Protein Alignment Pi3K68D and pik3c2b

DIOPT Version :10

• Sequence 1: NP_524028.2
• Gene: Pi3K68D / 39329
• FlyBaseID: FBgn0015278
• Length: 1876
• Species: Drosophila melanogaster
• Sequence 2: XP_003199535.2
• Gene: pik3c2b / 567938
• ZFINID: ZDB-GENE-050309-145
• Length: 1587
• Species: Danio rerio
• Alignment Length: 1700
• Identity: 582/1700 - (34%)
• Similarity: 856/1700 - (50%)
• Gaps: 275/1700 - (16%)

  Fly   297 AEANGVAFPA---RRQ---VPSTVGVSSSSHTGNNGHSSVPRR-----GNDLIDLNHEDYSRVSV 350
            |||..:.:.|   .||   ..||:...||..:.:...||:|||     .|:|         :...
Zfish    30 AEALQMEYDALARHRQDKGTSSTLPPDSSKSSPSRSESSLPRRVPSPSWNNL---------QQQG 85

  Fly   351 LEAFDPLLND-NTGNDTASDSTSYYAEYDPFDFLYSGDAATQYSDPMYEAVNRWDKTVATVSPNV 414
            :...||:||. ..|....|.|              ||::.....:|.|.
Zfish    86 VSGSDPMLNHVQPGVSNLSRS--------------SGESHGFTKEPRYI---------------- 120

  Fly   415 GLIGWRQDFLSQPSTSSSQYGVAPPEESLKLAENGSGTI-SPPPPLPPRN----QQCYESNQAAM 474
             |..|..||                |.:.::...|..|: .||||:||||    ...:..::::.
Zfish   121 -LDEWESDF----------------EGTSQMLSKGLPTLDEPPPPVPPRNPIPQNDPFIVHRSSA 168

  Fly   475 P---------VSRPPQS-------SVLTDSYTS-------------------------------S 492
            |         |.:|..|       ..|.||.:.                               .
Zfish   169 PRDVNLFTPEVDQPKLSFGETLNYDNLNDSLSKINGDWLSPGRSRRANGDKSGKAVARSNTLPPQ 233

  Fly   493 IPANVVLDRRKTCTRL-------------------YEL--ISDQRTDDPELLEFYHMVKEVRARY 536
            ||....|...|: ||.                   |||  :|::|  |.|:..|.|::..:|:.|
Zfish   234 IPPRTYLPTPKS-TRSQRRVSVDPVSLGSRPNGFGYELFQVSEER--DEEVAAFCHVLDLLRSAY 295

  Fly   537 PHDDAPTNVGHV---VAAEFNYHYMMDTSIKVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFT 598
            |.:|...|.|.|   ..|:......:..||||.|:.                   ..:..|:||:
Zfish   296 PCNDYSKNSGFVWSPCVAQDELQQGLGVSIKVTVYS-------------------DHFREPLTFS 341

  Fly   599 CDIDSVVAQVVAQALASLEGQVKG-TVTDYAVKPIGLLEWLAPTSRLSQLECVHNSFQLEKDVHL 662
            ||..|.:..::.|.|......:.. .|.||.:|.....|:|..|..|:..|.:....:.:.|:.|
Zfish   342 CDGSSTIDLLIYQTLCYAHDDLDMIDVDDYLLKICSQAEFLKNTQTLASFEYIQQCLKFDWDIRL 406

  Fly   663 GLCLSTAANMQAIARTERDDEHDADLLPEHLLPNEVVPI---VTYDNMMILIETLEMEIDKLESA 724
            .|...::.||: :|||..||:..:.:  .|.:..:..||   ||.:.:.:|::|...|.:....:
Zfish   407 ILTKRSSVNME-LARTTEDDDTPSTM--NHSILLQERPIKQTVTKEALTLLLDTFHNEAESFLLS 468

  Fly   725 ADGVPGRSVVSCSGVVQAVKAICALLGSIDTMEIARCVADLKRI-CEVEQKKYSTGASNPEIVSD 788
            ...:|    :....:||:|||:|..|.:::|.:|...:..|... |.::          |::..|
Zfish   469 EVELP----LHVERLVQSVKALCTSLAAVETPDITAALNQLPACPCRLQ----------PKVQKD 519

  Fly   789 YGDYAQVVLRPRSMLEQIKVKCNELRDAVQELVELYANVFRVAFSVKTPDYSTTPIPI---SCVS 850
                ..|:.:..:.:..::    :|..|:.:|||||.:.|...|.. .|..|.:..||   ..|:
Zfish   520 ----VSVLAKKENRVAIVE----KLTAAILDLVELYCSTFNANFQT-MPHSSRSTAPIQEAGMVT 575

  Fly   851 KPIVVCISCLHRPLPNW--KFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFSAWLTF 913
            ..:...:...||....|  .::::.|...:.:|...|..|. .|.....|..||   :...|
Zfish   576 NVLSFSVYAAHRVPITWAASYENFFLSCSLTHGGVELCAPQ-HTSKQSVSKYLF---HLVVW--- 633

  Fly   914 DQHPIC------TLPREARLTFVLYGKQAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRVMI 972
            ||. :|      .||||::||..||.......|  .|::..::::....|||.::.||:|:.|:.
Zfish   634 DQR-VCFPVQINQLPRESQLTVTLYATPLPPPG--GAEEKSKQKRSIESLGWVTMPLFNFRHVLT 695

  Fly   973 CGPYLLSLWPPMTDKMLGPAPARGCHP---QPDFCPVLSIEVPPYGGRIEFPEHQEVPKPA---P 1031
            ||..||.|||...    |...||...|   ||| ..:|.::.|.....:.|    ..|.||   |
Zfish   696 CGRKLLGLWPSTP----GSGNARSSTPNFSQPD-SVILQVDFPTSSFEVRF----STPAPAEFSP 751

  Fly  1032 HYDFASLDANLQEELLDT---AELGYTGATERREVFWEKRLYLQSYPNALPKVLHAAHSWDYANL 1093
            .|:|:.||...|.:|.|.   ..|.:....:|| :.||||.:.....:.||.||.:|.||::|.|
Zfish   752 QYEFSHLDQVSQRQLHDVLHKKSLFWLSPEDRR-LLWEKRYFCHVEASRLPLVLASAPSWEWACL 815

  Fly  1094 IDLHALLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEG 1158
            .|::|||..|..::.|.:|.||...:||.:.|..||:|:..:.:.:|:||||||||:||::.|..
Zfish   816 PDIYALLRQWGCMNHLDALGLLNATFPDQECRRTAVQWMDSISDPELLDFLPQLVQALKYECYLD 880

  Fly  1159 SAMARFLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLR 1223
            |.:.||||.:.:...|.||:::|||..:|.|                 ||.: |||    :.:|.
Zfish   881 SHLVRFLLRRAIGDVRIAHYLFWLLKDTLQD-----------------SQFS-VRY----QYLLA 923

  Fly  1224 ALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQPTC-LPLG 1287
            ||:...|..:.:.|..|..:...|..:|:.|:||..|.||..|..|:|:|.|......:| |||.
Zfish   924 ALLCCSGRGLREEFDRQCWLVNVLAKVAQRVREASPSSRQAILREGLDDVKQFFSINSSCRLPLN 988

  Fly  1288 PELEVTGVSVRNCSYFNSNTLPLKINFVGPD--AESLPAIFKCGDDLQQDQLTIQLIRIMNKMWL 1350
            |.|.|.|:::::|||||||.:|||::|...|  .:::..|||.||||:||.||:|:||||||:|:
Zfish   989 PGLLVKGINIQSCSYFNSNAVPLKLSFQNQDHLGDNINVIFKAGDDLRQDMLTLQIIRIMNKIWV 1053

  Fly  1351 AERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVECGLTGSFKDRPIAEWLGKQNPSPLEYQ 1415
            .|.||::||.|.|..||...||:|::..||||||||||.|:||||||||:|:||.|.||:..||:
Zfish  1054 QEGLDMRMVIFRCFSTGRGRGMVEMIPSAETLRKIQVEHGVTGSFKDRPLADWLQKHNPTEEEYE 1118

  Fly  1416 SAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVL 1480
            .||.||..||||..||||:||||||||||||||||||:||||||||||.||||||.||||.|||.
Zfish  1119 KAVENFIYSCAGCCVATYILGICDRHNDNIMLKTSGHMFHIDFGKFLGHAQMFGNIKRDRAPFVF 1183

  Fly  1481 TSDMAYVINGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNS-NAVQYVRR 1544
            |||||||||||||||:.||.||||||.|:|.:||:|.|.|:.|..|.::|:|.::. :.::||..
Zfish  1184 TSDMAYVINGGDKPSSRFHDFVDLCCEAYNRIRKHAHLFLNLLGLMLSSGIPELSDVDDLKYVYD 1248

  Fly  1545 ALLPSQSNPEAAATFAKMIQSSLKSWFTQFNFFLHNLAQMRFTPDEGSGELLSFVPRKYTMQQDG 1609
            ||.|.:|..:|...|.::|:|||.|..|:.|||:||||||:|...| ...:|||.||.|||:.||
Zfish  1249 ALRPHESEADATMHFTRLIESSLGSVATKLNFFIHNLAQMKFASSE-ERPVLSFAPRVYTMKTDG 1312

  Fly  1610 RLKIVKVVCFQKHYSMEKFYMYILEVTRHGQP-DPTHLFRSYREFTEFHQKLCMHFPLVKLHSLP 1673
            .::.:.|....|.||..|.|.|:::|.|.||. .||.:.|::.||.|.|.||.:.||..||.|.|
Zfish  1313 VIRSLFVCRHIKTYSPSKGYSYVVKVEREGQQGSPTLVQRTFEEFNELHSKLQLIFPSSKLPSFP 1377

  Fly  1674 AGVHVGRSNIKSVAEKRLPLIQRFLKSLFDASEEIAHSELVYTFFHPLLRDQQEAKLG-----MP 1733
            :...:|||..:::|::|...:..::..|..|::|:|..:|:|||||||.||::...:|     :.
Zfish  1378 SRFVIGRSRGEALADRRKDELNGYVWHLIHAAQEVAQCDLIYTFFHPLPRDERAGSVGNVVNTLH 1442

  Fly  1734 KIKEVKQQPSRDNPHEI-GQIRLSLQYQRGVLTVMIHHAKGLPMLQGGQEPNTYVKCYLKPDPKK 1797
            |..:|...|.   |..: |:::||:.|:...|.:|:.|.:||..||.|.:|:.|||.||.|||:|
Zfish  1443 KPTDVSWAPV---PGAMAGEVKLSVLYKSDKLFIMVMHIRGLQPLQDGTDPDPYVKLYLLPDPQK 1504

  Fly  1798 ETKRKTKVVRKTCVPSFMETLEY-RMPLNIIQERRLQVTVWSHDTLQENELLGGFDMDLSKYDLR 1861
            .:|||||..|:||.|::.|.|.| ::|...:|:|.:.:.|.|.....||.|||...:.|......
Zfish  1505 TSKRKTKAARRTCNPTYNEMLVYDKIPHGDLQQRTVHLRVLSEGAFWENTLLGETIIHLKDLTPG 1569

  Fly  1862 QELVDWYRLG 1871
            ...|||::||
Zfish  1570 HRWVDWHQLG 1579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_524028.2	PHA03247	<56..294	CDD:223021
		PI3K_rbd	561..669	CDD:197540	25/108 (23%)
		C2A_PI3K_class_II	844..1021	CDD:175979	51/190 (27%)
		PI3Ka_II	1038..1202	CDD:238441	61/166 (37%)
		PI3Kc_II	1235..1583	CDD:270710	200/351 (57%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794	41/110 (37%)
		C2B_PI3K_class_II	1751..1871	CDD:176027	48/120 (40%)
pik3c2b	XP_003199535.2	None