Protein Alignment Pi3K68D and pi4kab

DIOPT Version :9

• Sequence 1: NP_001163420.1
• Gene: Pi3K68D / 39329
• FlyBaseID: FBgn0015278
• Length: 1876
• Species: Drosophila melanogaster
• Sequence 2: NP_001106813.1
• Gene: pi4kab / 793349
• ZFINID: ZDB-GENE-080220-34
• Length: 1099
• Species: Danio rerio
• Alignment Length: 1136
• Identity: 213/1136 - (18%)
• Similarity: 374/1136 - (32%)
• Gaps: 408/1136 - (35%)

  Fly   454 SPPPPLPPR--------NQQCYESNQAAMPVSRPPQSSVLTDSYTSSIPANVVLDRRKTCTRLYE 510
            :|||..|.|        .::.:...::.:|      ||:||      :..:..|.|:.|.|.|..
Zfish   155 APPPATPVRGSVETEGIRRRSFNDFRSILP------SSLLT------VCQSDTLRRKSTATNLDA 207

  Fly   511 LISDQR---------TDDPELLEFYHMVKEVRARYPHDDAPTNVGH---VVAAEFNYHYMMDTSI 563
            ..|..|         ...|:..|         ..|..:.:..|..:   .|::.|:...:...:.
Zfish   208 QASPDRGGPSPCSPTAPGPQYFE---------GSYLSEGSAVNPDYYFTTVSSSFSMSPLFSGAS 263

  Fly   564 KVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDIDSVVAQVVAQALASLEGQVKGTVTDYA 628
            ...::..|..|:..:       :.||.: :..:|...:|:||.: |.:|.|.::...||......
Zfish   264 GPEINVPLELLRRLL-------QMVKQF-VSDSFLKSLDAVVTE-VTEANAGVDLFYKGFSDPLY 319

  Fly   629 VKPIGLLEWLAPTSRLSQLECVHNSFQLEKDVH---LGLCLSTAANMQAIARTERDDEHDADLLP 690
            |....:|.     ..|..::.||..|  .|:||   |....|:.:.:|.:...||
Zfish   320 VSMFKMLR-----DTLYYMKDVHAGF--VKEVHDFVLEQFSSSQSELQRVLHEER---------- 367

  Fly   691 EHLLPNEVVPIVTYDNMMILIETLEMEIDKLESAADGVPGRSVVSCSGVVQAVKAICALLG---- 751
               ||.|..|:                  ||...|:......:|......|..:.:|..|.
Zfish   368 ---LPGEASPL------------------KLRCHANAACVDLMVWAVKDEQGAENLCTKLSEKLQ 411

  Fly   752 --SIDTMEIAR------CVADLKRICEVEQKKYSTGASNPEI-VSDYGDYAQVVLRPRSMLEQIK 807
              :...:.||.      |:..|.|:||    ::...|.:..: :.|:      ::.|.::|  ||
Zfish   412 SKTSSKVIIAHMPLLICCLQGLGRLCE----RFPVIAHSASLSLKDF------LVVPSAVL--IK 464

  Fly   808 VKCNELRDAVQELVELYANVFRVAFSVK---TPDYSTTPIPISCVSKPIVVCISCLHRPLPNWKF 869
                        |.:.::.....|..:|   |.::|.:.:.:....|
Zfish   465 ------------LYKYHSQCSSGAGGIKINVTNEHSQSSLNLLSSRK------------------ 499

  Fly   870 DDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFSAWLTFDQHPICTLPREARLTFVLYGK 934
            |..|:..|:    |.:|..|:..|             ..|.||.|  |:......|.|:..||..
Zfish   500 DQPSMYEQL----RDISIDNICRC-------------LKAGLTMD--PVIVEAFLASLSNRLYIS 545

  Fly   935 QAASEGEPNADQNGERRQVTTE-----LGWCSIQLFDFKRVMICGPYLLSLWPPMTDKMLGPAPA 994
            |          :|.:...:..:     ||..::.:.|..:||              :.:|.....
Zfish   546 Q----------ENDKEAHLIPDHTIRALGHIAVAMRDSPKVM--------------EPILQILQQ 586

  Fly   995 RGCHPQPDFCPVLSIE----VPPYGGRIEFPE----HQEVPKPAPHYDF---------------- 1035
            :.|.| |....||.|:    :...|.:..:.|    .|::...|.:..:
Zfish   587 KFCQP-PSPLDVLIIDQLGCMIITGNQYIYQEVWNLFQQISVKASNVVYSATKDYKDHGYRHCSL 650

  Fly  1036 ------ASLDANLQ-EELLDT---------AELGYTG--ATERREVFWEKRLYLQSYPNA----- 1077
                  |::.|||| |.|:|.         .:||..|  |.||..   :|...|::..:|
Zfish   651 AVINALANIAANLQGEPLVDELLVNLLELFVQLGLEGKRACERAS---DKGPALKASSSAGNLGV 712

  Fly  1078 -----------LPKVLHA--------AHSWDYANLIDLHALLHS------W-------APLSPLQ 1110
                       ||.:..|        ...|.|:.::.. |:..|      |       |..|||.
Zfish   713 LIPVIAVLTRRLPPIKEAKPRLQKLFRDFWLYSVVMGF-AVEGSGLWPEEWYEGVCEIATKSPLL 776

  Fly  1111 SLELLLPRYPDAKVREKAVEWISKMPND-----QLVDFLPQLVQSLKHDTYEGSAMARFLLSKCL 1170
            :       :|..:.....:::.|.:.||     :|.|....::..|     :.|..|..|::|.
Zfish   777 T-------FPSGEPLRSELQYNSALKNDTVTPAELSDLRSTIINLL-----DPSPEAAALINKL- 828

  Fly  1171 ESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEY---------DESQVTQVRYY-----RRNKMM 1221
               .||...|.|.|:.|               ||         |..|| ..||:     :::|..
Zfish   829 ---DFAMCTYLLSVYRL---------------EYMRMLHSNDADRFQV-MFRYFEDKAIQKDKSG 874

  Fly  1222 LRALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKS--LAAGMDEVHQ--------- 1275
            :...:...|:|:.:.|:  ..|.:|..|     ||.:|.:.:.:  |....:..|:
Zfish   875 MMQCVICVGDKVFEVFL--QMMAEKPKT-----KEHEEELERHAQFLLVNFNHTHKRIRRVADKY 932

  Fly  1276 ----------------------DLLEQPTCLPLGPELEVTGVSVRNCSYFNSNTLPLKINFVGPD 1318
                                  |:| |...|.|..::.      ::..|::....|.:|..  ||
Zfish   933 LSGLAETFPHLLWSGRVLKTMLDIL-QTLSLSLSADIH------KDQPYYDIPDTPYRITV--PD 988

  Fly  1319 A----ESLPAIF--KCGDDLQQ------DQLTIQLIRIMNK--MW---LAERLDLKMVTFNCVP- 1365
            .    ||:...|  :||:.|::      ......|...:||  .|   |::...|.|.|.:.:.
Zfish   989 THEARESIVKDFAARCGEILKEAMKWAASVTKSHLQEYLNKHQNWLSGLSQHTGLAMATESILNF 1053

  Fly  1366 TGYKS-----GMIELVSE--AETLRKIQVEC 1389
            .||..     ||  :|||  .|...:::|.|
Zfish  1054 AGYNRQSTTLGM--MVSERVTEVFVQMKVSC 1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540	24/110 (22%)
		C2A_PI3K_class_II	844..1021	CDD:175979	32/185 (17%)
		PI3Ka_II	1038..1202	CDD:238441	45/217 (21%)
		PI3Kc_II	1235..1583	CDD:270710	43/213 (20%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
pi4kab	NP_001106813.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900