DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K68D and Pi4KIIIalpha

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_001259191.1	Gene:	Pi4KIIIalpha / 31247	FlyBaseID:	FBgn0267350	Length:	2154	Species:	Drosophila melanogaster

Alignment Length:	1325	Identity:	288/1325 - (21%)
Similarity:	493/1325 - (37%)	Gaps:	360/1325 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   477 SRPPQSSVLTDSYTSSIPANVVLDRRKT----CTRLYELISDQRTDDPELLEFYHMVKEVRARYP 537
            |..|..|.|.|:         .|.|.||    |.:   .::||      :.|.:..|     .|.
  Fly   948 SLEPIMSYLCDT---------ALQRDKTGIWQCVK---CVADQ------VFEKFRNV-----LYA 989

  Fly   538 HDDAPTNV----GHVVAAEFNYHYMMDTSIKVIVHPALNTL---------QSTVLAASMGKEQVK 589
            ||:....|    ..::...||:   :...|:::....|:.|         ...||...:...|:.
  Fly   990 HDEIREKVLESQATLLLVYFNH---IHKPIQMVADQYLSFLVDRFPHLLWNRRVLWCMLDILQLL 1051

  Fly   590 GYGM---PVTFTCDIDSVVAQVVAQALASLEGQVKGTVTDYAVKPIGL----LEWLAPTSRLSQL 647
            .|.:   |...|..:..|......|.:.||..: :..:.|:|.:..|:    ::| ||.|..|.|
  Fly  1052 AYSLSLDPNEETPTLRVVSTPYTLQLMDSLPAR-ELRLKDFADRCQGIVNEAMKW-APRSTRSHL 1114

  Fly   648 ECVHNSFQLEKDV---HLGLCLSTAANMQAIARTERDDEHDADLLPEHLLPNEVVPIVTYDNMMI 709
            :...|  |:...|   |.||.|:..:.:.:.|      :|...:.......|...|  .:.:::.
  Fly  1115 QEYPN--QIPTPVLAHHSGLALAFDSVVSSSA------QHTGTMSKRPSCVNSDTP--RFVSVLC 1169

  Fly   710 LIETLEMEIDKL-----ESAADGVPGRSVVSCSGVVQAVKAICALLGSIDTME---IARCVADLK 766
            |......||..|     |....|:..|.|   |.|.:|    ||  ...|...   :.|..|.|.
  Fly  1170 LRSKYAGEISGLLSVLSEKDKAGLADRLV---SDVWEA----CA--EKSDARHRGALWRATAYLI 1225

  Fly   767 RICEVEQK-KYSTGASNPEIVSDYG-----DYAQVVLRPRSMLEQIKVKCNELRDAVQELVELYA 825
            ...|:.:| .::..:|..|:.::..     :..|.||..|..||    .|     .:||:|..:.
  Fly  1226 ICSEISRKLLHAVASSQLELFTESAMETAVECWQWVLTARQDLE----LC-----FIQEMVSAWQ 1281

  Fly   826 NVFRVAFSVKTPDYSTTPIPISC------VSKPIVV----------------------------C 856
            ..|.....:...:...|. |::.      |||||::                            |
  Fly  1282 TTFEKRMGLFAWETEVTH-PLAAYEGCKLVSKPILIAPHLIWLQLLSEMVDTAKYCNRDKVEMFC 1345

  Fly   857 ISCLHRPLPNWKFDDYSLCVQIVYGTRLLSKPNVLTCS-NDTSGGLFP----------RLNFSAW 910
            : .|||.||..|....:..|..| |.|.    .:|.|. :...|...|          |:..:|.
  Fly  1346 L-LLHRCLPVLKSSKQNRQVSTV-GCRF----KLLQCGLSLLQGNTIPKSLSRNILRERIYSNAL 1404

  Fly   911 LTFDQHPICTLPREAR-------LTFVLYGKQAASEGEPNADQNGERRQVTTELGWCSIQLFDFK 968
            ..|...|.|  |.::|       :..:.:.:...||         ::..||:|:|     .:|..
  Fly  1405 DYFCGPPTC--PNQSREQLLEDIMILLKFWQTMRSE---------KKHLVTSEVG-----DYDLT 1453

  Fly   969 RVMICGPYLLSLW-PPMTDKMLGPAPARGCHPQPDFCPVLS-------IEVPPYGGRIEFPEHQE 1025
            ...:....:|::. .|.|..::.     |.....|:...:|       :.:...||......:..
  Fly  1454 NASVSSTQMLAVRNNPETASLIS-----GGGLVNDYTRSMSASGNAVGMGMGVAGGGSSSGWYNT 1513

  Fly  1026 VPKPAP------------HYDFASLD------ANLQEELLDTAELGYTGATERREVFWEKRLYLQ 1072
            :|....            .|...|.|      .||..||| ..||.:.       :.|..
  Fly  1514 IPHSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELL-AVELEFL-------ITWYN----- 1565

  Fly  1073 SYPNALPKVL----------------------HAAHSWDY--------------ANLIDLH---- 1097
              ||:||.::                      :|..:|.|              |.:||..
  Fly  1566 --PNSLPDLIVPGEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRL 1628

  Fly  1098 ------ALLH-------------------------SWAPLSPLQSLELLLPRYPDAKV-REKAVE 1130
                  |:.|                         ||:|::|:|:|.....:||...: .:.||:
  Fly  1629 VCSDPIAVCHIPEALKYLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQYPSHPLTAQYAVK 1693

  Fly  1131 WISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESPRFAHHMYWLLVHSLPDDPHNSI 1195
            .:|..|.:.::.::|||||:|:|||.  ..:..|:.:....|...||.:.|.:..::..|.
  Fly  1694 TLSSYPAESVLPYIPQLVQALRHDTM--GYVVEFIKNISRRSQIVAHQLIWNMQTNMYMDE---- 1752

  Fly  1196 GAAMVDQEYDESQVTQVRYYRRNKMMLRALMAICGEKMLQRFMYQHRMCQKLTTIAESVKE-AKE 1259
                 ||::.:..:     |.....:.::::|.......:.:..:.....|:|.::..::. ||.
  Fly  1753 -----DQQHKDPNL-----YEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKG 1807

  Fly  1260 SMRQKSLAAGMDEVHQDLLEQPTC-LPLGPELEVTGVS--------------------VRNCSYF 1303
            ..|:.:..|.:..:.    .|..| ||..||..|..:.                    |..|...
  Fly  1808 IERKNACLAALSRIK----VQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGIT 1868

  Fly  1304 NSNTLPLKINFVGPDAES-----------LPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLK 1357
            ...|..:::: ..|:::.           ..||||.|||::||.|.:|:|.|...::....|||.
  Fly  1869 ELETRAMEVS-NNPNSQEDAKMTLGVESWQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLF 1932

  Fly  1358 MVTFNCVPTGYKSGMIELVSEAETLRKI--QVECGLTGSFKDRPIAEWLGKQNPSPLEYQSAVRN 1420
            :..:..|.|....|:||.|..|::..::  |.:.||:..|:.:     .|.:  |..|:|:|..|
  Fly  1933 LFPYRVVATAPGCGVIECVPNAKSRDQLGRQTDSGLSEYFQHQ-----YGDE--SSKEFQAARAN 1990

  Fly  1421 FTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGN--FKRDRTPFVLTSD 1483
            |..|.|.||:..|:|.|.||||.|||:...||:.||||| |:.::...||  |:.|   ..||.:
  Fly  1991 FVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFG-FMFESSPGGNIGFEPD---MKLTDE 2051

  Fly  1484 MAYVINGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNSNAVQYVRRALLP 1548
            |. :|.||...|..|.:|.:||.:||..||...|.::..::.|...|:|......:..:::..:.
  Fly  2052 MV-MIMGGKMDSPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLDTGLPCFRGQTINLLKQRFVA 2115

  Fly  1549 SQSNPEAAATFAKMIQSSLKSWFTQ 1573
            :::|.||||....:|::|.:::.|:
  Fly  2116 TKNNKEAAAHMLAVIRNSYQNFRTR 2140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540	29/126 (23%)
		C2A_PI3K_class_II	844..1021	CDD:175979	43/236 (18%)
		PI3Ka_II	1038..1202	CDD:238441	48/241 (20%)
		PI3Kc_II	1235..1583	CDD:270710	104/376 (28%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	37/190 (19%)
Pi4KIIIalpha	NP_001259191.1	PI4Kc_III_alpha	1836..2153	CDD:270711	92/318 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447460
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10048
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840