DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5964 and FBF1

DIOPT Version :9

Sequence 1:	NP_648507.1	Gene:	CG5964 / 39330	FlyBaseID:	FBgn0036206	Length:	928	Species:	Drosophila melanogaster
Sequence 2:	NP_001306122.1	Gene:	FBF1 / 85302	HGNCID:	24674	Length:	1148	Species:	Homo sapiens

Alignment Length:	1068	Identity:	236/1068 - (22%)
Similarity:	429/1068 - (40%)	Gaps:	257/1068 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DDPLAELLSDNSLDNDNFFETPAGVGHKKPAKLAKPKGKLEDLFGIQEETEADVQGQGTGARKTP 69
            :|||..|||.:.          .|:..:.|...:|.         ..:::.:.|:.||.....||
Human   161 EDPLRGLLSYDE----------GGITKQPPVTQSKT---------ASDKSPSTVRDQGPSIPLTP 206

  Fly    70 NAISTPRIVKQKPSISLD--DDLVEDDDLGFDPKRPKSGGTKRSLFDDLLTSNAEPKKNIFDEIL 132
            .  .||  :::|..:..|  ||::.....|..||     ..||.:.|.   ....|.::..||:|
Human   207 G--DTP--IRKKEELLFDDGDDIMATLGFGDSPK-----AEKRQIGDQ---EGPRPARSTLDELL 259

  Fly   133 A-GDAVK---RPAT------------SKPSMSRQ---STDTTTDNSQARPKTSTGRRSSAQSAT- 177
            . |.|.|   ||.|            .:|..|..   ..|.|....|....:|.||:|..||.:
Human   260 GRGMATKLLARPGTGEHREFKLDKKYQRPQDSEDMWGDEDFTFGAYQPTVVSSEGRQSRRQSVSR 324

  Fly   178 --INMNADPLGLFGRDTNATVSGMSTPVSKKRGTTADWLGLEQE--------PDQR-------PI 225
              .:..|||.|..|...:..::  |:|:..::| .||||||:.|        |.:.       |:
Human   325 FFADSGADPKGEPGSKQSPPMA--SSPIQPRKG-GADWLGLKDEDLDLFPASPTREAHRESSVPV 386

  Fly   226 TPKA-------------QTAKAQPSSE---SPSK-NTADILRLPDSDEN---------------G 258
            ||..             ..::|:|.:|   ||:| :.|..||....::.               .
Human   387 TPSVPPPASQHSTPAGLPPSRAKPPTEGAGSPAKASQASKLRASKEEKEDWLSHALSRKKSQGLA 451

  Fly   259 MEQEA----------------------------EMAAVPAPSVVTAATQNILM--LSNLNLESNH 293
            .||.|                            |.||....|..||..:..:.  :|...:..||
Human   452 REQHAGTSEGLHLAGTAGHPPSGSQPLTSTQGLEHAAAGGSSGTTARERPCVRPGVSGSPVTQNH 516

  Fly   294 KFNAL-----QQQEAQLVIAAQMKSQERTLLEMQRRQEDQDRKFQALIQQQLQRQQQMEEHIKGQ 353
            ..:||     ::..|...::|   ::..|.....::..:.....|.|:.:.|.|  .:....:.|
Human   517 AASALPTGSPKRGTAPGDLSA---TEPATCFPSTQKPTEPSVPVQPLLPESLAR--SLLPSTEYQ 576

  Fly   354 QERINMHLQLMMSQPVRVQDVVSTPPLVEKPEPEPERKEHHKATSQEQEHLLLLEMDAKRNLLEK 418
            ::.:...:||..| |..:|                      ......|..|..||...::..||:
Human   577 KQLLAAQVQLQCS-PAELQ----------------------AELLHSQARLAELEAQVRKLELER 618

  Fly   419 QRLDELVANMKVNYEQEIEMIDSSYKKQIKVLEEHLSVVEKRLKDENSELRQYYIEKLEKQKEDY 483
            .:.:.|:.:::..::.::|:|:|:::.:|||||......|:||:.||.||...|:.:.::.::..
Human   619 AQHELLLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQAR 683

  Fly   484 VE-------QISSLRQDHEDEVRKLRQ-----------SHELDLEGIRQAKMVELSA---VQDHG 527
            .|       :::::.|:.:.|:.:||:           .||..|:.::..|..|:.|   ...|.
Human   684 AELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHT 748

  Fly   528 NYLDT----LRLASSNLQEL-----RDGMSDNQERERQLEARERRLADQERRLKMDEETADDEKR 583
            ..|::    :...||:|.||     ...::.:||||..:..|:.:|...:.||...:...::|:.
Human   749 RSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERS 813

  Fly   584 RLMELVSTLELQLGRLSKESAEENWQLRQRMSSLEAERKAFEREKEFHREQMQRDEKRVEDLKAL 648
            |..|::..:|.:|...|:...:|.|::....|..|:.::|.|.:::...:||..:...:|..|:.
Human   814 RQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSA 878

  Fly   649 QLAEMERLHHDLQEERNQLTVERQQIELRQQLNEHGDPDRDRRELEAQLQV-----------ARE 702
            .|.|.:.:.....|||.:|..|..:...:|:|::    :|..||.|..|||           |:|
Human   879 LLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSK----ERAEREAERALQVDTQREGTLISLAKE 939

  Fly   703 AIR---RADEERDRYHKLQRE---MEQRKRHL-LDKEH------ALNLKEDELGQATGAYRLATS 754
            ...   ||.|.|....:|..|   :||.::.| |:||.      .:.|:.:|:...:   ::|:.
Human   940 QAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMS---KVASE 1001

  Fly   755 RQHLAEQKAREADQL---LQAKLKVMAKRAQEIAEKEAQLAHERMLVAQDRMALVNLKKQISRSR 816
            :....|:..|||.|:   .||:|:.:.::.:.:.::|..:..|.:.:||.|:.|...::.:..|.
Human  1002 KYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQDLPSSL 1066

  Fly   817 CAICKMGAESAEIAQRRANVNPTAATDLQLPQ----VTPS----HAELLL--KMSQEPGQVQSDI 871
            ..:.......|  |..::.:.|.|.|.....|    :.||    ||.|.|  .|:::
Human  1067 VGLFPRAQGPA--ASSQSALMPPAPTTRWCSQPPTGLDPSPLHLHARLALLRHMAEQ-------- 1121

  Fly   872 VDRMLDEN----IEASYRRMYNAPPSSS 895
             ||...||    :|...:..||....|:
Human  1122 -DRDFLENEQFFLETLKKGSYNLTSHSA 1148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5964	NP_648507.1	PRK14971	<139..320	CDD:237874	59/280 (21%)
		Smc	410..>743	CDD:224117	93/386 (24%)
		SMC_prok_B	610..>882	CDD:274008	73/312 (23%)
FBF1	NP_001306122.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..212		16/73 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..558		72/346 (21%)
		DUF4515	787..976	CDD:291649	48/192 (25%)
		Spc24	932..>987	CDD:285486	14/54 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1077..1100		6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009885
OrthoInspector	1	1.000	-	-		oto90021
orthoMCL	1	0.900	-	-		OOG6_107222
Panther	1	1.100	-	-	LDO	PTHR33689
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4442
SonicParanoid	1	1.000	-	-		X7598
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.940