DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K68D and nonC

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster

Alignment Length:	1828	Identity:	331/1828 - (18%)
Similarity:	555/1828 - (30%)	Gaps:	706/1828 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   421 QDFLSQPSTSSSQYGVAPPEESL--KLAENGSGTISPPPP-----LPPRNQQCYE-SNQ------ 471
            ::.||..|..|...|.....|.|  ..||..:..:.||..     ....|..|.. .|:
  Fly   910 EELLSMQSNLSLLLGFLDALEKLIYNAAEGSAFALRPPEKQVAAFFRLNNPTCQSWFNRIRIGVV 974

  Fly   472 -AAMPVSRPPQSSVLTDSYTSSIPANVVLDRRKTCTRLY---------ELISDQRTDDPELLEFY 526
             .||.|.:|.    |...|...|..|     .||....|         .|:|.|..|....|..:
  Fly   975 IIAMHVQQPE----LVIRYAQQILVN-----SKTQDPTYSQAIVYMAWSLVSCQEADSLRGLRLW 1030

  Fly   527 HMVKEVRA----RYPHDDAPTNVGHVVAAEFNYHYMMDTSIKVIVHPALNTLQSTVLAASMGKEQ 587
            ...|..::    :|..|.|   .|...:|...|.                    |:||....:.:
  Fly  1031 ARGKSCKSYKWLKYAADQA---AGKRESALAGYR--------------------TILAEKELQSE 1072

  Fly   588 VKGYGMPVTFTCDIDSVVAQVVA--------QALASLEGQVKGTVTDYAVKP--------IGLLE 636
            ::.:..        ..||:|::.        ..|..|:.|......|..:.|        :..||
  Fly  1073 LEPHTR--------QFVVSQMMQCLQDLGQWSQLVELKQQQMTRPEDRELNPFLQRSNVEVNALE 1129

  Fly   637 WLAPTSR--LSQLECVHNSFQLEKDVHLGLC------------LSTAANMQAIARTERDDEHDAD 687
            .|...|.  .|.::.:...||     .|.|.            ||..|:..:|...:|.:    |
  Fly  1130 RLLAKSEESCSSMDALGGVFQ-----QLSLWPSNWDESVSSSGLSERASFSSIHMRQRTE----D 1185

  Fly   688 LLPEHLLPNEVVPIVTYDNMMILIET------LEMEIDK--------LESAADGVPGRSVVS--- 735
            ::...||.:..||    |....|::|      |....|:        |.....||.|...:|
  Fly  1186 IVLHKLLEDRCVP----DQAKNLLDTQWRDSLLNPSFDQRSCKELTLLRHIVQGVSGGQELSLLP 1246

  Fly   736 --------------------CSGVVQAVKAICA----------------------LLGSIDTMEI 758
                                |....|.::..||                      |..::.|...
  Fly  1247 VSSGRCQNRSKFISSAILMRCLAWTQLLRQHCAPGSWETLCLDAAAAAREEGNLQLAETLLTQFF 1311

  Fly   759 ARCVADLKRICEVEQKKYSTGASNPEIVSDYGDYAQVVLRPRSMLEQIKVKCNELRDAVQELVEL 823
            .:.:.::..:..:||   .....|||::..|.:.               |||..|:   |:..:.
  Fly  1312 GQPIGEIAALFSLEQ---GVQTDNPEMLRGYSEL---------------VKCLHLQ---QQQSQT 1355

  Fly   824 YANVFRVAFSVKTPDYSTTPIPISCVSKPIVVCISCLHRPLPNWKFDDYSLCVQIVYGTRLLSKP 888
            ::.           |.|::          |.||.               :||:
  Fly  1356 HSG-----------DLSSS----------IDVCA---------------ALCL------------ 1372

  Fly   889 NVLTCSNDTSGGLFPRLNFSAW--------LTFDQHPIC-----TLPREARLTFVLYGKQAASEG 940
            |:...:|..:.|....||.:.|        ||.:|.|:.     .|| |..||        ....
  Fly  1373 NIQKSNNQPAAGADLLLNLADWIAVRTCNGLTTNQSPVLIQLLDQLP-ECPLT--------CDSS 1428

  Fly   941 EPNADQNGERRQVTTELGWCSIQLFDFKRVMIC-GPYLLSLWPPMTDK--MLGPAPARGCH---- 998
            :|.|....| |.|...:..|..|..::...:|. |.:.......:.|.  :|..|.|....
  Fly  1429 QPLAIPQAE-RMVARLVHSCLQQRPNYAEALIAYGNWCYRWGKKVADSCCVLTQADATAISQALD 1492

  Fly   999 -PQP-------DFCPVLSIEVPPYGGRIEFPEHQEVPKPAPHYDFASLDANLQEELLDTAELGYT 1055
             |||       :....||.|.||                          ||..|...|.|.....
  Fly  1493 IPQPLESEKLDELLQALSTEQPP--------------------------ANCVEVCPDAARARDD 1531

  Fly  1056 GATERREVFWEKRL--YLQSYPNALPKVLH-----AAHSWDY----------------------- 1090
            .|.:.|    .:||  .....|.||..:|.     .|:::||
  Fly  1532 EAAKNR----LRRLTFLADKTPEALDAILQIWRRAIANTYDYYKDAARSYFQYLSFKSGSGPEKP 1592

  Fly  1091 ----------------ANLI---------------DLHALLHSWAPLSPLQSLELLLPR------ 1118
                            :||:               .|..:|......:|:...::::|:
  Fly  1593 EGEGVVSQRERLHVDDSNLVTTTLRLLRLIVKHASGLQEVLEQGLHTTPIAPWKVIIPQLFSRLN 1657

  Fly  1119 YPDAKVREKAVEWISKMPND--QLVDFLPQLVQSLKHD------------TYEGSAMARFLLSK- 1168
            :.:..||:...:.:.::...  |||.| |.:|.:.:..            |.|.:....:||.:
  Fly  1658 HHEPYVRKSVCDLLCRLAKSRPQLVIF-PAVVGANREQQDATAPPATARPTTEDACCYGYLLGEL 1721

  Fly  1169 CLESPRFAHHM----------------YWLLVHSLPDDPH------NSIGAAMVDQEYDESQVTQ 1211
            ..::|....|:                ||  :|||   .|      :.:.|...|...|:.:...
  Fly  1722 SKQAPEAVQHVKLMVKELRRVCLLWDEYW--IHSL---AHIYNTYVSRVSALATDFRPDDHEGKN 1781

  Fly  1212 VRY--YRRNKMM-LRALMAICG--------EKMLQRF---------MYQHR-------MCQKLTT 1249
            .|:  :|...:. |.||:|:..        ....:||         ..:||       ..::|..
  Fly  1782 NRFNVWRPQLLADLEALVAVTSRPPETTYERSFRKRFDAPIRLTVDALRHRRYPEAWDKLKQLYH 1846

  Fly  1250 IAES--VKEAKESMRQKSLAAGMDEVHQDLLEQPTCLPLGP---ELEVTGVSVRNCSYFNSNTLP 1309
            |.:|  ::.:..:::.:|::..:..:.:..:..|.....||   ::.:..|....| ...:.|.|
  Fly  1847 ILQSNMIRGSGSTLKMQSISPVLCGIGRMRISMPGLDAHGPDGDQVYIESVESSVC-VLPTKTKP 1910

  Fly  1310 LKINFVGPDAESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLD------LKMVTFNCVPTGY 1368
            .|:.|.|.:.:....:||..:||..|:..:|.:.|.|.: :|.|.|      .:...::.:|.|.
  Fly  1911 KKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAI-MACRSDAPGNGCYRAHHYSVIPLGP 1974

  Fly  1369 KSGMIELVSEAETL---------RKIQVECGLTGS---------FKD------------------ 1397
            :||:|..|.....:         |:.|| .|..|:         |.|
  Fly  1975 QSGLISWVDGVTPVFALYKKWQQRRSQV-AGNAGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVS 2038

  Fly  1398 RPIAEW-----------LGKQNPSPL-------------EYQSAVRNFTLSCAGYSVATYVLGIC 1438
            .|..:|           |.::.|:.|             |::.:||.|....:..|:..||:|:.
  Fly  2039 DPRRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLG 2103

  Fly  1439 DRHNDNIMLKT-SGHLFHIDFGKFLGDAQMFGNFKRDRT-------PFVLTSDM--AYVINGGDK 1493
            |||.||:::.. ||.:.|||:...         |::.||       ||.||.::  |..|.|.:.
  Fly  2104 DRHLDNVLINLGSGDIVHIDYNVC---------FEKGRTLRIPEKVPFRLTQNLVQAMGITGIEG 2159

  Fly  1494 PSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNSNAVQYVRRALLPSQSNPEAAAT 1558
            |      |...|.....::||..:.||..|.               .:|...|:...:|.:|.|
  Fly  2160 P------FRLGCEYVLKVMRKERETLLTLLE---------------AFVYDPLVDWTTNDDAQA- 2202

  Fly  1559 FAKMIQSSLKSWFTQFNFFLHNLAQMRFTPDEGSGELLSFVPRKYTMQQDGRLK----------- 1612
                ::.||.             |:::.:.|.|....|.....||..:...:.|
  Fly  2203 ----LRRSLN-------------AKLQESADGGGAGGLGVGDLKYHKKDKNKGKPLDSDVKRQPF 2250

  Fly  1613 IVKVVCFQKHYSMEKFYMYILEVTRHGQPDPTHLFRSYREFTEFHQKLCMHFPLVKLHSLPAGVH 1677
            :.|:...||::|..|                |.|.....|..:                     .
  Fly  2251 LSKLGMLQKYWSTNK----------------TELMPQLEEMEQ---------------------E 2278

  Fly  1678 VGRSNIKSVAEKRLPLIQRFLKSLFDASEEIAHSELVYTFFHPLLRDQQEAKLGMPKIKEVKQQP 1742
            ||  |:::...|::                :|..|||        :..|.:.|    |.|:|...
  Fly  2279 VG--NLQAAQAKQV----------------VAEEELV--------KLNQRSAL----IAEIKSLG 2313

  Fly  1743 SRDNPHEIGQIRLSLQYQRGVLTVMIHHAKGLPMLQGGQEPN---------TYVKCY-------- 1790
            :....|......|....:||       |::.|.:|...:.|:         :|.:|.
  Fly  2314 TAIESHSFNTASLRNAVRRG-------HSEALALLSTERLPDFGRVQCILRSYGQCLQLYHLLDL 2371

  Fly  1791 ------LKPDPKKETKRKTKVVRKTCVPSFMETLEYRMPLNIIQERRLQVTVWSHDTLQENELLG 1849
                  |:.:...|..|:            ...|...:.|:.:...|.|:          |||||
  Fly  2372 QGQLVKLQMESNSENARE------------FSALTEALQLSGLDSMRSQL----------NELLG 2414

  Fly  1850 GFDMDLSK 1857
            ..||...|
  Fly  2415 RMDMVAQK 2422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540	22/137 (16%)
		C2A_PI3K_class_II	844..1021	CDD:175979	41/204 (20%)
		PI3Ka_II	1038..1202	CDD:238441	43/267 (16%)
		PI3Kc_II	1235..1583	CDD:270710	90/444 (20%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794	17/120 (14%)
		C2B_PI3K_class_II	1751..1871	CDD:176027	24/130 (18%)
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	52/269 (19%)
		Rapamycin_bind	1738..1845	CDD:285924	19/111 (17%)
		PIKKc_SMG1	1894..2196	CDD:270714	74/334 (22%)
		FATC	3189..3217	CDD:280430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900