Protein Alignment Pi3K68D and PI4KB

DIOPT Version :9

• Sequence 1: NP_001163420.1
• Gene: Pi3K68D / 39329
• FlyBaseID: FBgn0015278
• Length: 1876
• Species: Drosophila melanogaster
• Sequence 2: XP_011507936.1
• Gene: PI4KB / 5298
• HGNCID: 8984
• Length: 849
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 118/536 - (22%)
• Similarity: 212/536 - (39%)
• Gaps: 135/536 - (25%)

  Fly  1109 LQSLELLLPRYPDAKVREKAVEW---------ISKMPNDQLV-----DFLPQL--VQSLKHDTYE 1157
            :..|.||..:.| |:|      |         :.::|:.|.|     |..|.|  |:.|:.:.::
Human   365 ISELSLLNHKLP-ARV------WLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFD 422

  Fly  1158 GSAMARFLLSKCLESPRFAHHMYWLLVHSLPD---DPHNSIGAAMVDQEYDES----QVTQVRYY 1215
            .:::...:....:.|.|        .|.:||:   ......|:......||..    .|..:
Human   423 TTSVPARIPENRIRSTR--------SVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDI--- 476

  Fly  1216 RRNKMMLRALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQ 1280
                          ||..::........|..::..:.....::||.....:|||  ::.:.|.||
Human   477 --------------GELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAG--DIRRRLSEQ 525

  Fly  1281 ----PTCLPLGPELEVTGVSVRNCSYFNSNTLPL--KINFVG--------PDAESLPAIFKCGDD 1331
                ||.....|| :.:.|:::.         |.  |:..:.        |:...|..|.|||||
Human   526 LAHTPTAFKRDPE-DPSAVALKE---------PWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDD 580

  Fly  1332 LQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVECGLT---- 1392
            |:|:.|..|:::.:..:|..||:.|.:..:..:.....|||||.|..|.::.:::.:..|:
Human   581 LRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDY 645

  Fly  1393 -----GSFKDRPIAEWLGKQNPSPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGH 1452
                 ||:...              .:.||.|||..|||||.:..|:|.:.||||.||:|...||
Human   646 FLQEHGSYTTE--------------AFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGH 696

  Fly  1453 LFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVING--GDKPSTDFHYFVDLCCRAFNIVRKN 1515
            :.|||||..|..:..  |...:.:.|.||::...|:.|  ||.    |:|:..|..:.....||:
Human   697 IIHIDFGFILSSSPR--NLGFETSAFKLTTEFVDVMGGLDGDM----FNYYKMLMLQGLIAARKH 755

  Fly  1516 ADLLLH----------------------TLAHMATAGMPGVN-SNAVQYVRRALLPSQSNPEAAA 1557
            .|.::.                      |:|.:..:.:|..: |:.::.::.....|.:..:...
Human   756 MDKVVQIVEIMQQGCRRCSGSSPSGPMMTVAQVICSQLPCFHGSSTIRNLKERFHMSMTEEQLQL 820

  Fly  1558 TFAKMIQSSLKSWFTQ 1573
            ...:|:..|::|..|:
Human   821 LVEQMVDGSMRSITTK 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540
		C2A_PI3K_class_II	844..1021	CDD:175979
		PI3Ka_II	1038..1202	CDD:238441	21/111 (19%)
		PI3Kc_II	1235..1583	CDD:270710	92/387 (24%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
PI4KB	XP_011507936.1	PI4Kc_III_beta	541..849	CDD:270712	79/325 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810