DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K68D and PIK3C3

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_002638.2	Gene:	PIK3C3 / 5289	HGNCID:	8974	Length:	887	Species:	Homo sapiens

Alignment Length:	890	Identity:	203/890 - (22%)
Similarity:	338/890 - (37%)	Gaps:	238/890 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   870 DDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLF-PRLNFSAWLTFD-QHPICTLPREARLTFVLY 932
            |.|..|.....|     ||..|...  ||...| .|.|::.||... ::|  .|||.|::...::
Human    56 DLYVTCQVFAEG-----KPLALPVR--TSYKAFSTRWNWNEWLKLPVKYP--DLPRNAQVALTIW 111

  Fly   933 GKQAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLWPPM------------- 984
            ......:..|              :|..::.||....:...|.:.|.:||.:
Human   112 DVYGPGKAVP--------------VGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGR 162

  Fly   985 ------TDKMLGPAPARGCHPQPDFCPV--------------------------LSIEV------ 1011
                  .|:|...|.....|.|.....|                          |.:|.
Human   163 TSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCD 227

  Fly  1012 -PPYG-------GRIEFP-----EHQEVPKP---------APHYDFA-SL-----------DANL 1042
             ..||       |....|     |..:||.|         :.|:..| ||           :|..
Human   228 DKEYGIVYYEKDGDESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAAT 292

  Fly  1043 QEEL------LDTAELGYTGATERREVFWEKRLYLQSYPNALPKVLHAAHSWDYANLIDLHA--- 1098
            :::|      ..|.:|.|    |.:::.|:.|.||.:...||.|.|... :||    :...|
Human   293 RDQLNIIVSYPPTKQLTY----EEQDLVWKFRYYLTNQEKALTKFLKCV-NWD----LPQEAKQA 348

  Fly  1099 --LLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYE---- 1157
              ||..|.|:....|||||...|.:..||..||..:.:..::.|:.:|.||||:||::.::
Human   349 LELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKN 413

  Fly  1158 ----------------------GSA------------------------------------MARF 1164
                                  .||                                    :..|
Human   414 GLEPTKKDSQSSVSENVSNSGINSAEIDSSQIITSPLPSVSSPPPASKTKEVPDGENLEQDLCTF 478

  Fly  1165 LLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYR-------RNKMML 1222
            |:|:..::...|:::||.::....|.     .....|.:..|..:..:|.:.       ::..::
Human   479 LISRACKNSTLANYLYWYVIVECEDQ-----DTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVM 538

  Fly  1223 RALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVH-QDLLEQPTCLPL 1286
            |:|:| ..:..:.|.::..:..|:     ||....|::.|.::|....:::: .|:...|  |||
Human   539 RSLLA-AQQTFVDRLVHLMKAVQR-----ESGNRKKKNERLQALLGDNEKMNLSDVELIP--LPL 595

  Fly  1287 GPELEVTGVSVRNCSYFNSNTLPLKINFVGPDAESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLA 1351
            .|::::.|:.....:.|.|..:|.::.|...|....|.|||.||||:||||.:|:|.:|:|:...
Human   596 EPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRK 660

  Fly  1352 ERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVECGLTGSFKDRPIAEWLGKQNPSPLEYQS 1416
            |.||||:..:..:.|..|.|.::.:........:..|..:...|:....:|    ..|:.:..:
Human   661 ENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSE----NGPNGISAE- 720

  Fly  1417 AVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRD----RTP 1477
            .:..:..|||||.|.||:||:.|||.||::|..:|.|||||||..||         ||    ..|
Human   721 VMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILG---------RDPKPLPPP 776

  Fly  1478 FVLTSDMAYVING-GDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGV---NSNA 1538
            ..|..:|   :.| |...|..:..|...|..||..:|:.::|:|:..:.|..|.:|.:   ....
Human   777 MKLNKEM---VEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKT 838

  Fly  1539 VQYVRRALLPSQSNPEAAATFAKMIQSSLKSWFTQFNFFLHNLAQ 1583
            |:.|:.......|:.||......:|..|:.:.|......:|..||
Human   839 VKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQ 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540
		C2A_PI3K_class_II	844..1021	CDD:175979	38/211 (18%)
		PI3Ka_II	1038..1202	CDD:238441	49/247 (20%)
		PI3Kc_II	1235..1583	CDD:270710	100/356 (28%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
PIK3C3	NP_002638.2	C2_PI3K_class_III	26..186	CDD:176042	32/152 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..170		0/20 (0%)
		PI3Ka_III	283..503	CDD:238442	47/228 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..467		0/19 (0%)
		PI3Kc_III	539..883	CDD:270628	103/368 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820