DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K68D and pik3c3

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	XP_021333200.1	Gene:	pik3c3 / 548346	ZFINID:	ZDB-GENE-050410-13	Length:	887	Species:	Danio rerio

Alignment Length:	902	Identity:	214/902 - (23%)
Similarity:	339/902 - (37%)	Gaps:	261/902 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   870 DDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLF-PRLNFSAWLTFD-QHPICTLPREARLTFVLY 932
            |.|..|.....|     ||..|...  ||...| .|.|::.||... ::|  .||:.|::|..::
Zfish    55 DLYVTCQVFAEG-----KPLALPVR--TSYKAFSTRWNWNEWLRLPVKYP--DLPQSAQVTLTVW 110

  Fly   933 GKQAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLWPPMTDKMLGPAPARG- 996
                        |..|..|  .|.:|..::.||....:...|.:.|.:||.:......|....|
Zfish   111 ------------DVYGPGR--ATPVGGTTVTLFGKYGMFRQGMHDLKVWPGVEGDGTEPTSTPGR 161

  Fly   997 ---------------------------CHPQPDFCPV--------------------------LS 1008
                                       .|.|.....|                          |.
Zfish   162 TSSSLAEDQMGRLAKGPDLEILSDLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLM 226

  Fly  1009 IEVPPYGGRIEFPEHQ-----------------------EVPKP---------APHYDFA-SL-- 1038
            :|.|    |::..|.:                       :||.|         :.|:..| ||
Zfish   227 VEFP----RVKSGEREYSIVYYEKDADESSPLPTSSDIVKVPDPQMCMENLVESKHHKLARSLRS 287

  Fly  1039 ---DANLQEELLDTAELGYTG--------ATERREVFWEKRLYLQSYPNALPKVLHAAHSWDYAN 1092
               |.:|:.......:|....        ::|.:::.|:.|.||.:...||.|.|... :||
Zfish   288 GPSDHDLKPNAATRDQLNIIVSYPPTKQLSSEEQDLVWKFRYYLTTQEKALTKFLKCV-NWD--- 348

  Fly  1093 LIDLHA-----LLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLK 1152
             :...|     ||..|.|:....|||||..::.:..||..||..:.:..::.|:.:|.||||:||
Zfish   349 -LPQEAKQALELLGKWRPMDVEDSLELLSSQFTNPTVRRYAVARLQQADDEDLLMYLLQLVQALK 412

  Fly  1153 HDTYE--------------------------------GSAMA----------------------R 1163
            ::.:.                                .||:|                      .
Zfish   413 YENFNDIQGGLEPANKRDNQGGLTESSTTGDLDSSQLASAIAVMPSSQKGKEGTDGENLEQDLCT 477

  Fly  1164 FLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRAL--- 1225
            ||:|:..::...|:::||.::...                  |.|.||.|..:.:.|.|..:
Zfish   478 FLISRACKNSTLANYLYWYVIVEC------------------EDQDTQQRDPKTHDMYLNVMRRF 524

  Fly  1226 --MAICGEKMLQRFM---------YQHRMCQKLTTI-AESVKEAKESMRQKSLAAGMDEVHQDLL 1278
              ..:.|:|.: |.|         :..|:.|.:..: .||....|::.|.:||.|..::|:...:
Zfish   525 SQALLKGDKSV-RVMRSLLASQQTFVDRLVQLMKAVQRESGNRKKKTERLQSLLADNEKVNLSEI 588

  Fly  1279 EQPTCLPLGPELEVTGVSVRNCSYFNSNTLPLKINFVGPDAESLPAIFKCGDDLQQDQLTIQLIR 1343
            | |..|||.|::.:.|:.....:.|.|..:|.|:.|...|.|..|.|||.||||:||||.:|:|.
Zfish   589 E-PIPLPLEPQIRIKGIIPETATLFKSALMPAKLIFKTEDGEQYPVIFKHGDDLRQDQLILQIIS 652

  Fly  1344 IMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVECGLTGSFKDRPIAEWLGKQN 1408
            :|:|:...|.||||:..:..:.|..|.|.::.|........:..|..:...|:         |..
Zfish   653 LMDKLLRKENLDLKLTPYKVLATSTKHGFMQFVQSVPVAEVLATEGNIQSFFR---------KYA 708

  Fly  1409 PS---PLEYQSAVRN-FTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFG 1469
            |:   |....|.|.: :..|||||.|.||:||:.|||.||::|..:|.|||||||..||
Zfish   709 PNDKGPYGISSEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILG------ 767

  Fly  1470 NFKRD----RTPFVLTSDMAYVING-GDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATA 1529
               ||    ..|..|:.:|   :.| |...|..:..|...|..||..:|:.::|:|:..:.|..|
Zfish   768 ---RDPKPLPPPMKLSKEM---VEGMGGMQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDA 826

  Fly  1530 GMPGV---NSNAVQYVRRALLPSQSNPEAAATFAKMIQSSLKSWFTQFNFFLHNLAQ 1583
            .:|.:   ....|:.|:.......|:.||......:|..|:.:.|......:|..||
Zfish   827 NIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVGALFAAVVEQIHKFAQ 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540
		C2A_PI3K_class_II	844..1021	CDD:175979	39/206 (19%)
		PI3Ka_II	1038..1202	CDD:238441	46/235 (20%)
		PI3Kc_II	1235..1583	CDD:270710	111/369 (30%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
pik3c3	XP_021333200.1	C2_PI3K_class_III	25..194	CDD:176042	34/161 (21%)
		PI3Ka_III	291..503	CDD:238442	45/234 (19%)
		PI3Kc_III	539..883	CDD:270628	109/365 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820