DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K68D and Pik3cg

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_001139672.1	Gene:	Pik3cg / 30955	MGIID:	1353576	Length:	1102	Species:	Mus musculus

Alignment Length:	1176	Identity:	311/1176 - (26%)
Similarity:	510/1176 - (43%)	Gaps:	276/1176 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   561 TSIKVI----VHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDIDSVVAQVVAQALAS------ 615
            :|:::|    |.|....:..|...|.:   .|.|:|       :::.:.|||..:||.:
Mouse    33 SSMELIPIEFVLPTSQRISKTPETALL---HVAGHG-------NVEQMKAQVWLRALETSVAAEF 87

  Fly   616 ----------LEGQVKGTVTDYAVKPIGLLEWLAPTSR---LSQLECVHN--------------- 652
                      |..|.||             :|.....|   :..|:|:|.
Mouse    88 YHRLGPDQFLLLYQKKG-------------QWYEIYDRYQVVQTLDCLHYWKLMHKSPGQIHVVQ 139

  Fly   653 ---------SFQLEKDVHLGLCLSTAANMQAIARTERDDE------------------HDADL-- 688
                     :||.:....:|..::..:|:       .|||                  .||.|
Mouse   140 RHVPSEETLAFQKQLTSLIGYDVTDISNV-------HDDELEFTRRRLVTPRMAEVAGRDAKLYA 197

  Fly   689 ---------LPEHL---LPNEVVPIVTYDNMMILIETLEMEIDKLESAADGVPGRSVVSCSGVVQ 741
                     ||::|   :.|..:.||.:..  ...:|:::       :||..||..:.|....:.
Mouse   198 MHPWVTSKPLPDYLSKKIANNCIFIVIHRG--TTSQTIKV-------SADDTPGTILQSFFTKMA 253

  Fly   742 AVKAICALLGSIDTMEIARCVAD---LKRICEVEQKKYSTGAS---NPEIVSD---YGDYAQVVL 797
            ..|::         |.|:...::   :.|:|  .:.:|..|.:   |.:.|..   .||...:||
Mouse   254 KKKSL---------MNISESQSEQDFVLRVC--GRDEYLVGETPLKNFQWVRQCLKNGDEIHLVL 307

  Fly   798 --RPRSMLEQIKVK-------CNELRDAVQELV---ELYANVFRVA-------FSVKTPDYSTTP 843
              .|...|::::.:       |..:....::|.   :.:.:||.|:       |.||
Mouse   308 DTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVK-------- 364

  Fly   844 IPISCVSKPIVVCISCLHRPLPNWKFDDYSLCVQ--IVYGTRLLSKPNVLTCSNDTSGGLF-PRL 905
              |..:..|:          ||  :..|.::.|:  |.:|.::|       |...||...| ..:
Mouse   365 --IRGIDIPV----------LP--RNTDLTVFVEANIQHGQQVL-------CQRRTSPKPFAEEV 408

  Fly   906 NFSAWLTFDQHPICTLPREARLTFVLY-------GKQAASEGEPNADQNGERRQVTTELGWCSIQ 963
            .::.||.|. ..|..||:.|.|...:|       ..:|::| .|.::..|:.:.    |.:.::.
Mouse   409 LWNVWLEFG-IKIKDLPKGALLNLQIYCCKTPSLSSKASAE-TPGSESKGKAQL----LYYVNLL 467

  Fly   964 LFDFKRVMICGPYLLSLWPPMTDKMLGPAPARG----------CHPQPDFCPVLSIEVPPYGGRI 1018
            |.|.:.::..|.|:|.:|     ::.|.|..:|          .:|..:....:||.:..|...|
Mouse   468 LIDHRFLLRHGDYVLHMW-----QISGKAEEQGSFNADKLTSATNPDKENSMSISILLDNYCHPI 527

  Fly  1019 EFPEHQEVPKPAPHYDFASLDANLQEEL---LDTAELGYTGATERREVFWEKRLYLQSYPNALPK 1080
            ..|:|:..|.|......|.:...|:::|   :.|..|....| |.:|:.|..|.....:|.|.||
Mouse   528 ALPKHRPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTA-EDKELLWHFRYESLKHPKAYPK 591

  Fly  1081 VLHAAHSWDYANLI----DLHALLHSW--APLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQ 1139
             |.::..|....::    .|.|....|  :.|....:::||...:.|..||..||:.:..:.:|.
Mouse   592 -LFSSVKWGQQEIVAKTYQLLARREIWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDD 655

  Fly  1140 LVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEY 1204
            ::.:|.||||::|.:.|..||:|||||.:.|.:.|..|.::|.|
Mouse   656 VLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFL--------------------- 699

  Fly  1205 DESQVTQVRYY-RRNKMMLRALMAICGEKMLQRFMYQ-H--RMCQKLTTIAESVKEAK------- 1258
             .|::.|.|:| :|..::|.|.:..||..|||.|..| |  .|.||:|...:|:...|
Mouse   700 -RSEIAQSRHYQQRFAVILEAYLRGCGTAMLQDFTQQVHVIEMLQKVTIDIKSLSAEKYDVSSQV 763

  Fly  1259 -ESMRQKSLAAGMDEVHQDLLEQPTCLPLGPELEVTGVSVRNCSYFNSNTLPLKINFVGPDA--- 1319
             ..::||     ::.:....|.:...:|..|.|:...:.:..|....|...||.:.|...|.
Mouse   764 ISQLKQK-----LESLQNSNLPESFRVPYDPGLKAGTLVIEKCKVMASKKKPLWLEFKCADPTVL 823

  Fly  1320 --ESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETL 1382
              |::..|||.||||:||.|.:|::|||..:|..|.|||.::.:.|:.||.|.||||:|.:|.|:
Mouse   824 SNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTI 888

  Fly  1383 RKIQVE-CGLTGSFKDRPIAEWLGKQNPSPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIM 1446
            .:||.. .|.||:|||..:..||.::.|...::|:||..|..|||||.|||:||||.||||||||
Mouse   889 AQIQQSTVGNTGAFKDEVLNHWLKEKCPIEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIM 953

  Fly  1447 LKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVI-NGGDKPSTDFHYFVDLCCRAFN 1510
            :..:|:|||||||..||:.:.|....::|.|||||.|..:|: :.|.|.|..|..|.|:|.||:.
Mouse   954 ISETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGSSGKKTSPHFQKFQDVCVRAYL 1018

  Fly  1511 IVRKNADLLLHTLAHMATAGMPGVNSNA-VQYVRRALLPSQSNPEAAATFAKMIQSSL-KSWFTQ 1573
            .:|.:.:||:...:.|...|||.:.|.. ::|:|.||...:|..:|...|...|:... |.|..|
Mouse  1019 ALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKSEEDAKKYFLDQIEVCRDKGWTVQ 1083

  Fly  1574 FNFFLH 1579
            ||:|||
Mouse  1084 FNWFLH 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540	26/154 (17%)
		C2A_PI3K_class_II	844..1021	CDD:175979	41/196 (21%)
		PI3Ka_II	1038..1202	CDD:238441	46/172 (27%)
		PI3Kc_II	1235..1583	CDD:270710	140/365 (38%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
Pik3cg	NP_001139672.1	PI3K_rbd	203..312	CDD:197540	25/128 (20%)
		C2_PI3K_class_I_gamma	350..527	CDD:176044	45/216 (21%)
		PI3Ka_I	549..725	CDD:238444	53/199 (27%)
		PI3Kc_IB_gamma	729..1095	CDD:270627	141/366 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836279
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750