DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pi3K68D and STT4

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_013408.1	Gene:	STT4 / 851014	SGDID:	S000004296	Length:	1900	Species:	Saccharomyces cerevisiae

Alignment Length:	532	Identity:	141/532 - (26%)
Similarity:	246/532 - (46%)	Gaps:	79/532 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1075 PNALPKVLHAAHSWDYANLIDLHALLHSWAPLSPLQSLELLLPRYP-DAKVREKAVEWISKMPND 1138
            |:||...:..:|   .::..||||.|: |||:|||:|:.|.||.:. ::.:.:.::..:.....:
Yeast  1401 PSALDLFIKGSH---LSSKKDLHATLY-WAPVSPLKSINLFLPEWQGNSFILQFSIYSLESQDVN 1461

  Fly  1139 QLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESPRFAHHMYW-LLVHSLPDDPHNSIGAAMVDQ 1202
            ....::||:||.|::|  :...:.|.:|.....|..|:|.:.| :|.:...||..       :.:
Yeast  1462 LAFFYVPQIVQCLRYD--KTGYVERLILDTAKISVLFSHQIIWNMLANCYKDDEG-------IQE 1517

  Fly  1203 EYDESQVTQVRYYRRNKMMLRALMAICGEKMLQRFMYQHR--------MCQKLTTIAES----VK 1255
            :..:..:.::|                 |:|:..|...||        ...::|.|:..    :|
Yeast  1518 DEIKPTLDRIR-----------------ERMVSSFSQSHRDFYEREFEFFDEVTGISGKLKPYIK 1565

  Fly  1256 EAKESMRQKSLAAGMDEVHQDLLEQP-TCLPLGPELEVTGVSVRNCSYFNSN-------TLPLKI 1312
            ::|...:.|     :||....:..:| ..||..|:..|..:..::.....|:       |..:|.
Yeast  1566 KSKAEKKHK-----IDEEMSKIEVKPDVYLPSNPDGVVIDIDRKSGKPLQSHAKAPFMATFKIKK 1625

  Fly  1313 NFVGP------DAES-LPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKS 1370
            :...|      :.|. ..||||.|||.:||.|.:|||.:...:|.:..||:.:..:....|....
Yeast  1626 DVKDPLTGKNKEVEKWQAAIFKVGDDCRQDVLALQLISLFRTIWSSIGLDVYVFPYRVTATAPGC 1690

  Fly  1371 GMIELVSEAETLRKIQVEC--GLTGSFKDRPIAEWLGKQNPSPLEYQSAVRNFTLSCAGYSVATY 1433
            |:|:::..:.:...:..|.  ||...|..:     .|  |.|.:|:|:|..||..|.|||||.:|
Yeast  1691 GVIDVLPNSVSRDMLGREAVNGLYEYFTSK-----FG--NESTIEFQNARNNFVKSLAGYSVISY 1748

  Fly  1434 VLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVINGGDKPSTDF 1498
            :|...||||.|||....||..||||| |:.|. :.|..|.:..||.||.:|..|:.|  .|.|..
Yeast  1749 LLQFKDRHNGNIMYDDQGHCLHIDFG-FIFDI-VPGGIKFEAVPFKLTKEMVKVMGG--SPQTPA 1809

  Fly  1499 HY-FVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNSN-AVQYVRRALLPSQSNPEAAATFAK 1561
            :. |.:||.:|:...|.:.:.::..:..|..:|:|....: .::.:|....|.:::.|||.....
Yeast  1810 YLDFEELCIKAYLAARPHVEAIIECVNPMLGSGLPCFKGHKTIRNLRARFQPQKTDHEAALYMKA 1874

  Fly  1562 MIQSSLKSWFTQ 1573
            :|:.|.:|.||:
Yeast  1875 LIRKSYESIFTK 1886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540
		C2A_PI3K_class_II	844..1021	CDD:175979
		PI3Ka_II	1038..1202	CDD:238441	34/128 (27%)
		PI3Kc_II	1235..1583	CDD:270710	104/370 (28%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
STT4	NP_013408.1	TEL1	1..1900	CDD:227365	141/532 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810