Protein Alignment Pi3K68D and Tor

DIOPT Version :9

• Sequence 1: NP_001163420.1
• Gene: Pi3K68D / 39329
• FlyBaseID: FBgn0015278
• Length: 1876
• Species: Drosophila melanogaster
• Sequence 2: NP_001260427.1
• Gene: Tor / 47396
• FlyBaseID: FBgn0021796
• Length: 2471
• Species: Drosophila melanogaster
• Alignment Length: 1034
• Identity: 202/1034 - (19%)
• Similarity: 313/1034 - (30%)
• Gaps: 354/1034 - (34%)

  Fly   748 ALLGSIDTMEIARCVADLKRICEVEQKKYSTGASN--------------------------PEIV 786
            |.||.:..:|.....::|..:.:.|.:.:.|.|.:                          ||..
  Fly  1444 ARLGHMRCLEALGDWSELSNVTKHEWENFGTEAKSRAGPLAAVAAWGLQDWEAMREYVRCIPEDT 1508

  Fly   787 SDYGDYAQVVLRPRSMLEQIKVKCNELRDAVQ-ELVELYANVFRVAFSVKTPDYSTTPIPISCVS 850
            .|...|..|:.......|..:...:|.||.:. ||..:....:..|:..
  Fly  1509 QDGSYYRAVLAVHHDDFETAQRLIDETRDLLDTELTSMAGESYERAYGA---------------- 1557

  Fly   851 KPIVVCISCL---------------HRPLPN--WKFDDYSLCVQIVYGTRLLSKPNVLTCSNDTS 898
               :||:..|               ..||..  ||        ::..|.||:..
  Fly  1558 ---MVCVQMLAELEEVIQYKLIPERREPLKTMWWK--------RLQGGQRLVED----------- 1600

  Fly   899 GGLFPRLNFSAWLTFDQ-HPICTLPREARLTFVLYGKQAASEGEPNADQNGERRQVTTELGWCSI 962
                       |....| |.:...|.|...|::.|.......|                    |:
  Fly  1601 -----------WRRIIQVHSLVVKPHEDIHTWLKYASLCRKSG--------------------SL 1634

  Fly   963 QLFDFKRVMICGPYLLSLWPPMTDKMLGPAPARGCHPQPDFCPVLSIEVPPYGGRIEFPEHQEVP 1027
            .|.....||:.|          ||..|.|.     .|.|...|.::.....|.....  :.||..
  Fly  1635 HLSHKTLVMLLG----------TDPKLNPN-----QPLPCNQPQVTYAYTKYMAANN--QLQEAY 1682

  Fly  1028 KPAPHY--DFASLDANLQEELLDTAELGYTGATERREVFWEKRLYLQSYPNAL------------ 1078
            :...|:  .::...:.|..|.|...:.........|...|:.:|.....|:|:
  Fly  1683 EQLTHFVSTYSQELSCLPPEALKQQDQRLMARCYLRMATWQNKLQDSIRPDAIQGALECFEKATS 1747

  Fly  1079 --PKVLHAAHSWDYANLIDLHALLHSWAPLSP------------LQSLELLLPRYP--------- 1120
              |....|.|.|.|.|...:.|...:.....|            |.|..:::.||.
  Fly  1748 YDPNWYKAWHLWAYMNFKVVQAQKSALDKQQPPGASMGMTMGSGLDSDLMIIQRYAVPAVQGFFR 1812

  Fly  1121 -------------------------DAKVRE------KAVE---WISKMPNDQL---VDFLPQLV 1148
                                     .|:|.|      |.:|   |:..:|  ||   :|...|||
  Fly  1813 SISLIKGNSLQDTLRLLTLWFDYGNHAEVYEALLSGMKLIEINTWLQVIP--QLIARIDTHRQLV 1875

  Fly  1149 QSLKHD--------------------TYEGSAMARFLLSKCLESPRFAHHMYWLLVHSLPDDPHN 1193
            ..|.|.                    :...|...|....|.|:|.|  .|...|:..::......
  Fly  1876 GQLIHQLLMDIGKNHPQALVYPLTVASKSASLARRNAAFKILDSMR--KHSPTLVEQAVMCSEEL 1938

  Fly  1194 SIGAAMVDQEYDESQVTQVRYY---RRNKMMLRAL-----MAICGEKMLQRFMYQHRMCQKLTTI 1250
            ...|.:..:::.|......|.|   |..|.|...|     |...|.:.|:...:.....::||
  Fly  1939 IRVAILWHEQWHEGLEEASRLYFGDRNVKGMFEILEPLHAMLERGPQTLKETSFSQAYGRELT-- 2001

  Fly  1251 AESVKEAKE-SMRQKSLAAGMD---------EVHQDL---------LEQP-------TCLPL--- 1286
                 ||.| |.|.|:.|..||         .|.|.:         ||.|       ||..|
  Fly  2002 -----EAYEWSQRYKTSAVVMDLDRAWDIYYHVFQKISRQLPQLTSLELPYVSPKLMTCKDLELA 2061

  Fly  1287 -----GPELEVTGVSV--RNCSYFNSNTLPLKINFVGPDAESLPAIFKCGDDLQQDQLTIQLIRI 1344
                 .|..|:..:|:  .|.....|...|.|:...|.:.:....:.|..:||:||:..:||..:
  Fly  2062 VPGSYNPGQELIRISIIKTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSL 2126

  Fly  1345 MNKMWLAE----RLDLKMVTFNCVPTGYKSGMIELVSEAETL----------------------- 1382
            :|.:.|.:    |.:|.:..:..:|....||:|..|...:||
  Fly  2127 VNTLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTML 2191

  Fly  1383 ------------RKIQVECGLTGSFKDRPIAEWLGKQNPSPLEYQSAVRNFTLSCAGYSVATYVL 1435
                        :|::|.....|..:...:|:.|..::||...:.....|:|.|.|..|:..|:|
  Fly  2192 NFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYIL 2256

  Fly  1436 GICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDM--AYVING--GDKPS 1495
            |:.|||..|:|| :.||.:.|||||.....|.....|. ::.||.||..:  |..:.|  |....
  Fly  2257 GLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKFP-EKIPFRLTRMLIKAMEVTGIEGTYRR 2320

  Fly  1496 TDFHYFVDLCCRAFNIVRKNADLLLHTLA---------------------HMATAGMPG 1533
            |        |.....::|:|.|.|:..|.                     .:|.||.||
  Fly  2321 T--------CESVMLVLRRNKDSLMAVLEAFVYDPLLNWRLLDVDKKGNDAVAGAGAPG 2371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540
		C2A_PI3K_class_II	844..1021	CDD:175979	31/194 (16%)
		PI3Ka_II	1038..1202	CDD:238441	44/255 (17%)
		PI3Kc_II	1235..1583	CDD:270710	94/400 (24%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
Tor	NP_001260427.1	TEL1	308..2471	CDD:227365	202/1034 (20%)
		HEAT repeat	632..658	CDD:293787
		HEAT repeat	668..698	CDD:293787
		HEAT repeat	706..736	CDD:293787
		HEAT repeat	749..780	CDD:293787
		HEAT repeat	798..823	CDD:293787
		DUF3385	831..999	CDD:288698
		HEAT repeat	841..870	CDD:293787
		HEAT repeat	880..917	CDD:293787
		HEAT repeat	925..954	CDD:293787
		Rapamycin_bind	1937..2034	CDD:285924	24/103 (23%)
		PIKKc_TOR	2075..2353	CDD:270713	68/286 (24%)
		FATC	2440..2471	CDD:280430

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810