Protein Alignment Pi3K68D and Pik3cd

DIOPT Version :10

• Sequence 1: NP_524028.2
• Gene: Pi3K68D / 39329
• FlyBaseID: FBgn0015278
• Length: 1876
• Species: Drosophila melanogaster
• Sequence 2: XP_038966422.1
• Gene: Pik3cd / 366508
• RGDID: 1310990
• Length: 1048
• Species: Rattus norvegicus
• Alignment Length: 797
• Identity: 241/797 - (30%)
• Similarity: 390/797 - (48%)
• Gaps: 95/797 - (11%)

  Fly   834 VKTPDYSTTPIPISCVSKPIVVCISCLHRPLPNWKFDDYSLCVQIVYGTRL-------------L 885
            |:.|.....|||   ..||..|.:..|.:|          .|::::.|.::             |
  Rat   296 VQKPRVKPPPIP---AKKPSSVSLWSLEQP----------FCIELIEGRKVNADERMKLVVQAGL 347

  Fly   886 SKPNVLTCSNDTSGGLFPRLNFSA---W---LTFDQHPICTLPREARLTFVLY-----GKQAASE 939
            ...|.:.|...:|.    .:|..:   |   |.|| ..||.|||.|||.|.||     .|:|.|.
  Rat   348 FHGNEMLCKTVSSS----EVNVCSEPVWKQRLEFD-ISICDLPRMARLCFALYAVVEKAKKARST 407

  Fly   940 GEPNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLWPPMTD---KMLGPAPARGCHPQP 1001
            .:       :.::....:.|.::.|||:|..:..|...|.:||.:.|   :::.||.....:|..
  Rat   408 KK-------KSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELMNPAGTVRGNPNT 465

  Fly  1002 DFCPVLSI---EVPPYGGRIEFPEHQEVPKPAPHYDFASLDANLQEELLDTAELGYTGA--TERR 1061
            :....|.|   ||.|:  .:.||..:::.:...|.:...:....|.:|.:..|...:|.  ...:
  Rat   466 ESAAALVIYLPEVAPH--PVYFPALEKILELGRHGERGRITEEEQLQLREILERRGSGELYEHEK 528

  Fly  1062 EVFWEKRLYLQS-YPNALPKVLHAAHSW----DYANLIDLHALLHSWAPLSPLQSLELLLPRYPD 1121
            ::.|:.|..:|. :|.||.::| ....|    |.|.|..:..||.||..|..|.:||||...:||
  Rat   529 DLVWKMRHEVQEHFPEALARLL-LVTKWNKHEDVAQLSQMLYLLCSWPELPVLSALELLDFSFPD 592

  Fly  1122 AKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESPRFAHHMYWLLVHS 1186
            ..|...|::.:.|:.:|:|..:|.||||.||:::|....:.:|||.:.|.:.:..|.::|.| .|
  Rat   593 CYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLGRALANRKIGHFLFWHL-RS 656

  Fly  1187 LPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAICGEKMLQRFMYQHRMCQKLTTIA 1251
            ....|..::...::.:.|.......:      |::::...|:...|.|..|:   :...:.||..
  Rat   657 EMHVPSVALRFGLIMEAYCRGSTHHM------KVLMKQGEALSKLKALNDFV---KASSQKTTKP 712

  Fly  1252 ESVKEAKESMRQKSLAAGMDEVHQDLLEQPTCLPLGPELEVTGV-SVRNCSYFNSNTLPLKINFV 1315
            ::.:.....|||::....:..:..         ||.|...:..| ||..|::.:|...||.|.:.
  Rat   713 QTKEMMHMCMRQETYMEALSHLQS---------PLDPSTLLEEVCSVEQCTFMDSKMKPLWIMYS 768

  Fly  1316 GP---DAESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVS 1377
            ..   .|.|:..|||.||||:||.||:|:|::|:.:|..|.|||:|..:.|:|||.::|:||:|.
  Rat   769 SEKAGGAGSVGIIFKNGDDLRQDMLTLQMIQLMDFLWKQEGLDLRMTPYGCLPTGDRTGLIEVVL 833

  Fly  1378 EAETLRKIQV---ECGLTGSFKDRPIAEWLGKQNPSPLEYQSAVRNFTLSCAGYSVATYVLGICD 1439
            .::|:..||:   ....|.:|....:..||..:||.. ....|:..||||||||.||||||||.|
  Rat   834 HSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGE-ALDRAIEEFTLSCAGYCVATYVLGIGD 897

  Fly  1440 RHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVINGGDKPSTD-FHYFVD 1503
            ||:||||::.||.|||||||.|||:.:......|:|.||:||.|..:||..|...::: |..|..
  Rat   898 RHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRG 962

  Fly  1504 LCCRAFNIVRKNADLLLHTLAHMATAGMPGVN-SNAVQYVRRALLPSQSNPEAAATFAKMIQSSL 1567
            .|.||:.|:|::..|.||..|.|..||:|.:: |..:||::.:|...::..||...|......:|
  Rat   963 YCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEAL 1027

  Fly  1568 K-SWFTQFNFFLHNLAQ 1583
            : ||.|:.|:..||:::
  Rat  1028 RESWKTKVNWLAHNVSK 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_524028.2	PHA03247	<56..294	CDD:223021
		PI3K_rbd	561..669	CDD:197540
		C2A_PI3K_class_II	844..1021	CDD:175979	50/206 (24%)
		PI3Ka_II	1038..1202	CDD:238441	49/170 (29%)
		PI3Kc_II	1235..1583	CDD:270710	131/357 (37%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
Pik3cd	XP_038966422.1	PI3K_p85B	34..107	CDD:460483
		PI3K_rbd	182..281	CDD:395642
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	45/188 (24%)
		PI3Ka	504..687	CDD:214537	51/190 (27%)
		PI3Kc_IA_delta	679..1046	CDD:270718	135/385 (35%)