DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pi3K68D and PIK3C2B

DIOPT Version :9

Sequence 1:NP_001163420.1 Gene:Pi3K68D / 39329 FlyBaseID:FBgn0015278 Length:1876 Species:Drosophila melanogaster
Sequence 2:NP_001364263.1 Gene:PIK3C2B / 5287 HGNCID:8972 Length:1634 Species:Homo sapiens


Alignment Length:1949 Identity:623/1949 - (31%)
Similarity:906/1949 - (46%) Gaps:397/1949 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SNQAHIDYDKQFQD------DLAKATALSLEQHALDDYRRNKKYGSGYQQSSTVAGRDYQAAQRS 60
            |.|.:.::.|..:.      :||.|.||.:|..||...|.:|:                      
Human     3 STQGNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHDKE---------------------- 45

  Fly    61 QSLHQPRRHSEVHQVAISPENAERSRTPPA------QGTDNDLICFASPTSKQPESSSPFGKLIE 119
                               ||..:....|:      .|.|    .::.|..::.:.     ||:.
Human    46 -------------------ENRAKQNADPSLISWDEPGVD----FYSKPAGRRTDL-----KLLR 82

  Fly   120 DLQRMQPTNPQSALVPMGPVASASIPPQYGFPPH--QQRP-TAAQPTPYGMVA-----------G 170
            .|....||           :...|:.||.|.|.|  .|.| ..:.|.|.|.::           |
Human    83 GLSGSDPT-----------LNYNSLSPQEGPPNHSTSQGPQPGSDPWPKGSLSGDYLYIFDGSDG 136

  Fly   171 GVVGGPAYGDLQLVPYQPAAQQQRPLNSEELQRLYSMPAQMAVVPVPQPNAYMYYPGAVVTPYTA 235
            ||...|..||::                                            |:.......
Human   137 GVSSSPGPGDIE--------------------------------------------GSCKKLSPP 157

  Fly   236 PIVPGSAAFMPPQYPAQGYGFGGAYTHMDLRRPQSQPAPQQTAPTTSHHHSQPSNHSTSSPAEAN 300
            |:.|.::.:..|..|                       |::.:|::| ..||||:.:|.|..|  
Human   158 PLPPRASIWDTPPLP-----------------------PRKGSPSSS-KISQPSDINTFSLVE-- 196

  Fly   301 GVAFPARRQVPSTVGVSSSSHTGNNGHSSVPRRGNDLIDLNHEDYSRVSVLEAFDPLLNDNTGND 365
                    |:|..:                         |.|.      :||..:.|.....|..
Human   197 --------QLPGKL-------------------------LEHR------ILEEEEVLGGGGQGRL 222

  Fly   366 TASDSTSYYAEYDPFDFLYSGDAATQYS-DPMYEAVNRWDKTVATVSPNVGLIGWRQDFLSQPST 429
            ..|      .:||..:     ||.|:.: ...|:|....|.|          .||::        
Human   223 LGS------VDYDGIN-----DAITRLNLKSTYDAEMLRDAT----------RGWKE-------- 258

  Fly   430 SSSQYGVAPPEESLKLAENGSG-----TISPPPPLPPRNQQCYESNQAAMPVSRPPQSSVLTDSY 489
                 |..|    |..:::.||     :.:.||.:|||.   |.|.......:.|.::..::.:.
Human   259 -----GRGP----LDFSKDTSGKPVARSKTMPPQVPPRT---YASRYGNRKNATPGKNRRISAAP 311

  Fly   490 TSSIPANVVLDRRKTCTRLYELISDQRTDDPELLEFYHMVKEVRARYPHDD-------------A 541
            ..|.|..|....     .|:| :|::|  |.|:..|.||:..:|:.....|             :
Human   312 VGSRPHTVANGH-----ELFE-VSEER--DEEVAAFCHMLDILRSGSDIQDYFLTGYVWSAVTPS 368

  Fly   542 PTNVGHVVAAEFNYHYMMDTSIKVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDIDSVVA 606
            |.::|..|                       .|:.|||...:.:        .:||||:..|.|.
Human   369 PEHLGDEV-----------------------NLKVTVLCDRLQE--------ALTFTCNCSSTVD 402

  Fly   607 QVVAQALASLEGQVKGT-VTDYAVKPIGLLEWLAPTSRLSQLECVHNSFQLEKDVHLGLCLSTAA 670
            .::.|.|......::.. |.|:.:||.||.|:|.....|...|.:....:.:.|:.|.| :....
Human   403 LLIYQTLCYTHDDLRNVDVGDFVLKPCGLEEFLQNKHALGSHEYIQYCRKFDIDIRLQL-MEQKV 466

  Fly   671 NMQAIARTERDDEHDADL-LPEHLLPNEVVPIVTYDNMMILIETLEMEIDKLESAADGVPGRSVV 734
            ....:|||..||:..:.| ...||....|...::...:.:|.:|...|:|....|....|    :
Human   467 VRSDLARTVNDDQSPSTLNYLVHLQERPVKQTISRQALSLLFDTYHNEVDAFLLADGDFP----L 527

  Fly   735 SCSGVVQAVKAICALLGSIDTMEIARCVADLKRICEVEQKKYSTGASNPEIVSDYGDYAQVVLRP 799
            ....|||:|||||..|.:::|.||...:..|.. |....:        |:|..|     ..||..
Human   528 KADRVVQSVKAICNALAAVETPEITSALNQLPP-CPSRMQ--------PKIQKD-----PSVLAV 578

  Fly   800 RSMLEQIKVKCNELRDAVQELVELYANVFRVAFSVKTP-DYSTTPIPISC-VSKPIVVCISCLHR 862
            |...|::   ...|..|:.:|||||.|.|...|....| ......:..:| .::.:...:...||
Human   579 RENREKV---VEALTAAILDLVELYCNTFNADFQTAVPGSRKHDLVQEACHFARSLAFTVYATHR 640

  Fly   863 PLPNW--KFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFSAWL----TFDQHPIC-- 919
            ....|  .::|:.|...:.:|.:.|..|....           |.:||.:|    .:||. ||  
Human   641 IPIIWATSYEDFYLSCSLSHGGKELCSPLQTR-----------RAHFSKYLFHLIVWDQQ-ICFP 693

  Fly   920 ----TLPREARLTFVLYGKQAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSL 980
                .||||..|...||.......|  ::.:..::|:|...|||.:..||:|::|:.||..||.|
Human   694 VQVNRLPRETLLCATLYALPIPPPG--SSSEANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGL 756

  Fly   981 WPPMTDKMLGPAPARGCHPQPDFCPVLSIEVPPYGGRIEFPEHQEVP---KPAPHYDFASLDANL 1042
            ||...:.......|...| ||| ..:|.|:.|.....|:|..    |   |.:|.|:|.||....
Human   757 WPATQENPSARWSAPNFH-QPD-SVILQIDFPTSAFDIKFTS----PPGDKFSPRYEFGSLREED 815

  Fly  1043 QEELLDTAE----LGYTGATERREVFWEKRLYLQSYPNALPKVLHAAHSWDYANLIDLHALLHSW 1103
            |.:|.|..:    ...|.|.::|  .||||.|..|..::||.||.:|.||::|.|.|::.||..|
Human   816 QRKLKDIMQKESLYWLTDADKKR--LWEKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQW 878

  Fly  1104 APLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSK 1168
            ..::...:|.||...:||.:||..||:||..:.:.:|:|:||||||:||::.|..|.:.||||.:
Human   879 THMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKR 943

  Fly  1169 CLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAICGEKM 1233
            .:...|..|:.:|||...|.|                 ||.: :||    :.:|.||:..||:.:
Human   944 AVSDLRVTHYFFWLLKDGLKD-----------------SQFS-IRY----QYLLAALLCCCGKGL 986

  Fly  1234 LQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQPTC-LPLGPELEVTGVSV 1297
            .:.|..|..:...|..:|:.|:||..|.||..|..|::||.|......:| |||.|.|.|.|:..
Human   987 REEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGLEEVKQFFALNGSCRLPLSPSLLVKGIVP 1051

  Fly  1298 RNCSYFNSNTLPLKINF--VGPDAESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVT 1360
            |:|||||||.:|||::|  |.|..|::..||||||||:||.||:|:||||:|:|:.|.||::||.
Human  1052 RDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVI 1116

  Fly  1361 FNCVPTGYKSGMIELVSEAETLRKIQVECGLTGSFKDRPIAEWLGKQNPSPLEYQSAVRNFTLSC 1425
            |.|..||...||:|::..||||||||||.|:||||||||:|:||.|.||...||:.||.||..||
Human  1117 FRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSC 1181

  Fly  1426 AGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVING 1490
            ||..||||||||||||||||||||:||:||||||:|||.||||||.||||.|||.||||||||||
Human  1182 AGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVING 1246

  Fly  1491 GDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNS-NAVQYVRRALLPSQSNPE 1554
            |||||:.||.||||||:|:|::||:..|.|:.|..|.:.|:|.::. ..::||..||.|..:...
Human  1247 GDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEAN 1311

  Fly  1555 AAATFAKMIQSSLKSWFTQFNFFLHNLAQMRFTPDEGSGE--LLSFVPRKYTMQQDGRLKIVKVV 1617
            |...|.::|:|||.|..|:.|||:||||||:||   ||.:  .|||..|.:|::..||:..|.:.
Human  1312 ATTYFTRLIESSLGSVATKLNFFIHNLAQMKFT---GSDDRLTLSFASRTHTLKSSGRISDVFLC 1373

  Fly  1618 CFQKHYSMEKFYMYILEVTRHGQPDPTHLFRSYREFTEFHQKLCMHFPLVKLHSLPAGVHVGRSN 1682
            ..:|.:...|.|:|:::|.|....:.|::.|::.||.|.|.||.:.||...|.|.|:...:|||.
Human  1374 RHEKIFHPNKGYIYVVKVMRENTHEATYIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGRSR 1438

  Fly  1683 IKSVAEKRLPLIQRFLKSLFDASEEIAHSELVYTFFHPLLRDQQEAKLG-MPKIKEVKQQPSRDN 1746
            .::|||:|...:..::..|..|..|:|..:|||||||||.||  |..:| .|..|......:|..
Human  1439 GEAVAERRREELNGYIWHLIHAPPEVAECDLVYTFFHPLPRD--EKAMGTSPAPKSSDGTWARPV 1501

  Fly  1747 PHEIGQIRLSLQYQRGVLTVMIHHAKGLPMLQGGQEPNTYVKCYLKPDPKKETKRKTKVVRKTCV 1811
            ....|:::||:.|:...|.:|:.|.:||.:||.|.:|:.|||.||.|||:|.|||||||.||||.
Human  1502 GKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCN 1566

  Fly  1812 PSFMETLEY-RMPLNIIQERRLQVTVWSHDTLQENELLGGFDMDLSKYDLRQELVDWYRLGAVS 1874
            |::.|.|.| .:|...:|:|.||::|.|.....||.|||..::.|.:.||.||...|:.||:.|
Human  1567 PTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEKTGWFALGSRS 1630

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K68DNP_001163420.1 EIN3 <58..392 CDD:296674 57/353 (16%)
PI3K_rbd 561..669 CDD:197540 25/108 (23%)
C2A_PI3K_class_II 844..1021 CDD:175979 50/189 (26%)
PI3Ka_II 1038..1202 CDD:238441 60/167 (36%)
PI3Kc_II 1235..1583 CDD:270710 200/351 (57%)
PX_PI3K_C2_68D 1611..1721 CDD:132794 38/109 (35%)
C2B_PI3K_class_II 1751..1871 CDD:176027 55/120 (46%)
PIK3C2BNP_001364263.1 Interaction with GRB2. /evidence=ECO:0000269|PubMed:11533253 2..298 88/505 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 45..188 39/271 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 259..315 13/62 (21%)
PI3K_rbd 364..466 CDD:395642 28/133 (21%)
C2A_PI3K_class_II 622..794 CDD:175979 50/187 (27%)
PI3Ka_II 813..981 CDD:238441 66/191 (35%)
PI3Kc_C2_beta 987..1340 CDD:119421 200/352 (57%)
PX_PI3K_C2_beta 1369..1477 CDD:132823 38/107 (36%)
C2B_PI3K_class_II 1505..1627 CDD:176027 55/121 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146187
Domainoid 1 1.000 309 1.000 Domainoid score I1334
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 814 1.000 Inparanoid score I483
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49277
OrthoDB 1 1.010 - - D204282at2759
OrthoFinder 1 1.000 - - FOG0001789
OrthoInspector 1 1.000 - - otm40324
orthoMCL 1 0.900 - - OOG6_104124
Panther 1 1.100 - - O PTHR10048
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3211
SonicParanoid 1 1.000 - - X2272
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.800

Return to query results.
Submit another query.