DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K68D and Pik3c2b

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_001092746.2	Gene:	Pik3c2b / 240752	MGIID:	2685045	Length:	1632	Species:	Mus musculus

Alignment Length:	1962	Identity:	626/1962 - (31%)
Similarity:	897/1962 - (45%)	Gaps:	428/1962 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SNQAHIDYDKQFQD------DLAKATALSLEQHALDDYRRNKKYGSGYQQSSTVAGRDYQAAQRS 60
            |.|.:.::.|..:.      :||.|.||.:|..||...|.:|
Mouse     3 STQGNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHHK----------------------- 44

  Fly    61 QSLHQPRRHSEVHQVAISPENAERSRTPPAQGTDNDLICFASPTSKQPESSSPFG-----KLIED 120
                                  |.||.  .|.|:..||.:..|.  ....|.|.|     ||:..
Mouse    45 ----------------------EESRA--KQNTEPSLISWDEPA--LDFYSKPAGRRTDLKLLRG 83

  Fly   121 LQRMQPT-NPQSALVPMGPVASASIPPQYGFPPHQQRPTAAQPTPYGMVAGGVVGGPAYGDLQLV 184
            |....|| |..|...|.|...|.|..||.|          ..|.|.|.::|.
Mouse    84 LSGSDPTLNYNSISPPEGLPNSTSQDPQPG----------PDPWPKGSLSGD------------- 125

  Fly   185 PYQPAAQQQRPLNSEELQRLYSMPAQMAVVPVPQPNAYMY-YPGAVVTPYTAPIVPGSAAFMPPQ 248
                                                 |:| :.|:          .|..:..|
Mouse   126 -------------------------------------YLYIFDGS----------EGRCSLSP-- 141

  Fly   249 YPAQGYGFGGAYTHMDLRRPQSQPAPQQT----APTTSHHHSQPSNHSTSSPAEANGVAFPARRQ 309
                    |...|....::....|.|.:.    ||........||....|.|.:.|  :|.:..|
Mouse   142 --------GSGDTDGSCKKLSPPPLPPRVSIWDAPPLPPRKGSPSPSKISQPNDIN--SFSSAEQ 196

  Fly   310 VPSTVGVSSSSHTG------NNGHS--SVPRRG-NDLIDLNHEDYSRVSVLEAFDPLLNDNTGND 365
            .|..:.|:.....|      ..||:  ||...| ||.|       :|:::...:|        ::
Mouse   197 PPDKLLVAQDPEEGELPDGRGQGHTLGSVDYDGINDAI-------TRLNLKSTYD--------SE 246

  Fly   366 TASDSTSYYAE-YDPFDFLYSGDAATQYSDPMYEAVNRWDKTVATVSPNVGLIGWRQDFLSQPST 429
            .:||:|..:.| ..|.||                                     .:|...:|..
Mouse   247 ISSDATRGWKEGRGPLDF-------------------------------------NKDTSGKPVA 274

  Fly   430 SSSQYGVAPPEESLKLAENGSGTISPPPPLPPRNQQCYESNQAAMPVSRPPQSSVLTDSYTSSIP 494
            .|.                     :.||.:|||.   |.|..|....:.|..:..::.:...|.|
Mouse   275 RSK---------------------TMPPQVPPRT---YTSRYANRKNATPGNNRRISAAPVGSRP 315

  Fly   495 ANVVLDRRKTCTRLYELISDQRTDDPELLEFYHMVKEVRARYPHDD-------------APTNVG 546
            ..|....     .|:| :|::|  |.|:..|.||:..:|......|             :|.::|
Mouse   316 HTVANGH-----ELFE-VSEER--DEEVAAFCHMLDILRTGSDIQDYSLTGCVWSTVTPSPEHLG 372

  Fly   547 HVVAAEFNYHYMMDTSIKVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDIDSVVAQVVAQ 611
            ..|                       .|:.|||..|:.:        |:||||:..|.|..::.|
Mouse   373 DEV-----------------------NLKVTVLCDSLRE--------PLTFTCNCSSTVDLLIHQ 406

  Fly   612 ALASLEGQVKGT-VTDYAVKPIGLLEWLAPTSRLSQLECVHNSFQLEKDVHLGLCLSTAANMQAI 675
            .|.....:::.. |.|:.:||.||.|:|.....|...|.:....:.:..:.|.| :...|....:
Mouse   407 TLCYTHDELREVDVGDFVLKPCGLEEFLQNKHALGSHEYIQYCRKFDISIRLQL-MEQKAIRSDL 470

  Fly   676 ARTERDDEHDADL-LPEHLLPNEVVPIVTYDNMMILIETLEMEIDKLESAADGVPGRSVVSCSGV 739
            |||..||:..:.| ...||....|...::...:.:|.:|...|:|....|....|    :....|
Mouse   471 ARTVNDDQSPSTLNYLIHLQERPVKQTISRQALSLLFDTYHNEVDAFLLADGDFP----LKADRV 531

  Fly   740 VQAVKAICALLGSIDTMEIARCVADLKRICEVEQKKYSTGASNPEIVSDYGDYAQVVLRPRSMLE 804
            ||:|||||..|.:::|.||...:..|.. |....:        |:|..|     ..||..|...|
Mouse   532 VQSVKAICNALAAVETPEITSALNQLPP-CPSRMQ--------PKIQKD-----PSVLSVRENRE 582

  Fly   805 QIKVKCNELRDAVQELVELYANVFRVAFSVKTPD---------------------YSTTPIPISC 848
            ::   ...|..|:.:|||||.:.|...|....|.                     |.|..|||.
Mouse   583 KV---VEALTAAILDLVELYCSTFNADFQTAVPGSRKHDLVQEACHFPGALAFTVYGTHRIPII- 643

  Fly   849 VSKPIVVCISCLHRPLPNW--KFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFSAWL 911
                              |  .::|:.|...:.:|.:.|..|....           |.:||.:|
Mouse   644 ------------------WATSYEDFYLSCSLSHGGKELCSPLQTR-----------RAHFSKYL 679

  Fly   912 ----TFDQHPIC------TLPREARLTFVLYGKQAASEGEPNADQNGERRQVTTELGWCSIQLFD 966
                .:||. ||      .||||..|...||.......|  .:.:..::::|...|||.:..||:
Mouse   680 FHLIIWDQQ-ICFPVQVNRLPRETLLCATLYALPVPPPG--GSSEANKQKRVPEALGWVTTPLFN 741

  Fly   967 FKRVMICGPYLLSLWPPMTDKMLGPAPARGCHP---QPDFCPVLSIEVPPYGGRIEFPEHQEVP- 1027
            |::|:.||..||.|||...:.    :.||...|   ||| ..:|.|:.|.....|:|..    |
Mouse   742 FRQVLTCGRKLLGLWPATQEN----SGARWSAPNFHQPD-SVILQIDFPSSAFDIKFTS----PP 797

  Fly  1028 --KPAPHYDFASLDANLQEELLDTAE---LGYTGATERREVFWEKRLYLQSYPNALPKVLHAAHS 1087
              |.:|.|:|.||....|.:|.|..:   |.:....::::: ||||.|..:..::||.||.:|.|
Mouse   798 GDKFSPRYEFGSLREEDQRKLKDITQKESLYWLTDADKKQL-WEKRYYCHTEVSSLPLVLASAPS 861

  Fly  1088 WDYANLIDLHALLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLK 1152
            |::|.|.|::|||..|..::...:|.||...:||.:||..||:||..:.:.:|:|:||||||:||
Mouse   862 WEWACLPDIYALLQQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALK 926

  Fly  1153 HDTYEGSAMARFLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRR 1217
            ::.|..|.:.||||.:.:...|..|:.:|||..||.|                 ||.: :||
Mouse   927 YECYLDSPLVRFLLKRAISDLRVTHYFFWLLKDSLKD-----------------SQFS-IRY--- 970

  Fly  1218 NKMMLRALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQPT 1282
             :.:|.||:..||:.:.:.|..|..:...|..:|:.|:||..|.||..|..|::||.|......:
Mouse   971 -QYLLAALLCCCGKGLREEFNRQCWLVNTLAKLAQQVREATPSARQGILRVGLEEVKQFFALNGS 1034

  Fly  1283 C-LPLGPELEVTGVSVRNCSYFNSNTLPLKINF--VGPDAESLPAIFKCGDDLQQDQLTIQLIRI 1344
            | |||.|.|.|.|:..|:|||||||.:|||:.|  |.|..|::..||||||||:||.||:|:|||
Mouse  1035 CRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLAFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRI 1099

  Fly  1345 MNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVECGLTGSFKDRPIAEWLGKQNP 1409
            |:|:|:.|.||::||.|.|..||...||:|::..||||||||||.|:||||||||:|:||.|.||
Mouse  1100 MSKIWVQEGLDMRMVIFRCFSTGRGKGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQKHNP 1164

  Fly  1410 SPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRD 1474
            ...||:.||.||..||||..||||:|||||||||||||||:||:||||||:|||.||||||.|||
Mouse  1165 GEDEYEKAVENFIYSCAGCCVATYILGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRD 1229

  Fly  1475 RTPFVLTSDMAYVINGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNS-NA 1538
            |.|||.|||||||||||||||:.||.||||||:|:|::||:..|.|:.|..|.:.|:|.::. ..
Mouse  1230 RAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLED 1294

  Fly  1539 VQYVRRALLPSQSNPEAAATFAKMIQSSLKSWFTQFNFFLHNLAQMRFTPDEGSGE--LLSFVPR 1601
            ::||..||.|..:...|...|.::|:|||.|..|:.|||:||||||:||   ||.:  .|||.||
Mouse  1295 LKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNFFIHNLAQMKFT---GSDDRLTLSFAPR 1356

  Fly  1602 KYTMQQDGRLKIVKVVCFQKHYSMEKFYMYILEVTRHGQPDPTHLFRSYREFTEFHQKLCMHFPL 1666
            .:|::..||::.|.:...:|.:...|.|:|:::|.|....:.|::.|::.||.|.|.||.:.||.
Mouse  1357 THTLKSSGRIRDVFLCRHEKIFHPSKGYVYVVKVMRENAHEATYIQRTFEEFQELHNKLRLLFPS 1421

  Fly  1667 VKLHSLPAGVHVGRSNIKSVAEKRLPLIQRFLKSLFDASEEIAHSELVYTFFHPLLRDQQEAKLG 1731
            ..|.|.|:...:|||..::|||:|...:..::..|..|:.|:|..:|||||||||.|| ::|...
Mouse  1422 SFLPSFPSRFVIGRSRGEAVAERRKEELNGYIWHLIHAAPEVAECDLVYTFFHPLPRD-EKASGP 1485

  Fly  1732 MPKIKEVKQQPSRDNPHEIGQIRLSLQYQRGVLTVMIHHAKGLPMLQGGQEPNTYVKCYLKPDPK 1796
            .|..|......:|......|:::||:.|:...|.:|:.|.:||..||.|.:|:.|||.||.|||:
Mouse  1486 SPAPKSSDGTWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGLQPLQDGNDPDPYVKIYLLPDPQ 1550

  Fly  1797 KETKRKTKVVRKTCVPSFMETLEY-RMPLNIIQERRLQVTVWSHDTLQENELLGGFDMDLSKYDL 1860
            |.|||||||.||||.|::.|.|.| .:|...:|:|.||::|.|.....||.|||...:.|.:.||
Mouse  1551 KTTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENLLLGEVHIRLRELDL 1615

  Fly  1861 RQELVDWYRLGA 1872
            .||...|:.||:
Mouse  1616 AQEKTGWFGLGS 1627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674	67/354 (19%)
		PI3K_rbd	561..669	CDD:197540	26/108 (24%)
		C2A_PI3K_class_II	844..1021	CDD:175979	50/191 (26%)
		PI3Ka_II	1038..1202	CDD:238441	59/166 (36%)
		PI3Kc_II	1235..1583	CDD:270710	199/351 (57%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794	38/109 (35%)
		C2B_PI3K_class_II	1751..1871	CDD:176027	55/120 (46%)
Pik3c2b	NP_001092746.2	PI3K_rbd	363..465	CDD:366310	29/133 (22%)
		C2A_PI3K_class_II	621..793	CDD:175979	52/209 (25%)
		PI3Ka_II	812..980	CDD:238441	65/190 (34%)
		PI3Kc_C2_beta	986..1339	CDD:119421	199/352 (57%)
		PX_PI3K_C2_beta	1368..1476	CDD:132823	38/107 (36%)
		C2B_PI3K_class_II	1504..1626	CDD:176027	55/121 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836288
Domainoid	1	1.000	309	1.000	Domainoid score	I1329
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	816	1.000	Inparanoid score	I474
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49277
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001789
OrthoInspector	1	1.000	-	-		otm42389
orthoMCL	1	0.900	-	-		OOG6_104124
Panther	1	1.100	-	-	O	PTHR10048
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3211
SonicParanoid	1	1.000	-	-		X2272
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790