEYQ 576

  Fly   354 QERINMHLQLMMSQPVRVQDVVSTPPLVEKPEPEPERKEHHKATSQEQEHLLLLEMDAKRNLLEK 418
            ::.:...:||..| |..:|                      ......|..|..||...::..||:
Human   577 KQLLAAQVQLQCS-PAELQ----------------------AELLHSQARLAELEAQVRKLELER 618

  Fly   419 QRLDELVANMKVNYEQEIEMIDSSYKKQIKVLEEHLSVVEKRLKDENSELRQYYIEKLEKQKEDY 483
            .:.:.|:.:::..::.::|:|:|:::.:|||||......|:||:.||.||...|:.:.::.::..
Human   619 AQHELLLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQAR 683

  Fly   484 VE-------QISSLRQDHEDEVRKLRQ-----------SHELDLEGIRQAKMVELSA---VQDHG 527
            .|       :::::.|:.:.|:.:||:           .||..|:.::..|..|:.|   ...|.
Human   684 AELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHT 748

  Fly   528 NYLDT----LRLASSNLQEL-----RDGMSDNQERERQLEARERRLADQERRLKMDEETADDEKR 583
            ..|::    :...||:|.||     ...::.:||||..:..|:.:|...:.||...:...::|:.
Human   749 RSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERS 813

  Fly   584 RLMELVSTLELQLGRLSKESAEENWQLRQRMSSLEAERKAFEREKEFHREQMQRDEKRVEDLKAL 648
            |..|::..:|.:|...|:...:|.|::....|..|:.::|.|.:::...:||..:...:|..|:.
Human   814 RQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSA 878

  Fly   649 QLAEMERLHHDLQEERNQLTVERQQIELRQQLNEHGDPDRDRRELEAQLQV-----------ARE 702
            .|.|.:.:.....|||.:|..|..:...:|:|::    :|..||.|..|||           |:|
Human   879 LLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSK----ERAEREAERALQVDTQREGTLISLAKE 939

  Fly   703 AIR---RADEERDRYHKLQRE---MEQRKRHL-LDKEH------ALNLKEDELGQATGAYRLATS 754
            ...   ||.|.|....:|..|   :||.::.| |:||.      .:.|:.:|:...:   ::|:.
Human   940 QAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMS---KVASE 1001

  Fly   755 RQHLAEQKAREADQL---LQAKLKVMAKRAQEIAEKEAQLAHERMLVAQDRMALVNLKKQISRSR 816
            :....|:..|||.|:   .||:|:.:.::.:.:.::|..:..|.:.:||.|:.|...::.:..|.
Human  1002 KYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQDLPSSL 1066

  Fly   817 CAICKMGAESAEIAQRRANVNPTAATDLQLPQ----VTPS----HAELLL--KMSQEPGQVQSDI 871
            ..:.......|  |..::.:.|.|.|.....|    :.||    ||.|.|  .|:::
Human  1067 VGLFPRAQGPA--ASSQSALMPPAPTTRWCSQPPTGLDPSPLHLHARLALLRHMAEQ-------- 1121

  Fly   872 VDRMLDEN----IEASYRRMYNAPPSSS 895
             ||...||    :|...:..||....|:
Human  1122 -DRDFLENEQFFLETLKKGSYNLTSHSA 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
twy	NP_648507.1	PRK12323	<139..320	CDD:481241	59/280 (21%)
		COG2433	<416..>502	CDD:441980	22/92 (24%)
		Smc	<467..>805	CDD:440809	91/394 (23%)
FBF1	NP_001306122.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	103..212		16/73 (22%)
		PHA03247	<116..579	CDD:223021	97/456 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..558		72/346 (21%)
		Smc	<574..>1062	CDD:440809	118/517 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1077..1100		6/24 (25%)