Protein Alignment Pi3K68D and Pik3cg

DIOPT Version :10

• Sequence 1: NP_524028.2
• Gene: Pi3K68D / 39329
• FlyBaseID: FBgn0015278
• Length: 1876
• Species: Drosophila melanogaster
• Sequence 2: NP_001358229.1
• Gene: Pik3cg / 298947
• RGDID: 1306468
• Length: 1102
• Species: Rattus norvegicus
• Alignment Length: 758
• Identity: 241/758 - (31%)
• Similarity: 375/758 - (49%)
• Gaps: 95/758 - (12%)

  Fly   871 DYSLCVQ--IVYGTRLLSKPNVLTCSNDTSGGLF-PRLNFSAWLTFDQHPICTLPREARLTFVLY 932
            |.::.|:  |.:|.::|       |...||..|| ..:.::.||.|. ..|..||:.|.|...:|
  Rat   378 DLTVFVEANIQHGQQVL-------CQRRTSPKLFTEEVLWNVWLEFG-IKIKDLPKGALLNLQIY 434

  Fly   933 G------KQAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLWPPMTDKMLGP 991
            .      ...||...|.::..|:.:.    |.:.::.|.|.:.::..|.|:|.:|     ::.|.
  Rat   435 CCKTPSLSSKASVETPGSESKGKAQL----LYYVNLLLIDHRFLLRHGGYVLHMW-----QISGK 490

  Fly   992 APARG----------CHPQPDFCPVLSIEVPPYGGRIEFPEHQEVPKPAPHYDFASLDANLQEEL 1046
            |..:|          .:|..:....:||.:..|...|..|:|:..|.|......|.:...|:::|
  Rat   491 AEEQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHRPTPDPEGDRVRAEMPNQLRKQL 555

  Fly  1047 ---LDTAELGYTGATERREVFWEKRLYLQSYPNALPKVLHAAHSWDYANLI----DLHALLHSW- 1103
               :.|..|....| |.:|:.|..|.....:|.|.|| |.::..|....::    .|.|....|
  Rat   556 EAIIATDPLNPLTA-EDKELLWHFRYESLKHPKAYPK-LFSSVKWGQQEIVAKTYQLLARREIWD 618

  Fly  1104 -APLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLS 1167
             :.|....:::||...:.|..||..||:.:..:.:|.::.:|.||||::|.:.|..||:|||||.
  Rat   619 QSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLK 683

  Fly  1168 KCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYY-RRNKMMLRALMAICGE 1231
            :.|.:.|..|.::|.|                      .|::.|.|:| :|..::|.|.:..||:
  Rat   684 RGLRNKRIGHFLFWFL----------------------RSEIAQSRHYQQRFAVILEAYLRGCGK 726

  Fly  1232 KMLQRFMYQ-H--RMCQKLTTIAESVKEAK--------ESMRQKSLAAGMDEVHQDLLEQPTCLP 1285
            .|||.|..| |  .|.||:|...:|:...|        ..::||     ::.:....|.:...:|
  Rat   727 AMLQDFTQQVHVIEMLQKVTIDIKSLSAEKYDVSSQVISQLKQK-----LESLQNSSLPESFRVP 786

  Fly  1286 LGPELEVTGVSVRNCSYFNSNTLPLKINFVGPDA-----ESLPAIFKCGDDLQQDQLTIQLIRIM 1345
            ..|.|:...:.:..|....|...||.:.|...|.     |::..|||.||||:||.|.:|::|||
  Rat   787 YDPGLKAGTLVIEKCKVMASKKKPLWLEFKRADPTVLSNETIGIIFKHGDDLRQDMLILQILRIM 851

  Fly  1346 NKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVE-CGLTGSFKDRPIAEWLGKQNP 1409
            ..:|.||.|||.::.:.|:.||.|.||||:|.:|.|:.:||.. .|.||:|||..:..||.::.|
  Rat   852 ESIWEAESLDLCLLPYGCISTGDKIGMIEIVKDATTIAQIQQSTVGNTGAFKDEVLNHWLKEKCP 916

  Fly  1410 SPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRD 1474
            ...::|:||..|..|||||.|||:||||.||||||||:..:|:|||||||..||:.:.|....::
  Rat   917 IEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMISETGNLFHIDFGHILGNYKSFLGINKE 981

  Fly  1475 RTPFVLTSDMAYVI-NGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNSNA 1538
            |.|||||.|..:|: ..|.|.|..|..|.|:|.||:..:|.:.:||:...:.|...|||.:.|..
  Rat   982 RVPFVLTPDFLFVMGTSGKKTSPHFQKFQDVCVRAYLALRHHTNLLIILFSMMLMTGMPQLTSKE 1046

  Fly  1539 -VQYVRRALLPSQSNPEAAATFAKMIQSSL-KSWFTQFNFFLH 1579
             ::|:|.||:..:|..:|...|...|:... |.|..|||:|||
  Rat  1047 DIEYIRDALMVGRSEEDAKKYFLDQIEVCRDKGWTVQFNWFLH 1089

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_524028.2	PHA03247	<56..294	CDD:223021
		PI3K_rbd	561..669	CDD:197540
		C2A_PI3K_class_II	844..1021	CDD:175979	38/168 (23%)
		PI3Ka_II	1038..1202	CDD:238441	46/172 (27%)
		PI3Kc_II	1235..1583	CDD:270710	141/365 (39%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
Pik3cg	NP_001358229.1	PIK3CG_ABD	1..192	CDD:466155
		PI3K_rbd	203..312	CDD:197540
		C2_PI3K_class_I_gamma	350..527	CDD:176044	37/165 (22%)
		PI3Ka_I	549..725	CDD:238444	53/199 (27%)
		PI3Kc_IB_gamma	729..1095	CDD:270627	142/366 (39%)