DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pi3K68D and si:rp71-17i16.5

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	XP_021329311.1	Gene:	si:rp71-17i16.5 / 564261	ZFINID:	ZDB-GENE-090312-117	Length:	1069	Species:	Danio rerio

Alignment Length:	954	Identity:	273/954 - (28%)
Similarity:	435/954 - (45%)	Gaps:	136/954 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   693 LLPNE-------VVPIVTY---DNMMILIETLEMEIDKLESAADGVPGRSVVSCSGVVQAVKAIC 747
            :|||:       .:.:..|   .|:.|..:..:...|.|:...:.:|..|:...|.....|..:|
Zfish   191 VLPNDQQGYFQRTLSVTLYYNGSNLSIKADLTQKPSDILKIFWESLPKGSLPIESWTSDHVLKVC 255

  Fly   748 A----LLGSI---DTMEIARCVADLKRICEVEQKKYSTGASNPEIVS-DYGDYAQVVLRPRSMLE 804
            .    |.|..   :.:.:..|   ||...|:.....:..:...:.|| :|......:....|..|
Zfish   256 GREEFLSGDFQLSNYLWVRHC---LKNSLELHLSVVAISSLPDDTVSTEYWPLVDSLTGLSSSHE 317

  Fly   805 QIKVKCNELRDAVQELVELYANVFRVAFSVKTPDYSTTPIPISCVSK-PIVVCISCLHRPLPNWK 868
            ::.:|..|:.|.|  |:.|:.  ....|.||...:....:|    || |.:|.:.
Zfish   318 ELCLKKKEVEDIV--LISLWD--CERKFRVKLLGFDIPDLP----SKVPSLVYVE---------- 364

  Fly   869 FDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFSAWLTFDQHPICTLPREARLTFVLYG 933
                   ..|:||.:.:|.    .||  |.......:.::.||.|| ..|..:|:.|:|...:..
Zfish   365 -------ATIIYGKKTISS----ICS--TPKEFTDEVLWNTWLEFD-ILIRDIPQGAKLGLTINA 415

  Fly   934 KQAASEGEPNA----DQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLWP-PMTDK--MLGP 991
            .:||.|.:.::    |.:..:.||   |.:.::||.|.:.::..||:.|::|| |..|:  :...
Zfish   416 TEAAKETKSSSSKVPDHHKGKLQV---LYFVNLQLIDHRSLLSQGPHTLNMWPFPEWDEEAVTYE 477

  Fly   992 APARGCHPQPDFCPVLSIE--VPPYGGRIEFP--EHQEVPKPAPHYDFASLD----ANLQ---EE 1045
            |........||....::|.  :..|...:..|  ........:|..:.:|||    :.|.   .|
Zfish   478 ADKLSTATNPDVANSMAITFMLDRYSFPVVLPNGRSSSCSGTSPVSESSSLDLAGESRLSAPFSE 542

  Fly  1046 LLDTAELGYTGATERREV--FWEKRLYLQSYPNALPKVLHAAHSWDYANLI-DLHALLHSWAP-- 1105
            ...||.|     |..|.:  |.|:.::   |.:.||:.|... :|....:: ::|.||..|.|
Zfish   543 ASSTATL-----TRMRNLKKFKEESVH---YVSNLPQFLRTV-NWMLPTVVQEVHWLLSHWGPED 598

  Fly  1106 LSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCL 1170
            :....:||||...:.|.|||..||:.:..:.||:::.:|.||||:||.:.|..|.:|||||.:.|
Zfish   599 IELFVALELLSVDFADLKVRRLAVQRLEILSNDEVLKYLLQLVQTLKVEPYHDSFLARFLLKRAL 663

  Fly  1171 ESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYR-RNKMMLRALMAICGEKML 1234
            .|.|..|..:|                      |..|:|....::| |..::|.|.:..|||.||
Zfish   664 RSKRIGHFFFW----------------------YLRSEVAGCPFFRQRMAVILEAYLLGCGEAML 706

  Fly  1235 QRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQPTC-------LPLGPELEV 1292
            ..|..|.::...|..:|.:||.....  :..|.:...:..|:|||:  |       :|..|.:..
Zfish   707 AEFQSQVQVVSYLHDVALAVKLLYPD--RTDLPSTAPQKLQELLEK--CDLPSDFQVPFDPRVRA 767

  Fly  1293 TGVSVRNCSYFNSNTLPLKINFVGPDAESLPA-----IFKCGDDLQQDQLTIQLIRIMNKMWLAE 1352
            ..:.:::|....|...||.:.|....:|:.|:     |||.||||:||.|.||.:.:|:.:|..:
Zfish   768 GSIILKDCKIMASKKKPLWLEFSCIQSEAPPSPPVGIIFKHGDDLRQDMLIIQTLVVMDSIWQEK 832

  Fly  1353 RLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQ-VECGLTGSFKDRPIAEWLGKQNPSPLEYQS 1416
            .|||.:|.:.|:.||:..||||:|..|.|:..:| .:.|:.|:||:..:.:||..:.|...::..
Zfish   833 GLDLNLVPYGCISTGFNIGMIEIVRNAITIASVQRSQGGVAGAFKNNALYDWLQTKCPFQEKHFQ 897

  Fly  1417 AVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLT 1481
            |...|..|||||.||||||||.||||||||:...|:|||||||..||:.:.|....|:|.|||||
Zfish   898 ATEKFVNSCAGYCVATYVLGIGDRHNDNIMITDQGNLFHIDFGHILGNTKSFWGVNRERVPFVLT 962

  Fly  1482 SDMAYV---INGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVN-SNAVQYV 1542
            .|..||   :.|  :||..|..|.|.|..|:..:|..:.||:...:.|...|:|.:: |..:.|:
Zfish   963 PDFLYVMGRVKG--RPSLYFQRFRDTCINAYLSLRAQSRLLVTLFSLMLLTGIPELSMSQDMLYL 1025

  Fly  1543 RRALLPSQSNPEAAATFAKMIQ-SSLKSWFTQFNFFLHNLAQMR 1585
            |.||...||..||.....:.|. ...|.|..|.|::.|.:|.::
Zfish  1026 RTALQQDQSEEEARNHLLQQIALCEHKGWTVQANWWFHLMAGIK 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540
		C2A_PI3K_class_II	844..1021	CDD:175979	42/186 (23%)
		PI3Ka_II	1038..1202	CDD:238441	52/175 (30%)
		PI3Kc_II	1235..1583	CDD:270710	130/365 (36%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
si:rp71-17i16.5	XP_021329311.1	PI3K_rbd	189..292	CDD:321949	19/103 (18%)
		C2	332..506	CDD:326325	46/206 (22%)
		PI3Ka	557..702	CDD:320871	50/170 (29%)
		PI3Kc_IB_gamma	706..1069	CDD:270627	132/368 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579759
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750