Protein Alignment Pi3K68D and Pik3c2b

DIOPT Version :10

• Sequence 1: NP_524028.2
• Gene: Pi3K68D / 39329
• FlyBaseID: FBgn0015278
• Length: 1876
• Species: Drosophila melanogaster
• Sequence 2: XP_063128143.1
• Gene: Pik3c2b / 289021
• RGDID: 1306541
• Length: 1639
• Species: Rattus norvegicus
• Alignment Length: 1965
• Identity: 631/1965 - (32%)
• Similarity: 907/1965 - (46%)
• Gaps: 428/1965 - (21%)

  Fly     2 SNQAHIDYDKQFQD------DLAKATALSLEQHALDDYRRNKKYGSGYQQSSTVAGRDYQAAQRS 60
            |.|.:.::.|..:.      :||.|.||.:|..||...|.:|
  Rat     3 STQGNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHHK----------------------- 44

  Fly    61 QSLHQPRRHSEVHQVAISPENAERSRTPPAQGTDNDLICFASPTSKQPESSSPFG-----KLIED 120
                                  |.||.  .|.|:..||.:..|.  ....|.|.|     ||:..
  Rat    45 ----------------------EESRA--KQNTEPSLISWDEPA--LDFYSKPAGRRTELKLLRG 83

  Fly   121 LQRMQPT-NPQSALVPMGPVASASIPPQYGFPPHQQRPTAAQPTPYGMVAGGVVG----GPAYGD 180
            |....|| |..|...|.....|.|..||.|..|.   |..:|...|..:..|..|    .|..||
  Rat    84 LSGSDPTLNYNSISPPEELPNSTSQDPQPGTDPW---PKGSQSGDYLYIFDGSDGRCSLSPVSGD 145

  Fly   181 LQLVPYQPAAQQQRPLNSEELQRLYSMPAQMAVVPVPQPNAYMYYPGAVVTPYTAPIVPGSAAFM 245
                             ::...:..|.|      |:| |.         |:.:.||.:|
  Rat   146 -----------------TDGSCKKLSPP------PLP-PR---------VSIWDAPPLP------ 171

  Fly   246 PPQYPAQGYGFGGAYTHMDLRRPQSQPAPQQTAPTTSHHHSQPSNHSTSSPAEAN-----GVAFP 305
                |.:|                 .|:|.:.        |||.:.::.|..|..     |...|
  Rat   172 ----PRKG-----------------SPSPSKI--------SQPDDINSFSLVEQPSDKLLGAQDP 207

  Fly   306 ARRQVPSTVGVSSSSHTGNNGH--SSVPRRG-NDLIDLNHEDYSRVSVLEAFDPLLNDNTGNDTA 367
            ...::|         :.|...|  .||...| ||.|       :|:::...:|        ::..
  Rat   208 GEGELP---------NGGGQRHVLGSVDYDGINDAI-------TRLNLKSTYD--------SEIL 248

  Fly   368 SDSTSYYAE-YDPFDFLYSGDAATQYSDPMYEAVNRWDKTVATVSPNVGLIGWRQDFLSQPSTSS 431
            ||:|..:.| ..|.||                                     .:|...:|...|
  Rat   249 SDATRGWKEGRGPLDF-------------------------------------SKDTSGKPVARS 276

  Fly   432 SQYGVAPPEESLKLAENGSGTISPPPPLPPRN-QQCYESNQAAMP-----VSRPPQSSVLTDSYT 490
            .                     :.||.:|||. ...|.:.:.|.|     :|..|..:.|.
  Rat   277 K---------------------TMPPQVPPRTYTPRYANRKNATPGKNRRISAAPVRTFLP---- 316

  Fly   491 SSIPANVVLDRRKTCTRLYEL--ISDQRTDDPELLEFYHMVKEVRARYPHDD------------- 540
                   |..|..|.|..:||  :|::|  |.|:..|.||:..:|......|
  Rat   317 -------VSSRTHTVTNGHELFEVSEER--DEEVAAFCHMLDILRTGSDTQDYSLTGCVWSTVTP 372

  Fly   541 APTNVGHVVAAEFNYHYMMDTSIKVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDIDSVV 605
            :|.::|..|                       .|:.|||..|:.:        |:||||:..|.|
  Rat   373 SPEHLGDEV-----------------------NLKVTVLCDSLRE--------PLTFTCNCSSTV 406

  Fly   606 AQVVAQALASLEGQVKGT-VTDYAVKPIGLLEWLAPTSRLSQLECVHNSFQLEKDVHLGLCLSTA 669
            ..::.|.|.....:::.. |.|:.:||.||.|:|.....|...|.:.:..:.:.::.|.| :...
  Rat   407 DLLIYQTLCYTHDELREVDVGDFVLKPCGLEEFLQNKHALGSHEYIQHCRKFDINIRLQL-MEQK 470

  Fly   670 ANMQAIARTERDDEHDADL-LPEHLLPNEVVPIVTYDNMMILIETLEMEIDKLESAADGVPGRSV 733
            |....:|||..||:..:.| ...||....|...::...:.:|.:|...|:|....|....|
  Rat   471 AIRSDLARTVNDDQSPSTLNYLIHLQERPVKQTISRQALSLLFDTYHNEVDAFLLAEGDFP---- 531

  Fly   734 VSCSGVVQAVKAICALLGSIDTMEIARCVADLKRICEVEQKKYSTGASNPEIVSDYGDYAQVVLR 798
            :....|||:|||||..|.:::|.||...:..|.. |....:        |:|..|     ..||.
  Rat   532 LKADRVVQSVKAICNALAAVETPEITSALNQLPP-CPSRMQ--------PKIQKD-----PSVLT 582

  Fly   799 PRSMLEQIKVKCNELRDAVQELVELYANVFRVAFSVKTPD---------------------YSTT 842
            .|...|::   ...|..|:.:|||||.:.|...|....|.                     |.|.
  Rat   583 VRENREKV---VEALTAAILDLVELYCSTFNADFQTAVPGSRKHDLVQEACHFSGALAFTVYGTH 644

  Fly   843 PIPISCVSKPIVVCISCLHRPLPNW--KFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRL 905
            .|||.                   |  .::::.|...:.:|.:.|..|....           |.
  Rat   645 RIPII-------------------WATSYEEFYLSCSLSHGGKELCSPLQTR-----------RA 679

  Fly   906 NFSAWL----TFDQHPIC------TLPREARLTFVLYGKQAASEGEPNADQNGERRQVTTELGWC 960
            :||.:|    .:||. ||      .||||..|...||.......|  ::.:..::::|...|||.
  Rat   680 HFSKYLFHLIIWDQQ-ICFPVQVNRLPRETLLCATLYALPIPPPG--SSSEANKQKRVPEALGWV 741

  Fly   961 SIQLFDFKRVMICGPYLLSLWPPMTDKMLGPAPARGCHPQPDFCPVLSIEVPPYGGRIEFPEHQE 1025
            :..||:|::|:.||..||.|||...:.......|...| ||| ..:|.|:.|.....|:|..
  Rat   742 TTPLFNFRQVLTCGRKLLGLWPATQENSSARWSAPNFH-QPD-SVILQIDFPTSAFDIKFTS--- 801

  Fly  1026 VP---KPAPHYDFASLDANLQEELLDTAE---LGYTGATERREVFWEKRLYLQSYPNALPKVLHA 1084
             |   |.:|.|:|.||....|.:|.|..:   |.:....::::: ||||.|..:..::||.||.:
  Rat   802 -PPGDKFSPRYEFGSLREEDQRKLKDITQKESLYWLSDADKKQL-WEKRYYCHTEVSSLPLVLAS 864

  Fly  1085 AHSWDYANLIDLHALLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQ 1149
            |.||::|.|.|::|||..|..::...:|.||...:||.:||..||:||..:.:.:|:|:||||||
  Rat   865 APSWEWACLPDIYALLQQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQ 929

  Fly  1150 SLKHDTYEGSAMARFLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRY 1214
            :||::.|..|.:.||||.:.:...|..|:.:|||..||.|                 ||.: :||
  Rat   930 ALKYECYLDSPLVRFLLKRAISDLRVTHYFFWLLKDSLKD-----------------SQFS-IRY 976

  Fly  1215 YRRNKMMLRALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLE 1279
                :.:|.||:..||:.:.:.|..|..:...|..:|:.|:||..|.||..|.||::||.|....
  Rat   977 ----QYLLAALLCCCGKGLREEFNRQCWLVNTLAKLAQQVREATPSARQGILRAGLEEVRQFFAL 1037

  Fly  1280 QPTC-LPLGPELEVTGVSVRNCSYFNSNTLPLKINF--VGPDAESLPAIFKCGDDLQQDQLTIQL 1341
            ..:| |||.|.|.|.|:..|:|||||||.:|||:.|  |.|..|::..||||||||:||.||:|:
  Rat  1038 NGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLAFQNVDPLGENIRVIFKCGDDLRQDMLTLQM 1102

  Fly  1342 IRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVECGLTGSFKDRPIAEWLGK 1406
            ||||:|:|:.|.||::||.|.|..||...||:|::..||||||||||.|:||||||||:|:||.|
  Rat  1103 IRIMSKIWVQEGLDMRMVIFRCFSTGRGKGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQK 1167

  Fly  1407 QNPSPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNF 1471
            .||...||:.||.||..||||..||||:|||||||||||||||:||:||||||:|||.||||||.
  Rat  1168 HNPGEDEYEKAVENFIYSCAGCCVATYILGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNI 1232

  Fly  1472 KRDRTPFVLTSDMAYVINGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNS 1536
            ||||.|||.|||||||||||||||:.||.||||||:|:|::||:..|.|:.|..|.:.|:|.::.
  Rat  1233 KRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIPELSD 1297

  Fly  1537 -NAVQYVRRALLPSQSNPEAAATFAKMIQSSLKSWFTQFNFFLHNLAQMRFTPDEGSGE--LLSF 1598
             ..::||..||.|..:...|...|.::|:|||.|..|:.|||:||||||:||   ||.:  .|||
  Rat  1298 LEDLKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNFFIHNLAQMKFT---GSDDRLTLSF 1359

  Fly  1599 VPRKYTMQQDGRLKIVKVVCFQKHYSMEKFYMYILEVTRHGQPDPTHLFRSYREFTEFHQKLCMH 1663
            .||.:|::..||::.|.:...:|.:...|.|:|:::|.|....:.|::.|::.||.|.|.||.:.
  Rat  1360 APRTHTLKSSGRIRDVFLCRHEKVFHPSKGYIYVVKVMRENAHEATYIQRTFEEFQELHNKLRLL 1424

  Fly  1664 FPLVKLHSLPAGVHVGRSNIKSVAEKRLPLIQRFLKSLFDASEEIAHSELVYTFFHPLLRDQQEA 1728
            ||...|.|.|:...:|||..::|||:|...:..::..|..|:.|:|..:|||||||||.||::.:
  Rat  1425 FPSSFLPSFPSRFVIGRSRGEAVAERRKEELNGYIWHLIHAAPEVAECDLVYTFFHPLPRDEKTS 1489

  Fly  1729 KLGMPKIKEVKQQPSRDNPHEIGQIRLSLQYQRGVLTVMIHHAKGLPMLQGGQEPNTYVKCYLKP 1793
            . ..|..|......:|......|:::||:.|:...|.:|:.|.:||..||.|.:|:.|||.||.|
  Rat  1490 G-PSPAPKSSDGTWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGLQPLQDGSDPDPYVKIYLLP 1553

  Fly  1794 DPKKETKRKTKVVRKTCVPSFMETLEY-RMPLNIIQERRLQVTVWSHDTLQENELLGGFDMDLSK 1857
            ||:|.|||||||.||||.|::.|.|.| .:|...:|:|.||::|.|.....||.|||...:.|.:
  Rat  1554 DPQKATKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVHIRLRE 1618

  Fly  1858 YDLRQELVDWYRLGA 1872
            .||.||...|:.||:
  Rat  1619 LDLAQEKTGWFALGS 1633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_524028.2	PHA03247	<56..294	CDD:223021	49/247 (20%)
		PI3K_rbd	561..669	CDD:197540	26/108 (24%)
		C2A_PI3K_class_II	844..1021	CDD:175979	48/188 (26%)
		PI3Ka_II	1038..1202	CDD:238441	59/166 (36%)
		PI3Kc_II	1235..1583	CDD:270710	200/351 (57%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794	38/109 (35%)
		C2B_PI3K_class_II	1751..1871	CDD:176027	55/120 (46%)
Pik3c2b	XP_063128143.1	None