Protein Alignment Pi3K68D and PIK3CG

DIOPT Version :10

• Sequence 1: NP_524028.2
• Gene: Pi3K68D / 39329
• FlyBaseID: FBgn0015278
• Length: 1876
• Species: Drosophila melanogaster
• Sequence 2: NP_002640.2
• Gene: PIK3CG / 5294
• HGNCID: 8978
• Length: 1102
• Species: Homo sapiens
• Alignment Length: 1130
• Identity: 303/1130 - (26%)
• Similarity: 499/1130 - (44%)
• Gaps: 239/1130 - (21%)

  Fly   588 VKGYGMPVTFTCDIDSVVAQVVAQALAS----------------LEGQVKG---TVTD--YAVKP 631
            |.|:|       :::.:.|||..:||.:                |..|.||   .:.|  ..|:.
Human    61 VAGHG-------NVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQT 118

  Fly   632 IGLLE-WLAPTSRLSQLECVH--------NSFQLEKDVHLGLCLSTAANMQAIARTERDDE---- 683
            :..|. |.|......|:..|.        .:||.:....:|..::..:|:       .|||
Human   119 LDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNV-------HDDELEFT 176

  Fly   684 --------------HDADL-----------LPEHL---LPNEVVPIVTYDNMMILIETLEMEIDK 720
                          .|..|           |||:|   :.|..:.||.:.:  ...:|:::
Human   177 RRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRS--TTSQTIKV---- 235

  Fly   721 LESAADGVPGRSVVSCSGVVQAVKAICALLGSIDTMEIARCVAD---LKRICEVEQKKYSTGASN 782
               :.|..||..:.|....:...|::         |:|....::   :.|:|  .:.:|..|.:.
Human   236 ---SPDDTPGAILQSFFTKMAKKKSL---------MDIPESQSEQDFVLRVC--GRDEYLVGETP 286

  Fly   783 PEIVSDY---------GDYAQVVL--RPRSMLEQIKVK-------CNELRDAVQELV---ELYAN 826
               :.::         |:...|||  .|...|::::.:       |..:....::|.   :.:.:
Human   287 ---IKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHES 348

  Fly   827 VFRVA-------FSVKTPDYSTTPIPISCVSKPIVVCISCLHRPLPNWKFDDYSLCVQ--IVYGT 882
            ||.|:       |.||          |..:..|:          ||  :..|.::.|:  |.:|.
Human   349 VFTVSLWDCDRKFRVK----------IRGIDIPV----------LP--RNTDLTVFVEANIQHGQ 391

  Fly   883 RLLSKPNVLTCSNDTSGGLF-PRLNFSAWLTFDQHPICTLPREARLTFVLY-GKQAASEGEPNAD 945
            ::|       |...||...| ..:.::.||.| ...|..||:.|.|...:| ||..|...:.:|:
Human   392 QVL-------CQRRTSPKPFTEEVLWNVWLEF-SIKIKDLPKGALLNLQIYCGKAPALSSKASAE 448

  Fly   946 Q-NGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLWPPMTDKMLGPAPARG----------CHP 999
            . :.|.:.....|.:.::.|.|.:.::..|.|:|.:|     ::.|....:|          .:|
Human   449 SPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMW-----QISGKGEDQGSFNADKLTSATNP 508

  Fly  1000 QPDFCPVLSIEVPPYGGRIEFPEHQEVPKPAPHYDFASLDANLQEEL---LDTAELGYTGATERR 1061
            ..:....:||.:..|...|..|:||..|.|......|.:...|:::|   :.|..|....| |.:
Human   509 DKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTA-EDK 572

  Fly  1062 EVFWEKRLYLQSYPNALPKVLHAAHSWDYANLI----DLHALLHSW--APLSPLQSLELLLPRYP 1120
            |:.|..|.....:|.|.|| |.::..|....::    .|.|....|  :.|....:::||...:.
Human   573 ELLWHFRYESLKHPKAYPK-LFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFS 636

  Fly  1121 DAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESPRFAHHMYWLLVH 1185
            |..||..||:.:..:.:|.::.:|.||||::|.:.|..||:|||||.:.|.:.|..|.::|.|
Human   637 DENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFL-- 699

  Fly  1186 SLPDDPHNSIGAAMVDQEYDESQVTQVRYY-RRNKMMLRALMAICGEKMLQRFMYQHR---MCQK 1246
                                .|::.|.|:| :|..::|.|.:..||..||..|..|.:   |.||
Human   700 --------------------RSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQK 744

  Fly  1247 LTTIAESVKEAK--------ESMRQKSLAAGMDEVHQDLLEQPTCLPLGPELEVTGVSVRNCSYF 1303
            :|...:|:...|        ..::||     ::.:....|.:...:|..|.|:...:::..|...
Human   745 VTLDIKSLSAEKYDVSSQVISQLKQK-----LENLQNSQLPESFRVPYDPGLKAGALAIEKCKVM 804

  Fly  1304 NSNTLPLKINF--VGPDA---ESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNC 1363
            .|...||.:.|  ..|.|   |::..|||.||||:||.|.:|::|||..:|..|.|||.::.:.|
Human   805 ASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGC 869

  Fly  1364 VPTGYKSGMIELVSEAETLRKIQVE-CGLTGSFKDRPIAEWLGKQNPSPLEYQSAVRNFTLSCAG 1427
            :.||.|.||||:|.:|.|:.|||.. .|.||:|||..:..||.:::|:..::|:||..|..||||
Human   870 ISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAG 934

  Fly  1428 YSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVI-NGG 1491
            |.|||:||||.||||||||:..:|:|||||||..||:.:.|....::|.|||||.|..:|: ..|
Human   935 YCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSG 999

  Fly  1492 DKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNSNA-VQYVRRALLPSQSNPEA 1555
            .|.|..|..|.|:|.:|:..:|.:.:||:...:.|...|||.:.|.. ::|:|.||...::..:|
Human  1000 KKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDA 1064

  Fly  1556 AATFAKMIQSSL-KSWFTQFNFFLH 1579
            ...|...|:... |.|..|||:|||
Human  1065 KKYFLDQIEVCRDKGWTVQFNWFLH 1089

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_524028.2	PHA03247	<56..294	CDD:223021
		PI3K_rbd	561..669	CDD:197540	22/110 (20%)
		C2A_PI3K_class_II	844..1021	CDD:175979	41/191 (21%)
		PI3Ka_II	1038..1202	CDD:238441	46/172 (27%)
		PI3Kc_II	1235..1583	CDD:270710	138/365 (38%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
PIK3CG	NP_002640.2	PIK3CG_ABD	1..192	CDD:466155	26/144 (18%)
		PI3K_rbd	203..312	CDD:197540	23/131 (18%)
		C2_PI3K_class_I_gamma	350..527	CDD:176044	45/211 (21%)
		PI3Ka_I	549..725	CDD:238444	53/199 (27%)
		PI3Kc_IB_gamma	729..1095	CDD:270627	139/366 (38%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	803..809		1/5 (20%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	943..951		6/7 (86%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	962..988		12/25 (48%)