DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K68D and Y75B8A.24

DIOPT Version :9

Sequence 1:	NP_001163420.1	Gene:	Pi3K68D / 39329	FlyBaseID:	FBgn0015278	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_499596.2	Gene:	Y75B8A.24 / 176653	WormBaseID:	WBGene00013557	Length:	2106	Species:	Caenorhabditis elegans

Alignment Length:	1495	Identity:	300/1495 - (20%)
Similarity:	530/1495 - (35%)	Gaps:	502/1495 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   419 WRQDFLSQPSTSSSQYGVAPPEESLK--LAENG---SGTISPPPPLPPRNQQCYE-SNQA-AMP- 475
            |.:::.:....::::..|....|:|:  |.:|.   |.:|||......||....| |:|| |:|
Worm   780 WPEEWYNAVCETATKTPVLIATENLRSELIDNAAIRSDSISPQELQEMRNTVLAELSHQAEAVPL 844

  Fly   476 --------------VSRPPQSSVL----TDSYTSSIPANVVLDR--RK------TC-----TRLY 509
                          |.|.....::    .|:::|..  ..:.|:  ||      ||     .|::
Worm   845 INRFDFANCTYLLSVHRMETMRLIHANHVDAFSSFF--KYIEDKTMRKDKSGLWTCMLAAAPRIF 907

  Fly   510 -----ELISDQRTDDPE-----------LLEFYHMVKEVRARYPHDDAPTNVGHVVAAEFNYHYM 558
                 :::..:..|:|.           |.:|.|.::|||     ..|...:..:|.| |.| .:
Worm   908 LEWCEKMMKRRDNDEPTEEALVWHAQFLLFKFNHHLREVR-----KVADACLSQLVKA-FPY-LL 965

  Fly   559 MDTSIKVIVHPALNTLQSTVLAASMGKE---QVKGYGMPVTFTCDIDSVVAQVVAQALASLEGQV 620
            .:|.:...:...|..|:..:......:|   .::|:|   .:|..:..           |:||:
Worm   966 WNTKVLTTILRLLQELEDNLQKDPTCREPQFTIEGFG---GWTIQLQD-----------SIEGR- 1015

  Fly   621 KGTVTDYA--VKPI--GLLEWLAPTSRLSQLECVHNSFQLEKDVHLGLCLSTAANMQAIARTERD 681
            :..|.|::  ||.|  ..|.| ||.|..|.|....:.|..|:|..:.|.:.        |.:|..
Worm  1016 RSVVKDFSMRVKQILKEALRW-APASTHSNLLEYVSKFGSERDAAMQLAID--------ATSEGS 1071

  Fly   682 DEHDADLLPEHLLPNEV--------------VPIVTYDNMMILIETLEMEIDK-LESAADGVPGR 731
            .:..:.|...:...|.:              :..||.:|.  ||:.||.:..: .:|..|....:
Worm  1072 GKSGSYLTSLYKRSNYLGQVKGMLATTLSGDIDQVTAENQ--LIDRLEKDFQRACKSGKDMEMEQ 1134

  Fly   732 SVVSCSGVVQAVKA----ICALL------------GSIDTM------------------EIARCV 762
            :|:..:.:..::::    |.:||            .|:.||                  |.||..
Worm  1135 AVLLLTALFVSLRSLNERILSLLVRTPLLNFTESTVSLCTMAWNWLLSARPEAHSLFLHEQARAF 1199

  Fly   763 ADLKRICEVEQKKYSTGASNPEIVSDYGDYAQVVLRP---------RSMLEQIKVKCNELRDAVQ 818
            ||..|        :..|....|:|.. ....|.:.||         |..:|.|..:|:....:.:
Worm  1200 ADSSR--------FGLGLFEKEVVGG-SPLCQKLERPPPSANFRPHREWIEFIGERCDVASYSSR 1255

  Fly   819 ELVELYANVFRVAFSV-------------------------KTPDYSTTPIPISCVSKPIVVCI- 857
            |.:::...:|....|.                         :|.:..|..|....|...::.|:
Worm  1256 EQLDVLEMMFSQTLSAHIGTGHLHGSTACSNPASLAGPSRKETINQVTRGIEAVGVRFRLLSCVL 1320

  Fly   858 ------SCLHRPLPNWKFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFSAWLTFDQH 916
                  :||.||                  |.:|.:..|.:|:            |..:....|.
Worm  1321 GMVQQDACLLRP------------------TNVLIRQRVYSCA------------FHYFTIAPQG 1355

  Fly   917 PICTLPRE-----ARLTFVLY----------GKQAASEGEPNADQNGERRQVTTELGWCSIQLFD 966
            |  |.|.|     .||....:          .|:|.::.:.|...:....|:.|.        |:
Worm  1356 P--TQPEERLREDIRLLTRFFEHLKNDKHYMQKEALAKTDKNLVMSSTMSQMQTN--------FE 1410

  Fly   967 FKRVMICG----------PYLLSLWPPMTD----------KMLGPAPA----------------- 994
             |.::|.|          |....:.||.|:          |.:....|
Worm  1411 -KSLLISGTPVTATAAGTPNTSLMLPPSTNYANTLTLSSQKSMAATSASIRSGKSIETKLSIEED 1474

  Fly   995 ----------------------------------------------RGCHPQP------------ 1001
                                                          ||...|.
Worm  1475 RRIKTWMKQRNMLMLLVANEIERLSAWLHPLALAQEDCALDSEEFLRGAFTQAKATGGEKNIWRE 1539

  Fly  1002 ------DFCPVLSIEVPP-YGGRIEFPEHQEV-----PKPAPHYDFASLDANLQEELLDTAELGY 1054
                  |..|.|:|::|. :.|..|..::.:|     |:|..|
Worm  1540 QAQLAWDISPELAIQLPSRFRGSPELVKYVDVLVRGQPEPVAH---------------------- 1582

  Fly  1055 TGATERREVFWEKRLYLQSYPNALPKVL-HAAHSWDYANLIDLHALLHSWAPLSPLQSLELLLPR 1118
                               .|.|||..| :.:..::.:::  .|.|  :||..||:.:|.||.||
Worm  1583 -------------------IPEALPLFLGNGSTVFETSDM--SHVL--TWARCSPVMALSLLTPR 1624

  Fly  1119 -YPDAKV-REKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESPRFAHHMYW 1181
             ||...: .:.||..:.....|:|:.::||:||::::||.  ..::..::.....|...:|.:.|
Worm  1625 IYPMHPISMQYAVRVLRSYSADELLLYIPQIVQAVRYDTM--GYISELIIWLAGHSQLLSHQLIW 1687

  Fly  1182 LLVHSLPDDPHNSIGAAMVDQEYDESQVTQ-VRYYRRNKMMLRALMAICGEKMLQRF-MYQHRMC 1244
            .:..::..|              :||:|.. |.:...|.:|.:.|..:  |...:|| ..:.::.
Worm  1688 NMQTNMFTD--------------EESKVKDPVLFEALNDIMQKILSQL--EGAARRFHEAEFKLF 1736

  Fly  1245 QKLTTIAESVKE-AKESMRQKSLAAGMDEVHQDLLEQPTCLPLGPELEVTGVSVRNCSYFNSNTL 1308
            .:||.|:.::|. .|...|:|:....:.:|.   :|..|.||..||..:..:.      ::|.|
Worm  1737 HQLTAISGTIKPFPKGDARKKACLKALADVK---IETITYLPSNPEAVLLDLD------YSSGT- 1791

  Fly  1309 PL--------------------KINFVGPDAES------------------------LPAIFKCG 1329
            |:                    ::..:|..|:|                        ..||||.|
Worm  1792 PMQSAAKAPFLARFRVKRCGVRELEHIGLQAQSEHGGKTTEADLEELKKVQDSRVCWQAAIFKVG 1856

  Fly  1330 DDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKI--QVECGLT 1392
            ||::||.|.:||:::|..:|....|.:::..:..|.|....|:||.|..:::..::  |.:.||.
Worm  1857 DDVRQDMLALQLMQLMKNVWAGLGLPVRVFPYRVVATSPGCGVIECVPNSKSRDQLGRQTDFGLY 1921

  Fly  1393 GSFKDRPIAEWLGKQNPSPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHID 1457
            ..||.:     .|.:  |...:|.|.|||..|.|.|||.:::|.|.||||.|||:...||:.|||
Worm  1922 EYFKTQ-----YGDE--SSETFQEARRNFVRSMAAYSVFSFLLQIKDRHNGNIMIDLDGHIIHID 1979

  Fly  1458 FGKFLGDAQMFGN--FKRDRTPFVLTSDMAYVINGGDKPSTDFHYFVDLCCRAFNIVRKNADLLL 1520
            || |:.::...||  |:.|   |.|:.:|. .|.||...:..|..|..||..|:..||......:
Worm  1980 FG-FMFESSPGGNLGFEPD---FKLSEEMV-AIMGGKMEAAPFRQFASLCVHAYLAVRPYHKSFV 2039

  Fly  1521 HTLAHMATAGMPGVNSNAVQYVRRALLPSQSNPEAAATFAKMIQS---SLKS-WFTQFNFFLHNL 1581
            ..::.|....:|......:..:|....|..:..:||.....:|.:   :::| .:.|..:|.:.:
Worm  2040 SLVSLMLDTHLPCFRGKTINQLRARFAPEMNEKDAAKYMYSVITNCFLNIRSKMYDQLQYFQNEI 2104

Fly 1582 1581
Worm 2105 2104

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K68D	NP_001163420.1	EIN3	<58..392	CDD:296674
		PI3K_rbd	561..669	CDD:197540	26/114 (23%)
		C2A_PI3K_class_II	844..1021	CDD:175979	44/300 (15%)
		PI3Ka_II	1038..1202	CDD:238441	32/166 (19%)
		PI3Kc_II	1235..1583	CDD:270710	104/401 (26%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027
Y75B8A.24	NP_499596.2	PI4Ka	1544..1720	CDD:238443	50/236 (21%)
Y75B8A.24	NP_499596.2	PI4Kc_III_alpha	1781..2105	CDD:270711	88/343 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810