DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K68D and TRRAP

DIOPT Version :9

Sequence 1:NP_001163420.1 Gene:Pi3K68D / 39329 FlyBaseID:FBgn0015278 Length:1876 Species:Drosophila melanogaster
Sequence 2:NP_001362453.1 Gene:TRRAP / 8295 HGNCID:12347 Length:3873 Species:Homo sapiens


Alignment Length:1796 Identity:322/1796 - (17%)
Similarity:560/1796 - (31%) Gaps:599/1796 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   337 LIDLNHEDYSRVSVLEAFDPLLNDNTGNDTASDSTSYYAEY-DP--FDFLYSGDA-------ATQ 391
            |.|:|..|.:::.:::.    :::|..|.|:|...|.:.|: .|  ..||..|:.       |.|
Human    28 LTDVNTPDETKLKMMQE----VSENFENVTSSPQYSTFLEHIIPRFLTFLQDGEVQFLQEKPAQQ 88

  Fly   392 YSDPMYEAVNR--WDKTVATVSPNVGLIGWRQDFLSQPSTSSSQYGVAPPEES----LKLAENGS 450
            ....:.|.::|  .::.:...:.||..:.:|  ||...:           ||:    |::.....
Human    89 LRKLVLEIIHRIPTNEHLRPHTKNVLSVMFR--FLETEN-----------EENVLICLRIIIELH 140

  Fly   451 GTISPP----------------PPLPPRNQQCYESNQAAMPVSRPPQSSVLTDSYTSSIPANVVL 499
            ....||                ..||....:.:|:.|.....:.||...|   ...::|...|..
Human   141 KQFRPPITQEIHHFLDFVKQIYKELPKVVNRYFENPQVIPENTVPPPEMV---GMITTIAVKVNP 202

  Fly   500 DRRKTCTRLYELISDQRTDDPELLE-------FYHMVKEVRARYPHDDAPTNVGHVVAAEFNYHY 557
            :|..:.||.:.:|.........|.|       .|.:.|            .|: |.|.|||....
Human   203 EREDSETRTHSIIPRGSLSLKVLAELPIIVVLMYQLYK------------LNI-HNVVAEFVPLI 254

  Fly   558 MMDTSIKVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDIDSVVAQVVAQALASLEGQVKG 622
            |...:|:|......:.|.:..|.|.....|:|    .::|...|..:..::              
Human   255 MNTIAIQVSAQARQHKLYNKELYADFIAAQIK----TLSFLAYIIRIYQEL-------------- 301

  Fly   623 TVTDYAVKPI-GLLEWLAPTSRLSQLECVHNSFQLEKDV-----HLGLCLSTAANMQAIARTERD 681
             ||.|:.:.: |:|:.|:        .|...:..|.|::     |:   |:|....|.|...:: 
Human   302 -VTKYSQQMVKGMLQLLS--------NCPAETAHLRKELLIAAKHI---LTTELRNQFIPCMDK- 353

  Fly   682 DEHDADLLPEHLL------PNEVVPIVTYDNMMILIETLEMEID------KLESAADGVPGRSVV 734
                  |..|.:|      ..|.:..:.|..:..|:..:...:.      .::..|..:...|:.
Human   354 ------LFDESILIGSGYTARETLRPLAYSTLADLVHHVRQHLPLSDLSLAVQLFAKNIDDESLP 412

  Fly   735 SCSGVVQAVKAICALLGSIDTMEIARCVAD------------LKRICEVEQKKYSTGASNPEIVS 787
            |.   :|.:.  |.||     :.:..|:..            |.|:.||...|:.|.|       
Human   413 SS---IQTMS--CKLL-----LNLVDCIRSKSEQESGNGRDVLMRMLEVFVLKFHTIA------- 460

  Fly   788 DYGDYAQVVLRPRSMLEQIKVKCNELRDAVQELVELYANVFRVAFSVKTPDYSTTPIPISC---- 848
                        |..|..|..||.    ...||..:.|.:..|..:...|..:.:|.|:..    
Human   461 ------------RYQLSAIFKKCK----PQSELGAVEAALPGVPTAPAAPGPAPSPAPVPAPPPP 509

  Fly   849 -----VSKPIVVCISCLHRPLPNWK---------------FDDYSLCVQIVYGTRLLSKPNVLTC 893
                 .:.|:...      |:|.::               .|..||...:|.|.:.::. .:.:|
Human   510 PPPPPPATPVTPA------PVPPFEKQGEKDKEDKQTFQVTDCRSLVKTLVCGVKTITW-GITSC 567

  Fly   894 SNDTSGGLFPRLNFSAWLTFDQHPICTLPREAR--LTFVLYGKQAASEGEPNADQNGERRQVTTE 956
            .........|.....             |:|.:  :..|.|..||....:.....||   |....
Human   568 KAPGEAQFIPNKQLQ-------------PKETQIYIKLVKYAMQALDIYQVQIAGNG---QTYIR 616

  Fly   957 LGWC-SIQLFDFKRVMICGPYLLSLWPPMTDKMLGPAPARGCHPQPDFCPVLSIEVPPYGGRI-- 1018
            :..| ::::.:.|.|:.....:.::..|:|                 |..:....||....||  
Human   617 VANCQTVRMKEEKEVLEHFAGVFTMMNPLT-----------------FKEIFQTTVPYMVERISK 664

  Fly  1019 ----EFPEHQEVPKPAPHYDFASLDANLQEELLD-------TAELGYTGATERREVFWEKRLYLQ 1072
                :...:..:..|.....||::   |.|.|||       ..||........:.||....|:..
Human   665 NYALQIVANSFLANPTTSALFATI---LVEYLLDRLPEMGSNVELSNLYLKLFKLVFGSVSLFAA 726

  Fly  1073 SYPNALPKVLH------------AAHSWDYANLI---------DLHALLH-SWAPLSP--LQSLE 1113
            .....|...||            |...::|..|:         ..|.||: .:.||.|  ||.|.
Human   727 ENEQMLKPHLHKIVNSSMELAQTAKEPYNYFLLLRALFRSIGGGSHDLLYQEFLPLLPNLLQGLN 791

  Fly  1114 LLLPRYPDAKVREKAVEWISKMP--NDQLVDFLPQLVQSLKHDTYEGSAM--ARFLLSKCLESPR 1174
            :|........:::..||....:|  ...|:.:||.|:..|.      ||:  ::.|:|:.|.:..
Human   792 MLQSGLHKQHMKDLFVELCLTVPVRLSSLLPYLPMLMDPLV------SALNGSQTLVSQGLRTLE 850

  Fly  1175 FAHHMYWLLVHSL-PD---DPHNSIGAAMVDQEY-----DESQVTQVRYYRRNKMMLRALMAICG 1230
                   |.|.:| ||   |....:.|.::...:     ....::.|.|        |.|....|
Human   851 -------LCVDNLQPDFLYDHIQPVRAELMQALWRTLRNPADSISHVAY--------RVLGKFGG 900

  Fly  1231 --EKMLQRFMYQHRMCQKL--TTIAESVKEAKESMR---QKSLAAGMDEVHQDLLEQPTCLPLGP 1288
              .|||:.....|.:..::  .:|.....:.|.|::   :|::...:|           ||.   
Human   901 SNRKMLKESQKLHYVVTEVQGPSITVEFSDCKASLQLPMEKAIETALD-----------CLK--- 951

  Fly  1289 ELEVTGVSVRNCSYFNSNTLPLKINFVGPDAESLPAIFKCGDDLQQDQLTIQLIRIM----NKMW 1349
                           ::||.|..       ......:.||           .|:.:|    ||..
Human   952 ---------------SANTEPYY-------RRQAWEVIKC-----------FLVAMMSLEDNKHA 983

  Fly  1350 LAERLDLKMVTFNCVPT-----GYKSGMIELVSEAETLRKIQVECGLTGSFKDRPIAEWLGKQNP 1409
            |.:.|.....|...:|.     .||:        .:|..:...|..|||:|....|.:    ..|
Human   984 LYQLLAHPNFTEKTIPNVIISHRYKA--------QDTPARKTFEQALTGAFMSAVIKD----LRP 1036

  Fly  1410 SPLEY-QSAVRNFTL-----SCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMF 1468
            |.|.: .|.:|::|:     .|..:.:..|.:|          .:.|..:||.:           
Human  1037 SALPFVASLIRHYTMVAVAQQCGPFLLPCYQVG----------SQPSTAMFHSE----------- 1080

  Fly  1469 GNFKRDRTPFVLTS-------------------------DMAYVINGGDKPSTD---FHYFVDLC 1505
            .|..:...|.||..                         |:|.:|.|..:.:..   |.|.|:..
Human  1081 ENGSKGMDPLVLIDAIAICMAYEEKELCKIGEVALAVIFDVASIILGSKERACQLPLFSYIVERL 1145

  Fly  1506 CRA------------------------FNIVRKNADLLLHTLAHMATAGMPGVNSNAV------- 1539
            |..                        ...|.:|....|..|..:.......|::.||       
Human  1146 CACCYEQAWYAKLGGVVSIKFLMERLPLTWVLQNQQTFLKALLFVMMDLTGEVSNGAVAMAKTTL 1210

  Fly  1540 -QYVRRALLPSQSNPEAAATFAKMIQSSLKSWFTQFNFFLHNLAQMRFTPDEGSGELLSFVPRKY 1603
             |.:.|...|.:....|....|...:|        |:...|:|.:...:|:.        ..||.
Human  1211 EQLLMRCATPLKDEERAEEIVAAQEKS--------FHHVTHDLVREVTSPNS--------TVRKQ 1259

  Fly  1604 TM-------QQDGRLKIVKVVCFQKHYSMEKFYMYILEVTRHGQPDPTHLFRSY----------- 1650
            .|       |..|  |.|.|: .:.|          .||.:...|...||.|..           
Human  1260 AMHSLQVLAQVTG--KSVTVI-MEPH----------KEVLQDMVPPKKHLLRHQPANAQIGLMEG 1311

  Fly  1651 ---------REFT-------------------EFHQKLCMHFPLVKLHSLPAGVHVGRSNIKSVA 1687
                     |.||                   |.........|..|  |||:.|.:..:.:.::|
Human  1312 NTFCTTLQPRLFTMDLNVVEHKVFYTELLNLCEAEDSALTKLPCYK--SLPSLVPLRIAALNALA 1374

  Fly  1688 ------EKRLPLIQRFLKSLFDASEEIAHS----------------ELVYTFFHPLLR---DQQE 1727
                  :.|..:|....|:|...:.|:..:                :.::|...|||.   |.:.
Human  1375 ACNYLPQSREKIIAALFKALNSTNSELQEAGEACMRKFLEGATIEVDQIHTHMRPLLMMLGDYRS 1439

  Fly  1728 AKLG-MPKIKEVKQQ-PSRDNPHEIGQIRLSLQYQRGVLTVMIHHAKGLPMLQGGQEPNTYVKCY 1790
            ..|. :.::..|.:. |:..|.....|:   :|:.|..:.|::...||.....|.:..:...:|.
Human  1440 LTLNVVNRLTSVTRLFPNSFNDKFCDQM---MQHLRKWMEVVVITHKGGQRSDGNESISECGRCP 1501

  Fly  1791 LKP----DPKKETKRKTKVVRKTC---------VPSFMETL 1818
            |.|    :|..|...:.|:    |         :|:..:||
Human  1502 LSPFCQFEPAMEGVEEMKI----CSAIINLFHLIPAAPQTL 1538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K68DNP_001163420.1 EIN3 <58..392 CDD:296674 15/64 (23%)
PI3K_rbd 561..669 CDD:197540 20/113 (18%)
C2A_PI3K_class_II 844..1021 CDD:175979 30/209 (14%)
PI3Ka_II 1038..1202 CDD:238441 46/202 (23%)
PI3Kc_II 1235..1583 CDD:270710 70/427 (16%)
PX_PI3K_C2_68D 1611..1721 CDD:132794 27/170 (16%)
C2B_PI3K_class_II 1751..1871 CDD:176027 17/81 (21%)
TRRAPNP_001362453.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 491..541 6/55 (11%)
Interaction with TP53. /evidence=ECO:0000269|PubMed:12138177 2017..2395
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2030..2051
Bipartite nuclear localization signal. /evidence=ECO:0000255 2054..2069
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2550..2585
TEL1 <2552..3873 CDD:227365
FAT 2868..3200 CDD:367004
PIKK_TRRAP 3510..3797 CDD:270707
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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