| Sequence 1: | NP_001163420.1 | Gene: | Pi3K68D / 39329 | FlyBaseID: | FBgn0015278 | Length: | 1876 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_063971.1 | Gene: | Mtor / 56718 | RGDID: | 68371 | Length: | 2549 | Species: | Rattus norvegicus |
| Alignment Length: | 1472 | Identity: | 287/1472 - (19%) |
|---|---|---|---|
| Similarity: | 457/1472 - (31%) | Gaps: | 579/1472 - (39%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 454 SPPPPLPPRNQQCYESNQAAM-PVSRPPQSSVLTDSYTSSIPANVVLDRRKTCTRLYELISDQRT 517
Fly 518 DD--PELLEFYHMVKEVRARYPHDDAPTNVGHVVAAEFNYHYMMDTSIKVIVHPALNTLQSTVLA 580
Fly 581 ASMGKEQVKGYGM------PVTFTCDIDSVVAQVVAQALASLEGQVK-GTVTDYAVKPIGL---- 634
Fly 635 -----------LEWLAPTSRLSQLECVHNSFQLEKDVHLGLCLSTAANMQAIAR----------- 677
Fly 678 TERDDEHDADLLP--EHLLPNEVVPIVTYDNMMILIETLEMEIDKLESAADGVPGRSVVSCSGVV 740
Fly 741 QAVKAICALLGSIDTMEIARCVADLKRI--CEVEQKKYSTGA------------SNPEIVSDYGD 791
Fly 792 YAQVVLRPRSMLEQIKVKCNELRDAVQELVELYANVFRVAFSVKTPDYSTTPIPISCVSKPIVVC 856
Fly 857 ISCLHRPLPNWKFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFSA------WLTFDQ 915
Fly 916 HPICTLPREA------RLTFVLY-------------------GKQAASEGEPNADQNG------- 948
Fly 949 --------------ERRQVTTELGW-----CSIQLFDFKRVM---------------------IC 973
Fly 974 GPY-LLSLWPPMTDKMLGPAPARGC-HPQPDFCPVLSI----EVPPYGGRIEFPEH-----QEVP 1027
Fly 1028 KPAPHYDFASLDANLQEEL----------LDTAELGYTGATERREVFWEKRLYLQSYPNALPKVL 1082
Fly 1083 H--------------AAHSWDYANLIDLHALLH-------------------------------- 1101
Fly 1102 -----------------------SWAPLSPLQ-------SLELLL-------------------- 1116
Fly 1117 --------------PRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLS 1167
Fly 1168 KCLESPRFAHHMYWLLVHSLPDDPHNSIG-----AAMVDQEYDESQVTQVRYYRRNK-------- 1219
Fly 1220 ---MMLRALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEV----H--- 1274
Fly 1275 -----------------QDLLE-QPTC-----------------------------LPLGPELEV 1292
Fly 1293 TGVSVR-----------------------------NCSYFNSNTLPLKINFVGPDAESLPAIFKC 1328
Fly 1329 GDDLQQDQLTIQLIRIMNKMWLAE-----RLDLKMVTFNCVPTGYKSGMIELVSEAETL------ 1382
Fly 1383 -----------------------------RKIQV-ECGLTGSFKDRPIAEWLGKQNPSPLEYQSA 1417
Fly 1418 VRNFTLSCAGYSVATYVLGICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLT 1481
Fly 1482 SDMAYVINGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTL 1523 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Pi3K68D | NP_001163420.1 | EIN3 | <58..392 | CDD:296674 | |
| PI3K_rbd | 561..669 | CDD:197540 | 33/129 (26%) | ||
| C2A_PI3K_class_II | 844..1021 | CDD:175979 | 39/260 (15%) | ||
| PI3Ka_II | 1038..1202 | CDD:238441 | 49/288 (17%) | ||
| PI3Kc_II | 1235..1583 | CDD:270710 | 86/414 (21%) | ||
| PX_PI3K_C2_68D | 1611..1721 | CDD:132794 | |||
| C2B_PI3K_class_II | 1751..1871 | CDD:176027 | |||
| Mtor | NP_063971.1 | HEAT repeat | 993..1021 | CDD:293787 | |
| HEAT 25 | 1029..1068 | ||||
| HEAT repeat | 1033..1062 | CDD:293787 | |||
| HEAT 26 | 1069..1105 | ||||
| HEAT repeat | 1073..1099 | CDD:293787 | |||
| HEAT 27 | 1106..1144 | 9/27 (33%) | |||
| HEAT repeat | 1111..1142 | CDD:293787 | 8/25 (32%) | ||
| HEAT 28 | 1145..1188 | 16/74 (22%) | |||
| HEAT repeat | 1154..1180 | CDD:293787 | 10/54 (19%) | ||
| HEAT 29 | 1189..1225 | 10/39 (26%) | |||
| HEAT 30 | 1226..1273 | 11/51 (22%) | |||
| HEAT 31 | 1274..1311 | 13/44 (30%) | |||
| HEAT 32 | 1312..1345 | 5/32 (16%) | |||
| TPR 1 | 1346..1382 | 10/53 (19%) | |||
| TPR 2 | 1383..1408 | 9/28 (32%) | |||
| TPR 3 | 1409..1442 | 7/32 (22%) | |||
| TPR 4 | 1443..1473 | 7/41 (17%) | |||
| TPR 5 | 1474..1507 | 8/53 (15%) | |||
| TPR 6 | 1508..1541 | 6/33 (18%) | |||
| TPR 7 | 1542..1574 | 2/31 (6%) | |||
| TPR 8 | 1575..1614 | 7/38 (18%) | |||
| TPR 9 | 1615..1649 | 3/33 (9%) | |||
| TPR 10 | 1650..1693 | 11/42 (26%) | |||
| TPR 11 | 1694..1731 | 6/37 (16%) | |||
| TPR 12 | 1732..1786 | 12/69 (17%) | |||
| TPR 13 | 1787..1846 | 7/61 (11%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1812..1867 | 5/55 (9%) | |||
| TPR 14 | 1898..1930 | 6/33 (18%) | |||
| TPR 15 | 1931..1970 | 14/64 (22%) | |||
| TPR 16 | 1971..2005 | 5/33 (15%) | |||
| Sufficient for interaction with the FKBP1A/rapamycin complex. /evidence=ECO:0000250 | 2012..2144 | 22/139 (16%) | |||
| Rapamycin_bind | 2015..2112 | CDD:285924 | 15/102 (15%) | ||
| PIKKc_TOR | 2153..2431 | CDD:270713 | 65/273 (24%) | ||
| Interaction with MLST8. /evidence=ECO:0000250 | 2258..2296 | 3/37 (8%) | |||
| FATC | 2518..2549 | CDD:280430 | |||
| Interaction with NBN. /evidence=ECO:0000250 | 1..651 | ||||
| TEL1 | 363..2549 | CDD:227365 | 287/1472 (19%) | ||
| HEAT 16 | 637..683 | ||||
| HEAT repeat | 655..681 | CDD:293787 | |||
| HEAT 17 | 686..724 | ||||
| HEAT repeat | 691..721 | CDD:293787 | |||
| HEAT 18 | 727..766 | ||||
| HEAT repeat | 729..759 | CDD:293787 | |||
| HEAT 19 | 769..811 | ||||
| HEAT repeat | 772..805 | CDD:293787 | |||
| HEAT 20 | 814..853 | ||||
| HEAT repeat | 817..847 | CDD:293787 | |||
| DUF3385 | 854..1024 | CDD:288698 | |||
| HEAT 21 | 857..893 | ||||
| HEAT 22 | 894..942 | ||||
| HEAT 23 | 943..988 | ||||
| HEAT repeat | 955..981 | CDD:293787 | |||
| HEAT 24 | 989..1027 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_COG5032 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 2 | 1.810 | |||||