DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K68D and PIK3CB

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_006210.1	Gene:	PIK3CB / 5291	HGNCID:	8976	Length:	1070	Species:	Homo sapiens

Alignment Length:	1082	Identity:	296/1082 - (27%)
Similarity:	473/1082 - (43%)	Gaps:	224/1082 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   595 VTFTCD----IDSVVAQVVAQALASLEGQVKGTVTDYAVKP-----------IGL--LEWLAPTS 642
            ||.:||    :||.:..::.:.|...:......|.::..|.           :||  ::||..|
Human   112 VTRSCDPGEKLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQT- 175

  Fly   643 RLSQLECVHNSFQLEKDVHLGLCLSTAANMQAIARTERDDEHDADL---LPEHLLPNEVVPIVTY 704
                                                 ...||:..:   |.:.|...:::..|.:
Human   176 -------------------------------------YPPEHEPSIPENLEDKLYGGKLIVAVHF 203

  Fly   705 DNM-----------MILIETLEMEIDK---LESAADGV-PGRSVVSCSGVVQAVKAICALLGSID 754
            :|.           |..|:..|:.|.|   :....|.| |...|:..||.|:.|.....|   |.
Human   204 ENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEYVFGDHPL---IQ 265

  Fly   755 TMEIARCVADLKRICEVEQKKYSTGASNPEIVSDYGDYAQVVLRPRSMLEQIKVKCNELRDAV-Q 818
            ...|..||.:                                   |::...|.|:|.:::... |
Human   266 FQYIRNCVMN-----------------------------------RALPHFILVECCKIKKMYEQ 295

  Fly   819 ELVELYANVFRVAFSVKTPDYSTTPIPISCVSKPIVVCISCLHRPLP------NWKFDDYSLCVQ 877
            |::.:.|.:.|        :.|..|:|:......|:..:...:.|..      |....:.::.|.
Human   296 EMIAIEAAINR--------NSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVH 352

  Fly   878 I----VYGTRLLSKPNVLTCSNDTSGGLFPRLNFSAW---LTFDQHPICTLPREARLTFVLYG-- 933
            :    .:||.||.|..|   |::.||     .|...|   |.||.: ||.|||.|||.|.:|.
Human   353 VRAGLFHGTELLCKTIV---SSEVSG-----KNDHIWNEPLEFDIN-ICDLPRMARLCFAVYAVL 408

  Fly   934 -----KQAASEGEPNADQNGERR-QVTTELGWCSIQLFDFKRVMICGPYLLSLW---PPMTDKML 989
                 |::.....|:..|...:. :|...:.|.:..:||||..:..|..:|..|   |...::||
Human   409 DKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEML 473

  Fly   990 GPAPARGCHPQPDFCPVLSIEVPPYGGRIEFPEHQEVPKPAPHYD--------FASLD-ANLQ-- 1043
            .|......:|..:....|         .::|||:::.|...|.:|        .||.| ||:.
Human   474 NPMGTVQTNPYTENATAL---------HVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSR 529

  Fly  1044 ---------EELLDTAELGYTGATERREVFWEKRLYLQS-YPNALPKVLHAAHSWD-YANLIDLH 1097
                     :|:||...|......| .::.|..|...:. :|.:|||:| .:..|: ..::..|.
Human   530 GGKKFLPVLKEILDRDPLSQLCENE-MDLIWTLRQDCREIFPQSLPKLL-LSIKWNKLEDVAQLQ 592

  Fly  1098 ALLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMA 1162
            |||..|..|.|.::||||...|||..|||.||..:.:|.:::|..:|.||||.||::.:...|::
Human   593 ALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALS 657

  Fly  1163 RFLLSKCLESPRFAHHMYWLL---VHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRA 1224
            ||||.:.|.:.|....::|.|   ||.    |..|:...::.:.|....|..:      |::.:.
Human   658 RFLLERALGNRRIGQFLFWHLRSEVHI----PAVSVQFGVILEAYCRGSVGHM------KVLSKQ 712

  Fly  1225 LMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQPTCLPLGPE 1289
            :.|:...|.|...:       ||..:..:..:.||:|......:...|...||..     ||.|.
Human   713 VEALNKLKTLNSLI-------KLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQS-----PLNPC 765

  Fly  1290 LEVTGVSVRNCSYFNSNTLPLKINF----VGPDAESLPAIFKCGDDLQQDQLTIQLIRIMNKMWL 1350
            :.::.:.|..|.|.:|...||.:.:    .|.|  |:..|||.||||:||.||:|::|:|:.:|.
Human   766 VILSELYVEKCKYMDSKMKPLWLVYNNKVFGED--SVGVIFKNGDDLRQDMLTLQMLRLMDLLWK 828

  Fly  1351 AERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQV---ECGLTGSFKDRPIAEWLGKQNPSPL 1412
            ...|||:|:.:.|:.||.:||:||:||.:||:..||:   ......:|....:..||.:.| |..
Human   829 EAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYN-SGD 892

  Fly  1413 EYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTP 1477
            :...|:..||||||||.||:|||||.|||:||||:|.:|.|||||||..||:.:.....||:|.|
Human   893 DLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVP 957

  Fly  1478 FVLTSDMAYVINGGDKPSTD-FHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNS-NAVQ 1540
            |:||.|..:||..|...:|: |..|...|..|:.|:|::.:|.:...|.|.|||:|.:.| ..:|
Human   958 FILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQ 1022

  Fly  1541 YVRRALLPSQSNPEAAATFAKMIQSSLK-SWFTQFNFFLHNL 1581
            |::.:|...:|..||...|.:....:|: ||.|:.|:..|.:
Human  1023 YLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTV 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540	14/90 (16%)
		C2A_PI3K_class_II	844..1021	CDD:175979	47/200 (24%)
		PI3Ka_II	1038..1202	CDD:238441	57/180 (32%)
		PI3Kc_II	1235..1583	CDD:270710	130/357 (36%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
PIK3CB	NP_006210.1	PI3K_p85B	41..118	CDD:197539	3/5 (60%)
		PI3K_rbd	180..288	CDD:197540	27/145 (19%)
		C2_PI3K_class_I_beta_delta	324..501	CDD:176075	48/194 (25%)
		Nuclear localization signal	410..418		1/7 (14%)
		PI3Ka_I	532..702	CDD:238444	55/175 (31%)
		PI3Kc_IA_beta	706..1067	CDD:270717	134/380 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146188
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850