DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K68D and Smg1

DIOPT Version :9

Sequence 1:NP_001163420.1 Gene:Pi3K68D / 39329 FlyBaseID:FBgn0015278 Length:1876 Species:Drosophila melanogaster
Sequence 2:NP_001026984.1 Gene:Smg1 / 233789 MGIID:1919742 Length:3658 Species:Mus musculus


Alignment Length:1816 Identity:357/1816 - (19%)
Similarity:569/1816 - (31%) Gaps:623/1816 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   314 VGVSSSSHTGNN--GHSSVPRRGNDLIDLNHEDYSR--------VSVLEAFDP--LLNDNTGNDT 366
            :.|.|||..|.|  ..:||.::.....:....:|..        ...:.:||.  |...|.|.::
Mouse  1090 IAVWSSSAVGKNLLWINSVAQQAEGRFEKASVEYQEHLCAMTGVDCCISSFDKSVLTLANAGRNS 1154

  Fly   367 ASDSTSYYAE-----------YDPFDFLYSGDAATQ--YSDPMYEAVNRWDKTVATVSPNVG--L 416
            ||...|...|           ..|....|.|:.|.:  .|...:.||..|...|..:..|..  .
Mouse  1155 ASPKHSLNGESRKTVLSKSIDSSPEVISYLGNKACECYISIADWAAVQEWQNAVHDLKKNSSSTS 1219

  Fly   417 IGWRQDFLSQPSTSSSQYG---------VAPPEESLKLAENGS-----------GTISPPPPLPP 461
            :..:.||....|.||.:.|         ...|.|::.|...||           ..:||.|....
Mouse  1220 LNLKADFNYIKSLSSFESGEFVECTEQLELLPGENINLLAGGSKEKIDMKKLLPNMLSPDPRELQ 1284

  Fly   462 RN---------------------QQCYES---------NQAAMPVSRPPQSSVLTDS-------- 488
            ::                     .|.::|         .|.:.....|.:.|.||.|        
Mouse  1285 KSIEVQLLRSSVFLATALNHMEQDQKWQSLTENVVKYLKQTSRIAIGPLRLSTLTVSQSLPVLST 1349

  Fly   489 ---YTSSIPANVVLDRRKTCTRLYELISDQRTDDPELLEFYHMVKEVRARYPHDDAPTNVGHVVA 550
               |.||...|.|.:|..|...|..|.||                .:|:...||..|    .:.|
Mouse  1350 LQLYCSSALENTVSNRLSTEDCLIPLFSD----------------ALRSCKQHDVRP----WMQA 1394

  Fly   551 AEFN-YHYMMDTSIKVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDIDSV------VAQV 608
            ..:. |...:...||....|..:.|....|.|:....:.....:..........|      .||.
Mouse  1395 LRYTMYQNQLLEKIKEQTVPIRSHLMELGLTAAKFARKRGNVSLATRLLAQCSEVQLGKTTTAQD 1459

  Fly   609 VAQALASL--EGQV-------------------------------------KGTVTDYAVKP--I 632
            :.|....|  :|||                                     |....:|||..  :
Mouse  1460 LVQHFKKLSTQGQVDEKWGPELDIEKTKLLYTAGQSTHAMEMLSSCAISFCKSAKAEYAVAKSIL 1524

  Fly   633 GLLEWL-APTSRLS-QLECVHNSFQLEKDVHLGLCLSTAANMQAIARTERDDEHDADLLPEHLLP 695
            .|.:|: |....:| ||..|:.:.|.:             |:..::...|               
Mouse  1525 TLAKWVQAEWKEISGQLRQVYRAQQQQ-------------NLSGLSTLSR--------------- 1561

  Fly   696 NEVVPIVTYDNMMILIE-----TLEMEIDKLESAAD---GVPGRSVVSCSGVVQAVKAICALLGS 752
                      |::.|||     |:..|..::||.:.   ||         |....:......|.|
Mouse  1562 ----------NILALIELPSANTVGEEHPRIESESTVHIGV---------GEPDFILGQLYHLSS 1607

  Fly   753 IDTMEIARCVADLKRICEVEQKKYSTGASN------------------PEIVSD------YGDYA 793
            :...|:|:..|.|........:|....||.                  |:.:::      ||...
Mouse  1608 VQAPEVAKSWAALASWAYRWGRKVVDNASQGEGVRLLPREKSEVQNLLPDTITEEEKERIYGILG 1672

  Fly   794 QVVLRPRSML-EQIKVKCNELRD-AVQELVELYANVFRVAFS----VKTPDYSTTPIPISCVSKP 852
            |.|.||..:. |.|.::..|..| ...::|::   ::|...|    :...|.:.|...|. |.:.
Mouse  1673 QAVCRPAGIQDEDITLQITESEDNEDDDMVDV---IWRQLISSCPWLSELDENATEGVIK-VWRK 1733

  Fly   853 IVVCISCLHRPLPNWKFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFS---AWLTFD 914
            :|..|           |..|.|.....:....|:...||...:|      |||:.|   ...|.|
Mouse  1734 VVDRI-----------FSLYKLSCSAYFTFLKLNAGQVLLDEDD------PRLHLSHRAEQSTDD 1781

  Fly   915 QHPICTLPREARLTFVLYGKQAASEGEPNADQNGERRQ-------VTTELGWCSI--QLFD---- 966
            ...:.||    ||..:|. |.|           ||.||       .|....|..|  |||.    
Mouse  1782 VIVMATL----RLLRLLV-KHA-----------GELRQYLEHGLETTPTAPWRGIIPQLFSRLNH 1830

  Fly   967 ---FKRVMIC---------GPYLLSLWPPM--TDKMLGPAPARGCHPQPDFCPVLSIEVPPYGGR 1017
               :.|..||         .|:|: |:|.:  |..:...:.|.|        ...|..:|...|.
Mouse  1831 PEVYVRQSICNLLCRVAQDSPHLI-LYPAIVGTISLSSESQASG--------NKYSSAIPTLLGN 1886

  Fly  1018 IEFPE--HQEVPKPAPHYDFASLDANLQEELLDTAELGYTGATERREVFWEKRLYLQSYPNALPK 1080
            |:..|  ..|....:|.   ||.|:|..|.        .:|..|.:.:..:              
Mouse  1887 IQGEELLVSECEGGSPP---ASQDSNKDEP--------KSGLNEDQAMMQD-------------- 1926

  Fly  1081 VLHAAHSWDYANLIDLHALLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLP 1145
                    .|:.::|   .|.|..|...|| :::|:     |::|...|.|      |:|  :|.
Mouse  1927 --------CYSKIVD---KLSSANPTMVLQ-VQMLV-----AELRRVTVLW------DEL--WLG 1966

  Fly  1146 QLVQSLKHDTYEGSAMARFLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVT 1210
            .|:|                           .|||.|               ..:.|..||.:  
Mouse  1967 VLLQ---------------------------QHMYVL---------------RRIQQLEDEVK-- 1987

  Fly  1211 QVRYYRRNKMMLRALMAICGEK--MLQR---FMYQH--------------------------RMC 1244
              |....|.:.....:||..||  .|.:   |..:|                          ...
Mouse  1988 --RVQNNNTLRKEEKIAIMREKHTALMKPIVFALEHVRSITAAPAETPHEKWFQDNYGDAIDNAL 2050

  Fly  1245 QKLTTIAESVKEA------KESM--------RQKSLAAGMDEVHQDLLEQPTCLPLGPELEVTG- 1294
            :||.|.:...|..      ||.|        ::.|....:||:...|...     ...|:.:.| 
Mouse  2051 EKLKTPSNPAKPGSSWIPFKEIMLSLQQRAQKRASYILRLDEISPWLAAM-----TNTEIALPGE 2110

  Fly  1295 VSVRNCSYFNS----------NTLPLKINFVGPDAESLPAIFKCGDDLQQDQLTIQLIRIMNKMW 1349
            ||.|:....:|          .|.|.|:.|:|.|.:|.|.:||..:||..|:..:|.:.|:|.|:
Mouse  2111 VSARDTVTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMF 2175

  Fly  1350 LA----ERLDLKMVTFNCVPTGYKSGMIELVSEAETL-----RKIQVECGLTG------------ 1393
            ..    |........::..|.|.:||:|:.|..|..|     |..|.|..|..            
Mouse  2176 ATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQAQKAQDSYQTPQN 2240

  Fly  1394 -SFKDRPIAEWLGKQNPS---------------PLEYQSAV------------------------ 1418
             |...||...:..|..|:               ||....||                        
Mouse  2241 PSIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTP 2305

  Fly  1419 -------RNFTLSCAGYSVATYVLGICDRHNDNIML-KTSGHLFHIDF------GKFLGDAQMFG 1469
                   :::..|.|..|:..|::|:.|||.||::: .|:|.:.|||:      ||.|.      
Mouse  2306 DEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLR------ 2364

  Fly  1470 NFKRDRTPFVLTSDM--AYVINGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMA----- 1527
              ..::.||.:|.::  |..:.|.:      ..|...|.:..:|:|:..:.||..|....     
Mouse  2365 --VPEKVPFRMTQNIETALGVTGVE------GVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPLV 2421

  Fly  1528 --TAGMPGVNSNAVQYVRRALLPSQSNPEAAATFAKMIQSSLKSWFTQFNFFLHNLAQMRFTPDE 1590
              |||.....:.||.        .....:|.   :|..:..::...|: :.|...:|:::....:
Mouse  2422 DWTAGGEAGFAGAVY--------GGGGQQAE---SKQSKREMEREITR-SLFSSRVAEIKVNWFK 2474

  Fly  1591 GSGELLSFVPRKYTMQQDGRLKIVKVVCFQKHYSMEKFYMYILEVTR-----HGQPDPTH-LFRS 1649
            ...|:|..:| |.....|..|.:.:.:.     .:||....:||...     .|...|:| |...
Mouse  2475 NRDEMLVVLP-KLDSSLDEYLSLQEQLT-----DVEKLQGKLLEEIEFLEGAEGVDHPSHTLQHR 2533

  Fly  1650 YREFTEF--HQKLCMHFPLVKLHSLPAGVHVGRSNIKSVAEKRLPLIQRFLKSLFDASEEIAHSE 1712
            |.|.|:.  .|:.......|||:.....:...::...::...:|..:.:.:.:..|....   |.
Mouse  2534 YSEHTQLQTQQRAVQEAIQVKLNEFEQWITHYQAAFNNLEATQLASLLQEISTQMDLGPP---SY 2595

  Fly  1713 LVYTFFHPLLRDQQEAKLGMPKIKEVKQQPSRDNPHEIGQIRLSLQYQRGVL---TVMIHH 1770
            :..|.|   |::..:|.|    |.:.:|..        |::...||.:|.||   ...:||
Mouse  2596 VPATAF---LQNAGQAHL----ISQCEQLE--------GEVGALLQQRRSVLRGCLEQLHH 2641

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K68DNP_001163420.1 EIN3 <58..392 CDD:296674 22/102 (22%)
PI3K_rbd 561..669 CDD:197540 26/156 (17%)
C2A_PI3K_class_II 844..1021 CDD:175979 48/206 (23%)
PI3Ka_II 1038..1202 CDD:238441 26/163 (16%)
PI3Kc_II 1235..1583 CDD:270710 97/485 (20%)
PX_PI3K_C2_68D 1611..1721 CDD:132794 21/117 (18%)
C2B_PI3K_class_II 1751..1871 CDD:176027 8/23 (35%)
Smg1NP_001026984.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..99
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..142
SMG1 629..1240 CDD:292413 34/149 (23%)
HEAT 1815..1850 8/34 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1896..1917 7/31 (23%)
PIKKc_SMG1 2119..2424 CDD:270714 70/318 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3565..3588
FATC 3628..3657 CDD:280430
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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