DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K68D and Pik3cb

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_445933.1	Gene:	Pik3cb / 85243	RGDID:	620917	Length:	1070	Species:	Rattus norvegicus

Alignment Length:	1071	Identity:	303/1071 - (28%)
Similarity:	482/1071 - (45%)	Gaps:	202/1071 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   595 VTFTCD----IDSVVAQVVAQALASLEGQVKGTVTDYAVKP-----------IGL--LEWLAPT- 641
            ||.:||    :||.:..::.:.|...:......|.::..|.           :||  ::||..|
  Rat   112 VTRSCDPAEKLDSKIGVLIGKGLHEFDALKDPEVNEFRRKMRKFSEDKIQSLVGLSWIDWLKHTY 176

  Fly   642 ------SRLSQLECVHNSFQLEKDVHLGLCLSTAANMQAIARTERDDEHDADLLPEHLLPNEVVP 700
                  |.|..||......:|...||.                    |:..|:....:.|| :.|
  Rat   177 PPEHEPSVLENLEDKLYGGKLVVAVHF--------------------ENSQDVFSFQVSPN-LNP 220

  Fly   701 IVTYDNMMILIETLEMEIDKLESAADGVPGRSVVSCSGVVQAVKAICALLGSIDTMEIARCVADL 765
            |..  |.:.:.:.|.:. .|.|.|:   |...|:..||.|:.|.....|   |....|..||.:
  Rat   221 IKI--NELAIQKRLTIR-GKEEEAS---PCDYVLQVSGRVEYVFGDHPL---IQFQYIRNCVMN- 275

  Fly   766 KRICEVEQKKYSTGASNPEIVSDYGDYAQVVLRPRSMLEQIKVKCNELRDAV-QELVELYANVFR 829
                                              |::...|.|:|.:::... ||::.:.|.:.|
  Rat   276 ----------------------------------RTLPHFILVECCKIKKMYEQEMIAIEAAINR 306

  Fly   830 VAFSVKTPDYSTTPIPISCVSKPIVVCISCLHRPLP------NWKFDDYSLCVQI----VYGTRL 884
                    :.|:.|:|:......::..:...:.|..      |....:.::.|.:    .:||.|
  Rat   307 --------NSSSLPLPLPPKKTRVISHVWGNNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGTEL 363

  Fly   885 LSKPNVLTCSNDTSGGLFPRLNFSAW---LTFDQHPICTLPREARLTFVLYG-------KQAASE 939
            |.|..|   |::.||     .|...|   |.||.: ||.|||.|||.|.:|.       |::...
  Rat   364 LCKTVV---SSEISG-----KNDHIWNEQLEFDIN-ICDLPRMARLCFAVYAVLDKVKTKKSTKT 419

  Fly   940 GEPNADQNGERR-QVTTELGWCSIQLFDFKRVMICGPYLLSLW---PPMTDKMLGPAPARGCHPQ 1000
            ..|:..|...:. :|...:.|.:..:||||..:..|..:|..|   |...::||.|......:|.
  Rat   420 INPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRSGDVILHSWSSFPDELEEMLNPMGTVQTNPY 484

  Fly  1001 PDFCPVLSIEVPPYGGRIEFPEHQEVPKPAPHYD--------FASLD-ANLQ-----------EE 1045
            .:....|         .|:|||:::.|...|.:|        .||.| ||:.           :|
  Rat   485 AENATAL---------HIKFPENKKQPYYYPPFDKIIEKAAEIASGDSANVSSRGGKKFLAVLKE 540

  Fly  1046 LLDTAELGYTGATERREVFWEKRL-YLQSYPNALPKVLHAAHSWD-YANLIDLHALLHSWAPLSP 1108
            :||...|......| .::.|..|. ..:::|.:|||:| .:..|: ..::..|.|||..|..|.|
  Rat   541 ILDRDPLSQLCENE-MDLIWTLRQDCRENFPQSLPKLL-LSIKWNKLEDVAQLQALLQIWPKLPP 603

  Fly  1109 LQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESP 1173
            .::||||...|||..|||.||..:.:|.:::|..:|.||||.||::.:...|::||||.:.|::.
  Rat   604 REALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALDNR 668

  Fly  1174 RFAHHMYWLL---VHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAICGEKMLQ 1235
            |....::|.|   ||:    |..||...::.:.|....|..:      |::.:.:.|:...|.|.
  Rat   669 RIGQFLFWHLRSEVHT----PAVSIQFGVILEAYCRGSVGHM------KVLSKQVEALNKLKTLN 723

  Fly  1236 RFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQPTCLPLGPELEVTGVSVRNC 1300
            ..:       ||..:..:..:.||:|......:...|...||..     ||.|.:.::.:.|..|
  Rat   724 SLI-------KLNAMKLNRAKGKEAMHTCLKQSAYREALSDLQS-----PLNPCVILSELYVEKC 776

  Fly  1301 SYFNSNTLPLKINF----VGPDAESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTF 1361
            .|.:|...||.:.:    .|.||  :..|||.||||:||.||:|::|:|:.:|....|||:|:.:
  Rat   777 RYMDSKMKPLWLVYSNRAFGEDA--VGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPY 839

  Fly  1362 NCVPTGYKSGMIELVSEAETLRKIQV---ECGLTGSFKDRPIAEWLGKQNPSPLEYQSAVRNFTL 1423
            .|:.||.:||:||:||.:||:..||:   ....|.:|....:..||.:.| |..:...|:..|||
  Rat   840 GCLATGDRSGLIEVVSTSETIADIQLNSSNVAATAAFNKDALLNWLKEYN-SGDDLDRAIEEFTL 903

  Fly  1424 SCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVI 1488
            |||||.||:|||||.|||:||||:|.:|.|||||||..||:.:.....||:|.||:||.|..:||
  Rat   904 SCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVI 968

  Fly  1489 NGGDKPSTD-FHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNS-NAVQYVRRALLPSQS 1551
            ..|...:|: |..|...|..|:.|:|::.:|.:...|.|.|||:|.:.| ..:||::.:|...:|
  Rat   969 QQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLALGKS 1033

  Fly  1552 NPEAAATFAKMIQSSLK-SWFTQFNFFLHNL 1581
            ..||...|.:....:|: ||.|:.|:..|.:
  Rat  1034 EEEALKQFKQKFDEALRESWTTKVNWMAHTV 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540	21/97 (22%)
		C2A_PI3K_class_II	844..1021	CDD:175979	47/200 (24%)
		PI3Ka_II	1038..1202	CDD:238441	58/180 (32%)
		PI3Kc_II	1235..1583	CDD:270710	131/357 (37%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
Pik3cb	NP_445933.1	PI3K_p85B	41..118	CDD:197539	3/5 (60%)
		PI3K_rbd	180..288	CDD:197540	33/172 (19%)
		C2_PI3K_class_I_beta_delta	324..501	CDD:176075	49/194 (25%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250	410..418		1/7 (14%)
		PI3Ka_I	532..702	CDD:238444	56/175 (32%)
		PI3Kc_IA_beta	706..1067	CDD:270717	135/380 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339949
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750