DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5964 and Fbf1

DIOPT Version :9

Sequence 1:	NP_648507.1	Gene:	CG5964 / 39330	FlyBaseID:	FBgn0036206	Length:	928	Species:	Drosophila melanogaster
Sequence 2:	NP_001351006.1	Gene:	Fbf1 / 217335	MGIID:	1922033	Length:	1173	Species:	Mus musculus

Alignment Length:	1097	Identity:	236/1097 - (21%)
Similarity:	423/1097 - (38%)	Gaps:	304/1097 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NFND--DPLAELLSDNSLDNDNFFETPAGVGHKKPAKLAKPKGKLEDLFGIQEETEADVQGQGTG 64
            :|.|  ||||.||||...:          ...|.||...||..|          :.....|||..
Mouse   172 SFEDFEDPLAGLLSDEEEE----------TATKLPAVERKPAPK----------SPGAAAGQGPS 216

  Fly    65 ARKTPNAISTPRIVKQKPSISLDDDLVEDDDLGFD--PK--RPKSGGTKRSLFDDLLTSNAEPKK 125
            ...||.  .|| |.|::......||::  ..|||:  ||  |.|:|..:..|          |.:
Mouse   217 VPLTPG--DTP-IRKKELLFDEGDDIM--TTLGFEDSPKAERKKTGDQEGPL----------PAR 266

  Fly   126 NIFDEILA-GDAVK---RPAT-------------------SKPSMSRQST--DTTTDNSQARP-- 163
            :..||:|. |.|.|   ||.|                   |.|:..::.:  |.|......:|
Mouse   267 SKLDELLGRGTAAKLLTRPGTGERREFQLDKKYQKMGGEESVPARDKEDSWDDETLTFGAYKPTV 331

  Fly   164 KTSTGRRSSAQSATINMNADPLGLFGRDTNATVSGM-------STPVSKKRGTTADWLGLEQ--- 218
            .:|.||:|..||.     :..||..|.|......|.       |:|:..::| .||||||:.
Mouse   332 ASSEGRQSRRQSV-----SRFLGEGGPDPKGESLGFKQSSPPASSPIHPRKG-GADWLGLKDNDL 390

  Fly   219 -----------EPDQRPITPKAQTAKAQPSSESPSKNTADILRLPDSDENGMEQEAEMAAVPA-P 271
                       :.:..|:||.......|||:..           |.|...|:...|:..|..| |
Mouse   391 DLLSPSPVQKAQQEDSPMTPSLLPPTNQPSAPE-----------PQSAPTGLPSAAKPPAKGARP 444

  Fly   272 SVVTAATQNILMLSNLNLESNHKFNALQQQEAQLVIAAQMKSQERTLLEMQRRQEDQDRKFQALI 336
            |:  .|:|          .|:.|.:..::.:....:.:|.|||  .|...:|....:|......:
Mouse   445 SL--KASQ----------ASSPKASEEKEDDWLSHVISQKKSQ--NLAREERAGPPKDLASLGSL 495

  Fly   337 QQ----QLQRQQQMEEHIKGQQERINMH-----------LQLMMSQPVRV--------------Q 372
            .|    .|...|.:|:...|:..:....           ..:..||...|              .
Mouse   496 GQTPSGSLPVAQVLEQAPAGEASKPTTQGMAAVRPGVTGSSMSWSQATTVLPVDDPKKGAASASG 560

  Fly   373 DVVSTPPLVEKP---EPE----------PE-------------------RKEHHKATSQEQEHLL 405
            |..|..|.|..|   ||.          ||                   :.:...:|:|.|..||
Mouse   561 DFSSREPAVYIPHSQEPTGLSVPIQTLLPESMMQSLLPGSGYQKQLLAAQGQLQSSTAQLQVELL 625

  Fly   406 -----LLEMDAKRNLLEKQRLDE--LVANMKVNYEQEIEMIDSSYKKQIKVLEEHLSVVEKRLKD 463
                 |.|::|:...||.:|...  |:.:::..::.::|:|:.:::.:|||||......|::|:.
Mouse   626 QSQTKLSELEAQVRKLELERAQHRMLLESLQQRHQADLELIEDAHRSRIKVLETSYQQREEQLRR 690

  Fly   464 ENSEL---RQYYIEKLEKQKEDYV----EQISSLRQDHEDEVRKLRQ-----------SHELDLE 510
            |...|   ...|..:.|:.:.:.|    .|::...|:.:.||.:||:           .||..|:
Mouse   691 EKEVLSAQHASYCREAEQARAELVAQHQRQMAMAEQERDQEVARLRELQQASILEMRKDHEHQLQ 755

  Fly   511 GIRQAKMVELSAVQDHGNY-------LDTLRLASSNLQEL-----RDGMSDNQERERQLEARERR 563
            .::..|..|:.||....::       ::.:...||:|..|     ...::.:|:||..:..::.:
Mouse   756 RLKMLKDQEIDAVTSATSHTRSLNGIIEQMEKFSSSLNTLSSRVEASHLTTSQQRELGIRQQDEQ 820

  Fly   564 LADQERRLKMDEETADDEKRRLMELVSTLELQLGRLSKESAEENWQLRQRMSSLEAERKAFEREK 628
            |...:.||...:...::|:.||.|::..:|::|...|:...:|.|::....:..|:.::..|.::
Mouse   821 LRALQERLGRQQRDMEEERNRLQEVIGKMEVRLSEQSRLLEQERWRVAAEKTKAESAQRTLEEQR 885

  Fly   629 EFHREQMQRDEKRVEDLKALQLAEMERLHHDLQEERNQLTVERQQIELRQQLNE----------- 682
            :...:|:..:.:.:|..|:..|.|.:.:.:...|||.:|..|..:...:|:|::
Mouse   886 KIMVQQIAMEREELERAKSALLEEQKSVMNKCGEERRRLAAEWAEYFTQQKLSKERAEREAERAM 950

  Fly   683 HGDPDR-------------------DRRELEAQLQVAREAIRRADE----ERDRYHKLQREMEQR 724
            |.|..|                   :.|..|.:|...|||:.|..:    |:||.||....::.|
Mouse   951 HADSQREGTIISLTKEQAELTVRACELRAKEEKLLAEREALERERQELRLEKDRLHKASLRLQAR 1015

  Fly   725 KRHLLDKEHALNLKEDELGQATGAYRLATSRQHLAEQKAREADQL---LQAKLKVMAKRAQEIAE 786
            .:.:   ||              ..::|:.:....||..:||.|:   .|.:|:|:.::.:.:.:
Mouse  1016 AQEV---EH--------------MSKVASKKYEEGEQALQEAQQMQNEQQGRLQVVQRQQEWLRQ 1063

  Fly   787 KEAQLAHERMLVAQDRMALVNLKKQI---------------SRSRCAICKMGAESAEIAQRRANV 836
            :|.::..|.:.:||.|:.|..:::::               :.||.|:....:.|.:.:|
Mouse  1064 QEQRVHQEHLSLAQQRLQLDRVRQEVPASLPGLPPRVQGPAASSRDAVQAPASSSPQCSQ----- 1123

  Fly   837 NPTAATDLQLPQVTPSHAELLLKMSQEPGQVQSDIVDR---MLDENIEASYRRMYNA 890
             |.||      || |:|....|.:.:...:...|.::.   .|:...:|.|...|::
Mouse  1124 -PAAA------QV-PTHLLAKLLLLKHTAEEDHDFLENEQFFLETLKKAPYNMAYHS 1172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5964	NP_648507.1	PRK14971	<139..320	CDD:237874	51/225 (23%)
		Smc	410..>743	CDD:224117	83/398 (21%)
		SMC_prok_B	610..>882	CDD:274008	62/326 (19%)
Fbf1	NP_001351006.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..168
		PHA03247	<69..530	CDD:223021	101/423 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..225		17/66 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	241..566		79/365 (22%)
		SbcC	<602..1088	CDD:223496	105/502 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1091..1124		5/38 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2C3MX
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009885
OrthoInspector	1	1.000	-	-		oto93598
orthoMCL	1	0.900	-	-		OOG6_107222
Panther	1	1.100	-	-	LDO	PTHR33689
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4442
SonicParanoid	1	1.000	-	-		X7598
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.800