DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K68D and pik3c2a

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	XP_005159362.2	Gene:	pik3c2a / 571356	ZFINID:	ZDB-GENE-030328-39	Length:	1691	Species:	Danio rerio

Alignment Length:	1985	Identity:	616/1985 - (31%)
Similarity:	923/1985 - (46%)	Gaps:	414/1985 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AHIDYDKQFQDD-------------LAKATALSLEQHALDDYRRNKKYGSGYQQSSTVAGRDYQA 56
            |||.....|:.|             :.|..||.:|..|.|..:|.|:
Zfish     2 AHISSGNGFKFDRPASPGVVRPKGIVGKEEALRMEVEAFDKIKREKR------------------ 48

  Fly    57 AQRSQSLHQPRRHSEVHQVAISPENAERSRTPPAQGT----DNDLICFASPTSKQPESSSPFGKL 117
                            |.:.::..:......|.||.:    :.|||.|....:::.|....|..:
Zfish    49 ----------------HTLPVTASSVNPLPNPTAQTSTSRPEKDLIVFCESETQKKEQKDNFEDI 97

  Fly   118 ------IEDLQRM---------QPTNPQSALVPMGPVASASIPPQYGFPPHQ----QRPTAAQPT 163
                  .|:|:::         :.|.|.|.|   |...|||.|..:.|.|..    ..||.||
Zfish    98 DLENLTKEELEKLLLDDSFGANKMTRPSSLL---GCNLSASYPGGHAFNPSSFHWTPTPTHAQ-- 157

  Fly   164 PYGMVAGGVVGGPAYGDLQLVPYQPAAQQQRPLNSEELQRLYSMPAQMAVVPVP-------QPNA 221
                                .|..|:|...:|..|  .|..:|......:.|.|       ||.|
Zfish   158 --------------------TPIFPSAPFAKPPCS--FQNGFSPAMSPFIPPTPFLSFTPIQPPA 200

  Fly   222 YMYYPGAVVTPYTAPIVPGSAAFMPPQYPAQGYGFGGAYTHMDLRR---PQSQPAPQQTAPTTSH 283
            .:.|....|||..|.:....|:       ...|...|..:.|:...   ...:|.||.
Zfish   201 ALVYSQPAVTPEMAKLFDKIAS-------TSEYLKNGRSSSMETESASVKSLEPLPQP------- 251

  Fly   284 HHSQPSNHSTSSPAEANGVAFPARRQVPSTVGVSSSSHTGNNGHSSVPRRGNDLIDLNHEDYSRV 348
              |:|.|.|.....:.:.:......:|..|..|||......:|.:..|
Zfish   252 --SEPPNISRFEWLDLDPLNKRKEVEVEETPAVSSCPFIEESGKAKDP----------------- 297

  Fly   349 SVLEAFDPLLNDNTGNDTASDSTSYYAEYDPFDFLYSGDAATQYSDPMYEAVNRWDKTVATVSPN 413
                 :|.:|.|.  ::|. |:.|..||                           :|..||
Zfish   298 -----WDAVLQDE--HETV-DNGSPKAE---------------------------EKCKAT---- 323

  Fly   414 VGLIGWRQDFLSQPSTSSSQYGVAPPEESLKLAENGSGTISPPPPLPPRNQQCYESNQAAMPVSR 478
                        ||..:|:...|. ..:||.::.|                   .:||:......
Zfish   324 ------------QPRRASTGAAVT-KSQSLSISSN-------------------STNQSTGKQVN 356

  Fly   479 PPQSSVLTDSYTSSIPANVVLDRRKTCTRLYELISDQRTDDPELLEFYHMVKEVRARYPHDDAPT 543
            ...::||:.                     |..:.::...:.|::.|...:.::|:::||||..|
Zfish   357 KGSTNVLSK---------------------YSALQEKEAQNLEVVAFCEDISKLRSKFPHDDLST 400

  Fly   544 NVGHVVAAEFNYHYMMDT------SIKVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDID 602
            |.|:|::....   ..|.      |:||.:                   ::.....|||||||:.
Zfish   401 NPGYVLSPVIT---QRDAGGDNGGSVKVSI-------------------EISDSQQPVTFTCDVT 443

  Fly   603 SVVAQVVAQALASLEGQVKGT-VTDYAVKPIGLLEWLAPTSRLSQLECVHNSFQLEKDVHLGLC- 665
            |.|..::.|||..:...:... :..|.:|..|..|.|.....|...|.|.|..:.|.::.|.|.
Zfish   444 SPVDLLIMQALCWVHDDLNQVDINSYVLKVCGQEEVLQNKHSLGSHEYVQNCRKWESEIKLQLLF 508

  Fly   666 LSTAANMQAIARTERDDEHDADLLPEHLLPNEVVPIVTYDNMMILIETLEMEIDKLESAADGVPG 730
            |||.  .:.:|||..||....||                :..:.|:|....|....|..|:.:.|
Zfish   509 LSTM--RRDLARTAEDDISPIDL----------------EKYLGLVERPFKEAVTREGLAEYLEG 555

  Fly   731 --RSVVSC-----------SGVVQAVKAICALLGSIDTMEIARCVADLKR------------ICE 770
              :.|..|           ..|||:||.:|..|..::|..|...|..|||            ..|
Zfish   556 FHKQVNLCLQNENNQYKTVDNVVQSVKNLCCALDEVETPAITDAVKRLKRSVNLPRTRSPEHYAE 620

  Fly   771 VEQKKYSTGASNPEIVSDYGDYAQVVLRPRSMLEQIKVKCNELRDAVQELVELYANVF---RVAF 832
            ::....|:|.|    .:.|....:         |.:.|    |.|||.||.:||...|   ...|
Zfish   621 LQAGATSSGGS----ANGYSSPVE---------ESLAV----LTDAVYELAKLYLQSFCPISPGF 668

  Fly   833 SVK--------TPDYSTTPIPISCVSKPIVVCISCLHRPLPNW--KFDDYSLCVQIVYGTRLLSK 887
            .::        :.:.|.|       ::.:...:..:|.....|  .|:.|.|...:.:..|.|.|
Zfish   669 MIEEHKEDERDSKEASGT-------TEHLQFTLFAVHGIPATWVSSFEKYYLMCALTHNNRNLFK 726

  Fly   888 PNVLTCSNDTSGGLFPRLNFSAWLTFDQHPICT--LPREARLTFVLYGKQAASEGEPNADQNGER 950
            | |.:....|....|..:.:...:.|   ||..  ||.||.|:..|||  ..|:...|:..:.::
Zfish   727 P-VQSKKVGTYKSFFYHIKWDELINF---PISVSLLPLEAMLSLSLYG--VLSQNANNSPDSNKQ 785

  Fly   951 RQVTTELGWCSIQLFDFKRVMICGPYLLSLWPPMTDKMLGP-APARGCHP------QPDFCPVLS 1008
            |:....||..|:.||||:||:..|..|||||  .:.:.|.| |..:|.:|      |.|| |..:
Zfish   786 RKGPELLGKVSMPLFDFRRVLSRGSKLLSLW--TSPQALQPGAAGKGRNPTEKIILQVDF-PSPA 847

  Fly  1009 IEVPPYGGRIEFPEHQEVPKPAPHYDFASLDANLQEELLDTAELGYTGAT-----ERREVFWEKR 1068
            ::|...|     |:....|.|      .|||...|::..:..:|....:|     ..|::.|::|
Zfish   848 VDVLYVG-----PQENGCPNP------QSLDPLDQDDRSEIEKLCARASTFGLSRADRQLLWDQR 901

  Fly  1069 LYLQSYPNALPKVLHAAHSWDYANLIDLHALLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWIS 1133
            .|.:.|..:|||:|.:|.|||:.::.::|||||.|..|||:.:||||..::.|.:||:.||.||.
Zfish   902 YYCREYEYSLPKILASAPSWDWGSMGEIHALLHHWPALSPVSALELLESKFADTEVRKVAVSWIQ 966

  Fly  1134 KMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAA 1198
            ...:|:|.|:||||||::|.:.:..:|:.:||||:.|.:...||::||||..::.|.....
Zfish   967 SSSDDELADYLPQLVQAVKFECHLKNALVKFLLSRALGNVNIAHYLYWLLRDAVQDPAFGQ---- 1027

  Fly  1199 MVDQEYDESQVTQVRYYRRNKMMLRALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQ 1263
                          ||.|    :|..|:.:||..:......|.|:.|.|..:||.|::|..|.||
Zfish  1028 --------------RYER----ILCVLLCLCGTGLRAELEKQTRLVQLLGALAEKVRQASSSTRQ 1074

  Fly  1264 KSLAAGMDEVHQDLLEQPTC-LPLGPELEVTGVSVRNCSYFNSNTLPLKINFVGPD--AESLPAI 1325
            ..|..|::.| |...::.:| ||:.|.|....::::.||:||||.:||||..|..|  .:.:..:
Zfish  1075 VVLLEGLERV-QSFFQKNSCRLPISPSLVAKELNIKVCSFFNSNAVPLKIALVNADPLGDEINVM 1138

  Fly  1326 FKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVECG 1390
            ||.|:||:||.|.:|:||||:::||.|.|||::|.|.|:.||...||:|||..:|||||||||.|
Zfish  1139 FKVGEDLRQDMLALQMIRIMDRIWLQEGLDLRIVNFKCISTGKDKGMVELVPSSETLRKIQVEYG 1203

  Fly  1391 LTGSFKDRPIAEWLGKQNPSPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFH 1455
            :||||||:|:||||.|.||:..||:.|..||..:|||..||||:|||||||||||||:::||:||
Zfish  1204 VTGSFKDKPLAEWLRKYNPAEDEYEKASENFIYTCAGCCVATYILGICDRHNDNIMLRSTGHMFH 1268

  Fly  1456 IDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVINGGDKPSTDFHYFVDLCCRAFNIVRKNADLLL 1520
            ||||||||.|||.|:|||||.|||||||||||||||::|::.|..|||||.:|:|::||:::|.|
Zfish  1269 IDFGKFLGHAQMIGSFKRDRAPFVLTSDMAYVINGGERPTSRFQLFVDLCSQAYNLIRKHSNLFL 1333

  Fly  1521 HTLAHMATAGMP---GVNSNAVQYVRRALLPSQSNPEAAATFAKMIQSSLKSWFTQFNFFLHNLA 1582
            :.|:.|..:|:|   ||..  ::||..||.|..::.||...|.::|:|||.|..|:||||:||||
Zfish  1334 NLLSLMTQSGLPELTGVQD--LKYVYDALQPQTTDAEATIFFTRLIESSLGSVATKFNFFIHNLA 1396

  Fly  1583 QMRFTPDEGSGE-LLSFVPRKYTMQQDGRLKIVKVVCFQKHYSMEKFYMYILEVTRHGQPDPTHL 1646
            |:||:....:.| :|||.||.|||:|||:::...|..:||.|:.:|.|.|::.:.|.||.:|..:
Zfish  1397 QLRFSGLPSNDEPILSFAPRTYTMKQDGKIRDASVFSYQKRYNPDKHYTYVIRILREGQSEPQFV 1461

  Fly  1647 FRSYREFTEFHQKLCMHFPLVKLHSLPAGVHVGRSNIKSVAEKRLPLIQRFLKSLFDASEEIAHS 1711
            ||::.||.|.|.||.:.|.|.||...|:.:.:||::||.||.||...:..::.:|..:|.|:|..
Zfish  1462 FRTFDEFQELHNKLTILFQLWKLPGFPSKMVLGRTHIKDVASKRKVELNSYVHNLMRSSTEVAQC 1526

  Fly  1712 ELVYTFFHPLLRDQQEAKLGMPKIKEVKQQP--SRDNPHEIGQIRLSLQYQRGVLTVMIHHAKGL 1774
            :|:||||||:.||.:..  |:..:.:....|  |.......|:::||:.|:...|.:|:.|.|.|
Zfish  1527 DLIYTFFHPIARDDKTE--GVDTLSKTPDMPPVSPTTGRVEGEVKLSVSYRNSTLFIMVMHIKDL 1589

  Fly  1775 PMLQGGQEPNTYVKCYLKPDPKKETKRKTKVVRKTCVPSFMETLEYR-MPLNIIQERRLQVTVWS 1838
             |...|.:||.|||.||.|||.|.:|||||:.|||..|:|.|.|.|. .....:::|.||::|.|
Zfish  1590 -MSNDGADPNPYVKTYLLPDPHKTSKRKTKIARKTRNPTFNEMLVYSGYSKETLKQRELQLSVLS 1653

  Fly  1839 HDTLQENELLGGFDMDLSKYDLRQELVDWYRLGAV 1873
            .::|:||..|||..:.|..:||.:|.|.||:|..|
Zfish  1654 AESLRENCYLGGITLCLKDFDLSRETVKWYKLTTV 1688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674	70/366 (19%)
		PI3K_rbd	561..669	CDD:197540	29/115 (25%)
		C2A_PI3K_class_II	844..1021	CDD:175979	52/187 (28%)
		PI3Ka_II	1038..1202	CDD:238441	61/168 (36%)
		PI3Kc_II	1235..1583	CDD:270710	186/353 (53%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794	42/109 (39%)
		C2B_PI3K_class_II	1751..1871	CDD:176027	53/120 (44%)
pik3c2a	XP_005159362.2	Amelogenin	<137..207	CDD:330537	20/93 (22%)
		PI3K_rbd	420..507	CDD:307097	26/105 (25%)
		C2A_PI3K_class_II	681..852	CDD:175979	53/186 (28%)
		PI3Ka	872..1038	CDD:320871	63/187 (34%)
		PKc_like	1045..1397	CDD:328722	186/354 (53%)
		PX_PI3K_C2_alpha	1428..1536	CDD:132822	42/107 (39%)
		C2B_PI3K_class_II	1565..1686	CDD:176027	53/121 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579755
Domainoid	1	1.000	310	1.000	Domainoid score	I1297
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20581
Inparanoid	1	1.050	820	1.000	Inparanoid score	I454
OMA	1	1.010	-	-		QHG49277
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	1	1.000	-	-		FOG0001789
OrthoInspector	1	1.000	-	-		otm25107
orthoMCL	1	0.900	-	-		OOG6_104124
Panther	1	1.100	-	-	O	PTHR10048
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3211
SonicParanoid	1	1.000	-	-		X2272
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800