DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K68D and TOR2

DIOPT Version :9

Sequence 1:NP_001163420.1 Gene:Pi3K68D / 39329 FlyBaseID:FBgn0015278 Length:1876 Species:Drosophila melanogaster
Sequence 2:NP_012719.2 Gene:TOR2 / 853632 SGDID:S000001686 Length:2474 Species:Saccharomyces cerevisiae


Alignment Length:1338 Identity:265/1338 - (19%)
Similarity:408/1338 - (30%) Gaps:500/1338 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   349 SVLEAFDPLLNDNTGNDTASDSTSYYAEYDPFDFLYSGDAATQYSDPMYEAVNRWDKTVATVSPN 413
            |.:||...:.|.....|:|.....:..:::..          |..:..||.:.||:..:|..:  
Yeast  1367 STIEALISINNQLHQTDSAIGILKHAQQHNEL----------QLKETWYEKLQRWEDALAAYN-- 1419

  Fly   414 VGLIGWRQDFLSQPSTS------SSQYGVAPPEESLKLAENGSGTISPPPPLPPRNQQCYESNQA 472
                  .::...:.|..      .|.|.:...||..|||....||..|            |..:|
Yeast  1420 ------EKEAAGEDSVEVMMGKLRSLYALGEWEELSKLASEKWGTAKP------------EVKKA 1466

  Fly   473 AMPVSRPPQSSVLTDSYTSSIPANVVLDRRKTCTRLYELISDQRTDDPELLEFYHMVKEVRARYP 537
            ..|:               :..|...|::.....:...::..|..|.    |||..:..:. |..
Yeast  1467 MAPL---------------AAGAAWGLEQWDEIAQYTSVMKSQSPDK----EFYDAILCLH-RNN 1511

  Fly   538 HDDAPTNVGHVVAAEFNYHYMMDTSIKVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDID 602
            ...|..::       ||...::.|.:..:|:.:.|...:.|                        
Yeast  1512 FKKAEVHI-------FNARDLLVTELSALVNESYNRAYNVV------------------------ 1545

  Fly   603 SVVAQVVAQALASLEGQVK-GTVTDYAVKPIGLLE-WLAPTSRLSQLECVHN------------- 652
                 |.||.:|.||..:| ..:...:.|.:.:.| |   .:||  |.|..|             
Yeast  1546 -----VRAQIIAELEEIIKYKKLPQNSDKRLTMRETW---NTRL--LGCQKNIDVWQRILRVRSL 1600

  Fly   653 SFQLEKDVHL-----GLCLSTAANMQAIAR-------TERDDEHDADLLPEHLLPN--EVVPIVT 703
            ..:.::|..:     .||  ..:...|:|:       .|.||       |:|  ||  :..|.|.
Yeast  1601 VIKPKEDAQVRIKFANLC--RKSGRMALAKKVLNTLLEETDD-------PDH--PNTAKASPPVV 1654

  Fly   704 YDNMMILIET------------------LEMEIDKLESAADGVPGRSVVSCSGVVQAVKAICALL 750
            |..:..|..|                  .::.:|.....|..||.:|    ..|.:.|:....||
Yeast  1655 YAQLKYLWATGLQDEALKQLINFTSRMAHDLGLDPNNMIAQSVPQQS----KRVPRHVEDYTKLL 1715

  Fly   751 GSIDTMEIARCVADLK----RICEVEQKKYSTGASNPE-IVSDY--------------GDYAQVV 796
                    |||.  ||    |:|  .|.|:.  .|||: |:..|              .::|...
Yeast  1716 --------ARCF--LKQGEWRVC--LQPKWR--LSNPDSILGSYLLATHFDNTWYKAWHNWALAN 1766

  Fly   797 LRPRSMLEQIKVKCNELRDA--VQELVELYANVFRV-AFSVKTPDYSTTPIPISCVSKPIVVCIS 858
            ....|||..:..|..|..||  |.::.|....:..| .|..|...||:                :
Yeast  1767 FEVISMLTSVSKKKQEGSDASSVTDINEFDNGMIGVNTFDAKEVHYSS----------------N 1815

  Fly   859 CLHR---PLPNWKFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLN-FSAWLTFDQHPIC 919
            .:||   |.....|...||                     ..|..|...|. .:.|.||...|..
Yeast  1816 LIHRHVIPAIKGFFHSISL---------------------SESSSLQDALRLLTLWFTFGGIPEA 1859

  Fly   920 TLPREARLTFVLYGKQAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRV----MICGPYLLSL 980
            |              ||..||. |..|.|...:|..:|         ..|:    .|....||||
Yeast  1860 T--------------QAMHEGF-NLIQIGTWLEVLPQL---------ISRIHQPNQIVSRSLLSL 1900

  Fly   981 WPPMTDKMLGPAPARGCHPQ----PDFCPVLSIEVPPYGGRIEFPEHQEVPKPAPHYDFASLDAN 1041
               ::|  ||.|     |||    |....:.|..:......:...|...:..|.           
Yeast  1901 ---LSD--LGKA-----HPQALVYPLMVAIKSESLSRQKAALSIIEKMRIHSPV----------- 1944

  Fly  1042 LQEELLDTAELGYTGATERREVFWEKRLYLQSYPNALPKVLHAAHSWDYANLIDL-------HAL 1099
                |:|.||| .:....|..|.|.::                   | |..|.|.       |..
Yeast  1945 ----LVDQAEL-VSHELIRMAVLWHEQ-------------------W-YEGLDDASRQFFGEHNT 1984

  Fly  1100 LHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARF 1164
            ...:|.|.||..   :|.|.|:. :||              :.|.....:.| :|.||       
Yeast  1985 EKMFAALEPLYE---MLKRGPET-LRE--------------ISFQNSFGRDL-NDAYE------- 2023

  Fly  1165 LLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAIC 1229
                            ||:.:....|..|      ::|.:|       .||...:.:.:.|    
Yeast  2024 ----------------WLMNYKKSKDVSN------LNQAWD-------IYYNVFRKIGKQL---- 2055

  Fly  1230 GEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQPTCLPLGPELEVTG 1294
              ..||....||                   :..|.|:|      .||           ||.|.|
Yeast  2056 --PQLQTLELQH-------------------VSPKLLSA------HDL-----------ELAVPG 2082

  Fly  1295 VSVRN-------------CSYFNSNTLPLKINFVGPDAESLPAIFKCGDDLQQDQLTIQLIRIMN 1346
            .....             .|..:|...|.|....|.|.:....:.|..:|::||.|.:||..::|
Yeast  2083 TRASGGKPIVKISKFEPVFSVISSKQRPRKFCIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVN 2147

  Fly  1347 KMWLAE----RLDLKMVTFNCVPTGYKSGMIELVSEAET-------------------------- 1381
            .:...:    |..|.:..:..:|...|||::..|..::|                          
Yeast  2148 TLLQNDAECFRRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHREAKKIPLNIEHWVMLQM 2212

  Fly  1382 ---------LRKIQV-ECGLTGS----------FKDRPIAEWLGKQNPSPLEYQSAVRNFTLSCA 1426
                     |:|::| ...|..:          .|.|....||.::.           .:|.|.|
Yeast  2213 APDYDNLTLLQKVEVFTYALNNTEGQDLYKVLWLKSRSSETWLERRT-----------TYTRSLA 2266

  Fly  1427 GYSVATYVLGICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVIN- 1489
            ..|:..|:||:.|||..|:|| :.:|.:.|||||.....|.:...|. ::.||.||..:.|.:. 
Yeast  2267 VMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKFP-EKVPFRLTRMLTYAMEV 2330

  Fly  1490 GGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMA 1527
            .|.:.|     |...|.....::|.|...|:..|...|
Yeast  2331 SGIEGS-----FRITCENVMKVLRDNKGSLMAILEAFA 2363

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K68DNP_001163420.1 EIN3 <58..392 CDD:296674 6/42 (14%)
PI3K_rbd 561..669 CDD:197540 22/127 (17%)
C2A_PI3K_class_II 844..1021 CDD:175979 38/188 (20%)
PI3Ka_II 1038..1202 CDD:238441 31/170 (18%)
PI3Kc_II 1235..1583 CDD:270710 77/358 (22%)
PX_PI3K_C2_68D 1611..1721 CDD:132794
C2B_PI3K_class_II 1751..1871 CDD:176027
TOR2NP_012719.2 TEL1 290..2474 CDD:227365 265/1338 (20%)
HEAT repeat 599..620 CDD:293787
HEAT repeat 642..667 CDD:293787
HEAT repeat 677..707 CDD:293787
HEAT repeat 715..748 CDD:293787
HEAT repeat 758..787 CDD:293787
HEAT repeat 801..828 CDD:293787
HEAT repeat 843..873 CDD:293787
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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