Protein Alignment Pi3K68D and fwd

DIOPT Version :10

• Sequence 1: NP_524028.2
• Gene: Pi3K68D / 39329
• FlyBaseID: FBgn0015278
• Length: 1876
• Species: Drosophila melanogaster
• Sequence 2: NP_001356971.1
• Gene: fwd / 45374
• FlyBaseID: FBgn0004373
• Length: 1682
• Species: Drosophila melanogaster
• Alignment Length: 1693
• Identity: 328/1693 - (19%)
• Similarity: 551/1693 - (32%)
• Gaps: 461/1693 - (27%)

  Fly    87 TPPAQGTDNDLICF-----ASPTSKQPESSSPFGKLIEDLQRMQPT---NPQSALVPMGPVASAS 143
            |.|..|....:.|.     |:.|.|....|.|...|........|:   .|..:|.|.|  ...|
  Fly   254 TLPIGGQMPTIKCLPGASSAASTPKHSRYSKPRLSLSRVFNHSMPSVHGRPNLSLAPAG--VPGS 316

  Fly   144 IPPQYGFPPHQQRPTAAQPTPYGMVAGGVVGGPAYGDLQLVPYQPAAQ-QQRPLNSEELQRLYSM 207
            :.|......| ||..:......|:               |:|  |.:| ....:|..:..|..|:
  Fly   317 VNPPKRISTH-QRNLSLDFRSMGI---------------LLP--PVSQVTNNHINHTQHHRNRSL 363

  Fly   208 PAQMAVVP---VPQPNAYMYYPGAVVTPYTAPIVPG--------------SAAFMPPQYPAQGYG 255
            .:.:..:|   |..|||      .....:.:|.:.|              ::|..||..|.
  Fly   364 DSALQRIPEVEVSSPNA------ESENTFCSPSILGATMCSKIATTAATVTSALSPPGTPT---- 418

  Fly   256 FGGAYTHMDLRRPQSQPAPQQTA--PTT-----SHHHSQPSNHSTSSPAEA---NGV--AFPARR 308
                            ||...||  ||.     :..|..|.:..:.|.|.|   :.|  :.|..|
  Fly   419 ----------------PALMSTACTPTIGAVKGNVQHPVPKHEQSISLAAACRSSAVVESCPTLR 467

  Fly   309 QVPST-----------VGVSSSSHTGNNGHSS--------VPRRGNDLIDLNHEDYSRVSVLEAF 354
            ..|.:           :||..|| |||...||        ..::..||..|..:|...:...|:.
  Fly   468 MRPKSSESVAANGQEMIGVIVSS-TGNGSSSSNNSCSSAGSTKKREDLTSLGSDDSGIICGSESD 531

  Fly   355 DPLLNDNTGNDTASDSTSYYAEYDPFDFLYSGDAATQYSDPMYEAVNRWDKTVATVSPNVGLIGW 419
            ...||....:..:.||....|:                :|...|.|:..|.|
  Fly   532 QISLNRICHSHESLDSGEMDAD----------------ADAEEECVDLMDTT------------- 567

  Fly   420 RQDFLSQPSTSSSQYGVAPPEESLKLAENGSGTISPPPPLPPRNQQCYESNQAAMPVSRPPQSSV 484
                     :...:|.:..|:.........:.|......|.|..:|..:..|.....:.|.|:.:
  Fly   568 ---------SIDEEYNIMQPDHLCLYPPQAASTELDCRTLRPSRKQKRQQQQVLERKNLPSQNQI 623

  Fly   485 LT-DSYTSSIPANV---VLDRRKTCTRLYELISDQRTDDPELLEFYHMVKEVRARYPHD----DA 541
            .: ||..:.:.|..   |::..:....: ||.:.....||          :|..|..|.    ||
  Fly   624 ESEDSVDAGVDARTRYRVMNMSQAAINV-ELGTASNEIDP----------DVNYRESHQDPIADA 677

  Fly   542 PTNVGHVVAAEFNYHYMMDTSIKVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDIDSVVA 606
            |:               :.|........|..::..|.:|.....|..|  ...|.|.....:...
  Fly   678 PS---------------LSTPSVASTASATPSVTPTPIATPTPTESTK--NDQVLFKNFFGATKN 725

  Fly   607 QVVAQALASLEGQVKGTVTDYAVKP--IGLLEWLAPTSRLSQL--ECVHNSFQLEKDVHLGLCLS 667
            .:...|.:.:|...|........:|  .|.:..:...:..|.:  :.|.:...:.|.......|:
  Fly   726 AIFRTAQSIIENHEKKNAAKQKEQPDHSGTVSLVGSPNGGSSVPQDLVKSPTDISKKKEFFSLLT 790

  Fly   668 TAANMQAIARTERDDEHDADLLPEHLLPNEVVPIVTYDNMMILIE----------TLEMEIDKLE 722
            ::::::|.|....:..  |...|  ..|.|.:...:...:..|.:          ||.:   :|.
  Fly   791 SSSSIKAAAAAAANSA--ASTPP--ATPTEALAANSNSKLQPLSDPSADLKVKERTLNL---RLP 848

  Fly   723 SAADGVPGRSVVSCSGVVQAVKAICALLGSIDTMEIARCVADLKRICEVEQKKYSTGASNPEIVS 787
            ..::|..| ::..||.:....|....:.|.:                     ||        .:|
  Fly   849 GDSEGSEG-ALTKCSSINSIHKLKLPVPGVV---------------------KY--------FIS 883

  Fly   788 DYGDYAQVVLRPRSMLEQIKVKCNELRDAVQELVELYAN-VFRVAFSVKTPDYSTTPIPISCVSK 851
            :....:.|:.:|..              ....|:..:.: ||.:.|:|....||..|..:|.:..
  Fly   884 EKAPVSDVLQKPEK--------------GQSGLLRFFESPVFNIHFAVHYLFYSKEPGVLSFIGN 934

  Fly   852 PIVVCISCLHRPLPNWKFDDY-----SLCVQIVYGTRLLSKPNVLTCSNDTSGG-----LFPRLN 906
            .|.        ..|:.:.|.|     .:.:|:.....:|.....:.|.......     |....|
  Fly   935 KIF--------SFPDQEVDLYIPQLVVMYIQMDELAEVLDPYLTIRCRKSVDFSLKCLWLLEAYN 991

  Fly   907 FSAWLTFDQHPICTLPREARLTFVLYGKQAASEGEPNADQN------------GERRQVTT---- 955
            :......:.|   ...|:::|..:   |:..|:.|....||            ||.|.|..
  Fly   992 YQVDSLGNSH---NSSRKSKLALM---KEIFSKREHKQTQNDLKSAGTGGLHVGEPRSVVALAKK 1050

  Fly   956 ----ELGWCSIQLFDFKRVMICGPYLLSL------WPPMTDKMLGPAPARGC-------HPQPDF 1003
                .....::.|.||:     .|:.||:      .||.|.:.|...||:.|       |...:.
  Fly  1051 THHRSQSDATVLLADFR-----SPHTLSISHRMYQQPPYTTQTLPTTPAKLCLGDLTSGHAFDNG 1110

  Fly  1004 CPVLSIEVPPYGGRIEFPEHQE------VPKPAPHYDFASLDANLQEELLDTAELGYTGATERRE 1062
            |....    ...|::.....|.      .||.:|..:|.....|:.:.
  Fly  1111 CTCFE----TVRGQVNGLLGQRTLCSCGAPKTSPQKEFMKALMNVGKN----------------- 1154

  Fly  1063 VFWEKRLYLQSYPNALPKVLHAAHSWDYANLIDLHALLHSWAPLSPLQSLELLLPRYPDAKVREK 1127
                    |.|:|:...|......|   .|||:.:.....|.||..      .:|.:......||
  Fly  1155 --------LTSWPSKAEKTSALRMS---LNLINKNLPARVWLPLYS------DIPHHVVRITEEK 1202

  Fly  1128 AVEWISK-------------MPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESPRFAHHM 1179
            .....||             :|:......:|:::.||:|...|     ..|...||.|
  Fly  1203 TAVLNSKDKTPYIIYVEVVEIPDIYTSPLIPKMMPSLRHTKSE-----EHLDGSCLNS------- 1255

  Fly  1180 YWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAICGEKMLQRFMYQHRMC 1244
                        |..:..:.........|.|..   ||.|.  ..:...||:      ...|..|
  Fly  1256 ------------HQHLSCSRTSSCSSSQQGTSC---RRKKG--ADVDGGCGD------AGPHNSC 1297

  Fly  1245 QKLTTIA------ESVKEAKE--------SMRQKSLAAGMDEVHQDLLEQPTCLPLGPEL--EVT 1293
            ..:.::.      :.|...:|        :||:.|   ..|.:.|..|:.......||.:  .:.
  Fly  1298 SNVHSLGGLQFQEDDVWSQEEDEITAQYLNMRKVS---ERDTISQISLDSCDSRDQGPPVVFNIG 1359

  Fly  1294 GVSVRNCSYFN-SNTLPLKINFVGPDA---------------ESLP-----------AIFKCGDD 1331
            .|.:|:||..: .||.....:...|.|               ||.|           ||.|||||
  Fly  1360 DVRLRHCSNLSCENTKSFSNDPEDPSAAALKEPWHEKEKLIRESSPYGHLSNWRLLSAIVKCGDD 1424

  Fly  1332 LQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVECGLTGSFK 1396
            |:|:.:..||:::...:|..|::||.:..:..|.....||:||.:....:|.  |::.....|.|
  Fly  1425 LRQELMATQLLQMFKIIWQEEQVDLWVRPYKIVCLSNDSGLIEPILNTVSLH--QIKKNSNKSLK 1487

  Fly  1397 DRPIAEWLGKQNPSPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKF 1461
            :..|.|:   .:||...::.|.:||..|||.|.:.:|:|.:.||||.||:..:.||:.|||||..
  Fly  1488 EYFIDEY---GSPSGESFRRAQKNFVQSCAAYCLISYLLQVKDRHNGNILFHSDGHIIHIDFGFI 1549

  Fly  1462 LGDAQMFGNFKRDRTPFVLTSDMAYVINGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHM 1526
            |..:..  |...:::||.||.:...|:.|  ..|..:..|..|........||:.|.:::.:..|
  Fly  1550 LSISPK--NLGFEQSPFKLTPEFVEVMGG--TSSEHWREFNKLLLVGMMSARKHMDRIINFVEIM 1610

  Fly  1527 -ATAGMPGVN---SNAVQYVRRALLPSQSNPEAAATFAKMIQSSLKSWFTQ----FNFFLHNLAQ 1583
             :.|.:|...   |..||.:|:....:.:..|......:::|.||||..|:    :.::.:.:..
  Fly  1611 RSNAHLPCFKNGCSGTVQNLRKRFHMNLTEQEMERKVEQLVQDSLKSLSTKLYDGYQYYTNGILX 1675

  Fly  1584 MRF 1586
            .||
  Fly  1676 ERF 1678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_524028.2	PHA03247	<56..294	CDD:223021	47/239 (20%)
		PI3K_rbd	561..669	CDD:197540	17/111 (15%)
		C2A_PI3K_class_II	844..1021	CDD:175979	38/219 (17%)
		PI3Ka_II	1038..1202	CDD:238441	28/176 (16%)
		PI3Kc_II	1235..1583	CDD:270710	101/398 (25%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	82/297 (28%)