DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K68D and PIK3C2A

DIOPT Version :9

Sequence 1:NP_001163420.1 Gene:Pi3K68D / 39329 FlyBaseID:FBgn0015278 Length:1876 Species:Drosophila melanogaster
Sequence 2:NP_001308307.1 Gene:PIK3C2A / 5286 HGNCID:8971 Length:1686 Species:Homo sapiens


Alignment Length:1945 Identity:615/1945 - (31%)
Similarity:937/1945 - (48%) Gaps:371/1945 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 DLAKATALSLEQHALDDYRRNKKYGS---GYQQSSTVAGRDYQAAQRSQSLHQPRRHSEVHQVAI 77
            |:.|..||.:|..||...:::::...   |::.||:.                 |:.::|:    
Human    25 DVDKEEALQMEAEALAKLQKDRQVTDNQRGFELSSST-----------------RKKAQVY---- 68

  Fly    78 SPENAERSRTPPAQGTDNDLICFASPTSKQPESSSPFGKLIEDLQRMQPTNPQSAL--------- 133
               |.:          |.||:.|       |||.|....|..|::::.....:..|         
Human    69 ---NKQ----------DYDLMVF-------PESDSQKRALDIDVEKLTQAELEKLLLDDSFETKK 113

  Fly   134 ---VPMGPVASASIPPQYGFPPHQQRPTAAQPTPYGMVAGGVVGGPAYGDLQLVP--YQPAAQQQ 193
               :|:.|:.|.|...|..|.|..||         |....|:.|...|....:.|  |...|..|
Human   114 TPVLPVTPILSPSFSAQLYFRPTIQR---------GQWPPGLPGPSTYALPSIYPSTYSKQAAFQ 169

  Fly   194 RPLNSEELQRLYSMPAQMAVVPVPQPNAYMYYPGAVVTPY-TAPIVPGSAAFMPPQYPAQGYGFG 257
            ...|           .:|...|..:| .|:..||.  :|| :.|:.|.:     |.:| ||    
Human   170 NGFN-----------PRMPTFPSTEP-IYLSLPGQ--SPYFSYPLTPAT-----PFHP-QG---- 210

  Fly   258 GAYTHMDLRRPQSQPAPQQTAPTTSHHHSQPSNHSTSSPAEANGVAFPARRQVPST------VGV 316
                                                         :.|..|.|.||      ..:
Human   211 ---------------------------------------------SLPIYRPVVSTDMAKLFDKI 230

  Fly   317 SSSSHTGNNGHSSV------PRRGNDLIDLNHEDYSRVSVLEAFDPLLNDNTGNDTASD-----S 370
            :|:|....||.:..      .:..|..:....||.|:...|: .|||......|....|     :
Human   231 ASTSEFLKNGKARTDLEITDSKVSNLQVSPKSEDISKFDWLD-LDPLSKPKVDNVEVLDHEEEKN 294

  Fly   371 TSYYAEYDPFDFLYSGDAATQYSDPMYEAVNRWDKTVATVSPNVGLIGWRQDFLSQPSTSSSQYG 435
            .|.....||:|.:...:.:|. :..:...||....:||||                  |.|....
Human   295 VSSLLAKDPWDAVLLEERSTA-NCHLERKVNGKSLSVATV------------------TRSQSLN 340

  Fly   436 VAPPEESLKLAENGSGTISPPPPLPPRNQQCYESNQAAMPVSRPPQSSVLTDSYTSSIPANVVLD 500
            :    .:.:||: ..|.||...|                             :.|||:|..    
Human   341 I----RTTQLAK-AQGHISQKDP-----------------------------NGTSSLPTG---- 367

  Fly   501 RRKTCTRLYELISDQRTDDPELLEFYHMVKEVRARYPHDDAPTNVGHV---VAAEFNYHYMMDTS 562
                    ..|:.:....:.|:..|...:.:::.::|:.:..||.|::   |.|:.|. ...:.|
Human   368 --------SSLLQEVEVQNEEMAAFCRSITKLKTKFPYTNHRTNPGYLLSPVTAQRNI-CGENAS 423

  Fly   563 IKVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDIDSVVAQVVAQALASLEGQVKGT-VTD 626
            :||.:                   .::|:.:|||||||:.|.|..::.|||..:...:... |..
Human   424 VKVSI-------------------DIEGFQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQVDVGS 469

  Fly   627 YAVKPIGLLEWLAPTSRLSQLECVHNSFQLEKDVHLGLCLSTAANMQAIARTERDDEHDADLLPE 691
            |.:|..|..|.|.....|...|.:.|..:.:.::.|.| |:.:|..|.:|||..|||...| |.:
Human   470 YVLKVCGQEEVLQNNHCLGSHEHIQNCRKWDTEIRLQL-LTFSAMCQNLARTAEDDETPVD-LNK 532

  Fly   692 HLL-------------PNEVVPIVTYDNMMILIETLEMEIDKLESAADGVPGRSVVSCSGVVQAV 743
            ||.             |.|.: :.:|.|.:    .|.::|:....|.|           .|::||
Human   533 HLYQIEKPCKEAMTRHPVEEL-LDSYHNQV----ELALQIENQHRAVD-----------QVIKAV 581

  Fly   744 KAICALLGSIDTMEIARCVADLKRICEVEQKK----------------YSTGASNPEIVSDYGDY 792
            :.||:.|..::|:.|...|..|||...:.:.|                .:.|:.|||        
Human   582 RKICSALDGVETLAITESVKKLKRAVNLPRSKTADVTSLFGGEDTSRSSTRGSLNPE-------- 638

  Fly   793 AQVVLRPRSMLEQIKVKCNELRDAVQELVELYANVFR----VAFSVKTPDYSTTPIPISCVSKPI 853
                       ..::|..|:|..|:.:|:.|:||..|    .|.|.|:...:.|      .::.:
Human   639 -----------NPVQVSINQLTAAIYDLLRLHANSGRSPTDCAQSSKSVKEAWT------TTEQL 686

  Fly   854 VVCISCLHRPLPNW--KFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFSAWLTFDQH 916
            ...|...|....||  .::.|.|...:.:..:.|.|| :.:....|....|..:.:...:.|...
Human   687 QFTIFAAHGISSNWVSNYEKYYLICSLSHNGKDLFKP-IQSKKVGTYKNFFYLIKWDELIIFPIQ 750

  Fly   917 PICTLPREARLTFVLYGKQAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLW 981
             |..||.|:.|...|:|....|.|. :.|.| ::|:....||..|:.||||||.:.||..||.||
Human   751 -ISQLPLESVLHLTLFGILNQSSGS-SPDSN-KQRKGPEALGKVSLPLFDFKRFLTCGTKLLYLW 812

  Fly   982 PPM-TDKMLGPAPARGCHPQPDFCPVLSIEVPPYGGRIEFPEHQEVPKPAPHYDFASLDANLQEE 1045
            ... |:.:.|....:|...:.   .||.::.|.....|.:...|........::..:|:.:::.:
Human   813 TSSHTNSVPGTVTKKGYVMER---IVLQVDFPSPAFDIIYTTPQVDRSIIQQHNLETLENDIKGK 874

  Fly  1046 LLD----TAELGYTGATERREVFWEKRLYLQSYPNALPKVLHAAHSWDYANLIDLHALLHSWAPL 1106
            |||    .:.||.  :.|.:...||||.|...:||.|||:|.:|.:|.:.||...::|||.|..|
Human   875 LLDILHKDSSLGL--SKEDKAFLWEKRYYCFKHPNCLPKILASAPNWKWVNLAKTYSLLHQWPAL 937

  Fly  1107 SPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLE 1171
            .||.:||||..::.|.:||..||.||..:.:|:|.|.|||.||:||::.|..|::.:||||:.|.
Human   938 YPLIALELLDSKFADQEVRSLAVTWIEAISDDELTDLLPQFVQALKYEIYLNSSLVQFLLSRALG 1002

  Fly  1172 SPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAICGEKMLQR 1236
            :.:.||::||||..:|.|                      |::..|.:.:|.||:::.|:::.:.
Human  1003 NIQIAHNLYWLLKDALHD----------------------VQFSTRYEHVLGALLSVGGKRLREE 1045

  Fly  1237 FMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQPTC-LPLGPELEVTGVSVRNC 1300
            .:.|.::.|.|..:||.|::|..|.||..|...|:.| |...::..| |||.|.|....:::::|
Human  1046 LLKQTKLVQLLGGVAEKVRQASGSARQVVLQRSMERV-QSFFQKNKCRLPLKPSLVAKELNIKSC 1109

  Fly  1301 SYFNSNTLPLKINFVGPD--AESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNC 1363
            |:|:||.:|||:..|..|  .|.:..:||.|:||:||.|.:|:|:||:|:||.|.|||:||.|.|
Human  1110 SFFSSNAVPLKVTMVNADPMGEEINVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKC 1174

  Fly  1364 VPTGYKSGMIELVSEAETLRKIQVECGLTGSFKDRPIAEWLGKQNPSPLEYQSAVRNFTLSCAGY 1428
            :.||...||:|||..::||||||||.|:||||||:|:||||.|.|||..||:.|..||..||||.
Human  1175 LSTGRDRGMVELVPASDTLRKIQVEYGVTGSFKDKPLAEWLRKYNPSEEEYEKASENFIYSCAGC 1239

  Fly  1429 SVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVINGGDK 1493
            .||||||||||||||||||:::||:||||||||||.|||||:|||||.|||||||||||||||:|
Human  1240 CVATYVLGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEK 1304

  Fly  1494 PSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNS-NAVQYVRRALLPSQSNPEAAA 1557
            |:..|..||||||:|:|::||..:|.|:.|:.|..:|:|.:.| ..::|||.||.|..::.||..
Human  1305 PTIRFQLFVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATI 1369

  Fly  1558 TFAKMIQSSLKSWFTQFNFFLHNLAQMRFTPDEGSGE-LLSFVPRKYTMQQDGRLKIVKVVCFQK 1621
            .|.::|:|||.|..|:||||:|||||:||:....:.| :|||.|:.|:.:||||:|.|.|..:.|
Human  1370 FFTRLIESSLGSIATKFNFFIHNLAQLRFSGLPSNDEPILSFSPKTYSFRQDGRIKEVSVFTYHK 1434

  Fly  1622 HYSMEKFYMYILEVTRHGQPDPTHLFRSYREFTEFHQKLCMHFPLVKLHSLPAGVHVGRSNIKSV 1686
            .|:.:|.|:|::.:.|.||.:|:.:||::.||.|.|.||.:.|||.||...|..:.:||::||.|
Human  1435 KYNPDKHYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDV 1499

  Fly  1687 AEKRLPLIQRFLKSLFDASEEIAHSELVYTFFHPLLRDQQEAKLGMPKIKEVKQQPSRDNPHEI- 1750
            |.||...:..:|:||.:||.::|..:||.|||||||||::...:.    :..........|.:| 
Human  1500 AAKRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDEKAEGIA----RSADAGSFSPTPGQIG 1560

  Fly  1751 GQIRLSLQYQRGVLTVMIHHAKGLPMLQGGQEPNTYVKCYLKPDPKKETKRKTKVVRKTCVPSFM 1815
            |.::||:.|:.|.|.:|:.|.|.| :.:.|.:||.|||.||.||..|.:|||||:.|||..|:|.
Human  1561 GAVKLSISYRNGTLFIMVMHIKDL-VTEDGADPNPYVKTYLLPDNHKTSKRKTKISRKTRNPTFN 1624

  Fly  1816 ETLEYR-MPLNIIQERRLQVTVWSHDTLQENELLGGFDMDLSKYDLRQELVDWYRLGAVS 1874
            |.|.|. .....:::|.||::|.|.::|:||..|||..:.|..::|.:|.|.||:|.|.:
Human  1625 EMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFNLSKETVKWYQLTAAT 1684

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K68DNP_001163420.1 EIN3 <58..392 CDD:296674 70/365 (19%)
PI3K_rbd 561..669 CDD:197540 28/108 (26%)
C2A_PI3K_class_II 844..1021 CDD:175979 46/179 (26%)
PI3Ka_II 1038..1202 CDD:238441 65/167 (39%)
PI3Kc_II 1235..1583 CDD:270710 191/351 (54%)
PX_PI3K_C2_68D 1611..1721 CDD:132794 46/109 (42%)
C2B_PI3K_class_II 1751..1871 CDD:176027 51/120 (43%)
PIK3C2ANP_001308307.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..61 10/35 (29%)
Interaction with clathrin, sufficient to induce clathrin assembly. /evidence=ECO:0000269|PubMed:16215232 2..142 34/166 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 348..367 8/48 (17%)
PI3K_rbd 409..512 CDD:279173 31/123 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..639 4/39 (10%)
C2A_PI3K_class_II 677..849 CDD:175979 47/184 (26%)
PI3Ka_II 870..1038 CDD:238441 69/191 (36%)
PI3Kc_C2_alpha 1043..1395 CDD:270720 191/352 (54%)
PX_PI3K_C2_alpha 1426..1534 CDD:132822 45/107 (42%)
Interaction with PtdIns(4,5)P2-containing membranes. /evidence=ECO:0000250|UniProtKB:Q61194 1488..1493 0/4 (0%)
C2B_PI3K_class_II 1560..1681 CDD:176027 51/121 (42%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:11606566 1608..1619 7/10 (70%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146186
Domainoid 1 1.000 309 1.000 Domainoid score I1334
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20581
Inparanoid 1 1.050 814 1.000 Inparanoid score I483
Isobase 1 0.950 - 0 Normalized mean entropy S4067
OMA 1 1.010 - - QHG49277
OrthoDB 1 1.010 - - D204282at2759
OrthoFinder 1 1.000 - - FOG0001789
OrthoInspector 1 1.000 - - otm40324
orthoMCL 1 0.900 - - OOG6_104124
Panther 1 1.100 - - O PTHR10048
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2272
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.720

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