Protein Alignment Pi3K68D and VPS34

DIOPT Version :10

• Sequence 1: NP_524028.2
• Gene: Pi3K68D / 39329
• FlyBaseID: FBgn0015278
• Length: 1876
• Species: Drosophila melanogaster
• Sequence 2: NP_176251.1
• Gene: VPS34 / 842344
• AraportID: AT1G60490
• Length: 814
• Species: Arabidopsis thaliana
• Alignment Length: 882
• Identity: 209/882 - (23%)
• Similarity: 340/882 - (38%)
• Gaps: 224/882 - (25%)

  Fly   846 ISC-VSKPIVVCISCLHRPLPNWKFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFSA 909
            :|| ::.|:...|..|...||..|..|                ..|::.:.:..    |.|....
plant    10 LSCDINSPVTFRIEKLDGNLPVKKSSD----------------SGVVSIAEEKK----PELYIEC 54

  Fly   910 WLTFDQHPICTLPREARLTFVLYGKQAASEGEPNA-----DQNGERRQVT--------------- 954
            .|..|..|. .||...||         .:.|.|..     ..:.:.|.:|
plant    55 ALYIDGAPF-GLPMRTRL---------KTTGPPYCWNELITLSSKYRDLTAHSQLAITVWDVSCG 109

  Fly   955 -TE--LGWCSIQLFDFKRVMICGPYLLSLWPPMTDKMLGPAPARGCHPQP--------------- 1001
             ||  :|..::.||:.|..|..|...|.||.........|....|..|:.
plant   110 KTEGLIGGATVLLFNSKMQMKSGKQKLRLWQGKEADGSFPTSTPGKVPRHERGELERLEKLMNKY 174

  Fly  1002 ---------------------------------------DFCPVLSIE--------------VPP 1013
                                                   |||   |.|              ..|
plant   175 ERGQIQSIDWLDRLMLKSLDTIKEQESTKHGSSHLFVVIDFC---SFEHRVVFQESGANLFITAP 236

  Fly  1014 YGGRIEF------------PEHQEVPKPAPHYDFASLDANLQEELLDTAE----LGY----TGAT 1058
            .|...||            |...:..|.|...|...:|.:|:...::...    |.|    |.:.
plant   237 IGSTNEFVTVWDTELGKTNPSENKQLKLARSLDRGIIDRDLKPSNIERKSIQRVLKYPPTRTLSG 301

  Fly  1059 ERREVFWEKRLYLQSYPNALPKVLHAAHSWDYANLIDLHALLHSWAPLSPLQSLELLLPRYPDAK 1123
            :.|::.|:.|..|.|...||.|.|......|.........|::.|..:....:||||.|.:...:
plant   302 DERQLLWKFRFSLMSEKRALTKFLRCVEWSDVQEAKQAIQLMYKWEMIDVCDALELLSPLFESEE 366

  Fly  1124 VREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESPRFAHHMYWLLVHSLP 1188
            ||..||..:.:..:::|..:|.||||:|:.:..:.|.:::||:.:.|::...|..:.|.:...|.
plant   367 VRAYAVSVLERADDEELQCYLLQLVQALRFERSDRSCLSQFLVQRALQNIELASFLRWYVAVELH 431

  Fly  1189 DDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAI-------CGEKMLQRFMYQHRMCQK 1246
            |                  .|...|:|...:::...::.:       .|.::.|..:.|..:..:
plant   432 D------------------HVYAKRFYSTYELLEENIIKLPPGVNGEDGYQLWQSLVRQTELTAQ 478

  Fly  1247 LTTIAESVKEAKESMRQKSLAAGMDEVHQDL---------LEQPTCLPLGPELEVTGVSVRNCSY 1302
            |.:|...|:..:.:.::|     ::::.|.|         .|:|...||.|.:.:.|:.....|.
plant   479 LCSITREVRNVRGNTQKK-----IEKLRQLLGGLLSELTYFEEPIRSPLTPNVLIKGIVAGESSL 538

  Fly  1303 FNSNTLPLKINFVGP-DAESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPT 1366
            |.|...||::.|..| :..|...|||.||||:||||.:|::.:|:::...|.|||.:..:..:.|
plant   539 FKSALHPLRLTFRTPEEGGSCKLIFKKGDDLRQDQLVVQMVWLMDRLLKLENLDLCLTPYKVLAT 603

  Fly  1367 GYKSGMIELVSEAETLRKIQVECGLTGSFKDRPIAEWLGKQNP---SPLEY-QSAVRNFTLSCAG 1427
            |:..||:|.: .:.:|.:|..|        .|.|..:|.|.:|   :|... .:.:..|..||||
plant   604 GHDEGMLEFI-PSRSLAQILSE--------HRSITSYLQKFHPDEHAPFGITATCLDTFIKSCAG 659

  Fly  1428 YSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPF----VLTSDMAYVI 1488
            |||.||:|||.|||.||::|...|.|||:||...||         ||..||    .|..:|...:
plant   660 YSVITYILGIGDRHLDNLLLTDDGRLFHVDFAFILG---------RDPKPFPPPMKLCKEMVEAM 715

  Fly  1489 NGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNSNAVQYVRRALLPSQS-- 1551
            .|.:  |..:..|...||.|:||:||:::|:|:....||.:.:|.:.|:.    .:.:|..|.
plant   716 GGAE--SQYYTRFKSYCCEAYNILRKSSNLILNLFHLMAGSTIPDIASDP----EKGILKLQEKF 774

  Fly  1552 ----NPEAAATFAK-MIQSSLKSWFTQFNFFLHNLAQ 1583
                :.||...|.: :|..|:.:.|.|....:|..||
plant   775 RLDMDDEACIHFFQDLINESVSALFPQMVETIHRWAQ 811

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_524028.2	PHA03247	<56..294	CDD:223021
		PI3K_rbd	561..669	CDD:197540
		C2A_PI3K_class_II	844..1021	CDD:175979	46/278 (17%)
		PI3Ka_II	1038..1202	CDD:238441	41/171 (24%)
		PI3Kc_II	1235..1583	CDD:270710	112/372 (30%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
VPS34	NP_176251.1	C2_PI3K_class_III	25..178	CDD:176042	33/182 (18%)
		PI3Ka_III	274..432	CDD:238442	40/157 (25%)
		PI3Kc_III	466..811	CDD:270628	112/373 (30%)