DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pi3K68D and Pik3cb

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_083370.2	Gene:	Pik3cb / 74769	MGIID:	1922019	Length:	1064	Species:	Mus musculus

Alignment Length:	1071	Identity:	302/1071 - (28%)
Similarity:	480/1071 - (44%)	Gaps:	202/1071 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   595 VTFTCD----IDSVVAQVVAQALASLEGQVKGTVTDYAVKP-----------IGL--LEWLAPT- 641
            ||.:||    :||.:..::.:.|...:......|.::..|.           :||  ::||..|
Mouse   106 VTRSCDPAEKLDSKIGVLIGKGLHEFDALKDPEVNEFRRKMRKFSEAKIQSLVGLSWIDWLKHTY 170

  Fly   642 ------SRLSQLECVHNSFQLEKDVHLGLCLSTAANMQAIARTERDDEHDADLLPEHLLPNEVVP 700
                  |.|..||......:|...||.                    |:..|:....:.|| :.|
Mouse   171 PPEHEPSVLENLEDKLYGGKLVVAVHF--------------------ENSQDVFSFQVSPN-LNP 214

  Fly   701 IVTYDNMMILIETLEMEIDKLESAADGVPGRSVVSCSGVVQAVKAICALLGSIDTMEIARCVADL 765
            |..  |.:.:.:.|.:...:.|::    |...|:..||.|:.|.....|   |....|..||.:
Mouse   215 IKI--NELAIQKRLTIRGKEDEAS----PCDYVLQVSGRVEYVFGDHPL---IQFQYIRNCVMN- 269

  Fly   766 KRICEVEQKKYSTGASNPEIVSDYGDYAQVVLRPRSMLEQIKVKCNELRDAV-QELVELYANVFR 829
                                              |::...|.|:|.:::... ||::.:.|.:.|
Mouse   270 ----------------------------------RTLPHFILVECCKIKKMYEQEMIAIEAAINR 300

  Fly   830 VAFSVKTPDYSTTPIPISCVSKPIVVCISCLHRPLP------NWKFDDYSLCVQI----VYGTRL 884
                    :.|..|:|:......::..|...:.|..      |....:.::.|.:    .:||.|
Mouse   301 --------NSSNLPLPLPPKKTRVISHIWDNNNPFQITLVKGNKLNTEETVKVHVRAGLFHGTEL 357

  Fly   885 LSKPNVLTCSNDTSGGLFPRLNFSAW---LTFDQHPICTLPREARLTFVLYG-------KQAASE 939
            |.|..|   |::.||     .|...|   |.||.: ||.|||.|||.|.:|.       |::...
Mouse   358 LCKTVV---SSEISG-----KNDHIWNEQLEFDIN-ICDLPRMARLCFAVYAVLDKVKTKKSTKT 413

  Fly   940 GEPNADQNGERR-QVTTELGWCSIQLFDFKRVMICGPYLLSLW---PPMTDKMLGPAPARGCHPQ 1000
            ..|:..|...:. :|...:.|.:..:||||..:..|..:|..|   |...::||.|......:|.
Mouse   414 INPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRSGDVILHSWSSFPDELEEMLNPMGTVQTNPY 478

  Fly  1001 PDFCPVLSIEVPPYGGRIEFPEHQEVPKPAPHYD--------FASLD-ANLQ-----------EE 1045
            .:....|         .|.|||:::.|...|.:|        .||.| ||:.           :|
Mouse   479 AENATAL---------HITFPENKKQPCYYPPFDKIIEKAAELASGDSANVSSRGGKKFLAVLKE 534

  Fly  1046 LLDTAELGYTGATERREVFWEKRL-YLQSYPNALPKVLHAAHSWD-YANLIDLHALLHSWAPLSP 1108
            :||...|......| .::.|..|. ..:::|.:|||:| .:..|: ..::..|.|||..|..|.|
Mouse   535 ILDRDPLSQLCENE-MDLIWTLRQDCRENFPQSLPKLL-LSIKWNKLEDVAQLQALLQIWPKLPP 597

  Fly  1109 LQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESP 1173
            .::||||...|||..|||.||..:.:|.:::|..:|.||||.||::.:...|::||||.:.|::.
Mouse   598 REALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALDNR 662

  Fly  1174 RFAHHMYWLL---VHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAICGEKMLQ 1235
            |....::|.|   ||:    |..|:...::.:.|....|..:      |::.:.:.|:...|.|.
Mouse   663 RIGQFLFWHLRSEVHT----PAVSVQFGVILEAYCRGSVGHM------KVLSKQVEALNKLKTLN 717

  Fly  1236 RFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQPTCLPLGPELEVTGVSVRNC 1300
            ..:       ||..:..|..:.||:|......:...|...||..     ||.|.:.::.:.|..|
Mouse   718 SLI-------KLNAVKLSRAKGKEAMHTCLKQSAYREALSDLQS-----PLNPCVILSELYVEKC 770

  Fly  1301 SYFNSNTLPLKINF----VGPDAESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTF 1361
            .|.:|...||.:.:    .|.|  |:..|||.||||:||.||:|::|:|:.:|....|||:|:.:
Mouse   771 KYMDSKMKPLWLVYSSRAFGED--SVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPY 833

  Fly  1362 NCVPTGYKSGMIELVSEAETLRKIQV---ECGLTGSFKDRPIAEWLGKQNPSPLEYQSAVRNFTL 1423
            .|:.||.:||:||:||.:||:..||:   ....|.:|....:..||.:.| |..:...|:..|||
Mouse   834 GCLATGDRSGLIEVVSTSETIADIQLNSSNVAATAAFNKDALLNWLKEYN-SGDDLDRAIEEFTL 897

  Fly  1424 SCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVI 1488
            |||||.||:|||||.|||:||||:|.:|.|||||||..||:.:.....||:|.||:||.|..:||
Mouse   898 SCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVI 962

  Fly  1489 NGGDKPSTD-FHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNS-NAVQYVRRALLPSQS 1551
            ..|...:|: |..|...|..|:.|:|::.:|.:...|.|.|||:|.:.| ..:||::.:|...:|
Mouse   963 QQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLALGKS 1027

  Fly  1552 NPEAAATFAKMIQSSLK-SWFTQFNFFLHNL 1581
            ..||...|.:....:|: ||.|:.|:..|.:
Mouse  1028 EEEALKQFKQKFDEALRESWTTKVNWMAHTV 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540	21/97 (22%)
		C2A_PI3K_class_II	844..1021	CDD:175979	48/200 (24%)
		PI3Ka_II	1038..1202	CDD:238441	57/180 (32%)
		PI3Kc_II	1235..1583	CDD:270710	132/357 (37%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
Pik3cb	NP_083370.2	PI3K_p85B	35..112	CDD:197539	3/5 (60%)
		PI3K_rbd	174..282	CDD:366310	31/172 (18%)
		C2_PI3K_class_I_beta_delta	318..495	CDD:176075	50/194 (26%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250	404..412		1/7 (14%)
		PI3Ka_I	526..696	CDD:238444	55/175 (31%)
		PI3Kc_IA_beta	700..1061	CDD:270717	136/380 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836289
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750