DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K68D and Pik3cd

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	XP_006538704.1	Gene:	Pik3cd / 18707	MGIID:	1098211	Length:	1074	Species:	Mus musculus

Alignment Length:	820	Identity:	244/820 - (29%)
Similarity:	391/820 - (47%)	Gaps:	115/820 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   834 VKTPDYSTTPIPISCVSKPIVVCISCLHRP-----LPNWKF---DDYSLCVQ--IVYGTRLL--- 885
            |:.|.....|||   ..||..|.:..|.:|     :...|.   :...|.||  :.:|..:|
Mouse   296 VQKPRAKPPPIP---AKKPSSVSLWSLEQPFSIELIEGRKVNADERMKLVVQAGLFHGNEMLCKT 357

  Fly   886 -SKPNVLTCSNDTSGGLFPRLNFSAW---LTFDQHPICTLPREARLTFVLY-----GKQAASEGE 941
             |...|..||.            ..|   |.|| ..:|.|||.|||.|.||     .|:|.|..:
Mouse   358 VSSSEVNVCSE------------PVWKQRLEFD-ISVCDLPRMARLCFALYAVVEKAKKARSTKK 409

  Fly   942 PNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLWPPMTD---KMLGPAPARGCHPQPDF 1003
                   :.::....:.|.::.|||:|..:..|...|.:||.:.|   ::|.||.....:|..:.
Mouse   410 -------KSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPAGTVRGNPNTES 467

  Fly  1004 CPVLSI---EVPPYGGRIEFPEHQEVPKPAPHYDFASLDANLQEELLDTAELGYTGA--TERREV 1063
            ...|.|   ||.|:  .:.||..:::.:...|.:...:....|.:|.:..|...:|.  ...:::
Mouse   468 AAALVIYLPEVAPH--PVYFPALEKILELGRHGERGRITEEEQLQLREILERRGSGELYEHEKDL 530

  Fly  1064 FWEKRLYLQS-YPNALPKVL-------H----------------------AAHSWDYANLIDLHA 1098
            .|:.|..:|. :|.||.::|       |                      .||.:....|..:..
Mouse   531 VWKMRHEVQEHFPEALARLLLVTKWNKHEDVAQVSREGGSGRQPRGRWTVPAHPYLTTKLSQMLY 595

  Fly  1099 LLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMAR 1163
            ||.||..|..|.:||||...:||..|...|::.:.|:.:|:|..:|.||||.||:::|....:.:
Mouse   596 LLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTK 660

  Fly  1164 FLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAI 1228
            |||.:.|.:.:..|.::|.| .|....|..::...::.:.|.......:      |::::...|:
Mouse   661 FLLGRALANRKIGHFLFWHL-RSEMHVPSVALRFGLIMEAYCRGSTHHM------KVLMKQGEAL 718

  Fly  1229 CGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQPTCLPLGPELEVT 1293
            ...|.|..|:   ::..:.||..::.:.....|||::....:..:..         ||.|...:.
Mouse   719 SKLKALNDFV---KVSSQKTTKPQTKEMMHMCMRQETYMEALSHLQS---------PLDPSTLLE 771

  Fly  1294 GV-SVRNCSYFNSNTLPLKINFVGPDAES---LPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERL 1354
            .| ||..|::.:|...||.|.:...:|.|   :..|||.||||:||.||:|:|::|:.:|..|.|
Mouse   772 EVCSVEQCTFMDSKMKPLWIMYSSEEAGSAGNVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGL 836

  Fly  1355 DLKMVTFNCVPTGYKSGMIELVSEAETLRKIQV---ECGLTGSFKDRPIAEWLGKQNPSPLEYQS 1416
            ||:|..:.|:|||.::|:||:|..::|:..||:   ....|.:|....:..||..:||.. ....
Mouse   837 DLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGE-ALDR 900

  Fly  1417 AVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLT 1481
            |:..||||||||.||||||||.|||:||||::.||.|||||||.|||:.:......|:|.||:||
Mouse   901 AIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILT 965

  Fly  1482 SDMAYVINGGDKPSTD-FHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVN-SNAVQYVRR 1544
            .|..:||..|...::: |..|...|.||:.|:|::..|.||..|.|..||:|.:: |..:||::.
Mouse   966 YDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKD 1030

  Fly  1545 ALLPSQSNPEAAATFAKMIQSSLK-SWFTQFNFFLHNLAQ 1583
            :|...::..||...|......:|: ||.|:.|:..||:::
Mouse  1031 SLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSK 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540
		C2A_PI3K_class_II	844..1021	CDD:175979	53/204 (26%)
		PI3Ka_II	1038..1202	CDD:238441	49/195 (25%)
		PI3Kc_II	1235..1583	CDD:270710	131/357 (37%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
Pik3cd	XP_006538704.1	PI3K_p85B	32..107	CDD:396665
		PI3K_rbd	182..281	CDD:395642
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	48/186 (26%)
		PI3Ka	504..713	CDD:214537	51/215 (24%)
		PI3Kc_IA_delta	705..1072	CDD:270718	135/385 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836290
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750