Protein Alignment Pi3K68D and pik3

DIOPT Version :10

• Sequence 1: NP_524028.2
• Gene: Pi3K68D / 39329
• FlyBaseID: FBgn0015278
• Length: 1876
• Species: Drosophila melanogaster
• Sequence 2: NP_594699.1
• Gene: pik3 / 2543444
• PomBaseID: SPAC458.05
• Length: 801
• Species: Schizosaccharomyces pombe
• Alignment Length: 860
• Identity: 209/860 - (24%)
• Similarity: 357/860 - (41%)
• Gaps: 197/860 - (22%)

  Fly   821 VELYA-----NVFRVAFSVKTPDYSTTPIPISCVSKPIVVCISCLHRPLPNWKFDDYSLCVQIVY 880
            ::|::     ::.:..|..|.|:.|..|..:|.:|         .|..|      |:.:.|..:
pombe    38 IQLFSGNESGSLMQKCFVSKIPNKSLLPTELSKIS---------THEWL------DFGVTVSEL- 86

  Fly   881 GTRLLSKPNVLTCSNDTSGGLFPRLNFSAWL-TFDQHPI-----CTLPREARLTFVLYGKQAASE 939
                               .|..:...|||. :|:...:     ||       |:.|:
pombe    87 -------------------SLNAKFVVSAWKPSFNDEEVYEFVGCT-------TYRLF------- 118

  Fly   940 GEPNADQNGERR---QVTTEL---GWCSIQLFDFKRVMICGPYLLSLWPPMTDKMLGPAPA---- 994
            .|.|..:.|.::   |.:.|:   ...|::|...|.:......||.|       .||..|:
pombe   119 DENNLLRQGLQKIPLQTSKEIKKYSPTSLELEQVKEINRLDGLLLKL-------QLGDVPSVNWL 176

  Fly   995 -----------RGCHPQPDFCPVLSIEVPPYGGRIEFPEHQEVPKPAPHYDFASLDANLQEELLD 1048
                       |..|......|:|.::...:...:.| :....||......::|.|..|.   ||
pombe   177 DDISFGKIKDFRSKHMSLVTIPILYLDFLQFSFPVVF-QRSYYPKSENRVYYSSFDLELN---LD 237

  Fly  1049 T-AELGYTG------------------------------------ATERREVFWEKRLYLQSYPN 1076
            : |||.:..                                    :.|.:::.|:.|.||.....
pombe   238 SPAELKHRRLVRSQRNGPLDKDLKPNSKIRKELESILSYPPSEELSLEEKDLIWKFRFYLTRNKK 302

  Fly  1077 ALPKVLHAAHSWDYANLIDLHALLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLV 1141
            |:.|.|.:....|.:.:....:||.||..:....:||||.|.:...|||..||..:....|::|:
pombe   303 AMTKFLKSVVWTDSSEVNQALSLLDSWTEIDIDDALELLSPSFVHPKVRAYAVSRLETASNEELL 367

  Fly  1142 DFLPQLVQSLKHDT-------YEGSAMARFLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAM 1199
            .:|.||||:|::|.       ::.|.:|.||:::.:.||...:.:||.||..:.|:|.:.:.:::
pombe   368 LYLLQLVQALRYDNPISSDERFQPSPLALFLVNRAISSPSIGNDLYWYLVVEIEDEPVSKLFSSV 432

  Fly  1200 V---DQEYDESQVTQVRYYRRNKMMLRALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESM 1261
            :   .:|..:|                    :.|..:.:....|.:..:||..|::||:..:.:.
pombe   433 MFLFQKELSKS--------------------VEGRLIRETLSAQAKFVEKLLRISKSVQSFRGTR 477

  Fly  1262 RQK--SLAAGMDEVHQDLLE-QPTCLPLGPELEVTGVSVRNCSYFNSNTLPLKINFVGPDAESLP 1323
            .:|  .|...:::....||: ....|||.|.:.:.|:....|:.|.|...||::.|...|....|
pombe   478 LKKIEYLKVLLEDHKYHLLDFHALPLPLDPSVNIVGIIPDACTVFKSTMQPLRLLFKCQDGSKYP 542

  Fly  1324 AIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVE 1388
            .|||.||||:||||.||::.:|:|:...|:|||.:..:..:.||...|.::.| .::||..|..|
pombe   543 IIFKNGDDLRQDQLVIQILTLMDKLLKKEKLDLHLKPYRILATGPTHGAVQFV-PSKTLATILAE 606

  Fly  1389 CGLTGSFKDRPIAEWLGKQNP-----------SPLEYQSAVRNFTLSCAGYSVATYVLGICDRHN 1442
              ..||     :..:|.:.||           .|:    |:.|:..|||||.|.||:||:.|||.
pombe   607 --YHGS-----VLAYLRENNPDDGLNSANYGIDPV----AMDNYVRSCAGYCVITYLLGVGDRHL 660

  Fly  1443 DNIMLKTSGHLFHIDFGKFLG-DAQMFGNFKRDRTPFVLTSDMAYVINGGDKPSTDFHYFVDLCC 1506
            ||:::...||.||.|||..|| |.::|....:      |:.:|...:.|.:.|.  :..|...|.
pombe   661 DNLLITKDGHFFHADFGYILGRDPKLFSPAMK------LSKEMVEGMGGYNSPF--YQQFKSYCY 717

  Fly  1507 RAFNIVRKNADLLLHTLAHMATAGMPGV---NSNAVQYVRRALLPSQSNPEAAATFAKMIQSSLK 1568
            ..|..:||:::|:|:..:.|..|.:|.:   ....|..|:.......|..:|...|.::|..|:.
pombe   718 TTFTALRKSSNLILNLFSLMVDANIPDIKFDKEKVVYKVKERFCLQMSESDAIKYFEQLINDSVS 782

  Fly  1569 SWFTQFNFFLHNLAQ 1583
            :.|.|....:|||||
pombe   783 ALFPQIIDRMHNLAQ 797

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_524028.2	PHA03247	<56..294	CDD:223021
		PI3K_rbd	561..669	CDD:197540
		C2A_PI3K_class_II	844..1021	CDD:175979	33/203 (16%)
		PI3Ka_II	1038..1202	CDD:238441	51/210 (24%)
		PI3Kc_II	1235..1583	CDD:270710	110/365 (30%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
pik3	NP_594699.1	TEL1	<1..801	CDD:227365	209/860 (24%)
		PI3Kc_III	450..797	CDD:270628	110/366 (30%)