DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K68D and Mtor

DIOPT Version :9

Sequence 1:NP_001163420.1 Gene:Pi3K68D / 39329 FlyBaseID:FBgn0015278 Length:1876 Species:Drosophila melanogaster
Sequence 2:NP_064393.2 Gene:Mtor / 56717 MGIID:1928394 Length:2549 Species:Mus musculus


Alignment Length:1471 Identity:287/1471 - (19%)
Similarity:458/1471 - (31%) Gaps:577/1471 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   454 SPPPPLPPRNQQCYESNQAAM-PVSRPPQSSVLTDSYTSSIPANVVLDRRKTCTRLYELISDQRT 517
            :|..|||        |.:||: .|.|..:|...|| |.|.|...:|                 ||
Mouse  1124 APEVPLP--------SRKAALETVDRLTESLDFTD-YASRIIHPIV-----------------RT 1162

  Fly   518 DD--PELLEFYHMVKEVRARYPHDDAPTNVGHVVAAEFNYHYMMDTSIKVIVHPALNTLQSTVLA 580
            .|  |||            |....|..:::  |......|...:....||:|...:|..:..||.
Mouse  1163 LDQSPEL------------RSTAMDTLSSL--VFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLI 1213

  Fly   581 ASMGKEQVKGYGM------PVTFTCDIDSVVAQVVAQALASLEGQVK-GTVTDYAVKPIGL---- 634
            ..:    ||||.:      |:.:.   ..::......||||  |.|: |.:....|..|.|    
Mouse  1214 CRI----VKGYTLADEEEDPLIYQ---HRMLRSSQGDALAS--GPVETGPMKKLHVSTINLQKAW 1269

  Fly   635 -----------LEWLAPTSRLSQLECVHNSFQLEKDVHLGLCLSTAANMQAIAR----------- 677
                       ||||   .||| ||.:.:|    ....|..|.:.|.....:||           
Mouse  1270 GAARRVSKDDWLEWL---RRLS-LELLKDS----SSPSLRSCWALAQAYNPMARDLFNAAFVSCW 1326

  Fly   678 TERDDEHDADLLP--EHLLPNEVVPIVTYDNMMILIETLEMEIDKLESAADGVPGRSVVSCSGVV 740
            :|.:::...:|:.  |..|.::.:..|| ..::.|.|.:|      .|....:|.|   ..:|:|
Mouse  1327 SELNEDQQDELIRSIELALTSQDIAEVT-QTLLNLAEFME------HSDKGPLPLR---DDNGIV 1381

  Fly   741 QAVKAICALLGSIDTMEIARCVADLKRI--CEVEQKKYSTGA------------SNPEIVSDYGD 791
                    |||.    ..|:|.|..|.:  .|:|.:|..|.|            ..||..|...:
Mouse  1382 --------LLGE----RAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAASGVLE 1434

  Fly   792 YAQVVLRPRSMLEQIKVKCNELRDAVQELVELYANVFRVAFSVKTPDYSTTPIPISCVSKPIVVC 856
            ||........:......|.:|..||:            ||:..|.......|       :.::..
Mouse  1435 YAMKHFGELEIQATWYEKLHEWEDAL------------VAYDKKMDTNKEDP-------ELMLGR 1480

  Fly   857 ISCLHRPLPNWKFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFSA------WLTFDQ 915
            :.|| ..|..|.......|.:             .|..||.:.....|:..:|      |.:.::
Mouse  1481 MRCL-EALGEWGQLHQQCCEK-------------WTLVNDETQAKMARMAAAAAWGLGQWDSMEE 1531

  Fly   916 HPICTLPREA------RLTFVLY-------------------GKQAASEGEPNADQNG------- 948
            : .|.:||:.      |....|:                   .:..|..||..:...|       
Mouse  1532 Y-TCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHM 1595

  Fly   949 --------------ERRQVTTELGW-----CSIQLFDFKRVM---------------------IC 973
                          |||::..::.|     |...:.|:::::                     :|
Mouse  1596 LSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLC 1660

  Fly   974 GPY-LLSLWPPMTDKMLGPAPARGC-HPQPDFCPVLSI----EVPPYGGRIEFPEH-----QEVP 1027
            |.. .|:|.......:||..|:|.. ||.|...|.::.    .:.....:|:..:|     |.:.
Mouse  1661 GKSGRLALAHKTLVLLLGVDPSRQLDHPLPTAHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQ 1725

  Fly  1028 KPAPHYDFASLDANLQEEL----------LDTAELGYTGATERREVFWEKRLYLQSYPNALPKVL 1082
            :.|.| ..|:.|...::||          |...:|...|..|                :.:||||
Mouse  1726 QQAQH-AIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINE----------------STIPKVL 1773

  Fly  1083 H--------------AAHSWDYANLIDLHALLH-----------------SWAPL---------- 1106
            .              |.|:|...|   ..|:||                 |.|.:          
Mouse  1774 QYYSAATEHDRSWYKAWHAWAVMN---FEAVLHYKHQNQARDEKKKLRHASGANITNATTAATTA 1835

  Fly  1107 ---------------------------SPLQ-------SLELLL--------------------- 1116
                                       ||||       |..|||                     
Mouse  1836 ASAAAATSTEGSNSESEAESNENSPTPSPLQKKVTEDLSKTLLLYTVPAVQGFFRSISLSRGNNL 1900

  Fly  1117 -------------PRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSK 1168
                         ..:||  |.|..||.:..:..|..:..:|||:             ||     
Mouse  1901 QDTLRVLTLWFDYGHWPD--VNEALVEGVKAIQIDTWLQVIPQLI-------------AR----- 1945

  Fly  1169 CLESPRFAHHMYWLLVHSLPDDPHNSIG-----AAMVDQEYDESQVTQVRYYRRNK--------- 1219
             :::||   .:...|:|.|..|    ||     |.:..........|..|:...||         
Mouse  1946 -IDTPR---PLVGRLIHQLLTD----IGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHS 2002

  Fly  1220 --MMLRALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEV----H---- 1274
              ::.:|:|.  .|::::..:..|.|..      |.::||......:....||.||    |    
Mouse  2003 NTLVQQAMMV--SEELIRVAILWHEMWH------EGLEEASRLYFGERNVKGMFEVLEPLHAMME 2059

  Fly  1275 ----------------QDLLE-QPTC-----------------------------LPLGPELEVT 1293
                            :||:| |..|                             ||....||:.
Mouse  2060 RGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQ 2124

  Fly  1294 GVSVR-----------------------------NCSYFNSNTLPLKINFVGPDAESLPAIFKCG 1329
            .||.:                             :.....|...|.|:..:|.:......:.|..
Mouse  2125 YVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGH 2189

  Fly  1330 DDLQQDQLTIQLIRIMNKMWLAE-----RLDLKMVTFNCVPTGYKSGMIELVSEAETL------- 1382
            :||:||:..:||..::|.: ||.     |.:|.:..:..:|....||:|..|...:||       
Mouse  2190 EDLRQDERVMQLFGLVNTL-LANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDY 2253

  Fly  1383 ----------------------------RKIQV-ECGLTGSFKDRPIAEWLGKQNPSPLEYQSAV 1418
                                        :|::| |..:..:..| .:|:.|..::||...:....
Mouse  2254 REKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGD-DLAKLLWLKSPSSEVWFDRR 2317

  Fly  1419 RNFTLSCAGYSVATYVLGICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTS 1482
            .|:|.|.|..|:..|:||:.|||..|:|| :.||.:.|||||.....|.....|. ::.||.|| 
Mouse  2318 TNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFP-EKIPFRLT- 2380

  Fly  1483 DMAYVINGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTL 1523
              ..:.|..:....|.:|.. .|.....::|::.|.::..|
Mouse  2381 --RMLTNAMEVTGLDGNYRT-TCHTVMEVLREHKDSVMAVL 2418

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K68DNP_001163420.1 EIN3 <58..392 CDD:296674
PI3K_rbd 561..669 CDD:197540 33/129 (26%)
C2A_PI3K_class_II 844..1021 CDD:175979 39/260 (15%)
PI3Ka_II 1038..1202 CDD:238441 49/287 (17%)
PI3Kc_II 1235..1583 CDD:270710 86/414 (21%)
PX_PI3K_C2_68D 1611..1721 CDD:132794
C2B_PI3K_class_II 1751..1871 CDD:176027
MtorNP_064393.2 Interaction with NBN. /evidence=ECO:0000250 1..651
TEL1 363..2549 CDD:227365 287/1471 (20%)
HEAT 16 637..683
HEAT repeat 655..681 CDD:293787
HEAT 17 686..724
HEAT repeat 691..721 CDD:293787
HEAT 18 727..766
HEAT repeat 729..759 CDD:293787
HEAT 19 769..811
HEAT repeat 772..805 CDD:293787
HEAT 20 814..853
HEAT repeat 817..847 CDD:293787
DUF3385 854..1024 CDD:288698
HEAT 21 857..893
HEAT 22 894..942
HEAT 23 943..988
HEAT repeat 955..981 CDD:293787
HEAT 24 989..1027
HEAT repeat 993..1021 CDD:293787
HEAT 25 1029..1068
HEAT repeat 1033..1062 CDD:293787
HEAT 26 1069..1105
HEAT repeat 1073..1099 CDD:293787
HEAT 27 1106..1144 9/27 (33%)
HEAT repeat 1111..1142 CDD:293787 8/25 (32%)
HEAT 28 1145..1188 16/74 (22%)
HEAT repeat 1154..1180 CDD:293787 10/54 (19%)
HEAT 29 1189..1225 10/39 (26%)
HEAT 30 1226..1273 11/51 (22%)
HEAT 31 1274..1311 13/44 (30%)
HEAT 32 1312..1345 5/32 (16%)
TPR 1 1346..1382 10/53 (19%)
TPR 2 1383..1408 9/28 (32%)
TPR 3 1409..1442 7/32 (22%)
TPR 4 1443..1473 7/41 (17%)
TPR 5 1474..1507 8/53 (15%)
TPR 6 1508..1541 6/33 (18%)
TPR 7 1542..1574 2/31 (6%)
TPR 8 1575..1614 7/38 (18%)
TPR 9 1615..1649 3/33 (9%)
TPR 10 1650..1693 11/42 (26%)
TPR 11 1694..1731 6/37 (16%)
TPR 12 1732..1786 12/69 (17%)
TPR 13 1787..1846 9/61 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1825..1867 3/41 (7%)
TPR 14 1898..1930 6/33 (18%)
TPR 15 1931..1970 14/64 (22%)
TPR 16 1971..2005 5/33 (15%)
Sufficient for interaction with the FKBP1A/rapamycin complex 2012..2144 22/139 (16%)
Rapamycin_bind 2015..2112 CDD:285924 15/102 (15%)
PIKKc_TOR 2153..2431 CDD:270713 65/273 (24%)
Interaction with MLST8. /evidence=ECO:0000250 2258..2296 3/37 (8%)
FATC 2518..2549 CDD:280430
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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