DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K68D and Pi3K59F

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster

Alignment Length:	923	Identity:	208/923 - (22%)
Similarity:	326/923 - (35%)	Gaps:	313/923 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   904 RLNFSAWLTFDQHPI--CTLPREARLTFVLYGKQAASEGEPNADQNGERRQVTTELGWCSIQLFD 966
            |.:::.|:|.   |:  ..|||.|.|...:.....|.:              ||.:|..||.:|.
  Fly    85 RWSWNEWVTL---PLQFSDLPRSAMLVLTILDCSGAGQ--------------TTVIGGTSISMFG 132

  Fly   967 FKRVMICGPYLLSLW---------PPMTD-----------KMLGPAPAR---GCHPQPDFCPVLS 1008
            ...:...|.|.|.:|         |..|.           :.||....:   |...:.|:...|:
  Fly   133 KDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQMQRLGKLAKKHRNGQVQKVDWLDRLT 197

  Fly  1009 I-EVPPYGGR-----------IEFP---------------------EHQEVPKPAPHYDFASL-D 1039
            . |:.....|           ||||                     :::...||    ...|: |
  Fly   198 FREIEVINEREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGDVKYKLPAKP----KLVSVPD 258

  Fly  1040 ANLQEELL----------------------DTAEL-------------GYTGATERREVFWEKRL 1069
            :.:|.|.|                      .||.:             .|..::|.:::.|:.|.
  Fly   259 SEIQMENLVERKHHRLARSERSGISDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRF 323

  Fly  1070 YLQSYPNALPKVLHAAHSWDYANLIDLHAL--LHSWAPLSPLQSLELLLPRYPDAKVREKAVEWI 1132
            ||.|:..||.|.|... :|...:.: ..||  |.:|||:....:||||.|.:...:||:.||..:
  Fly   324 YLSSHKKALTKFLKCI-NWKLEDEV-TQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRL 386

  Fly  1133 SKMPNDQLVDFLPQLVQSLKHD------------------------------------------- 1154
            ::.|::.|:.:|.||||:||::
  Fly   387 AQAPDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSS 451

  Fly  1155 -------------------------TYEGSA---------------------------------- 1160
                                     ...|||
  Fly   452 GLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSN 516

  Fly  1161 ----------------MARFLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQV 1209
                            :..||:.:...:...|::.||.|          ||....|:....:.:.
  Fly   517 ALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYL----------SIEVEEVESVRKQDER 571

  Fly  1210 TQVRYYRRNKMMLRALMAICGEKMLQRFMY----QHRMCQKLTTIAESV------KEAKESMRQK 1264
            ....|....||.|:.|..  |...|:...|    |.|...:|..:.:.|      :..|....||
  Fly   572 AHDMYAMVLKMFLKVLEN--GNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQK 634

  Fly  1265 SLAAGMDEVHQDLLE------QPTCLPLGPELEVTGVSVRNCSYFNSNTLPLKINFVGPDA-ESL 1322
            .||      .||:.:      :|...||.||:.:|.:.....|.|.|..:|.|:.||...| ...
  Fly   635 LLA------EQDMFKVNFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEY 693

  Fly  1323 PAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQV 1387
            .||||.||||:||||.:|:|.:|:|:...|.||||:..:..:.|..|.|.::.|........:..
  Fly   694 AAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTVAEVLAR 758

  Fly  1388 ECGLTGSFKDRPIAEWLGKQNP---SPLEYQSAVRN-FTLSCAGYSVATYVLGICDRHNDNIMLK 1448
            |..:...|:         |.:|   .|....:.|.: :..|||||.|.||:||:.|||.||::|.
  Fly   759 EGNIHNFFR---------KHHPCDNGPYGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLT 814

  Fly  1449 TSGHLFHIDFGKFLGDAQMFGNFKRD----RTPFVLTSDMAYVINGGDKPSTDFHYFVDLCCRAF 1509
            |:|.|||||||..||         ||    ..|..|:.:|...:.|  ..|...|.|...|..|:
  Fly   815 TNGKLFHIDFGYILG---------RDPKPMPPPMKLSKEMVEAMGG--ISSEHHHEFRKQCYTAY 868

  Fly  1510 NIVRKNADLLLHTLAHMATAGMPGV---NSNAVQYVRRALLPSQSNPEAAATFAKMIQSSLKS-- 1569
            ..:|::|:::|:..:.|..|.:|.:   ...||:.|...|....::.||......::..|:.:
  Fly   869 LHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHLQSLLDVSITAVM 933

  Fly  1570 --------WFTQF 1574
                    .|||:
  Fly   934 PALVEQIHRFTQY 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540
		C2A_PI3K_class_II	844..1021	CDD:175979	31/153 (20%)
		PI3Ka_II	1038..1202	CDD:238441	54/319 (17%)
		PI3Kc_II	1235..1583	CDD:270710	111/378 (29%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	24/117 (21%)
		PI3Ka_III	284..561	CDD:238442	49/288 (17%)
		PI3Kc_III	601..945	CDD:270628	108/369 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447463
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10048
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850