DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pi3K68D and SH3PXD2A

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_001380944.1	Gene:	SH3PXD2A / 9644	HGNCID:	23664	Length:	1133	Species:	Homo sapiens

Alignment Length:	300	Identity:	69/300 - (23%)
Similarity:	120/300 - (40%)	Gaps:	53/300 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1616 VVCFQKHYSMEKFYMYILEVTRHGQPDPTHLFRSYREFTEFHQKLCMHFPLVK---------LHS 1671
            ||..:|..:..|.|:||:.||.......| ::|.|.:|.:...:|...||:..         :..
Human    11 VVDVEKRRNPSKHYVYIINVTWSDSTSQT-IYRRYSKFFDLQMQLLDKFPIEGGQKDPKQRIIPF 74

  Fly  1672 LPAGVHVGRSNIKSVAEKRLPLIQRFLKSLFDASEEIAHSELVYTFFHPLLRDQQEAK--LGMPK 1734
            ||..:...||:|:.||.|||..|..:.::|......|:..:.|:.||.....|....|  .|..|
Human    75 LPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARPEDVNPPKEDYGSSK 139

  Fly  1735 IKEV-----KQQPSRD--------NPHEIGQI------------RLSLQYQRGVLTVMIHHAKGL 1774
            .|.|     .:.|.:|        .|..:.|.            .||||... |:.|:..:..|.
Human   140 RKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQENSELSLQAGE-VVDVIEKNESGW 203

  Fly  1775 PMLQGGQE----PNTYVKCY--LKPDPKKETKRKTKVVRKTCVPSFMETLEYRMPLNIIQERR-- 1831
            ..:...:|    |.||::..  .:.|....|.:..:|.::.  .:.:..|:.|..|..:..|:
Human   204 WFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEVSKRR--KAHLRRLDRRWTLGGMVNRQHS 266

  Fly  1832 ---LQVTVWSHDTLQENELLGGFDMDLSKYDLRQELVDWY 1868
               ..|||..:.:..::|:  ||:..::...:|:.|..|:
Human   267 REEKYVTVQPYTSQSKDEI--GFEKGVTVEVIRKNLEGWW 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540
		C2A_PI3K_class_II	844..1021	CDD:175979
		PI3Ka_II	1038..1202	CDD:238441
		PI3Kc_II	1235..1583	CDD:270710
		PX_PI3K_C2_68D	1611..1721	CDD:132794	32/113 (28%)
		C2B_PI3K_class_II	1751..1871	CDD:176027	28/140 (20%)
SH3PXD2A	NP_001380944.1	PX_FISH	6..124	CDD:132798	32/113 (28%)
		SH3_Tks5_1	170..222	CDD:213007	12/52 (23%)
		SH3_Tks5_2	269..322	CDD:213010	9/37 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..446
		SH3_Tks5_3	451..504	CDD:213012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	505..840
		SH3_Tks5_4	844..896	CDD:212952
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	899..924
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	941..964
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1029..1059
		SH3_Tks5_5	1076..1132	CDD:212953
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900