DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K68D and Pi4ka

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_001360884.1	Gene:	Pi4ka / 224020	MGIID:	2448506	Length:	2105	Species:	Mus musculus

Alignment Length:	1855	Identity:	367/1855 - (19%)
Similarity:	607/1855 - (32%)	Gaps:	604/1855 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 KYGSGYQQSSTVAGRDYQAA---QRSQSL--------HQPRRHSEVHQVAISPENAERSRTPPAQ 91
            ||.|.|.   ||||.|.:.:   :.|:|.        :||..:.::..:||
Mouse   526 KYHSQYH---TVAGSDIKISVTNEHSESTLNVLPGKKNQPSMYEQLRDIAI-------------- 573

  Fly    92 GTDNDLICFASPTSKQPESSSPF-GKLIEDLQRMQPTNPQSALVP------MGPVASASIPPQYG 149
              ||...|..:..:..|.....| ..|...|...|.::..:.|:|      :|.:|.|.
Mouse   574 --DNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIAVAL------ 630

  Fly   150 FPPHQQRPTAAQPTPYGMVAGGVVGGPAYGDLQLVPYQPAAQQQRPLNSEELQRLYSMPAQMAVV 214
                :..|...:|.                 ||:: .|...|...||:...:.:|..:
Mouse   631 ----RDTPKVMEPI-----------------LQIL-QQKFCQPPSPLDVLIIDQLGCL------- 666

  Fly   215 PVPQPNAYMYYPGAVVTPYTAPIVPGSAAFMPPQYPAQGYGFGGAYTHMDLRRPQSQPAPQQTAP 279
             |...|.|:|.  .|...:....|..|:.........:.:|    |.|..|....   |....|.
Mouse   667 -VITGNQYIYQ--EVWNLFQQISVKASSVVYSATKDYKDHG----YRHCSLAVIN---ALANIAA 721

  Fly   280 TTSHHHSQP---------------SNHSTSSPAEANGVAFPARRQVPSTVGVSSSSHTGNNG--- 326
            .....|...               .....|..|...|.|..|            ||..||.|
Mouse   722 NIQEEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKA------------SSSAGNLGVLI 774

  Fly   327 -------------HSSVPRRGNDLIDLNHEDYSRVSVLEAFDPLLNDNTGNDTASDSTSYYAEYD 378
                         ..:.||     :.....|:...|||..|            |.:.:..:.|
Mouse   775 PVIAVLTRRLPPIKEAKPR-----LQKLFRDFWLYSVLMGF------------AVEGSGLWPE-- 820

  Fly   379 PFDFLYSGDAATQYSDPMYEAVNRWDKTVATVSPNVGLIGWRQDFLSQPSTSSSQYGVA------ 437
                            ..||.|..    :||.||   |:.:..   .:|..|..||..|
Mouse   821 ----------------EWYEGVCE----IATKSP---LLTFPS---KEPLRSVLQYNSAMKNDTV 859

  Fly   438 PPEESLKLAENGSGTISPPPPL-------------------------------PPRNQQ--CYES 469
            .|.|..:|.......:.|||.:                               |.|.|.  ||..
Mouse   860 TPAELSELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLEYMRVLRSTDPDRFQVMFCYFE 924

  Fly   470 NQAAMPVSRPPQSSVLT------DSYTSSIPANVVLDRRKTCTRLYELISDQRTDDPELLEFYHM 528
            ::|...........|:.      |::     .|::.::.||.....||   :|.....|:.|.|:
Mouse   925 DKAIQKDKSGMMQCVIAVADKVFDAF-----LNMMAEKAKTKENEEEL---ERHAQFLLVNFNHI 981

  Fly   529 VKEVRA-----------RYPHDDAPTNVGHVVAAEFNYHYMMDTSIKVIVHPALNTLQSTVLAAS 582
            .|.:|.           ::||                 .....|.:|.:: ..|.|| |..|:|.
Mouse   982 HKRIRRVADKYLSGLVDKFPH-----------------LLWSGTVLKTML-DILQTL-SLSLSAD 1027

  Fly   583 MGKEQVKGYGMPVTFTCDIDSVVAQVVAQALASLEGQVKGTVTDYAVKPIGL-----LEWLAPT- 641
            :.|:| ..|.:|       |:.....|.....:.|..||    |:|.: .|:     ::| |||
Mouse  1028 IHKDQ-PYYDIP-------DAPYRITVPDTYEARESIVK----DFAAR-CGMILQEAMKW-APTV 1078

  Fly   642 --SRLSQLECVHNSFQLEKDVHLGLCLSTAA-------NMQ-----AIARTERD-------DEHD 685
              |.|.:....|.::......|.||.::|.:       |.|     |...|||.       ....
Mouse  1079 TKSHLQEYLNKHQNWVSGLSQHTGLAMATESILHFAGYNKQNTTLGATQLTERPACVKKDYSNFM 1143

  Fly   686 ADLLPEHLLPNEVVPIVTY--------DNMMILIETLEMEID----------------KLESAAD 726
            |.|...:....||..::.:        |...::::.|...:|                .|.|:.|
Mouse  1144 ASLNLRNRYAGEVHGMIRFSGATGQMSDLNKMMVQDLITALDHSHPQHYTQAMFKLTAMLISSKD 1208

  Fly   727 GVPG------------------RSVVSC--------SGV-VQAVKAICAL----------LGSID 754
            ..|.                  .:.::|        :|| |..::.:...          |.|::
Mouse  1209 CDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKNGVEVPFMREMAGAWHMTVEQKFGLFSVE 1273

  Fly   755 TME---IARCVADLKRICEVEQKKYSTGASNPEIVSDYGDYAQVVLRPRSMLEQIKVKCNELRDA 816
            |.|   :|...|...|.|.            ||:...|.....:|.|     .:|...|:
Mouse  1274 TKEADPLAASEASQPRPCP------------PEVTPHYIWIDFLVQR-----FEIAKYCS----- 1316

  Fly   817 VQELVELYANVFRVAFSVKT---------------PDYSTTPIPISCVSKPIV---VCISCLHRP 863
             .:.||:::::.:.:.|:..               |.:....:.:|.:...:|   ...:.|...
Mouse  1317 -SDQVEIFSSLLQRSMSLNIGGARGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREK 1380

  Fly   864 LPNWKFDDYS----------------LCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFSAWLT 912
            :.:..||.:|                :.:.|.:.|.:.|....||.|.     |.|..|...
Mouse  1381 IYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQ-----LVPPDNQDT--- 1437

  Fly   913 FDQHPICTLPREARLTFVLYGKQAASEGEPN-----------ADQNGERRQVTTELGWCSIQLFD 966
                       .:.|...:..:|.|::|..|           :.::|..::  |..| ..:..:.
Mouse  1438 -----------RSNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKK--TNRG-SQLHKYY 1488

  Fly   967 FKRVMICGPYLLSLWPPMTDKML---GPAPARGCHPQPDFCPVLSIE------VPPYGGR-IEFP 1021
            .||..:    ||||.....::::   .|..|          |.|.::      |..:..: |...
Mouse  1489 MKRRTL----LLSLLATEIERLITWYNPLSA----------PELELDQAGENSVANWRSKYISLS 1539

  Fly  1022 EHQEVPKP------APHYDFASLDANLQEELLDTAELGYTGATERREVFWEKRL---YLQSYPNA 1077
            |.|.....      :|:     |...|.....:|..:|       .||....||   .:...|.|
Mouse  1540 EKQWKDNVNLAWSISPY-----LAVQLPARFKNTEAIG-------NEVTRLVRLDPGAVSDVPEA 1592

  Fly  1078 LPKVLHAAHSWDYANLIDLHALLH--SWAPLSPLQSLELLLPRYPDAKV-REKAVEWISKMPNDQ 1139
            : |.|...|:.|    .|...|.|  .|||..|...|......||...: .:..|:.:...|.|.
Mouse  1593 I-KFLVTWHTID----ADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDA 1652

  Fly  1140 LVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESPRFAHHMYWLLVHS--LPDDPHN---SIGAAM 1199
            ::.::||:||:|::|  :...:..::|....:|...||...|.:..:  |.::.|.   .||..:
Mouse  1653 ILFYIPQIVQALRYD--KMGYVREYILWAAAKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLL 1715

  Fly  1200 VDQEYDESQVTQVR---------YYRRNKMMLRALMAICGEKMLQRFMYQHRMCQKLTTIAESVK 1255
                  |..|.::.         :|:|                      :.....|:|.::..:|
Mouse  1716 ------EQLVEEITGSLSGPAKDFYQR----------------------EFDFFNKITNVSAIIK 1752

  Fly  1256 E-AKESMRQKSLAAGMDEVHQDLLEQPTC-LPLGPELEVTGVSVRNCSYFNSNT-----LPLKIN 1313
            . .|...|:|:..:.:.||.    .||.| ||..||..|..:..::.:...|..     ...|:.
Mouse  1753 PYPKGDERKKACLSALSEVK----VQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVK 1813

  Fly  1314 FVG------------PDAES--------------LPAIFKCGDDLQQDQLTIQLIRIMNKMWLAE 1352
            ..|            .|||.              ..||||.|||.:||.|.:|:|.:...::...
Mouse  1814 RCGVSELEKEGLQCRSDAEDECFSQEADGKKICWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLV 1878

  Fly  1353 RLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVECGLTGSFKDRPIAEWLGKQ--NPSPLEYQ 1415
            .|||.:..:..|.|....|:||.:.:..:..::       |...|..:.::..:|  :.|.|.:|
Mouse  1879 GLDLFVFPYRVVATAPGCGVIECIPDCTSRDQL-------GRQTDFGMYDYFTRQYGDESTLAFQ 1936

  Fly  1416 SAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVL 1480
            .|..||..|.|.||:..::|.|.||||.||||...||:.||||| |:.::...||...:  |.:.
Mouse  1937 QARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFG-FMFESSPGGNLGWE--PDIK 1998

  Fly  1481 TSDMAYVINGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNSNAVQYVRRA 1545
            .:|...:|.||...:|.|.:|:::|.|.:..||...|.::..:..|...|:|......::.::..
Mouse  1999 LTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHR 2063

  Fly  1546 LLPSQSNPEAAATFAKMIQSSLKSWFTQFNFFLHN 1580
            ..|:.:..|||....|:||          |.||.|
Mouse  2064 FSPNMTEREAANFIMKVIQ----------NCFLSN 2088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674	61/379 (16%)
		PI3K_rbd	561..669	CDD:197540	30/115 (26%)
		C2A_PI3K_class_II	844..1021	CDD:175979	35/216 (16%)
		PI3Ka_II	1038..1202	CDD:238441	42/174 (24%)
		PI3Kc_II	1235..1583	CDD:270710	102/381 (27%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
Pi4ka	NP_001360884.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		PI4Ka	1550..1725	CDD:238443	45/199 (23%)
		PI4Kc_III_alpha	1786..2104	CDD:270711	87/323 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810