DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K68D and PIK3C2G

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	XP_016874959.1	Gene:	PIK3C2G / 5288	HGNCID:	8973	Length:	1492	Species:	Homo sapiens

Alignment Length:	1644	Identity:	426/1644 - (25%)
Similarity:	718/1644 - (43%)	Gaps:	324/1644 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 NNGHSSVPRRGNDLIDLNHEDYSRVSVLEAFDPLLNDNTGN----DTASDSTSYYAEYDP-FDFL 383
            |..|||                |:||:  .||.::::.:|.    ::..|..:::....| :|..
Human    28 NQPHSS----------------SQVSL--GFDQIVDEISGKIPHYESEIDENTFFVPTAPKWDST 74

  Fly   384 -YSGDAATQYSDPMYEAVNR---WDKTVATVSPNVGL--------------IGWRQDFLSQPSTS 430
             :|.:.|.|.|...:.:.:|   |.:  .:.:|.:|.              ..|...........
Human    75 GHSLNEAHQISLNEFTSKSRELSWHQ--VSKAPAIGFSPSVLPKPQNTNKECSWGSPIGKHHGAD 137

  Fly   431 SSQYGVAPP----------EESLKLAENGSGTISPPPPLPPRNQQCYESNQAAMPVSRPPQSSVL 485
            .|::.:..|          |:.|: .||.:..|.....:||.|.. :.|:  .||.....:|
Human   138 DSRFSILAPSFTSLDKINLEKELE-NENHNYHIGFESSIPPTNSS-FSSD--FMPKEENKRS--- 195

  Fly   486 TDSYTSSIPANVVLDRRKTCTRLYE---------------LISDQRTDDPELLEFYHMVKEVRAR 535
              .:.:.:..:::|.:......::|               |:...::.:..|..|.:.||::|.|
Human   196 --GHVNIVEPSLMLLKGSLQPGMWESTWQKNIESIGCSIQLVEVPQSSNTSLASFCNKVKKIRER 258

  Fly   536 YPHDDAPTNVGHVVA------------AEFNYHYMMDTSIKVIVH--PALNTLQSTVLAASMGKE 586
            |...|...|.|.:.:            .:||.|..:|.|.:.: |  |..|.|...::|
Human   259 YHAADVNFNSGKIWSTTTAFPYQLFSKTKFNIHIFIDNSTQPL-HFMPCANYLVKDLIA------ 316

  Fly   587 QVKGYGMPVTFTCDIDSVVAQVVAQALASLEGQVKGTVTDYAVKPIGLLEWLAPTSRLSQLECVH 651
                   .:...|..|.::.:                  |:.:...|..|:|.....|..    |
Human   317 -------EILHFCTNDQLLPK------------------DHILSVCGSEEFLQNDHCLGS----H 352

  Fly   652 NSFQLEKDVHLGLCLSTAANMQAIARTERDDEHD-ADLLPEHLLPNEVVPIVTYDNMMILIETLE 715
            ..||.:|.|   :.|....:.:|..:..|..|.| :......||....:..|:...::.||...:
Human   353 KMFQKDKSV---IQLHLQKSREAPGKLSRKHEEDHSQFYLNQLLEFMHIWKVSRQCLLTLIRKYD 414

  Fly   716 MEIDKLESAADGVPGRSVVSCSGVVQAVKAICALLGSIDTMEIARCVADLKRICEVEQKKYSTGA 780
            ..:..|....:.|        ..:::.||.||::||.::|.:|...|.:|..|.:.:.:.:
Human   415 FHLKYLLKTQENV--------YNIIEEVKKICSVLGCVETKQITDAVNELSLILQRKGENF---- 467

  Fly   781 SNPEIVSDYGDYAQVVLRPRSMLEQIKVKCNELRDAVQELVELYANVFRVAFSVKTPDYSTTPIP 845
                       |.......:.::|::   ..||..::.:|:.:|.|.|...|
Human   468 -----------YQSSETSAKGLIEKV---TTELSTSIYQLINVYCNSFYADF------------- 505

  Fly   846 ISCVSKPIVV--CISCLHRPLPNWKFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFS 908
                 :|:.|  |.|.|:..||:    ..|..|...:..     |.....|       :...:|:
Human   506 -----QPVNVPRCTSYLNPGLPS----HLSFTVYAAHNI-----PETWVHS-------YKAFSFT 549

  Fly   909 AWLTFDQHPIC-------------------------------TLPREARLTFVLYGKQAASEGEP 942
            .|||:....:|                               :||||:.||..|:|...|:.
Human   550 CWLTYAGKKLCQVRNYRNIPDKKLFFFLVNWNETINFPLEIKSLPRESMLTVKLFGIACATN--- 611

  Fly   943 NADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLW----PPMTDKMLGPAPARGCHPQPDF 1003
            ||:.          |.|..:.||. |...|.|..|.|:.    ||:  :|:.|.......|.|
Human   612 NANL----------LAWTCLPLFP-KEKSILGSMLFSMTLQSEPPV--EMITPGVWDVSQPSP-- 661

  Fly  1004 CPVLSIEVPPYGGRIEFPEHQEVPKPAPHYDFASLDANLQEELLDTAELGYTG-----ATERREV 1063
             ..|.|:.|..|        .|..||....:.::|:..|:|.:...|.|....     :.|::..
Human   662 -VTLQIDFPATG--------WEYMKPDSEENRSNLEEPLKECIKHIARLSQKQTPLLLSEEKKRY 717

  Fly  1064 FWEKRLYLQSYPNALPKVLHAAHSWDYANLIDLHALLHSWAPLSPLQSLELLLPRYPDAKVREKA 1128
            .|..|.|..:...:||.||.:|..||...:.::|.:|..|....||::|.||...:||.::|:.|
Human   718 LWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWTFSQPLEALGLLTSSFPDQEIRKVA 782

  Fly  1129 VEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESPRFAHHMYWLLVHSLPDDPHN 1193
            |:.:..:.||:|:::||||||::|.:....|.:.:.||.:.|:|.:.||.:||||.::
Human   783 VQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHRSLQSIQVAHRLYWLLKNA------- 840

  Fly  1194 SIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAK 1258
                        |::.....:|::   :|.||....|:.:...|..:.::.:.|..|.|.||.|.
Human   841 ------------ENEAYFKSWYQK---LLAALQFCAGKALNDEFSKEQKLIKILGDIGERVKSAS 890

  Fly  1259 ESMRQKSLAAGMDEVHQDLLEQPTC-LPLGPELEVTGVSVRNCSYFNSNTLPLKINFV--GPDAE 1320
            :..||:.|...:..:.:...:..|| |||.|.|.:.|:....||||.||.|||||.|:  .|..:
Human   891 DHQRQEVLKKEIGRLEEFFQDVNTCHLPLNPALCIKGIDHDACSYFTSNALPLKITFINANPMGK 955

  Fly  1321 SLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKI 1385
            ::..|||.||||:||.|.:|||::|:.:||.|.||::|:.:.|:.||...|::::|.:|.||.||
Human   956 NISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLAKI 1020

  Fly  1386 QVECGLTGSFKDRPIAEWLGKQNPSPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTS 1450
            ....||.|..|:..|.:|..:.|....:|:.|:|||..||||:.|.|::||:||||||||||..|
Human  1021 HRHSGLIGPLKENTIKKWFSQHNHLKADYEKALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKS 1085

  Fly  1451 GHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVINGGDKPSTDFHYFVDLCCRAFNIVRKN 1515
            ||:||||||||||.||.||..||||.||:.||:|.|.|..|.|....|..||:|||||:||:||:
Human  1086 GHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDFVELCCRAYNIIRKH 1150

  Fly  1516 ADLLLHTLAHMATAGMPGVNS-NAVQYVRRALLPSQSNPEAAATFAKMIQSSLKSWFTQFNFFLH 1579
            :.|||:.|..|..||:|.::. ..::||...|.|..::.||.:.|.|.|:.||:.:..:.|..:|
Human  1151 SQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQDTDLEATSHFTKKIKESLECFPVKLNNLIH 1215

  Fly  1580 NLAQM-RFTPDEGSGELLSFVPRKYTMQQDGRLKIVKVVCFQKHYSMEKFYMYILEVTRHGQPDP 1643
            .|||| ..:|.:.:.:  :|......:.....::...::.|.|..|    .:|:::|| |...:.
Human  1216 TLAQMSAISPAKSTSQ--TFPQESCLLSTTRSIERATILGFSKKSS----NLYLIQVT-HSNNET 1273

  Fly  1644 THLFRSYREFTEFHQKLCMHFPLVKLHSLPAGVHVGRSNIKSVAEKRLPLIQRFLKSLFDASEEI 1708
            :...:|:.:|::.|.:|...|..:.|...|...|:..:|..   .:|...:..:::.:.:.|.|:
Human  1274 SLTEKSFEQFSKLHSQLQKQFASLTLPEFPHWWHLPFTNSD---HRRFRDLNHYMEQILNVSHEV 1335

  Fly  1709 AHSELVYTFFHPLLRDQQEAKLGMPKIKEVKQQPSRDNPHEIGQ--------IRLSLQYQRGVLT 1765
            .:|:.|.:||      ..||         |:|.....:|..:|:        ::|.:.|:...||
Human  1336 TNSDCVLSFF------LSEA---------VQQTVEESSPVYLGEKFPDKKPKVQLVISYEDVKLT 1385

  Fly  1766 VMIHHAKGLPMLQGGQEPNTYVKCYLKPDPKKETKRKTKVVRKTCVPSFMETLEYRMPLNIIQER 1830
            :::.|.|.: .|..|..|:.:|:.||.|.|.:..:||||.|.|...|::.|.:....|   ..:.
Human  1386 ILVKHMKNI-HLPDGSAPSAHVEFYLLPYPSEVRRRKTKSVPKCTDPTYNEIMGSLSP---TLKC 1446

  Fly  1831 RLQVTVWSHDTLQENELLG 1849
            .|:|...||.....::|.|
Human  1447 SLEVLDASHHPTSASKLAG 1465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674	15/73 (21%)
		PI3K_rbd	561..669	CDD:197540	19/109 (17%)
		C2A_PI3K_class_II	844..1021	CDD:175979	46/213 (22%)
		PI3Ka_II	1038..1202	CDD:238441	50/168 (30%)
		PI3Kc_II	1235..1583	CDD:270710	155/351 (44%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794	23/109 (21%)
		C2B_PI3K_class_II	1751..1871	CDD:176027	30/107 (28%)
PIK3C2G	XP_016874959.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146180
Domainoid	1	1.000	65	1.000	Domainoid score	I10034
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	1	1.000	-	-		FOG0001789
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104124
Panther	1	1.100	-	-	LDO	PTHR10048
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.710