DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pi3K68D and pik3cd

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_957493.1	Gene:	pik3cd / 394174	ZFINID:	ZDB-GENE-040426-1128	Length:	1039	Species:	Danio rerio

Alignment Length:	869	Identity:	258/869 - (29%)
Similarity:	404/869 - (46%)	Gaps:	136/869 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   806 IKVKCNELRDAVQELVELYANVFRVAFSVKTPDYSTT----------PIPISCVSKPIVVCISCL 860
            :.:|.|.||..        :.|||.....|..|||..          ..|: |..|.|   .:||
Zfish   213 VVLKRNALRKK--------STVFRSVKQEKPEDYSLQVNERWEFIYGKYPL-CQFKYI---FTCL 265

  Fly   861 HRPL-PNWKFDDYSLCVQI----------VYGTRLLSKPNVL------TCS-------------- 894
            |..| |:.....||..|:.          |..:|..|||..|      |||
Zfish   266 HGGLTPHLTMVHYSSIVKYQEEQSGLSNQVSRSRAQSKPPPLPLKRQNTCSLWSIQEPFYIYLLQ 330

  Fly   895 ----NDTSG-------GLFPRLNF---------------SAW---LTFDQHPICTLPREARLTFV 930
                |...|       |||.....               ..|   |.||.: :..|||.:||.|.
Zfish   331 GSRVNADEGMKLVVQAGLFHGSELLCKVVTSNEVSVCFDPVWDQKLVFDIN-VSDLPRMSRLCFA 394

  Fly   931 LYGKQAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLWPPMTD---KMLGPA 992
            |||....::..|...:|   ::....|.|.:..:||:|..:..|.:.||.||.:.|   .:|.|.
Zfish   395 LYGVIEKTKKRPTKKKN---KRADCPLAWVNTMVFDYKDQLKTGEFSLSTWPSVPDDKGDLLNPM 456

  Fly   993 PARGCHPQPDFCPVLSIEVP---PYGGRIEFPEHQEVPKPAPHYD--FASLDANLQ-EELLDTAE 1051
            .....:|..|....|.|..|   |:  .:.:|..:::.:..|:.:  .|:.:.:.: :|::|.
Zfish   457 GTVEKNPNIDSTAGLLIRFPNIRPH--PLYYPPIEKLNELGPNGEKVIATKEEHQKLKEIVDN-- 517

  Fly  1052 LGYTGATE----RREVFWEKRLYLQ-SYPNALPKVLHAAHSWD-YANLIDLHALLHSWAPLSPLQ 1110
               ..:||    .:|..|:.|..|: .||.:|||:| ....|: :.::..:..||..|..|..|.
Zfish   518 ---KNSTEFFEDEKEPLWKLREELRLKYPESLPKLL-LITKWNKHEDVAQMVGLLQKWPELPALH 578

  Fly  1111 SLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESPRF 1175
            :||||...:||..||...:..:.|:|:|:|..:|.||||.||:::|....:..|||.:.|.:.:.
Zfish   579 ALELLDYSFPDPHVRFFTIRCLRKLPDDKLFQYLLQLVQVLKYESYLDCDLTSFLLERALANKKI 643

  Fly  1176 AHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAICGEKMLQRFMYQ 1240
            .|.::|.| .|....|..|:...::.:.|....:..:      |.:::...|:...|.|..|:
Zfish   644 GHFLFWHL-RSEMHVPSVSLRFGLILEAYCRGSIFHI------KSLMKQNEALNKMKALNDFV-- 699

  Fly  1241 HRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQPTCLPLGPELEVTGVSVRNCSYFNS 1305
            ....||.|.| ::.::.|..::|::....:.:|         ..||.|.:.:..:....|.:.:|
Zfish   700 KSASQKATRI-QTTEDMKVCIKQETYMEALSDV---------VSPLSPSIILCELCADKCKFMDS 754

  Fly  1306 NTLPLKINFVGPDAESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKS 1370
            ...||.:.:.. ..:|:..|||.||||:||.||:|:|:||:.:|..|.|||:|..:.|:.||.|:
Zfish   755 KMKPLWLMYKS-KYDSVGIIFKNGDDLRQDMLTLQMIQIMDILWKTEGLDLRMQPYGCLSTGNKT 818

  Fly  1371 GMIELVSEAETLRKIQ---VECGLTGSFKDRPIAEWLGKQNPSPLEYQSAVRNFTLSCAGYSVAT 1432
            |:||:|..::|:..||   .....|.:|....:..||..:||.. :...|:..||||||||.|||
Zfish   819 GLIEVVKNSDTIANIQRNNSNSAATAAFNKDALLNWLKSKNPGD-KLDQAIEEFTLSCAGYCVAT 882

  Fly  1433 YVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVI-NGGDKPST 1496
            |||||.|||:||||::.||.|||||||.|||:.:......|:|.||:||.|..:|| .|....|.
Zfish   883 YVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKSKFGINRERVPFILTYDFVHVIQEGRTNNSE 947

  Fly  1497 DFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNSNA-VQYVRRALLPSQSNPEAAATFA 1560
            .|..|...|.:|:.|:.:|..|.::..|.|..||:|.:||:. :||::.:|...:|..||...|.
Zfish   948 KFERFRVCCEQAYKILCRNGTLFVNLFALMKAAGLPELNSSKDIQYLKDSLALGKSEEEALKNFK 1012

  Fly  1561 KMIQSSLK-SWFTQFNFFLHNLAQ 1583
            .....:|: ||.|:.|:.:|..|:
Zfish  1013 VKFNEALRESWKTKVNWMMHTFAK 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540
		C2A_PI3K_class_II	844..1021	CDD:175979	60/242 (25%)
		PI3Ka_II	1038..1202	CDD:238441	50/170 (29%)
		PI3Kc_II	1235..1583	CDD:270710	128/353 (36%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
pik3cd	NP_957493.1	PI3K_p85B	32..107	CDD:280372
		PI3K_rbd	188..280	CDD:295323	21/78 (27%)
		C2_PI3K_class_I_beta_delta	315..481	CDD:176075	40/169 (24%)
		PI3Ka_I	505..676	CDD:238444	51/177 (29%)
		PI3Kc_IA_delta	676..1038	CDD:270718	133/381 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579760
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750