DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K68D and PIK3CA

DIOPT Version :9

Sequence 1:NP_001163420.1 Gene:Pi3K68D / 39329 FlyBaseID:FBgn0015278 Length:1876 Species:Drosophila melanogaster
Sequence 2:NP_006209.2 Gene:PIK3CA / 5290 HGNCID:8975 Length:1068 Species:Homo sapiens


Alignment Length:1219 Identity:306/1219 - (25%)
Similarity:519/1219 - (42%) Gaps:246/1219 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   455 PPPP----------LPPR-NQQCYESNQAAMPVSRPPQSSVLTDSYTSSIPANVVLDRRKTCTRL 508
            ||.|          :||| ..:|...|...:.:....:::::|      |...:..:.||  ..|
Human     2 PPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLIT------IKHELFKEARK--YPL 58

  Fly   509 YELISDQR-------TDDPELLEFYHMVK---EVRARYPHDDAPTNVGHVVAAEFNYHYMMDTSI 563
            ::|:.|:.       |.:.|..||:...:   ::|...|.                        :
Human    59 HQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPF------------------------L 99

  Fly   564 KVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDIDSVVAQVVAQALASLEGQVKGTVTDYA 628
            ||| .|..|. :..:|...:|    ...||||   |:.|.|....|.        ..:..:.:..
Human   100 KVI-EPVGNR-EEKILNREIG----FAIGMPV---CEFDMVKDPEVQ--------DFRRNILNVC 147

  Fly   629 VKPIGLLEWLAPTSRLSQL--ECVHNSFQLEKDVHLGLCLSTAANMQAIARTERDDEHDADLLPE 691
            .:.:.|.:..:|.||...:  ..|.:|.:|.|.::..|.......:..:..:..:|:....|...
Human   148 KEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKIN 212

  Fly   692 H-LLPNEVV-PIVTYDNMMILIETLEMEIDKLESAADGVPGRSVVSCSGV---------VQAVKA 745
            | .:|.:|: ..:......:|:.:.::::..||     ..|:.::...|.         :...|.
Human   213 HDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLE-----YQGKYILKVCGCDEYFLEKYPLSQYKY 272

  Fly   746 I--CALLGSIDTMEIARCVADLKRICEVEQKKYSTGASNPEIVSDYGDYAQVVLRPRSMLEQIKV 808
            |  |.:||.:..:                                      :::...|:..|:.:
Human   273 IRSCIMLGRMPNL--------------------------------------MLMAKESLYSQLPM 299

  Fly   809 KCNELRDAVQELVELYANVFRVAFSVKTP--DYSTTPIPISCVSKPIVVCISCLHRPLPNWK-FD 870
            .|..:....:.:            |..||  :..|:...:..::..:.:.|.|......|.: .|
Human   300 DCFTMPSYSRRI------------STATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDID 352

  Fly   871 DYSLCVQIVYGTRLLSKPNVLT----CSNDTSGGLFPRLNFSAWLTFDQHPICTLPREARLTFVL 931
            ...:...|.:|...|. .||.|    |||       ||.|  .||.:|.: |..|||.|||...:
Human   353 KIYVRTGIYHGGEPLC-DNVNTQRVPCSN-------PRWN--EWLNYDIY-IPDLPRAARLCLSI 406

  Fly   932 ---YGKQAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLWPPM--TDKMLGP 991
               .|::.|.|..             ..|.|.:|.|||:...::.|...|:|||..  .:.:|.|
Human   407 CSVKGRKGAKEEH-------------CPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNP 458

  Fly   992 APARGCHPQPDFCPVLSIEVPPYGGRIEFPEHQEVPKPAP---------HYDFASL------DAN 1041
            ....|.:|..: .|.|.:|...:...::||:...:.:.|.         .|..|.|      |..
Human   459 IGVTGSNPNKE-TPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNE 522

  Fly  1042 LQEELLDTAEL-------GYTGATERREVF-WEKRLYLQSYPNALPKVLHAAHSWDYAN-LIDLH 1097
            |:|.  |..:|       ..:..||:.:.| |..|.|..:.|..|||:|.:. .|:..: :..::
Human   523 LREN--DKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSV-KWNSRDEVAQMY 584

  Fly  1098 ALLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISK-MPNDQLVDFLPQLVQSLKHDTYEGSAM 1161
            .|:..|.|:.|.|::|||...|||..||..||..:.| :.:|:|..:|.||||.||::.|..:.:
Human   585 CLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLL 649

  Fly  1162 ARFLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALM 1226
            .||||.|.|.:.|..|..:|    .|..:.||.    .|.|.:.              ::|.:..
Human   650 VRFLLKKALTNQRIGHFFFW----HLKSEMHNK----TVSQRFG--------------LLLESYC 692

  Fly  1227 AICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQK-SLAAGMDEVHQ-DLLE--QPTCLPLG 1287
            ..|| ..|:....|....:||..:.:.:|:.|:...|| .:...::::.: |.::  |....||.
Human   693 RACG-MYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLN 756

  Fly  1288 PELEVTGVSVRNCSYFNSNTLPLKINFVGPDA------ESLPAIFKCGDDLQQDQLTIQLIRIMN 1346
            |..::..:.:..|...:|...||.:|:..||.      ::...|||.||||:||.||:|:||||.
Human   757 PAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIME 821

  Fly  1347 KMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVECGLTGS--FKDRPIAEWLGKQNP 1409
            .:|..:.|||:|:.:.|:..|...|:||:|..:.|:.:||.:.||.|:  |....:.:||..:|.
Human   822 NIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNK 886

  Fly  1410 SPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRD 1474
            ..: |.:|:..||.|||||.|||::|||.||||.|||:|..|.|||||||.||...:....:||:
Human   887 GEI-YDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRE 950

  Fly  1475 RTPFVLTSDMAYVINGGDKPST---DFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNS 1536
            |.|||||.|...||:.|.:..|   :|..|.::|.:|:..:|::|:|.::..:.|..:|||.:.|
Human   951 RVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQS 1015

  Fly  1537 -NAVQYVRRALLPSQSNPEAAATFAKMIQSSLK-SWFTQFNFFLHNLAQ 1583
             :.:.|:|:.|...::..||...|.|.:..:.. .|.|:.::..|.:.|
Human  1016 FDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQ 1064

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K68DNP_001163420.1 EIN3 <58..392 CDD:296674
PI3K_rbd 561..669 CDD:197540 24/109 (22%)
C2A_PI3K_class_II 844..1021 CDD:175979 47/186 (25%)
PI3Ka_II 1038..1202 CDD:238441 57/179 (32%)
PI3Kc_II 1235..1583 CDD:270710 124/364 (34%)
PX_PI3K_C2_68D 1611..1721 CDD:132794
C2B_PI3K_class_II 1751..1871 CDD:176027
PIK3CANP_006209.2 PI3K_p85B 32..107 CDD:396665 17/107 (16%)
PI3K_rbd 173..292 CDD:197540 19/161 (12%)
C2_PI3K_class_I_alpha 325..484 CDD:176043 47/183 (26%)
PI3Ka_I 525..696 CDD:238444 56/195 (29%)
PI3Kc_IA_alpha 695..1064 CDD:270719 127/370 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146181
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D204282at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.750

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