DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K68D and Pik3c2a

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_001101970.1	Gene:	Pik3c2a / 361632	RGDID:	1310389	Length:	1687	Species:	Rattus norvegicus

Alignment Length:	1943	Identity:	610/1943 - (31%)
Similarity:	930/1943 - (47%)	Gaps:	332/1943 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AHIDYDKQFQD------------DLAKATALSLEQHALDDYRRNKKYGSGYQQSSTVAGRDYQAA 57
            |.|..:.:|:.            |:.||.||.:|..||...::::        ..|.:.|.::.:
  Rat     2 AQISNNSEFKQCSSSHPEPIRTKDVDKAEALQMEAEALAKLQKDR--------HMTDSPRGFELS 58

  Fly    58 QRSQSLHQPRRHSEVHQVAISPENAERSRTPPAQGTDNDLICFASPTSKQPESSSPFGKLIEDLQ 122
                                   |:.|.||......|.||:.|       |||.|....|..|::
  Rat    59 -----------------------NSTRQRTQGFNKQDYDLMVF-------PESDSQKRALDIDVE 93

  Fly   123 RMQPTNPQSALV------------PMGPVASASIPPQYGFPPHQQRPTAAQPTPYGMVAGGVVGG 175
            ::.....:..|:            |:.||.|.|...|....|..||    ...|.|:.      |
  Rat    94 KLTQAELEKILLDDNFETRKTPASPVTPVLSPSFSAQLYLRPAVQR----SQWPPGLC------G 148

  Fly   176 PAYGDLQLVPYQPAAQQQRPLNSEELQRLYSMPAQMAVVPVPQPNAYMYYPGAVVTPY-TAPIVP 239
            |:...|..: |..|..:|....:....|:.:.|:..::        |:..||.  :|| :.|:.|
  Rat   149 PSTYTLPSI-YPSAYSKQATFQNGFSPRMPTFPSTESI--------YLRLPGQ--SPYFSYPLTP 202

  Fly   240 GSAAFMPPQYPAQGYGFGGAYTHMDLRRPQSQPAPQQTAPTTSHHHSQPSNHSTSSPAE-ANGVA 303
            .:     |.:| ||        .:.:.||...|...:.....:.......|....:..| ||..|
  Rat   203 AT-----PFHP-QG--------SLPVYRPLVSPDMAKLFDKIASTSEFLKNGKARTDLEIANSKA 253

  Fly   304 FPARRQV-PSTVGVSSSSHTGNNGHSSVPRRGNDLIDLN--------------HEDYSRVSVLEA 353
            .....|: |.:..::..                |.:||:              ||:..:..||.|
  Rat   254 SVCNLQISPKSEDINKF----------------DWLDLDPLSKPKIDCVEVLEHEEEKKNPVLLA 302

  Fly   354 FDP----LLNDNTGNDTASDSTSYYAEYDPFDFLYSGDAATQYSDPMYEAVNRWDKTVATVSPNV 414
            .||    ||.:.:       .||.:.|                     ..||....:.|||:.:.
  Rat   303 EDPWDAVLLEERS-------PTSRHLE---------------------RKVNGKSLSGATVTRSQ 339

  Fly   415 GLIGWRQDFLSQPSTSSSQYGVAPPEESLKLAENGSGTISPPPPLPPRNQQCYESNQAAMPVSRP 479
            .||    ...:|.:.:.||.....|        ||:
  Rat   340 SLI----VRTTQVTKAQSQVSQKDP--------NGT----------------------------- 363

  Fly   480 PQSSVLTDSYTSSIPANVVLDRRKTCTRLYELISDQRTDDPELLEFYHMVKEVRARYPHDDAPTN 544
              ||:.|.|                     .|:.:....:.|:..|...:.:::.::|:.|..||
  Rat   364 --SSLATGS---------------------SLLQEFEVQNEEVAAFCQSIMKLKTKFPYTDHCTN 405

  Fly   545 VGHVVAAEFNYHYMM--DTSIKVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDIDSVVAQ 607
            .|::::.......|.  :.|:||.:                   :::|:..|||||||:.|.|..
  Rat   406 PGYLLSPVTVQRNMCGENASVKVSI-------------------EIEGFQQPVTFTCDVSSTVDI 451

  Fly   608 VVAQALASLEGQVKGT-VTDYAVKPIGLLEWLAPTSRLSQLECVHNSFQLEKDVHLGLCLSTAAN 671
            ::.|||..:...:... |..|.:|..|..|.|.....|...|.:.|..:.:.::.|.| |:.:|.
  Rat   452 IIMQALCWVHDDLNQVDVGSYILKVCGQEEVLQNNHCLGSHEHIQNCRKWDTEIKLQL-LTFSAM 515

  Fly   672 MQAIARTERDDEHDADL----------LPEHLLPNEVVPIVTYDNMMILIETLEMEIDKLESAAD 726
            .|.:|||..|||...||          ..|.:..:.|..::  |:....:| |.::.:....|.|
  Rat   516 CQNLARTAEDDEAPVDLNKYLYQIEKPYKEVMTRHPVEELL--DSYHYQVE-LALQTENQHRAID 577

  Fly   727 GVPGRSVVSCSGVVQAVKAICALLGSIDTMEIARCVADLKRICEVEQKKYSTGASNPEIVS-DYG 790
                       .|::||:.||:.|..::|..:...|..|||...:.:.|      :.::.| ..|
  Rat   578 -----------QVIKAVRKICSALDGVETPAVTEAVKKLKRAVNLPRNK------SADVTSLSGG 625

  Fly   791 DYAQVVLRPRSMLEQ-IKVKCNELRDAVQELVELYANVFRVAFSVKTPDYSTTPIPISCVSKPIV 854
            |.::...|....||. ::|..:.|..|:.:|:.|:.|..:  .|...|..|.........::.:.
  Rat   626 DTSKNSTRGSLNLENPVQVSMDHLTAAIYDLLRLHTNSCK--SSTVCPQGSRNIKEAWTATEQLQ 688

  Fly   855 VCISCLHRPLPNW--KFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFSAWLTFDQHP 917
            ..:...|....||  .::.|.|...:.:..:.|.|| :.:....|....|..:.:...:.|...
  Rat   689 FTVYAAHGISSNWVSNYEKYYLICSLSHNGKDLFKP-IQSKKVGTYKNFFYLIKWDELIIFPIQ- 751

  Fly   918 ICTLPREARLTFVLYGKQAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLWP 982
            |..||.|:.|...|:|....|.|. :.|.| ::|:....||..|:.||||||.:.||..||.||
  Rat   752 ISQLPLESVLHLTLFGVLNQSSGS-SPDSN-KQRKGPEALGKVSLTLFDFKRFLTCGTKLLYLW- 813

  Fly   983 PMTDKMLGPAPARGCHPQPDFCP---VLSIEVPPYGGRIEFPEHQEVPKPAPHYDFASLDANLQE 1044
              |.......|  |..||..:..   ||.::.|.....|.:...|........|...:|:..::.
  Rat   814 --TSSHTNSIP--GAIPQKSYVMERIVLQVDFPSPAFDIIYTSPQIDRNIIQQYKLEALENEIKG 874

  Fly  1045 ELLDTA--ELGYTGATERREVFWEKRLYLQSYPNALPKVLHAAHSWDYANLIDLHALLHSWAPLS 1107
            :|||..  :..:..:.|.:...||||.|...:||.|||:|.:|.:|.:|||...::|||.|.||.
  Rat   875 KLLDIVHRDSSFGLSKEDKAFLWEKRYYCLKHPNCLPKILASAPNWKWANLAKTYSLLHQWPPLC 939

  Fly  1108 PLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLES 1172
            ||.:||||..::.|.:||..||.||..:.:|:|.|.|||.||:||::.|..|::.|||||:.|.:
  Rat   940 PLAALELLDAKFADQEVRSLAVSWIEAISDDELTDLLPQFVQALKYEIYLNSSLVRFLLSRALGN 1004

  Fly  1173 PRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAICGEKMLQRF 1237
            .:.||.:||||..:|.|                      .|:..|.:.:|.||:::.|:.:.:..
  Rat  1005 IQIAHSLYWLLKDALHD----------------------TRFGSRYEHVLGALLSVGGKGLREEL 1047

  Fly  1238 MYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQPTCLPLGPELEVTGVSVRNCSY 1302
            ..|.::.|.|..:||.|::|..|.||..|...|:.|....|.....:||.|.|....:::::||:
  Rat  1048 SKQMKLVQLLGGVAEKVRQASGSARQVVLQKSMERVQSFFLRNKCRVPLKPSLVAKELNIKSCSF 1112

  Fly  1303 FNSNTLPLKINFVGPD--AESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVP 1365
            |:||.:|||:..|..|  .|.:..:||.|:||:||.|.:|:|:||:|:||.|.|||:||.|.|:.
  Rat  1113 FSSNAMPLKVTMVNADPLGEEINVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLS 1177

  Fly  1366 TGYKSGMIELVSEAETLRKIQVECGLTGSFKDRPIAEWLGKQNPSPLEYQSAVRNFTLSCAGYSV 1430
            ||...||:|||..::||||||||.|:||||||:|:||||.|.|||..||:.|..||..||||..|
  Rat  1178 TGRDQGMVELVPASDTLRKIQVEYGVTGSFKDKPLAEWLRKYNPSEEEYEKASENFIYSCAGCCV 1242

  Fly  1431 ATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVINGGDKPS 1495
            |||||||||||||||||:::||:||||||||||.|||||:|||||.|||||||||||||||:||:
  Rat  1243 ATYVLGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPT 1307

  Fly  1496 TDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNS-NAVQYVRRALLPSQSNPEAAATF 1559
            ..|..||||||:|:|::||..:|.|:.|:.|..:|:|.:.| ..::|||.||.|..::.||...|
  Rat  1308 IRFQLFVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATIFF 1372

  Fly  1560 AKMIQSSLKSWFTQFNFFLHNLAQMRFTPDEGSGE-LLSFVPRKYTMQQDGRLKIVKVVCFQKHY 1623
            .::|:|||.|..|:||||:|||||:||:....:.| :|||.|:.|:.:||||:|.|.|..:.|.|
  Rat  1373 TRLIESSLGSIATKFNFFIHNLAQLRFSGLPSNDEPILSFSPKTYSFRQDGRIKEVSVFTYHKKY 1437

  Fly  1624 SMEKFYMYILEVTRHGQPDPTHLFRSYREFTEFHQKLCMHFPLVKLHSLPAGVHVGRSNIKSVAE 1688
            :.:|.|:|::.:.|.|..:|:.:||::.||.|.|.||.:.|||.||...|..:.:||::||.||.
  Rat  1438 NPDKHYIYVVRILREGHLEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVAA 1502

  Fly  1689 KRLPLIQRFLKSLFDASEEIAHSELVYTFFHPLLRDQQEAKLGMPKIKEVKQQPSRDNPHEI-GQ 1752
            ||...:..:|:||.:||.::|..:||.|||||||||::...:.    :.....|......:| |.
  Rat  1503 KRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDEKAEGIA----RSTGTSPFSPTLGQIGGA 1563

  Fly  1753 IRLSLQYQRGVLTVMIHHAKGLPMLQGGQEPNTYVKCYLKPDPKKETKRKTKVVRKTCVPSFMET 1817
            ::||:.|:.|.|.:|:.|.|.| :.:.|.:||.|||.||.||..|.:|||||:.|||..|:|.|.
  Rat  1564 VKLSVSYRNGTLFIMVMHIKDL-VTEDGADPNPYVKTYLLPDTHKTSKRKTKISRKTRNPTFNEM 1627

  Fly  1818 LEYR-MPLNIIQERRLQVTVWSHDTLQENELLGGFDMDLSKYDLRQELVDWYRLGAVS 1874
            |.|. .....:::|.||::|.|.::|:||..|||..:.|..::|.:|.|.||:|.|.:
  Rat  1628 LVYSGYSRETLRQRELQLSVLSAESLRENFFLGGITLPLKDFNLSKETVKWYQLTAAT 1685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674	70/366 (19%)
		PI3K_rbd	561..669	CDD:197540	28/108 (26%)
		C2A_PI3K_class_II	844..1021	CDD:175979	47/181 (26%)
		PI3Ka_II	1038..1202	CDD:238441	66/165 (40%)
		PI3Kc_II	1235..1583	CDD:270710	189/350 (54%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794	45/109 (41%)
		C2B_PI3K_class_II	1751..1871	CDD:176027	51/120 (43%)
Pik3c2a	NP_001101970.1	PI3K_rbd	411..514	CDD:279173	29/122 (24%)
		C2A_PI3K_class_II	678..850	CDD:175979	47/180 (26%)
		PI3Ka_II	871..1039	CDD:238441	70/189 (37%)
		PI3Kc_C2_alpha	1044..1396	CDD:270720	189/351 (54%)
		PX_PI3K_C2_alpha	1427..1535	CDD:132822	44/107 (41%)
		C2B_PI3K_class_II	1561..1682	CDD:176027	51/121 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339947
Domainoid	1	1.000	309	1.000	Domainoid score	I1286
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20581
Inparanoid	1	1.050	819	1.000	Inparanoid score	I443
OMA	1	1.010	-	-		QHG49277
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	1	1.000	-	-		FOG0001789
OrthoInspector	1	1.000	-	-		otm44452
orthoMCL	1	0.900	-	-		OOG6_104124
Panther	1	1.100	-	-	O	PTHR10048
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2272
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770