Protein Alignment twy and dyf-19

DIOPT Version :10

• Sequence 1: NP_648507.1
• Gene: twy / 39330
• FlyBaseID: FBgn0036206
• Length: 928
• Species: Drosophila melanogaster
• Sequence 2: NP_507804.2
• Gene: dyf-19 / 180283
• WormBaseID: WBGene00012826
• Length: 534
• Species: Caenorhabditis elegans
• Alignment Length: 720
• Identity: 152/720 - (21%)
• Similarity: 258/720 - (35%)
• Gaps: 232/720 - (32%)

  Fly    86 LDDDLVED--DDLGFDPKRPK-------SGGTKRSLFDDLLTSNAEPKKNIFDEILAGDAVKRPA 141
            :.||...|  |:|..:|.:|.       .|.:|          |:.||.:..|.:|..|..|.|
 Worm     1 MSDDEWGDLLDNLDTEPPQPAPPPPPNLPGNSK----------NSRPKSSGLDFLLDSDLDKEP- 54

  Fly   142 TSKPSMSRQSTDTTTDNSQARPKTSTGRRSSAQSATINMNADPLGLFGRDTNATV--SGMSTPVS 204
             ..|.....:|:...:.|:.|   :.||.::|.|          .|||..|.:.:  ||.::...
 Worm    55 -QAPKTVNFATNREENTSEMR---AAGRSTNALS----------DLFGTSTGSGLGASGAASAPR 105

  Fly   205 KKRG--TTADWLGLEQEPDQRPITP---KAQTAKAQPSSESPSKNTAD---ILRLPDSDENGMEQ 261
            :..|  |..|..|  ..|....:||   .|..|.:||::.:|..:..|   ||||
 Worm   106 RPAGASTLDDLFG--TAPRAATVTPGVTVAAPAASQPTATAPPPDNFDAGRILRL---------- 158

  Fly   262 EAEMAAVPAPSVVTAATQNILMLSNLNLESNHKFNALQQQEAQ----LVIAAQMKSQERTLLEMQ 322
            |||:..|                 |..||...:.....:::.:    ..:..|.|..|:.|.:.:
 Worm   159 EAELERV-----------------NRELEDTKRKKREDEEDLENFWKTKLEIQSKDSEKALEDSK 206

  Fly   323 RRQEDQDRKFQALIQQQLQRQQQMEEHIKGQQERINMHLQLMMSQPVRVQDVVSTPPLVEKPEPE 387
            ..|..|..|.|.            |.|::.::.:.|...||        ::|.|
 Worm   207 TAQRAQISKLQD------------EHHVELERLKANYDRQL--------ENVTS----------- 240

  Fly   388 PERKEHHKATSQEQEHLLLL-EMDAKRNLLEKQRLDELVANMKVNYEQEIEMIDSSYKKQIKVLE 451
                    :|||..:.:.:: ::|.....::|...|.:.:..||:.||         .....:.|
 Worm   241 --------STSQVGDLVAVVGKVDTISTNIDKIAADVVASTNKVSSEQ---------SALFHLQE 288

  Fly   452 EHLSVVEKRLKDENSELRQYYIEKLEKQKEDYVEQISSLRQDHEDEVRKLRQSHELDLEGIRQAK 516
            |.|.:.|.:|.::.:.|      |||:.|                       .|||:|
 Worm   289 ELLKIRETKLSEDVAAL------KLEQLK-----------------------VHELNL------- 317

  Fly   517 MVELSAVQDHGNYLDTLRLASSNLQELRDGMSDNQERERQLEARERRLADQERRLKMDEETADDE 581
                                  :|::|.....|..|:|:.      |..::..|||::.:...:.
 Worm   318 ----------------------SLKDLVKNQQDENEQEKW------RTKEEWNRLKIERQIFKEN 354

  Fly   582 KRRLMELVSTLELQLGRLSKESAEENWQLRQRMSSLEAERKAFEREKEFHREQMQRDEKRVE--- 643
            :.|::|.|...:|.|....|...::..:|..|:||   ||:..|:||.....:..:|.||::
 Worm   355 QDRVIENVQREKLDLANKLKFYHKDQTELLFRLSS---ERELLEQEKSEFFAKRDQDIKRIKAEA 416

  Fly   644 ---DLKALQLA-------EM----ERLHHDLQEERNQLTVERQQIEL---RQQLNEHGDPDRDRR 691
               |||:.|::       ||    |..:..||.....||.|..:||.   .|::..:.|..||.|
 Worm   417 YELDLKSQQISTADQHVTEMKLVTEAKYRQLQHLETLLTAECSEIERIRNEQKIGGNVDSGRDAR 481

  Fly   692 ELEAQLQVAREAIRRADEERDRYHKLQREMEQRKRHLLDKEHALNLKEDELGQATGAYRLATSRQ 756
            .:..:.::........:..|.|...::..:         |:|..|| |...||...
 Worm   482 RISREEELFGSNNSNQNSHRHRSESVRASL---------KKHYENL-EKYAGQKVA--------- 527

  Fly   757 HLAEQ 761
            |:|.|
 Worm   528 HVAPQ 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
twy	NP_648507.1	PRK12323	<139..320	CDD:481241	43/194 (22%)
		COG2433	<416..>502	CDD:441980	16/85 (19%)
		Smc	<467..>805	CDD:440809	67/315 (21%)
dyf-19	NP_507804.2	PRK12438	<54..177	CDD:171499	39/166 (23%)
		Smc	<154..>425	CDD:440809	80/412 (19%)