DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K68D and prkdc

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	XP_009301676.1	Gene:	prkdc / 562283	ZFINID:	ZDB-GENE-030131-9008	Length:	4119	Species:	Danio rerio

Alignment Length:	1354	Identity:	244/1354 - (18%)
Similarity:	422/1354 - (31%)	Gaps:	529/1354 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 LNHEDYSRVSVLEAFDPLLNDNTGNDTASDSTSYYAEYDPFDFLYSGDAATQYSDPMYEAVNRWD 404
            :..:|:..::.|||::.|        |...|..|.|..:..|           |.|:     |.|
Zfish  2999 ITEKDFWEIAALEAYNHL--------TEWKSLEYCATVNIDD-----------SSPI-----RLD 3039

  Fly   405 KTVATVSPNVGLIGWRQDFLSQPSTSSSQYGVAPPEESLKLAENGSGTISPPPPLPPRNQQCYES 469
            :.            |.:.|..:   :..||.:....:.|::.|.              ||.....
Zfish  3040 RM------------WTETFYVE---TYLQYMMRSMLKQLQMGET--------------NQDLLSF 3075

  Fly   470 NQAAMPVSRPPQSSVLTDSYTSSIPANVVL----DRRK----TCTRLYELISDQRTDDP------ 520
            ..|||....  ...::...|:..:....:|    ||.|    .|.:::  :.:..:.||
Zfish  3076 VDAAMKTEE--HKIIMETHYSQELSLLYILQEDYDRAKYYANNCMQVF--MQNYSSIDPLLNRSR 3136

  Fly   521 -----------ELLEFYH-------------MVKEVRARYPHDDA---PTNV-GHVVAAEFNYHY 557
                       |:.:|.:             |::...:.||  ||   |.|| ..::.:..   :
Zfish  3137 LTVLQSVQALTEIQDFLNYITGDVSVNSLKFMIRRWTSHYP--DAKLDPMNVWDDIITSRC---F 3196

  Fly   558 MMDTSIKVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDI-------DSVVAQ----VVAQ 611
            .:|..:|.:.....|:::  |..|..|..:..|.   :..||..       ||...|    |.::
Zfish  3197 FLDKILKRLKSTPENSME--VDGADQGSGEELGV---LVKTCKFNMKLQMADSAWKQNNFPVASK 3256

  Fly   612 ALASLEGQVKGTVTDYAVKPIGLLEWLAPTSRLSQLECVHNSFQLEKDVHLGLCLSTAANMQAIA 676
            .|..|....|       :....||.|:...||          |..::...||    .:..:.|:.
Zfish  3257 LLKELHRHAK-------IDDARLLRWVHSFSR----------FTHKRIARLG----PSEKINALL 3300

  Fly   677 RTE---RDDEHDADLLPEHLLPNEVVPI-VTYDNMM-------ILIETL-EMEIDKLESAADGVP 729
            :|.   :|.|..::.|...:|.::.:.: .|||.|.       ..:||| |.::.|:
Zfish  3301 KTVPLLKDAERQSEALSARMLRDQRILLGTTYDLMAGAADRSPFALETLGEEKVQKI-------- 3357

  Fly   730 GRSVVSCSGVVQAVKAICALLGSIDTMEIARCVADLKRICEVEQKKYSTGASNPE---IVSDY-- 789
             ..:...|.:.|.|:.:     .|..:|:.|..|     |:.|:::.|....:..   ||..|
Zfish  3358 -LQLSQASSIAQVVEGL-----QIQALELLRSAA-----CKAEEEEQSFSQQHVNTHGIVEAYMT 3411

  Fly   790 -GDYAQVVLRP--------------------RSMLEQIKVKCNELR---DAVQELVELYANVFRV 830
             .::....||.                    :.||:.:|:...|.|   ..:.:|||:|
Zfish  3412 MANFCDRRLRESEQKEEAISSKLQSLPEHVVKMMLKALKLSSEEARLKFPRLLQLVEVY------ 3470

  Fly   831 AFSVKTPDYSTTPIPISCVSKPIVVCISCLHRPLPNWKFDDYSLCVQIVYGTRLLSKPNVLTCSN 895
              ..:|.|.....:    ||.|..:.|..:.:.:                  .||.||..
Zfish  3471 --PAETLDLMVREV----VSVPCWLLIGWISQMM------------------ALLDKPQA----- 3506

  Fly   896 DTSGGLFPRLNFSAWLTFDQHPICTLPREARLTFVLYGKQAASEGEPNADQNGERRQVTTELGWC 960
                            |..||                                    |..|:..|
Zfish  3507 ----------------TAVQH------------------------------------VIEEIAEC 3519

  Fly   961 SIQLFDFKRVMICGPYLLSLWPPMTDKMLGPAPARGCHPQPDFCPVLSIEVPPYGGRIEFPEHQE 1025
            ..|...:       ||::|
Zfish  3520 YPQALIY-------PYMIS---------------------------------------------- 3531

  Fly  1026 VPKPAPHYDFASLDANLQEELLDTAELGYTGATERREVFWEKRLYLQSYPNALPKVLHAAHSWDY 1090
                :.:|.|        ||         :.:.:|...|.||   |:|
Zfish  3532 ----SENYTF--------EE---------SASGQRNREFVEK---LES----------------- 3555

  Fly  1091 ANLIDLHALLHSWA-PLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHD 1154
              |:|...::..:. .|..|.:.|:|..            :|..::.|......|.:....|::.
Zfish  3556 --LLDKGGVIQGFVDALQQLSNPEMLFK------------DWWDEVKNQLDKPNLDKKKMKLQYM 3606

  Fly  1155 TYEGSAMARFLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNK 1219
            |.        ||... :||||..:                                :.::.::..
Zfish  3607 TE--------LLGDA-KSPRFGSY--------------------------------RRKFIQKFS 3630

  Fly  1220 MMLRALMAICGEKMLQR-----FMYQ-HRMCQKLTTIAESVKEAKESMRQKS--LAAGMDEVHQD 1276
            ..:..|:...|.|:.:|     |:.| .||.|.:    ...::...:|::.|  |::...|..::
Zfish  3631 KEVEKLLGAGGSKLYERRKDKDFLQQVDRMVQSM----RGFQKEPGNMKEYSPWLSSFKAETLKN 3691

  Fly  1277 LLEQP-----TCLPLGPE--LEVTGVSVRNCSYFNSNTLPLKINFVGPDAESLPAIFKCGDDLQQ 1334
            .||.|     ...|| ||  .::||...| .....|...|.:|...|.|....|.:.|.|:||:|
Zfish  3692 ELEVPGQYDGKSKPL-PEYHAKITGFDER-VKVMTSIRRPKRIIIRGDDERDYPFLVKGGEDLRQ 3754

  Fly  1335 DQLTIQLIRIMNKMWLAE-----RLDLKMVTFNCVPTGYKSGMIELVSEAETL-------RKIQV 1387
            ||...||..:|| |.|::     :..|.:.|:..:|...:.|:||.:....||       |..|.
Zfish  3755 DQRIEQLFGVMN-MILSQDTACSQRSLALRTYQVIPITSRIGLIEWMENTCTLKDFLSSRRTEQE 3818

  Fly  1388 ECGLT--GSFKDRPIAEWLGK-------------------------------------------- 1406
            :..:|  ..|.|    ||:.|
Zfish  3819 QKTITRPNEFYD----EWISKVAGKVEGIRRYAELYKKAKRVDTVNNFRRIEQMVPDDLLKRAFV 3879

  Fly  1407 -QNPSPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKT-SGHLFHIDFGKFLGDAQMFG 1469
             .:.:|..:.|...:|:.|.|...::.::|||.|||..|.|:.| :|.:..||||...|.|..|.
Zfish  3880 RMSTTPEAFLSLRSHFSSSHAVLCISHWILGIGDRHLSNFMINTETGGMIGIDFGHAFGSATQFL 3944

  Fly  1470 NFKRDRTPFVLTSDMAYVINGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTL 1523
            ... :..||.||.....::    :|..:......:...:....|...||||:|:
Zfish  3945 PVP-ELMPFRLTRQFINLM----RPLAESGLIQSVMVHSLRAFRAEPDLLLNTM 3993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674	10/51 (20%)
		PI3K_rbd	561..669	CDD:197540	23/118 (19%)
		C2A_PI3K_class_II	844..1021	CDD:175979	18/176 (10%)
		PI3Ka_II	1038..1202	CDD:238441	25/164 (15%)
		PI3Kc_II	1235..1583	CDD:270710	88/364 (24%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
prkdc	XP_009301676.1	NUC194	1830..2211	CDD:285387
		FAT	3070..3465	CDD:280429	81/448 (18%)
		PIKKc_DNA-PK	3713..4006	CDD:270716	71/292 (24%)
		FATC	4089..4119	CDD:280430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900