Protein Alignment Pi3K68D and pik3cb

DIOPT Version :9

• Sequence 1: NP_001163420.1
• Gene: Pi3K68D / 39329
• FlyBaseID: FBgn0015278
• Length: 1876
• Species: Drosophila melanogaster
• Sequence 2: NP_001072928.1
• Gene: pik3cb / 780390
• XenbaseID: XB-GENE-482674
• Length: 1065
• Species: Xenopus tropicalis
• Alignment Length: 1084
• Identity: 285/1084 - (26%)
• Similarity: 469/1084 - (43%)
• Gaps: 224/1084 - (20%)

  Fly   595 VTFTCD----IDSVVAQVVAQALASLEGQVKGTVTDYAVKP-----------IGL--LEWLAPTS 642
            |:.:|:    :||.:..::.:.|...:......|.::..|.           :||  :|||..|.
 Frog   103 VSRSCNPAEKLDSKIGVLIGKGLQEFDALKDNEVMEFRSKMRSISEAKIQSLLGLTWVEWLKRTF 167

  Fly   643 RLSQLECVHNSFQ-------LEKDVHLGLCLSTAANMQAIARTERDDEHDADLLPEHLLPNEVVP 700
            .......:.::.|       :...:|...|                    .|:....:.||
 Frog   168 PPELEPSIQDNIQGKLYGGNIVVAIHFENC--------------------QDVFSFQVSPN---- 208

  Fly   701 IVTYDNMMILIETLEMEIDKL-----ESAADGVPGRSVVSCSGVVQAVKA-----------ICAL 749
                   |:.::..|:.|.|.     ..|.:..|...|:..:|.::.|..           .|.:
 Frog   209 -------MVPVKVNELAIRKRLTIHGREAEEVDPEDFVLQVNGRLEFVFGDHPLIQFQYIRNCVM 266

  Fly   750 LGSIDTMEIARCVADLKRI-----CEVEQKKYSTGASNPEIVSDYGDYAQVVLRPRSMLEQIKVK 809
            ..::..:.:..| .::|::     .|:|.......:.:|.:        .:.|.|:.  ....:|
 Frog   267 NKALPHLTLVEC-CNIKKLFDQEMSEIEHAVRRKSSMHPAL--------PMPLPPKK--RGASMK 320

  Fly   810 CNELRDAVQELVELYANVFRVAFSVKTPDYSTTPIPISCVSKPIVVCISCLHRPLPNWKFDDYSL 874
            ...:||.|..:|:.|..:......:.|.|                   |.|.|
 Frog   321 TLNMRDIVWNIVQPYKIILSKGSRLNTED-------------------SVLVR------------ 354

  Fly   875 CVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFSAW---LTFDQHPICTLPREARLTFVLYGKQA 936
             ..:.:||.||.||   |.:.:..|     .|...|   |.|:.: :|.|||.|||.|.:|
 Frog   355 -AGLFHGTELLCKP---TMTPEVQG-----KNDHVWNETLEFEIN-VCDLPRMARLCFAIY---- 405

  Fly   937 ASEGEPNADQNGERRQVTTELG-------WCSIQLFDFKRVMICGPYLLSLW---PPMTDKMLGP 991
            |...:|. ::|..:.|...:.|       |.:..:||:|..:..|.::|..|   |...::||.|
 Frog   406 AVLDKPR-NKNKTKYQTIKKSGKMHFPVAWVNTMVFDYKGQLRSGDHVLHCWSSFPDELEEMLNP 469

  Fly   992 APARGCHPQPDFCPVLSIEVPPYGGR-IEFPEHQEVPKPAP----HYDFASLDA------NLQ-E 1044
            ......:|..:....|.|:...|... |.:|...::.:.|.    :.|..|...      |:: :
 Frog   470 MGTVRTNPYTENTTTLHIKFHDYSKEPISYPPFDKILEKAAEIARNSDSLSTSGRGGKKLNIELK 534

  Fly  1045 ELLDTAELGYTGATERREVFWEKRL-YLQSYPNALPKVLHAAHSWD-YANLIDLHALLHSWAPLS 1107
            |:::...|......| :::.|..|. ..:::|.:|||:|.:. .|: ..::..|.|||..|:.|.
 Frog   535 EIMERDPLCQLSENE-KDLIWTLRYDCRENFPGSLPKLLLSV-KWNKLEDVAQLQALLQIWSKLP 597

  Fly  1108 PLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLES 1172
            |..:||||...|||..|||.||..:..|.:::|..:|.||||.||::.:...|::||||.:.|::
 Frog   598 PRDALELLDFNYPDQYVREYAVNCLKPMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLQRALDN 662

  Fly  1173 PRFAHHMYWLL---VHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAICGEKML 1234
            .|....::|.|   ||    :|..|:...::.:.|....|..::...|....|..|..:.|
 Frog   663 RRIGQFLFWHLRSEVH----NPAVSVQFGLLLEAYCRGSVAHMKVLSRQVEALNKLRTLNG---- 719

  Fly  1235 QRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQPTCL--------------P 1285
                     ..||..:..|..:.|::|.                   |||              |
 Frog   720 ---------LIKLNAVKLSKVKNKDNMH-------------------TCLRENAYKEALMHIQSP 756

  Fly  1286 LGPELEVTGVSVRNCSYFNSNTLPLKI--NFVGPDAESLPAIFKCGDDLQQDQLTIQLIRIMNKM 1348
            |.|.:.::.:.|..|.|.:|...||.|  |..|..::||..|||.||||:||.|.:||:|:|:.:
 Frog   757 LNPSITLSELVVEKCKYMDSKMKPLWIVYNNRGFGSDSLGIIFKNGDDLRQDMLALQLLRLMDML 821

  Fly  1349 WLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVE---CGLTGSFKDRPIAEWLGKQNPS 1410
            |....|||::|.:.|:.||.:.|.||:||.|||:..||::   .....:|....:..|: |:..|
 Frog   822 WKEAGLDLRIVPYGCLATGDRCGFIEVVSAAETIADIQLDSSNLAAAAAFNKDALLNWI-KECHS 885

  Fly  1411 PLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDR 1475
            ..:.:.|:..||||||||.||||||||.||||||||::.:|.|||||||..||:.:.....||:|
 Frog   886 GDDLERAIEEFTLSCAGYCVATYVLGIGDRHNDNIMVRKTGQLFHIDFGHILGNFKSKFKIKRER 950

  Fly  1476 TPFVLTSDMAYVINGGDKPSTD-FHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNS-NA 1538
            .||:||.|..:||..|...:|: |..|...|..|:.|:|:|.:|::...|.|.|||:|.::| ..
 Frog   951 GPFILTYDFIHVIQQGKPGNTEKFGRFRQCCEDAYLILRRNGNLIITLFALMLTAGLPELSSVKD 1015

  Fly  1539 VQYVRRALLPSQSNPEAAATFAKMIQSSLK-SWFTQFNFFLHNL 1581
            :|||:.:|...:...:|...|.:....:|| ||.|:.|:..|.:
 Frog  1016 IQYVKDSLALGKKEEDALKQFRQKFDEALKESWTTKVNWMAHTM 1059

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540	16/97 (16%)
		C2A_PI3K_class_II	844..1021	CDD:175979	45/190 (24%)
		PI3Ka_II	1038..1202	CDD:238441	53/175 (30%)
		PI3Kc_II	1235..1583	CDD:270710	133/369 (36%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
pik3cb	NP_001072928.1	PI3K_p85B	33..108	CDD:308030	1/4 (25%)
		PI3K_rbd	171..279	CDD:307097	17/139 (12%)
		C2_PI3K_class_I_beta_delta	328..495	CDD:176075	49/212 (23%)
		PI3Ka_I	533..697	CDD:238444	53/169 (31%)
		PI3Kc_IA_beta	701..1062	CDD:270717	137/392 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010