DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K68D and zgc:158659

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	XP_005170630.1	Gene:	zgc:158659 / 791141	ZFINID:	ZDB-GENE-070112-492	Length:	1070	Species:	Danio rerio

Alignment Length:	1225	Identity:	312/1225 - (25%)
Similarity:	514/1225 - (41%)	Gaps:	285/1225 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   479 PPQSSVLTDSYTSSIPANVVLDRRKTCTRLYEL--ISDQRTDDPELLEFYHMVKEVRARYPHDDA 541
            ||:  :|.|   ..:|..:::...  |.|...|  |..|...:......||:::|       :..
Zfish    17 PPR--ILVD---CCLPNGILVSLE--CLREAPLTSIKQQLFSEARKYPLYHLLQE-------ESC 67

  Fly   542 PTNVGHVVAAEFNYHYMMDTSIKV----IVHPALNTLQSTVLAASMGKEQVK------GY--GMP 594
            ...||....||....|  |.:.::    :.||.|..::      .:|..:.|      |:  |||
Zfish    68 YIFVGVTQEAEREEFY--DETRRLCDLRLFHPILKVIE------PLGNREEKILNREIGFAIGMP 124

  Fly   595 VTFTCDIDSV-----------VAQVVAQALASLEGQVKGTVTDYAVKPIGLLEWLAPTSRLSQLE 648
            :   |:.:.|           :..|..:|:...||
Zfish   125 I---CEFELVKDPEVQDFRRNILSVCREAVEEREG------------------------------ 156

  Fly   649 CVHNSFQLEKDVHLGLCLSTAANMQAIARTERDDEHDADLLPEHLLP--NEVVPIVTYDNMMILI 711
                               ..|:.||:.....:.|...| ||:|:..  ::...|||.  .:|:.
Zfish   157 -------------------GGAHTQALYVYPPNVESSPD-LPQHIYSKLDKGRLIVTI--WVIVS 199

  Fly   712 ETLEMEIDKLESAADGVPGRSVVSCSGVVQAVKAICALLGSIDTMEIARCVAD-----LKRICEV 771
            .:...:...|:.|.|.:|.:.      :.:|::.....: .:...::..||.:     :.::|..
Zfish   200 PSNSKQKYTLKIAHDSLPEQL------IAEAIRKKTRSM-HLSAQQLRLCVQEYQGQYILKVCGC 257

  Fly   772 EQ---KKYSTGASNPEIVSDYGDYAQVVLR----PRSMLEQIKVKCNELRDAVQELVELYANVFR 829
            ::   :||.        :|.| .|.:..:.    |..||..        :|:      ||:.:..
Zfish   258 DEYFLEKYP--------LSQY-KYIRSCITLCRLPHLMLVS--------KDS------LYSQLPS 299

  Fly   830 VAFSVKTPDYS-TTPIPISCV--SKPIVVCISCLHRPLPNWKFDDY----SLC----------VQ 877
            ..|  ..|.|| .||.|..|.  ..|        ..|...|.|:.:    .||          :.
Zfish   300 SGF--MAPSYSRRTPQPSPCPGGGDP--------GSPRSLWAFNTHLRVRLLCATYVNVNIRDID 354

  Fly   878 IVY--------GTRLLSKPNV--LTCSNDTSGGLFPRLNFSAWLTFDQHPICTLPREARLTFVL- 931
            .:|        |..|....|.  :.|||       ||.|  .||::|.: :..:||.|||...:
Zfish   355 KIYVRTGIYHGGEPLCDNVNTQRVPCSN-------PRWN--EWLSYDIY-LTDVPRSARLCLSIC 409

  Fly   932 --YGKQAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLWPPM--TDKMLGPA 992
              .|::.|.|..             ..|.|.:|.|||:|..::.|...|.|||..  .:.:|.|.
Zfish   410 SVKGRKGAKEEH-------------CPLAWGNINLFDYKDTLVSGKVALGLWPVPHGLEDLLNPI 461

  Fly   993 PARGCHPQPDFCPVLSIEVPPYGGRIEFPEHQEVPKPAP-------HYDFA-------SLDANLQ 1043
            ...|.:|..: .|.:.:|.|.:...:.||:.|::.:.|.       .|.:.       :.|:::.
Zfish   462 GVSGSNPNKE-TPCVELEFPWFNQTVVFPDEQQIEEHANWSISRELGYSYCLGLSSRLACDSSIS 525

  Fly  1044 EELLDTAELG--------YTGATERREVFWEKRLYLQSYPNALPKVLHAAHSWDYANLI-DLHAL 1099
            :  .|..:|.        |..:.:.::..|..|.|..:.|.:|||:|.:. .|:..:.: .::.|
Zfish   526 Q--ADAEQLRTLCSRDPLYELSEQEKDFLWRHRHYCVNIPESLPKLLLSV-KWNSRDEVSQIYCL 587

  Fly  1100 LHSWAPLSPLQSLELLLPRYPDAKVREKAVE-WISKMPNDQLVDFLPQLVQSLKHDTYEGSAMAR 1163
            |..|..:.|..|||||...:||..|||.|:. .|..:.:|:|..:|.||||.||::.|..:.:||
Zfish   588 LKDWPLMQPESSLELLDCNFPDPMVREFALRCLIQGLTDDKLSQYLLQLVQVLKYEMYLDNPLAR 652

  Fly  1164 FLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAI 1228
            ||:.|.|.:.|..|..:|    .|..:.||...:                  ||..::|.|....
Zfish   653 FLIKKALTNQRIGHFFFW----HLKSEMHNKTVS------------------RRFGLLLEAFCRA 695

  Fly  1229 CGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQ---DLLE--QPTCLPLGP 1288
            || ..|:....|.....||..:.:::|:.|:...||:....:.| |.   |.:|  |....||.|
Zfish   696 CG-MYLKHLNRQVEAMDKLVNLTDTLKQEKKDETQKTQMKFLVE-HMSRPDYMEALQGFVSPLNP 758

  Fly  1289 ELEVTGVSVRNCSYFNSNTLPLKINFVGPD--AESL----PAIFKCGDDLQQDQLTIQLIRIMNK 1347
            ..::..:.:..|...:|...||.:|:..||  :|.|    ..|||.||||:||.||:|:|:||..
Zfish   759 VHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFTNNEIIFKNGDDLRQDMLTLQIIKIMEN 823

  Fly  1348 MWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVECGLTGS--FKDRPIAEWLGKQNPS 1410
            :|..:.|||:|:.:.|:..|...|:||:|..:.|:.:||.:.||.|:  |....:..|:..:|..
Zfish   824 IWQNQGLDLRMLPYGCLSIGDCVGLIEVVKNSHTIMQIQCKGGLKGALQFNSNTLHHWIRDRNKG 888

  Fly  1411 PLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDR 1475
            . .|..|:..||.|||||.|||::|||.||||.|||:|.:|.|||||||.||...:....:||:|
Zfish   889 E-AYDRAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKENGQLFHIDFGHFLDHKKKKFGYKRER 952

  Fly  1476 TPFVLTSDMAYVINGGDKPST---DFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNS- 1536
            .|||||.|...||:.|.:..|   :|..|.::|.:|:..:|::|.|.::..:.:...|||.:.|
Zfish   953 VPFVLTQDFLIVISKGVQECTKTKEFERFQEMCYKAYLAIRQHASLFINLFSLLLGCGMPELQSF 1017

  Fly  1537 NAVQYVRRALLPSQSNPEAAATFAKMIQSSLK-SWFTQFNFFLHNLAQMRFTPDE 1590
            :.:.|:|:.|...:|..||...|.|.:..:.. .|.|:.::..|.:..|   |:|
Zfish  1018 DDIAYLRKTLALEKSQQEALEYFTKQMNDAHHGGWTTKMDWIFHTIRHM---PNE 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540	15/130 (12%)
		C2A_PI3K_class_II	844..1021	CDD:175979	48/207 (23%)
		PI3Ka_II	1038..1202	CDD:238441	51/173 (29%)
		PI3Kc_II	1235..1583	CDD:270710	127/365 (35%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
zgc:158659	XP_005170630.1	PI3K_p85B	32..107	CDD:280372	17/91 (19%)
		PI3K_rbd	173..292	CDD:279173	24/145 (17%)
		C2_PI3K_class_I_alpha	327..486	CDD:176043	44/182 (24%)
		PI3Ka_I	528..697	CDD:238444	54/191 (28%)
		PKc_like	696..1065	CDD:304357	130/371 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579756
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750