DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K68D and ATR

DIOPT Version :9

Sequence 1:NP_001163420.1 Gene:Pi3K68D / 39329 FlyBaseID:FBgn0015278 Length:1876 Species:Drosophila melanogaster
Sequence 2:XP_011511226.1 Gene:ATR / 545 HGNCID:882 Length:2646 Species:Homo sapiens


Alignment Length:1298 Identity:248/1298 - (19%)
Similarity:423/1298 - (32%) Gaps:418/1298 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   543 TNVGHVVAAEF--NYHYMMDTSIKVIVHPALNTLQSTVLAASMGKEQVKGYG--MPVTFTCDIDS 603
            |.|.|.:|::.  ....||....||.::...:.|...:|..:. ::|.:.|.  |.|....|..:
Human  1502 TKVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQ-EDQQEVYAEIMAVLKHDDQHT 1565

  Fly   604 VVAQVVAQALASLEGQVKGTVTDYAVKPIGLLEWLAPTSRLSQLE-CVHNSFQLEKDVHLGLCLS 667
            :..|.:|..|..|..|...::.|:      |.:|.....:..:.| |.|:.....|   :...:|
Human  1566 INTQDIASDLCQLSTQTVFSMLDH------LTQWARHKFQALKAEKCPHSKSNRNK---VDSMVS 1621

  Fly   668 TA--ANMQAIARTERDDEHDADLLPEHLLPNEVVPIVTYDNMMILIETLEME-----------ID 719
            |.  .:.|::.|.       .||:|:..|.........|...::..|:...|           :.
Human  1622 TVDYEDYQSVTRF-------LDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQEHLGFLQ 1679

  Fly   720 KLESA---ADGVPGRSVVSCSGVVQAVKAICALLGSI---DTMEIAR-CVADLKRICEVEQKKYS 777
            ||.:|   .|||.|.|.:.        ||..:|...|   :::.:.| ..|...|..::|.    
Human  1680 KLYAAMHEPDGVAGVSAIR--------KAEPSLKEQILEHESLGLLRDATACYDRAIQLEP---- 1732

  Fly   778 TGASNPEIVSDYGDYAQVVLRPRSMLEQIKVKCNELRDAVQELVELYANVFRVAFSVKTPDYSTT 842
                 .:|:..:|    ||   :|||     ...:|...:.::..::||     .|..|.:.:| 
Human  1733 -----DQIIHYHG----VV---KSML-----GLGQLSTVITQVNGVHAN-----RSEWTDELNT- 1774

  Fly   843 PIPISCVSKPIVVCISCLHRPLPNWKFDDYSLCV------------QIVYGTRLLS-KPNVLTCS 894
                              :|....||...:.|..            .:..|..||| |...:|..
Human  1775 ------------------YRVEAAWKLSQWDLVENYLAADGKSTTWSVRLGQLLLSAKKRDITAF 1821

  Fly   895 NDT------------SGGLFPRLNFSAWLTF--DQHPICTLPREARLTFVLYGKQAASEGEPN-- 943
            .|:            |...|.|.::.....:  ..|.:|.|....:..|......::.|...|  
Human  1822 YDSLKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCELEHSIKPLFQHSPGDSSQEDSLNWV 1886

  Fly   944 ----ADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSL-WPPMTDKMLGP-------APARG 996
                ..||..|.:               :.::.....|||| ..|..::|:|.       ...:.
Human  1887 ARLEMTQNSYRAK---------------EPILALRRALLSLNKRPDYNEMVGECWLQSARVARKA 1936

  Fly   997 CHPQPDFCPVL--------------------------SIEVPPYGGRIEFPEHQEVPKPAP---H 1032
            .|.|..:..:|                          ::.|...|..:.|||::..|:...   |
Human  1937 GHHQTAYNALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQKGVELCFPENETPPEGKNMLIH 2001

  Fly  1033 YDFASLDANLQEELLDTAELGYTGATER-REVF-----WEK-RLYLQSY---------PNALPK- 1080
            .....|.....||   ||........:: ::|.     ||. ..||..|         .|.:.| 
Human  2002 GRAMLLVGRFMEE---TANFESNAIMKKYKDVTACLPEWEDGHFYLAKYYDKLMPMVTDNKMEKQ 2063

  Fly  1081 -------VLHAAHSWDYANLIDLHALLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWIS----- 1133
                   |||...|..|.|..             ..||:..:|..:.|  ...||.||..     
Human  2064 GDLIRYIVLHFGRSLQYGNQF-------------IYQSMPRMLTLWLD--YGTKAYEWEKAGRSD 2113

  Fly  1134 --KMPND------------------QLVDFLPQLVQSLKHDTYEGSAMARFLLSKC-LESPRFAH 1177
              :|.||                  |.:....||:..:.|...|...:...:::|. |..|:.| 
Human  2114 RVQMRNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQA- 2177

  Fly  1178 HMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAICGEKMLQRFMYQ-H 1241
              .|::             .|:....|      .:|..|..:::.:|:..   :|.|::|:.. .
Human  2178 --MWMM-------------TAVSKSSY------PMRVNRCKEILNKAIHM---KKSLEKFVGDAT 2218

  Fly  1242 RMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQPT----CLPLG----PEL-EVTGVSV 1297
            |:..||..:.....:...|....|....|   .:.|:|:.|    .:||.    |.| .:.|...
Human  2219 RLTDKLLELCNKPVDGSSSTLSMSTHFKM---LKKLVEEATFSEILIPLQSVMIPTLPSILGTHA 2280

  Fly  1298 RNCSY-------------------FNSNTLPLKINFVGPDAESLPAIFKCGDDLQQDQLTIQLIR 1343
            .:.|:                   ..|...|.||:..|.|.:....:.|..|||::|...::...
Human  2281 NHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNS 2345

  Fly  1344 IMNKMWL----AERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVECGLTGSFKDR------ 1398
            ::||...    :.|.:|.:.|:..:|...:.|:||.|:....||.|     ||..:|::      
Human  2346 LINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPI-----LTKLYKEKGVYMTG 2405

  Fly  1399 ------------------------------PI-AEWLGKQNPSPLEYQSAVRNFTLSCAGYSVAT 1432
                                          || .||..:..|.|..:.|:...:..|.|..|:..
Human  2406 KELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVG 2470

  Fly  1433 YVLGICDRHNDNIMLKT-SGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVINGGDKPST 1496
            |:||:.|||.:||:..: :|...|:||.......:.|.  ..:..||.||.:|   :||      
Human  2471 YILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFE--VPEIVPFRLTHNM---VNG------ 2524

  Fly  1497 DFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNSNAVQYVRRALLPSQSNPEAAATFAK 1561
                                         |...|..|:...|.:...| |:..|..|        
Human  2525 -----------------------------MGPMGTEGLFRRACEVTMR-LMRDQREP-------- 2551

  Fly  1562 MIQSSLKSWFTQFNFFLHNLAQMRFTPDEG--------SGELLSFVPRKYTMQQDGRLK-IVK 1615
             :.|.||:       |||:.......|.:|        :||:::...:.:.:..:.||: ::|
Human  2552 -LMSVLKT-------FLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIK 2606

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K68DNP_001163420.1 EIN3 <58..392 CDD:296674
PI3K_rbd 561..669 CDD:197540 22/110 (20%)
C2A_PI3K_class_II 844..1021 CDD:175979 35/243 (14%)
PI3Ka_II 1038..1202 CDD:238441 41/213 (19%)
PI3Kc_II 1235..1583 CDD:270710 87/418 (21%)
PX_PI3K_C2_68D 1611..1721 CDD:132794 2/6 (33%)
C2B_PI3K_class_II 1751..1871 CDD:176027
ATRXP_011511226.1 UME 1119..1224 CDD:214825
FAT 1773..2094 CDD:280429 62/370 (17%)
TEL1 <2135..2646 CDD:227365 111/562 (20%)
PIKKc_ATR 2295..2569 CDD:270625 71/335 (21%)
FATC 2615..2646 CDD:280430
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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