Protein Alignment Pi3K68D and pik3cg

DIOPT Version :10

• Sequence 1: NP_524028.2
• Gene: Pi3K68D / 39329
• FlyBaseID: FBgn0015278
• Length: 1876
• Species: Drosophila melanogaster
• Sequence 2: XP_021330656.1
• Gene: pik3cg / 406598
• ZFINID: ZDB-GENE-040426-2532
• Length: 1113
• Species: Danio rerio
• Alignment Length: 1045
• Identity: 274/1045 - (26%)
• Similarity: 451/1045 - (43%)
• Gaps: 192/1045 - (18%)

  Fly   647 LECVHNSFQLEKDV---HLGLCLSTAANMQAIAR----------TERDDEHDADL---------- 688
            |:|:.....|.|||   ||.:....|.:.....|          |:..:.||.:|
Zfish   135 LDCIRYWKALRKDVGKIHLVVRQQPAEDSLQYQRFLNHLIGYDVTDVSNVHDDELEFTRRKLLTP 199

  Fly   689 -----------------------LPEHLLPNEVVPIVTYDNMMILIETLEMEIDKLESAADGVPG 730
                                   :||:||..      ..:|.::::...|.....::.:.|..|.
Zfish   200 RKIELSDRDPNLYSMDPWMTTTPMPEYLLSK------ISNNHILMVIHKETTSQTIKVSIDDTPV 258

  Fly   731 RSVVSCSGVVQAVKAICALLGSIDTMEIARCVADLKRICEVEQKKYSTGASNPEIVSDY------ 789
            :.:.|....:...:|:..:...:...:.      :.|:|..|:..|...|     :.|:
Zfish   259 QVLQSFFAKITNKRALLGISEDVSESDF------VLRVCGREEYLYGNNA-----IKDFHWIRQC 312

  Fly   790 ---GDYAQVVLRPRSMLEQIKVK---------CNELRDAVQELV---ELYANVFRVA-------F 832
               |:...:||......||..|:         |..:....::|.   :.:..||.::       |
Zfish   313 LKNGEEIHLVLEHPPNPEQDVVQKEDWSQVDDCTGVAGTHEQLTITEKDHEKVFTISLWDCNRKF 377

  Fly   833 SVKTPDYSTTPIPISCVSKPIVVCISCLHRPLPNWKFDDYSLCVQIVYGTRLLSKPNVLTCSNDT 897
            .||.....   ||:...:..::|.:.                 ..|.:|.:||::..       |
Zfish   378 RVKILGID---IPVLPRNSELIVFVE-----------------ASIFHGQQLLAQER-------T 415

  Fly   898 SGGLF-PRLNFSAWLTFDQHPICTLPREARLTF-VLYGKQAASEGEPNADQNGERRQVTTELGWC 960
            |...| ..:.::.||.|: ..|..||:.|||:. |..||......:....:|..|.     |.:.
Zfish   416 SSKPFTEEVIWNTWLEFN-IKIKDLPKGARLSLQVSCGKAQTQTSKETECKNKSRL-----LYYV 474

  Fly   961 SIQLFDFKRVMICGPYLLSLW--PPMT--------DKMLGPAPARGCHPQPDFCPVLSIEVPPYG 1015
            ::.|.|.:.::..|.::|.:|  |..:        ||:     ....:|..:....::|.:..|.
Zfish   475 NLLLVDHRSLLRQGEFILHMWKMPEKSEDNSSVNADKL-----TSATNPDKNNSMAVAILLDKYC 534

  Fly  1016 GRIEFPEHQEVPKPAPHYDFASLDANLQ---EELLDTAELGYTGATERREVFWEKRLYLQSYPNA 1077
            ..:..|:.::.|..........:..:|:   |:::.|..| :...:|.:|:.|..|......|.|
Zfish   535 YPVALPKSKDSPDIEGERGQREMPNHLRKQFEQIIATDPL-HPLTSEDKELLWHFRQECMRDPKA 598

  Fly  1078 LPKVLHAAHSWDYANLIDL-HALLHS---W--APLSPLQSLELLLPRYPDAKVREKAVEWISKMP 1136
            .||.|.:. .|.....:.: |.||..   |  :.|.....|:||...:.|..||..||..:..:.
Zfish   599 YPKFLSSV-KWGKQEAVAITHYLLERSTIWDRSVLDVGLVLQLLDCHFSDENVRTIAVRKLETLG 662

  Fly  1137 NDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVD 1201
            :|.::.:|.||||::|.:.|..||:|||||.:.|.|.|..|.::|.|
Zfish   663 DDDVLRYLLQLVQAVKFEPYHDSALARFLLKRALRSKRIGHFLFWFL------------------ 709

  Fly  1202 QEYDESQVTQ-VRYYRRNKMMLRALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKS 1265
                .|::.| :.|.:|..::|.|.:..|||:|||.|..|..:.:.|..:|..:|:........|
Zfish   710 ----RSEIAQSMHYQQRYAVILEAYLRGCGEEMLQDFRKQVEITEALQKVAREIKQISAEKYDIS 770

  Fly  1266 LAAGMDEVHQDL-------LEQPTCLPLGPELEVTGVSVRNCSYFNSNTLPLKINFVGPD----- 1318
             |..:.::.|.|       |.....:|..|.|....:.:..|....|...||.:.|...|
Zfish   771 -AQVVFQLRQKLEGLQVLGLPDSFKVPYDPGLRAGALVIEQCKVMASKKKPLWLQFKRADPTTLS 834

  Fly  1319 AESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLR 1383
            ::::..|||.||||:||.|.:|::.||..:|..|.|||.::.:.|:.||.|.||||:|.:|.|:.
Zfish   835 SDTIGIIFKDGDDLRQDMLILQILLIMESIWELESLDLSLLPYGCISTGNKIGMIEIVKDATTIA 899

  Fly  1384 KIQVE-CGLTGSFKDRPIAEWLGKQNPSPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIML 1447
            .||.. .|.||:|||..:::||.::..:..::|.||..|..||.||.||||||||.||||||||:
Zfish   900 NIQQSTVGNTGAFKDEILSQWLREKCVNEDKHQQAVDRFVFSCGGYCVATYVLGIGDRHNDNIMI 964

  Fly  1448 KTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVI-NGGDKPSTDFHYFVDLCCRAFNI 1511
            ..:|:|||||||..||:.:.|....::|.|||||.|..|:: ..|.|.|.:|..|.::|.:|:..
Zfish   965 TETGNLFHIDFGHILGNYKSFLGISKERVPFVLTPDFLYLMGTTGKKSSPNFLQFQNVCLKAYLA 1029

  Fly  1512 VRKNADLLLHTLAHMATAGMPGVNSNA-VQYVRRALLPSQSNPEAAATFAKMIQSSL-KSWFTQF 1574
            :|.:.:||:...:.|...|||.:.|.. ::|:|.||...:|..||...|...|:... |.|..||
Zfish  1030 LRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIREALTVGRSEDEAKQHFLDQIEICRDKGWTVQF 1094

  Fly  1575 NFFLH 1579
            |:|||
Zfish  1095 NWFLH 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_524028.2	PHA03247	<56..294	CDD:223021
		PI3K_rbd	561..669	CDD:197540	8/24 (33%)
		C2A_PI3K_class_II	844..1021	CDD:175979	36/188 (19%)
		PI3Ka_II	1038..1202	CDD:238441	48/172 (28%)
		PI3Kc_II	1235..1583	CDD:270710	134/361 (37%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
pik3cg	XP_021330656.1	PIK3CG_ABD	16..208	CDD:466155	14/72 (19%)
		PI3K_rbd	221..327	CDD:395642	19/122 (16%)
		C2_PI3K_class_I_gamma	366..537	CDD:176044	40/208 (19%)
		PI3Ka_I	559..735	CDD:238444	54/199 (27%)
		PI3Kc_IB_gamma	739..1105	CDD:270627	135/362 (37%)