Protein Alignment Pi3K68D and Pik3cd

DIOPT Version :10

• Sequence 1: NP_524028.2
• Gene: Pi3K68D / 39329
• FlyBaseID: FBgn0015278
• Length: 1876
• Species: Drosophila melanogaster
• Sequence 2: XP_006538704.1
• Gene: Pik3cd / 18707
• MGIID: 1098211
• Length: 1074
• Species: Mus musculus
• Alignment Length: 820
• Identity: 244/820 - (29%)
• Similarity: 391/820 - (47%)
• Gaps: 115/820 - (14%)

  Fly   834 VKTPDYSTTPIPISCVSKPIVVCISCLHRP-----LPNWKF---DDYSLCVQ--IVYGTRLL--- 885
            |:.|.....|||   ..||..|.:..|.:|     :...|.   :...|.||  :.:|..:|
Mouse   296 VQKPRAKPPPIP---AKKPSSVSLWSLEQPFSIELIEGRKVNADERMKLVVQAGLFHGNEMLCKT 357

  Fly   886 -SKPNVLTCSNDTSGGLFPRLNFSAW---LTFDQHPICTLPREARLTFVLY-----GKQAASEGE 941
             |...|..||.            ..|   |.|| ..:|.|||.|||.|.||     .|:|.|..:
Mouse   358 VSSSEVNVCSE------------PVWKQRLEFD-ISVCDLPRMARLCFALYAVVEKAKKARSTKK 409

  Fly   942 PNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLWPPMTD---KMLGPAPARGCHPQPDF 1003
                   :.::....:.|.::.|||:|..:..|...|.:||.:.|   ::|.||.....:|..:.
Mouse   410 -------KSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPAGTVRGNPNTES 467

  Fly  1004 CPVLSI---EVPPYGGRIEFPEHQEVPKPAPHYDFASLDANLQEELLDTAELGYTGA--TERREV 1063
            ...|.|   ||.|:  .:.||..:::.:...|.:...:....|.:|.:..|...:|.  ...:::
Mouse   468 AAALVIYLPEVAPH--PVYFPALEKILELGRHGERGRITEEEQLQLREILERRGSGELYEHEKDL 530

  Fly  1064 FWEKRLYLQS-YPNALPKVL-------H----------------------AAHSWDYANLIDLHA 1098
            .|:.|..:|. :|.||.::|       |                      .||.:....|..:..
Mouse   531 VWKMRHEVQEHFPEALARLLLVTKWNKHEDVAQVSREGGSGRQPRGRWTVPAHPYLTTKLSQMLY 595

  Fly  1099 LLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMAR 1163
            ||.||..|..|.:||||...:||..|...|::.:.|:.:|:|..:|.||||.||:::|....:.:
Mouse   596 LLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTK 660

  Fly  1164 FLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAI 1228
            |||.:.|.:.:..|.::|.| .|....|..::...::.:.|.......:      |::::...|:
Mouse   661 FLLGRALANRKIGHFLFWHL-RSEMHVPSVALRFGLIMEAYCRGSTHHM------KVLMKQGEAL 718

  Fly  1229 CGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQPTCLPLGPELEVT 1293
            ...|.|..|:   ::..:.||..::.:.....|||::....:..:..         ||.|...:.
Mouse   719 SKLKALNDFV---KVSSQKTTKPQTKEMMHMCMRQETYMEALSHLQS---------PLDPSTLLE 771

  Fly  1294 GV-SVRNCSYFNSNTLPLKINFVGPDAES---LPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERL 1354
            .| ||..|::.:|...||.|.:...:|.|   :..|||.||||:||.||:|:|::|:.:|..|.|
Mouse   772 EVCSVEQCTFMDSKMKPLWIMYSSEEAGSAGNVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGL 836

  Fly  1355 DLKMVTFNCVPTGYKSGMIELVSEAETLRKIQV---ECGLTGSFKDRPIAEWLGKQNPSPLEYQS 1416
            ||:|..:.|:|||.::|:||:|..::|:..||:   ....|.:|....:..||..:||.. ....
Mouse   837 DLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGE-ALDR 900

  Fly  1417 AVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLT 1481
            |:..||||||||.||||||||.|||:||||::.||.|||||||.|||:.:......|:|.||:||
Mouse   901 AIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILT 965

  Fly  1482 SDMAYVINGGDKPSTD-FHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVN-SNAVQYVRR 1544
            .|..:||..|...::: |..|...|.||:.|:|::..|.||..|.|..||:|.:: |..:||::.
Mouse   966 YDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKD 1030

  Fly  1545 ALLPSQSNPEAAATFAKMIQSSLK-SWFTQFNFFLHNLAQ 1583
            :|...::..||...|......:|: ||.|:.|:..||:::
Mouse  1031 SLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSK 1070

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_524028.2	PHA03247	<56..294	CDD:223021
		PI3K_rbd	561..669	CDD:197540
		C2A_PI3K_class_II	844..1021	CDD:175979	53/204 (26%)
		PI3Ka_II	1038..1202	CDD:238441	49/195 (25%)
		PI3Kc_II	1235..1583	CDD:270710	131/357 (37%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
Pik3cd	XP_006538704.1	PI3K_p85B	34..107	CDD:460483
		PI3K_rbd	182..281	CDD:395642
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	48/186 (26%)
		PI3Ka	504..713	CDD:214537	51/215 (24%)
		PI3Kc_IA_delta	705..1072	CDD:270718	135/385 (35%)