Protein Alignment Pi3K68D and PIK3CD

DIOPT Version :10

• Sequence 1: NP_524028.2
• Gene: Pi3K68D / 39329
• FlyBaseID: FBgn0015278
• Length: 1876
• Species: Drosophila melanogaster
• Sequence 2: NP_005017.3
• Gene: PIK3CD / 5293
• HGNCID: 8977
• Length: 1044
• Species: Homo sapiens
• Alignment Length: 904
• Identity: 266/904 - (29%)
• Similarity: 422/904 - (46%)
• Gaps: 124/904 - (13%)

  Fly   734 VSCSGVVQAVKAICALLGSIDTMEIARCVADLKRICEVEQKKYSTGASNPEIVSDYGDYAQVVLR 798
            ||...|..|:.| |||          |..|.:.|...|||.:..|...|......||.|.
Human   207 VSTKDVPLALMA-CAL----------RKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYP----- 255

  Fly   799 PRSMLEQIKVKCNELRDAV---------QELVELYANVFRVAFSVKTPDYSTTPIPISCVSKPIV 854
                |.|.:..|:.|...:         ..::.:.......|..|:.|.....|||   ..||..
Human   256 ----LCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIP---AKKPSS 313

  Fly   855 VCISCLHRP-----LPNWKF---DDYSLCVQ--IVYGTRLL----SKPNVLTCSNDTSGGLFPRL 905
            |.:..|.:|     :...|.   :...|.||  :.:|..:|    |...|..||.
Human   314 VSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSE---------- 368

  Fly   906 NFSAW---LTFDQHPICTLPREARLTFVLY-----GKQAASEGEPNADQNGERRQVTTELGWCSI 962
              ..|   |.||.: ||.|||.|||.|.||     .|:|.|..:       :.::....:.|.::
Human   369 --PVWKQRLEFDIN-ICDLPRMARLCFALYAVIEKAKKARSTKK-------KSKKADCPIAWANL 423

  Fly   963 QLFDFKRVMICGPYLLSLWPPMTD---KMLGPAPARGCHPQPDFCPVLSI---EVPPYGGRIEFP 1021
            .|||:|..:..|...|.:||.:.|   ::|.|......:|..|....|.|   ||.|:  .:.:|
Human   424 MLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPH--PVYYP 486

  Fly  1022 EHQEVPKPAPHYDFASLDANLQEELLDTAELGYTGA--TERREVFWEKRLYLQS-YPNALPKVLH 1083
            ..:::.:...|.:...:....|.:|.:..|...:|.  ...:::.|:.|..:|. :|.||.::|
Human   487 ALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLL- 550

  Fly  1084 AAHSWD-YANLIDLHALLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQL 1147
            ....|: :.::..:..||.||..|..|.:||||...:||..|...|::.:.|:.:|:|..:|.||
Human   551 LVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQL 615

  Fly  1148 VQSLKHDTYEGSAMARFLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQV 1212
            ||.||:::|....:.:|||.:.|.:.:..|.::|.| .|....|..::...::.:.|.......:
Human   616 VQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHL-RSEMHVPSVALRFGLILEAYCRGSTHHM 679

  Fly  1213 RYYRRNKMMLRALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKE----SMRQKSLAAGMDEV 1273
                  |::::...|:...|.|..|:       ||::......:.||    .|||::....:..:
Human   680 ------KVLMKQGEALSKLKALNDFV-------KLSSQKTPKPQTKELMHLCMRQEAYLEALSHL 731

  Fly  1274 HQDLLEQPTCLPLGPELEVTGVSVRNCSYFNSNTLPLKINFVGPDA---ESLPAIFKCGDDLQQD 1335
            ..         ||.|...:..|.|..|::.:|...||.|.:...:|   .|:..|||.||||:||
Human   732 QS---------PLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQD 787

  Fly  1336 QLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQV---ECGLTGSFKD 1397
            .||:|:|::|:.:|..|.|||:|..:.|:|||.::|:||:|..::|:..||:   ....|.:|..
Human   788 MLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNK 852

  Fly  1398 RPIAEWLGKQNPSPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFL 1462
            ..:..||..:||.. ....|:..||||||||.||||||||.|||:||||::.||.|||||||.||
Human   853 DALLNWLKSKNPGE-ALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFL 916

  Fly  1463 GDAQMFGNFKRDRTPFVLTSDMAYVINGGDKPSTD-FHYFVDLCCRAFNIVRKNADLLLHTLAHM 1526
            |:.:......|:|.||:||.|..:||..|...::: |..|...|.||:.|:|::..|.||..|.|
Human   917 GNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALM 981

  Fly  1527 ATAGMPGVN-SNAVQYVRRALLPSQSNPEAAATFAKMIQSSLK-SWFTQFNFFLHNLAQ 1583
            ..||:|.:: |..:||::.:|...::..||...|......:|: ||.|:.|:..||:::
Human   982 RAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSK 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_524028.2	PHA03247	<56..294	CDD:223021
		PI3K_rbd	561..669	CDD:197540
		C2A_PI3K_class_II	844..1021	CDD:175979	54/204 (26%)
		PI3Ka_II	1038..1202	CDD:238441	46/167 (28%)
		PI3Kc_II	1235..1583	CDD:270710	132/360 (37%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
PIK3CD	NP_005017.3	PI3K_p85B	34..107	CDD:460483
		PI3K_rbd	175..281	CDD:395642	23/93 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..312		7/27 (26%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	49/186 (26%)
		PI3Ka	503..684	CDD:214537	48/188 (26%)
		PI3Kc_IA_delta	676..1042	CDD:270718	136/388 (35%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	751..757		1/5 (20%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	890..898		5/7 (71%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	909..935		12/25 (48%)