DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pi3K68D and atr

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	XP_696163.5	Gene:	atr / 567770	ZFINID:	ZDB-GENE-070912-458	Length:	2633	Species:	Danio rerio

Alignment Length:	955	Identity:	184/955 - (19%)
Similarity:	322/955 - (33%)	Gaps:	318/955 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   865 PNWKFD-------------------DY--SLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFS 908
            |.||.|                   ||  |.|....:|.||  ...:|......|...:.:|..:
Zfish  1753 PRWKSDLNAYRVEAAWKLSKWDLVEDYLASDCKSSTWGVRL--GQMLLAAKKQDSEAFYEKLKIA 1815

  Fly   909 --------AWLTFD-------------QHPICTLPREARLTFVLYGKQAASEGEPNADQNGERRQ 952
                    :..:|:             .|.:|.|            :...:|.:..:.:.|..::
Zfish  1816 RKEQVVPLSAASFECGTYQRGYEYIVRLHMLCEL------------EHVFTELQKESSEAGRSKK 1868

  Fly   953 VTTELGWCSIQLFDFKRVMICGPYLLSLWPPMTDKMLGPAPARGCHPQPDFCPVLSIEVPPYGGR 1017
            ...:|.|.:..|..........|.|     .:...:|..:....|..|...|.:.|..|....|
Zfish  1869 PEPKLNWDAHLLMTQNSFRAKEPVL-----ALRRALLSLSKGSSCEEQVGECWLQSARVARRAG- 1927

  Fly  1018 IEFPEHQEVPKPAPHYDFASL----DANLQEELLDTAE-LGYTGATERREVFWEKRLYLQSYP-- 1075
                .||..        |.:|    :::|.|..::.|: |...|...:..:..:|.:. |.:|
Zfish  1928 ----HHQTA--------FNALLNAENSHLSELFIEKAKWLWSKGDVHQALIVLQKGVQ-QCFPDD 1979

  Fly  1076 -------------NALPKVLHAAHSWDYANLIDLHALLHSWAPLSPLQSLELLLPRYPD-----A 1122
                         ||:  :|...:..:.|| .:.:|::.::      :.:..|||.:.|     |
Zfish  1980 QTLTDPKRIQVKGNAM--LLVGRYMEETAN-FESNAIMKTY------KDVTTLLPEWEDGNFYLA 2035

  Fly  1123 KVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEG-----------SAMARFL----------- 1165
            |..:|    :..|..|..::....|::.:.  ||.|           .||.|.|
Zfish  2036 KYYDK----VMPMVTDNKLERQGNLIRYIV--TYFGKALQFGNQYIYQAMPRMLTLWLDFGAKVY 2094

  Fly  1166 -LSKCLESPRFAHHMYWLLVHSLPDD------PHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLR 1223
             ..|...|.|.........::|:..|      |:..:.|.        ||:.. |....:..:..
Zfish  2095 EFEKAGRSDRVQMRTELTKINSVISDHTSNLSPYQFLTAF--------SQLIS-RICHSSNEVFA 2150

  Fly  1224 ALMAICGEKML---QRFM----------YQHRM--CQKLTTIAESVKEA-------KESMRQKSL 1266
            .||.|..:..|   |:.|          |..||  |:::...|.|:.::       ...:..|.|
Zfish  2151 VLMEIVAKVFLAYPQQAMWMMTAVSKSSYPTRMNRCKEILKKAISLNDSFMKFIGDANRLTDKLL 2215

  Fly  1267 AAG---MD--------EVH----QDLLEQPT----CLPLG----PELEVTGVSVRNCSYFNSNTL 1308
            ..|   :|        .||    :.|:|:||    .:||.    |.|..||.:......|..:.:
Zfish  2216 ELGNKPVDGNSSTLSMSVHFKMLKKLVEEPTFSQILIPLQSVLIPTLPSTGGANPKHDAFPGHWV 2280

  Fly  1309 -----------------PLKINFVGPDAESLPAIFKCGDDLQQDQLTIQLIRIMNKMWL----AE 1352
                             |.||:..|.|.:....:.|..|||::|...::...::||...    :.
Zfish  2281 YLSGFDDTVEILASLQKPKKISLKGSDGKFYTMMCKPKDDLRKDCRLMEFNCLINKSLRKDAESR 2345

  Fly  1353 RLDLKMVTFNCVPTGYKSGMIELVSEAETLR----KIQVECGL--------------TGSFKDR- 1398
            |.||::.|:..:|...:.|:||.|::...||    |:..|.|:              |..|:::
Zfish  2346 RRDLRIRTYAVIPLNEECGIIEWVNKTAGLRHILTKLYKEKGIYVSGTELKKLILPKTAPFQEKL 2410

  Fly  1399 ------------PI-AEWLGKQNPSPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKT- 1449
                        |: .||..:..|.|..:.::...:..|.|..|:..|:||:.|||.:||:..:
Zfish  2411 KLHKDVLCARHPPVFHEWFLRTFPDPTSWYNSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSF 2475

  Fly  1450 SGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVINGGDKPSTDFHYFVDLCCRAFNIVRK 1514
            :|...|:||.......:.|.  ..:..||.||.:|
Zfish  2476 TGECVHVDFNCLFNKGETFD--VPEVVPFRLTQNM------------------------------ 2508

  Fly  1515 NADLLLHTLAHMATAGMPGVNSNAVQYVRRALLPSQSNPEAAATFAKMIQSSLKSWFTQFNFFLH 1579
                 :|.:..|.|.|:   ...|.:.:.| |:..|..|         :.|.||:       |||
Zfish  2509 -----VHAMGPMGTEGL---FRQACEVILR-LMRDQREP---------LMSVLKT-------FLH 2548

  Fly  1580 NLAQMRFTPDEG--------SGELLSFVPRKYTMQQDGRLK-IVK 1615
            :.......|.:|        |||:|:...:.:.:..:.||: ::|
Zfish  2549 DPLVEWSKPVKGFSKTQVNESGEILNEKAKTHVLDIEQRLQGVIK 2593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540
		C2A_PI3K_class_II	844..1021	CDD:175979	32/197 (16%)
		PI3Ka_II	1038..1202	CDD:238441	39/217 (18%)
		PI3Kc_II	1235..1583	CDD:270710	94/443 (21%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794	2/6 (33%)
		C2B_PI3K_class_II	1751..1871	CDD:176027
atr	XP_696163.5	HEAT repeat	683..715	CDD:293787
		HEAT repeat	753..780	CDD:293787
		HEAT repeat	794..823	CDD:293787
		UME	1110..1216	CDD:214825
		HEAT repeat	1275..1301	CDD:293787
		HEAT repeat	1324..1353	CDD:293787
		FAT	1760..2084	CDD:280429	62/371 (17%)
		TEL1	<2125..2633	CDD:227365	112/535 (21%)
		PIKKc_ATR	2282..2556	CDD:270625	69/330 (21%)
		FATC	2602..2633	CDD:280430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910