DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K68D and Pi3K68D

DIOPT Version :10

Sequence 1:NP_524028.2 Gene:Pi3K68D / 39329 FlyBaseID:FBgn0015278 Length:1876 Species:Drosophila melanogaster
Sequence 2:XP_061511792.1 Gene:Pi3K68D / 4577553 VectorBaseID:AGAMI1_000983 Length:2016 Species:Anopheles gambiae


Alignment Length:2065 Identity:1051/2065 - (50%)
Similarity:1305/2065 - (63%) Gaps:243/2065 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SNQAHIDYDKQFQDDLAKATALSLE-------------------------QHALDDYR----RNK 37
            :|...::::|::..|:.:|.|||||                         ...|::||    |..
Mosquito     3 TNPNDLEFEKKYLADIERAMALSLETLELEKIRARQRQMTPELANDPKAVSQTLEEYRAYLQRRV 67

  Fly    38 KYGSGYQQSSTVAGRDYQAAQRSQSLHQP--------RRHSEVHQVAISPENAERSRTPPAQGTD 94
            ..|:|...::..:|    |.....:|..|        ||||:.....|        :.|||:|.|
Mosquito    68 ACGTGKVAAAPASG----AGTSGSTLEPPPGPGGPAVRRHSDSRNPGI--------QGPPARGKD 120

  Fly    95 N-DLICFAS---PTSKQPESSSPFGKLIEDLQRMQPTNPQSALVPMGPVASASIPPQY--GFPPH 153
            . |||.|::   |...:.|:.:...:|:|.:.|:....|.    |..||.      ||  ||  .
Mosquito   121 EADLISFSAVPKPPDPKEEARNNLKELVEQMHRLNTQAPP----PQPPVG------QYEQGF--K 173

  Fly   154 QQRPTAAQPTPYG--MVAGGVVGGPAYGDL---------QLVPYQPAAQQQRPLNSEELQRLYSM 207
            .||..:.....||  ..|...||.|....|         |||||...|.:.:||..:||.|||:.
Mosquito   174 TQRSLSMSAASYGFHQAAYQPVGVPGQAHLQGPYNAAAMQLVPYSSQAAKPKPLTPDELHRLYNS 238

  Fly   208 PAQMAVVPVPQPNAYMY---YPGAV---------VTPYTAPIVPGSAAFMPPQYP-AQGYGFGGA 259
            |...||.....|.|.:.   |||.|         ..|..|...|...|.:|.|.. |..:|.||.
Mosquito   239 PPMYAVATAGGPAAMVVPPAYPGTVAYGGVPAYGTVPTMANYGPAHQAPLPQQSAGAAPFGVGGT 303

  Fly   260 YTHMDLRRPQS--QPAPQQTAPTTSHHHSQPSNHSTSSPAEAN-----------GV--------- 302
                    |.:  .||.||   ||..:.:..|..||||...||           |.         
Mosquito   304 --------PGTPLYPALQQ---TTGMNGTTGSTTSTSSSTVANPETALVHVPKLGAAGRSYSQPQ 357

  Fly   303 ----------AFPARRQVPSTV-GVSSSSHTGNNGHSSVPR---RGNDLIDLNHEDYSRVSVLEA 353
                      |.|||.:.|:.| ...|....|..|.|...|   :|.|||||..||..|||||||
Mosquito   358 AVLASALRRQASPARGEQPAVVMRPKSDPANGGAGPSQQQRLGAKGTDLIDLGFEDNPRVSVLEA 422

  Fly   354 FDPLLNDN------TGNDTASDSTS-YYAEYDPFDFLYSGDAATQYSDPMYEA-VNR--WDKTVA 408
            |||||..|      :|:|...|:.| ||.:|||||::|||  .||||||:|:| |||  .|||..
Mosquito   423 FDPLLCGNRSSSGSSGDDDKDDTASTYYEDYDPFDYIYSG--GTQYSDPVYDAVVNRSLSDKTGT 485

  Fly   409 TVSPNVGLIGWRQDFLSQPST--SSSQYG-VAPPEESLKLAENGSGTISP-------PPPLPPRN 463
            .:||...|.|........|.|  .|..|| |..|.|    |.:.|.|.||       ||||||||
Mosquito   486 PLSPPASLYGAVGVLPPPPGTPGGSCTYGWVNAPVE----ASSSSSTQSPVGGGDGEPPPLPPRN 546

  Fly   464 QQCYESNQA-----AMPVSRPPQSSVLTDSYTSSIPANVVLDRRKTCTRLYELISDQRTDDPELL 523
            .....:..:     .:|..:..:.|..........||:.| :||.|..:|||.:...::.|.||:
Mosquito   547 STAAAAGYSHTMLRGIPAGQADEQSNYEIMQRKLAPASGV-ERRATPYKLYENVVIAKSYDKELI 610

  Fly   524 EFYHMVKEVRARYPHDDAPTNVGHVVAAEFNYHYMMDTSIKVIVHPALNTLQSTVLAASMGKEQV 588
            .||.|||::||:|.|||..|||||:||||....|:..||||::|||||:..    ......|.|:
Mosquito   611 AFYSMVKQLRAQYRHDDEATNVGHIVAAEIENRYVEGTSIKLLVHPALDCF----AGGEQTKGQI 671

  Fly   589 KGYGMPVTFTCDIDSVVAQVVAQALASLEGQVKGTVTDYAVKPIGLLEWLAPTSRLSQLECVHNS 653
            .|||.|:.|||||.:.|..|:||...:||||::.||:|||:|.||:.|.|...|||:||:|||:|
Mosquito   672 DGYGPPIPFTCDITTTVEHVIAQVYCALEGQIRNTVSDYALKAIGIQEILCVRSRLNQLQCVHDS 736

  Fly   654 FQLEKDVHLGLCLSTAANMQAIARTERDDEHDADLLPEHLLPNEVVPIVTYDNMMILIETLEMEI 718
            .:||.||.||....||..|:.||||.:||..|||:..|||||.|....:.||::|||:||||.||
Mosquito   737 IKLEHDVQLGFVAKTARTMRVIARTAQDDGRDADMRLEHLLPKETSHAIGYDDLMILLETLEAEI 801

  Fly   719 DKLESAA-DGVPGRSVVSCSGVVQAVKAICALLGSIDTMEIARCVADLKRICEVEQ--------- 773
            |||:|:| ||..||::::||||:|||||||.|||.:||:|||:.:.||:..|:..|         
Mosquito   802 DKLQSSADDGPSGRTILTCSGVIQAVKAICNLLGPLDTLEIAKSIEDLRACCDQGQTVYSYRDSV 866

  Fly   774 ---KKYSTGASNPEIVSDYGDYAQVVLRPRSMLEQIKVKCNELRDAVQELVELYANVFRVAFSVK 835
               :.||.|:.  .|||:.||||:|.||||::.|||:.:|||:|.|:|.|:|:||..|||.|||.
Mosquito   867 ASDEAYSNGSL--AIVSESGDYAEVKLRPRTVAEQIRYRCNEVRHAIQSLLEIYAQAFRVNFSVN 929

  Fly   836 TPDYSTTPIPISCVSKPIVVCISCLHRPLPNWKFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGG 900
            .|:|:..||.|..:|:.::|.:||||||..:|:.|:|:|.|||.:|.|.:|:|.|:.|||:.| |
Mosquito   930 VPEYNANPISICNISQAVMVNVSCLHRPPLHWRHDEYNLGVQIYHGARYISEPYVVQCSNELS-G 993

  Fly   901 LFPRLNFSAWLTFDQHPICTLPREARLTFVLYG---------------------KQAASEG-EPN 943
            ::|||.|::|:.| ::|:|||||||||..||||                     ...||.| .|.
Mosquito   994 IYPRLTFNSWIMF-RNPVCTLPREARLVVVLYGCVREPVDGGGTSDGGGASGGASGGASGGAAPG 1057

  Fly   944 ADQNG--ERRQVTTELGWCSIQLFDFKRVMICGPYLLSLWPPMTDKMLGPAPARGCHPQPDFCPV 1006
            .:..|  |.|....||||.|:|.|||:|.|:.|.|||.:|||.|||..||||::|.:|.....|:
Mosquito  1058 VNDPGGSEGRMTKVELGWSSLQFFDFERKMVQGSYLLPMWPPTTDKFFGPAPSKGTYPIGGSFPI 1122

  Fly  1007 LSIEVPPYGGRIEFPEHQEVPKPAPHYDFASLDANLQEELLDTAELGYT-GATERREVFWEKRLY 1070
            ||||:|.|||.:.|||......|....||||||.|||:||:||||.||: ...|:|||.||||.|
Mosquito  1123 LSIEIPSYGGAVVFPEPIRNLPPVVQLDFASLDRNLQQELIDTAEQGYSPDKLEKREVLWEKRHY 1187

  Fly  1071 LQSYPNALPKVLHAAHSWDYANLIDLHALLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISKM 1135
            |..:|:||||:||||||||||.|.|||||:.||..|||:|:||||||||||.:||.:|||||:.|
Mosquito  1188 LHRFPHALPKILHAAHSWDYACLSDLHALIKSWTALSPVQALELLLPRYPDLEVRRQAVEWIAAM 1252

  Fly  1136 PNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESPRFAHHMYWLLVHSLPDD-PHNSIGAAM 1199
            |||:.||:||||:|:|||||||||.:|..||.|.|||||.|||:||||:||||.: |.|.|.|. 
Mosquito  1253 PNDEFVDYLPQLLQALKHDTYEGSPLAMLLLRKSLESPRIAHHLYWLLLHSLPGEAPQNMIDAQ- 1316

  Fly  1200 VDQEYDESQVTQVRYYRRNKMMLRALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQK 1264
             :...|...:.|.||:|||::|||||:||||||:..||:.|:.||::|..:|:|||.||:|.|.:
Mosquito  1317 -ETACDAVLMNQARYHRRNQLMLRALLAICGEKLTGRFLSQNMMCKRLGEVAQSVKLAKDSHRLQ 1380

  Fly  1265 SLAAGMDEVHQDLLEQPTCLPLGPELEVTGVSVRNCSYFNSNTLPLKINFVGPDAESLPAIFKCG 1329
            .|..|::.|:|.|::.||.|||.|..|||||.||:|:|||||||||||||.|||...:|||||.|
Mosquito  1381 VLKQGLESVNQLLIDGPTVLPLEPGAEVTGVIVRSCNYFNSNTLPLKINFAGPDRVVVPAIFKAG 1445

  Fly  1330 DDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVECGLTGS 1394
            ||||||.||||::|||:||||.|.|||||||||||||.||.||||||||:|||||||||.|:|||
Mosquito  1446 DDLQQDALTIQMVRIMDKMWLREGLDLKMVTFNCVPTAYKKGMIELVSESETLRKIQVEWGVTGS 1510

  Fly  1395 FKDRPIAEWLGKQNPSPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFG 1459
            |||:.|||||.|||||.||||.||.|||.||||||||||:|||||||||||||||||||||||||
Mosquito  1511 FKDKSIAEWLAKQNPSQLEYQRAVENFTRSCAGYSVATYILGICDRHNDNIMLKTSGHLFHIDFG 1575

  Fly  1460 KFLGDAQMFGNFKRDRTPFVLTSDMAYVINGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLA 1524
            |||||||||||||||||||||||||||||||||:||..||.||||||.||||||:::|||||..|
Mosquito  1576 KFLGDAQMFGNFKRDRTPFVLTSDMAYVINGGDRPSAKFHQFVDLCCTAFNIVRRHSDLLLHMFA 1640

  Fly  1525 HMATAGMPGVNSNAVQYVRRALLPSQSNPEAAATFAKMIQSSLKSWFTQFNFFLHNLAQMRFTPD 1589
            .|||:|:|||...||.|||.||||.||||||||||||||..|||||||||||||||:|||:|:.:
Mosquito  1641 LMATSGIPGVTVEAVNYVRNALLPGQSNPEAAATFAKMIHISLKSWFTQFNFFLHNIAQMKFSAE 1705

  Fly  1590 EGSGELLSFVPRKYTMQQDGRLKIVKVVCFQKHYSMEKFYMYILEVTRHGQPDPTHLFRSYREFT 1654
            .|.||||||:||.|||.||||||.|.|..:||.|..||:|.|||.|.|..|||..:|||||:||.
Mosquito  1706 SGDGELLSFIPRVYTMAQDGRLKTVYVHGYQKRYDQEKYYTYILRVERQHQPDAAYLFRSYKEFC 1770

  Fly  1655 EFHQKLCMHFPLVKLHSLPAGVHVGRSNIKSVAEKRLPLIQRFLKSLFDASEEIAHSELVYTFFH 1719
            ||||||||||||.||||||:|:||||||:|.|||:|||.|::||.|||::::|||||:|||||||
Mosquito  1771 EFHQKLCMHFPLAKLHSLPSGIHVGRSNVKVVAERRLPEIRQFLISLFNSADEIAHSDLVYTFFH 1835

  Fly  1720 PLLRDQQEAKLGMPKIKEVKQQPSRDNPHEI-GQIRLSLQYQRGVLTVMIHHAKGLPMLQGGQEP 1783
            |||||||||.:...|:|.:........|.:: |:|::|:||.|..|.|||||...||...|||.|
Mosquito  1836 PLLRDQQEADISSAKVKGIPAAMEDGQPPQVGGKIKISMQYHRDTLIVMIHHVVALPNTPGGQPP 1900

  Fly  1784 NTYVKCYLKPDPKKETKRKTKVVRKTCVPSFMET-----------------------LEYRMPLN 1825
            |||||.|||||..|.||||||||||.|.||||||                       ||||:||.
Mosquito  1901 NTYVKVYLKPDSSKATKRKTKVVRKNCNPSFMETVSGTLPVQRYAARVHPQSLFNLQLEYRLPLE 1965

  Fly  1826 IIQERRLQVTVWSHDTLQENELLGGFDMDLSKYDLRQELVDWYRLGAVSR 1875
            .||::.||||:||||:||||..|||.::.|::.|||:|.:.|::||.::|
Mosquito  1966 FIQKKVLQVTIWSHDSLQENAFLGGIELPLAEIDLRRETIQWHQLGYLTR 2015

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K68DNP_524028.2 PHA03247 <56..294 CDD:223021 80/277 (29%)
PI3K_rbd 561..669 CDD:197540 53/107 (50%)
C2A_PI3K_class_II 844..1021 CDD:175979 90/200 (45%)
PI3Ka_II 1038..1202 CDD:238441 111/165 (67%)
PI3Kc_II 1235..1583 CDD:270710 266/347 (77%)
PX_PI3K_C2_68D 1611..1721 CDD:132794 75/109 (69%)
C2B_PI3K_class_II 1751..1871 CDD:176027 75/142 (53%)
Pi3K68DXP_061511792.1 None

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