Protein Alignment Pi3K68D and Pik3c2a

DIOPT Version :10

• Sequence 1: NP_524028.2
• Gene: Pi3K68D / 39329
• FlyBaseID: FBgn0015278
• Length: 1876
• Species: Drosophila melanogaster
• Sequence 2: NP_001101970.1
• Gene: Pik3c2a / 361632
• RGDID: 1310389
• Length: 1687
• Species: Rattus norvegicus
• Alignment Length: 1941
• Identity: 609/1941 - (31%)
• Similarity: 932/1941 - (48%)
• Gaps: 328/1941 - (16%)

  Fly     5 AHIDYDKQFQD------------DLAKATALSLEQHALDDYRRNKKYGSGYQQSSTVAGRDYQAA 57
            |.|..:.:|:.            |:.||.||.:|..||...::::        ..|.:.|.::.:
  Rat     2 AQISNNSEFKQCSSSHPEPIRTKDVDKAEALQMEAEALAKLQKDR--------HMTDSPRGFELS 58

  Fly    58 QRSQSLHQPRRHSEVHQVAISPENAERSRTPPAQGTDNDLICFASPTSKQPESSSPFGKLIEDLQ 122
                                   |:.|.||......|.||:.|       |||.|....|..|::
  Rat    59 -----------------------NSTRQRTQGFNKQDYDLMVF-------PESDSQKRALDIDVE 93

  Fly   123 RMQPTNPQSALV------------PMGPVASASIPPQYGFPPHQQRPTAAQPTPYGMVAGGVVGG 175
            ::.....:..|:            |:.||.|.|...|....|..||    ...|.|:.      |
  Rat    94 KLTQAELEKILLDDNFETRKTPASPVTPVLSPSFSAQLYLRPAVQR----SQWPPGLC------G 148

  Fly   176 PAYGDLQLVPYQPAAQQQRPLNSEELQRLYSMPAQMAVVPVPQPNAYMYYPGAVVTPY-TAPIVP 239
            |:...|..: |..|..:|....:....|:.:.|:..::        |:..||.  :|| :.|:.|
  Rat   149 PSTYTLPSI-YPSAYSKQATFQNGFSPRMPTFPSTESI--------YLRLPGQ--SPYFSYPLTP 202

  Fly   240 GSAAFMPPQYPAQGYGFGGAYTHMDLRRPQSQPAPQQTAPTTSHHHSQPSNHSTSSPAE-ANGVA 303
            .:     |.:| ||        .:.:.||...|...:.....:.......|....:..| ||..|
  Rat   203 AT-----PFHP-QG--------SLPVYRPLVSPDMAKLFDKIASTSEFLKNGKARTDLEIANSKA 253

  Fly   304 FPARRQV-PSTVGVSSSSHTGNNGHSSVPRRGNDLIDLN--------------HEDYSRVSVLEA 353
            .....|: |.:..::..                |.:||:              ||:..:..||.|
  Rat   254 SVCNLQISPKSEDINKF----------------DWLDLDPLSKPKIDCVEVLEHEEEKKNPVLLA 302

  Fly   354 FDP----LLNDNTGNDTASDSTSYYAEYDPFDFLYSGDAATQYSDPMYEAVNRWDKTVATVSPNV 414
            .||    ||.:.:       .||.:.|                     ..||....:.|||:.:.
  Rat   303 EDPWDAVLLEERS-------PTSRHLE---------------------RKVNGKSLSGATVTRSQ 339

  Fly   415 GLIGWRQDFLSQPSTSSSQYGVAPPEESLKLAENGSGTISPPPPLPPRNQQCYESNQAAMPVSRP 479
            .||    ...:|.:.:.||.....|        ||:
  Rat   340 SLI----VRTTQVTKAQSQVSQKDP--------NGT----------------------------- 363

  Fly   480 PQSSVLTDSYTSSIPANVVLDRRKTCTRLYELISDQRTDDPELLEFYHMVKEVRARYPHDDAPTN 544
              ||:.|.|                     .|:.:....:.|:..|...:.:::.::|:.|..||
  Rat   364 --SSLATGS---------------------SLLQEFEVQNEEVAAFCQSIMKLKTKFPYTDHCTN 405

  Fly   545 VGHVVAAEFNYHYMM--DTSIKVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDIDSVVAQ 607
            .|::::.......|.  :.|:||.:                   :::|:..|||||||:.|.|..
  Rat   406 PGYLLSPVTVQRNMCGENASVKVSI-------------------EIEGFQQPVTFTCDVSSTVDI 451

  Fly   608 VVAQALASLEGQVKGT-VTDYAVKPIGLLEWLAPTSRLSQLECVHNSFQLEKDVHLGLCLSTAAN 671
            ::.|||..:...:... |..|.:|..|..|.|.....|...|.:.|..:.:.::.|.| |:.:|.
  Rat   452 IIMQALCWVHDDLNQVDVGSYILKVCGQEEVLQNNHCLGSHEHIQNCRKWDTEIKLQL-LTFSAM 515

  Fly   672 MQAIARTERDDEHDADLLPEHL--LPNEVVPIVTYDNMMILIET------LEMEIDKLESAADGV 728
            .|.:|||..|||...| |.::|  :......::|...:..|:::      |.::.:....|.|
  Rat   516 CQNLARTAEDDEAPVD-LNKYLYQIEKPYKEVMTRHPVEELLDSYHYQVELALQTENQHRAID-- 577

  Fly   729 PGRSVVSCSGVVQAVKAICALLGSIDTMEIARCVADLKRICEVEQKKYSTGASNPEIVS-DYGDY 792
                     .|::||:.||:.|..::|..:...|..|||...:.:.|      :.::.| ..||.
  Rat   578 ---------QVIKAVRKICSALDGVETPAVTEAVKKLKRAVNLPRNK------SADVTSLSGGDT 627

  Fly   793 AQVVLRPRSMLEQ-IKVKCNELRDAVQELVELYANVFRVAFSVKTPDYSTTPIPISCVSKPIVVC 856
            ::...|....||. ::|..:.|..|:.:|:.|:.|..:  .|...|..|.........::.:...
  Rat   628 SKNSTRGSLNLENPVQVSMDHLTAAIYDLLRLHTNSCK--SSTVCPQGSRNIKEAWTATEQLQFT 690

  Fly   857 ISCLHRPLPNW--KFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFSAWLTFDQHPIC 919
            :...|....||  .::.|.|...:.:..:.|.|| :.:....|....|..:.:...:.|... |.
  Rat   691 VYAAHGISSNWVSNYEKYYLICSLSHNGKDLFKP-IQSKKVGTYKNFFYLIKWDELIIFPIQ-IS 753

  Fly   920 TLPREARLTFVLYGKQAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLWPPM 984
            .||.|:.|...|:|....|.|. :.|.| ::|:....||..|:.||||||.:.||..||.||
  Rat   754 QLPLESVLHLTLFGVLNQSSGS-SPDSN-KQRKGPEALGKVSLTLFDFKRFLTCGTKLLYLW--- 813

  Fly   985 TDKMLGPAPARGCHPQPDFCP---VLSIEVPPYGGRIEFPEHQEVPKPAPHYDFASLDANLQEEL 1046
            |.......|  |..||..:..   ||.::.|.....|.:...|........|...:|:..::.:|
  Rat   814 TSSHTNSIP--GAIPQKSYVMERIVLQVDFPSPAFDIIYTSPQIDRNIIQQYKLEALENEIKGKL 876

  Fly  1047 LDTA--ELGYTGATERREVFWEKRLYLQSYPNALPKVLHAAHSWDYANLIDLHALLHSWAPLSPL 1109
            ||..  :..:..:.|.:...||||.|...:||.|||:|.:|.:|.:|||...::|||.|.||.||
  Rat   877 LDIVHRDSSFGLSKEDKAFLWEKRYYCLKHPNCLPKILASAPNWKWANLAKTYSLLHQWPPLCPL 941

  Fly  1110 QSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESPR 1174
            .:||||..::.|.:||..||.||..:.:|:|.|.|||.||:||::.|..|::.|||||:.|.:.:
  Rat   942 AALELLDAKFADQEVRSLAVSWIEAISDDELTDLLPQFVQALKYEIYLNSSLVRFLLSRALGNIQ 1006

  Fly  1175 FAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAICGEKMLQRFMY 1239
            .||.:||||..:|.|                      .|:..|.:.:|.||:::.|:.:.:....
  Rat  1007 IAHSLYWLLKDALHD----------------------TRFGSRYEHVLGALLSVGGKGLREELSK 1049

  Fly  1240 QHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQPTCLPLGPELEVTGVSVRNCSYFN 1304
            |.::.|.|..:||.|::|..|.||..|...|:.|....|.....:||.|.|....:::::||:|:
  Rat  1050 QMKLVQLLGGVAEKVRQASGSARQVVLQKSMERVQSFFLRNKCRVPLKPSLVAKELNIKSCSFFS 1114

  Fly  1305 SNTLPLKINFVGPD--AESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTG 1367
            ||.:|||:..|..|  .|.:..:||.|:||:||.|.:|:|:||:|:||.|.|||:||.|.|:.||
  Rat  1115 SNAMPLKVTMVNADPLGEEINVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTG 1179

  Fly  1368 YKSGMIELVSEAETLRKIQVECGLTGSFKDRPIAEWLGKQNPSPLEYQSAVRNFTLSCAGYSVAT 1432
            ...||:|||..::||||||||.|:||||||:|:||||.|.|||..||:.|..||..||||..|||
  Rat  1180 RDQGMVELVPASDTLRKIQVEYGVTGSFKDKPLAEWLRKYNPSEEEYEKASENFIYSCAGCCVAT 1244

  Fly  1433 YVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVINGGDKPSTD 1497
            |||||||||||||||:::||:||||||||||.|||||:|||||.|||||||||||||||:||:..
  Rat  1245 YVLGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIR 1309

  Fly  1498 FHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNS-NAVQYVRRALLPSQSNPEAAATFAK 1561
            |..||||||:|:|::||..:|.|:.|:.|..:|:|.:.| ..::|||.||.|..::.||...|.:
  Rat  1310 FQLFVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATIFFTR 1374

  Fly  1562 MIQSSLKSWFTQFNFFLHNLAQMRFTPDEGSGE-LLSFVPRKYTMQQDGRLKIVKVVCFQKHYSM 1625
            :|:|||.|..|:||||:|||||:||:....:.| :|||.|:.|:.:||||:|.|.|..:.|.|:.
  Rat  1375 LIESSLGSIATKFNFFIHNLAQLRFSGLPSNDEPILSFSPKTYSFRQDGRIKEVSVFTYHKKYNP 1439

  Fly  1626 EKFYMYILEVTRHGQPDPTHLFRSYREFTEFHQKLCMHFPLVKLHSLPAGVHVGRSNIKSVAEKR 1690
            :|.|:|::.:.|.|..:|:.:||::.||.|.|.||.:.|||.||...|..:.:||::||.||.||
  Rat  1440 DKHYIYVVRILREGHLEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVAAKR 1504

  Fly  1691 LPLIQRFLKSLFDASEEIAHSELVYTFFHPLLRDQQEAKLGMPKIKEVKQQPSRDNPHEI-GQIR 1754
            ...:..:|:||.:||.::|..:||.|||||||||::...:.    :.....|......:| |.::
  Rat  1505 KIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDEKAEGIA----RSTGTSPFSPTLGQIGGAVK 1565

  Fly  1755 LSLQYQRGVLTVMIHHAKGLPMLQGGQEPNTYVKCYLKPDPKKETKRKTKVVRKTCVPSFMETLE 1819
            ||:.|:.|.|.:|:.|.|.| :.:.|.:||.|||.||.||..|.:|||||:.|||..|:|.|.|.
  Rat  1566 LSVSYRNGTLFIMVMHIKDL-VTEDGADPNPYVKTYLLPDTHKTSKRKTKISRKTRNPTFNEMLV 1629

  Fly  1820 YR-MPLNIIQERRLQVTVWSHDTLQENELLGGFDMDLSKYDLRQELVDWYRLGAVS 1874
            |. .....:::|.||::|.|.::|:||..|||..:.|..::|.:|.|.||:|.|.:
  Rat  1630 YSGYSRETLRQRELQLSVLSAESLRENFFLGGITLPLKDFNLSKETVKWYQLTAAT 1685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_524028.2	PHA03247	<56..294	CDD:223021	49/250 (20%)
		PI3K_rbd	561..669	CDD:197540	28/108 (26%)
		C2A_PI3K_class_II	844..1021	CDD:175979	47/181 (26%)
		PI3Ka_II	1038..1202	CDD:238441	66/165 (40%)
		PI3Kc_II	1235..1583	CDD:270710	189/350 (54%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794	45/109 (41%)
		C2B_PI3K_class_II	1751..1871	CDD:176027	51/120 (43%)
Pik3c2a	NP_001101970.1	PI3K_rbd	421..514	CDD:395642	28/112 (25%)
		C2A_PI3K_class_II	678..850	CDD:175979	47/180 (26%)
		PI3Ka_II	871..1039	CDD:238441	70/189 (37%)
		PI3Kc_C2_alpha	1044..1396	CDD:270720	189/351 (54%)
		PX_PI3K_C2_alpha	1427..1535	CDD:132822	44/107 (41%)
		C2B_PI3K_class_II	1561..1682	CDD:176027	51/121 (42%)